Beige adipocytes can interconvert between white and brown-like states and switch between energy storage versus expenditure. Here we report that beige adipocyte plasticity is important for feeding-associated changes in energy expenditure and is coordinated by the hypothalamus and the phosphatase TCPTP. A fasting-induced and glucocorticoid-mediated induction of TCPTP, inhibited insulin signaling in AgRP/NPY neurons, repressed the browning of white fat and decreased energy expenditure. Conversely feeding reduced hypothalamic TCPTP, to increase AgRP/NPY neuronal insulin signaling, white adipose tissue browning and energy expenditure. The feeding-induced repression of hypothalamic TCPTP was defective in obesity. Mice lacking TCPTP in AgRP/NPY neurons were resistant to diet-induced obesity and had increased beige fat activity and energy expenditure. The deletion of hypothalamic TCPTP in obesity restored feeding-induced browning and increased energy expenditure to promote weight loss. Our studies define a hypothalamic switch that coordinates energy expenditure with feeding for the maintenance of energy balance.
Pubmed ID: 28768176 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This monoclonal targets Stat3
View all literature mentionsThis monoclonal targets Phospho-Stat3 (Tyr705)
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis polyclonal targets SOCS3
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets c-Fos (H-125)
View all literature mentionsThis unknown targets Phospho-IR/IGF1R (Tyr1162, Tyr1163)
View all literature mentionsThis polyclonal targets INSR
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets PTP1B
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis polyclonal targets Phospho-Stat3 (Tyr705) Antibody detects endogenous levels of Stat3 only when phosphorylated at Tyr705. The antibody does not cross-react with other Stat proteins when phosphorylated on the corresponding tyrosine residue. Does cross-react withPhospho-EGFR
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis polyclonal targets UCP1
View all literature mentionsMus musculus with name B6.Cg-Tg(Nes-cre)1Kln/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Pomc-EGFP)1Low/J from IMSR.
View all literature mentionsMus musculus with name B6.129S4(FVB)-Insrtm1Khn/J from IMSR.
View all literature mentionsMus musculus with name B6.FVB-Tg(Npy-hrGFP)1Lowl/J from IMSR.
View all literature mentionsMus musculus with name STOCK Agrptm1(cre)Lowl/J from IMSR.
View all literature mentionsThis monoclonal targets Stat3
View all literature mentions