Searching across hundreds of databases
Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of NPGL induced de novo lipogenesis in WAT, increased insulin, and it selectively induced carbohydrate intake. Neutralizing antibody administration decreased the size of lipid droplets in WAT. Npgl mRNA expression was upregulated by fasting and low insulin levels. Additionally, NPGL-producing cells were responsive to insulin. These results point to NPGL as a novel neuronal regulator that drives food intake and fat deposition through de novo lipogenesis and acts to maintain steady-state fat level in concert with insulin. Dysregulation of NPGL may be a root cause of obesity.
Pubmed ID: 28799896 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
A commercial antibody supplier and provider of various services.
View all literature mentionsCommercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsA commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.
View all literature mentionsThis polyclonal targets mouse and rat NPGL
View all literature mentionsThis polyclonal targets mouse and rat NPGL
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Guinea pig
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis unknown targets Digoxigenin
View all literature mentionsThis polyclonal targets α-Tubulin
View all literature mentionsThis polyclonal targets Phospho-HSL (Ser660)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets mouse and rat NPGL
View all literature mentionsThis polyclonal targets mouse and rat NPGL
View all literature mentionsThis polyclonal targets mouse and rat NPGL
View all literature mentionsThis polyclonal targets Phospho-HSL (Ser660)
View all literature mentionsThis polyclonal targets mouse and rat NPGL
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Guinea pig
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis unknown targets Digoxigenin
View all literature mentionsThis polyclonal targets α-Tubulin
View all literature mentionsThis unknown targets IgG
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
