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Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic (PSNS) and sympathetic nervous system (SNS), respectively. Central T3 promotes hepatic lipogenesis with parallel stimulation of the thermogenic program in BAT. The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Of note, ablation of AMPKα1 in steroidogenic factor 1 (SF1) neurons of the VMH fully recapitulated the effect of central T3, pointing to this population in mediating the effect of central THs on metabolism. Overall, these findings uncover the underlying pathways through which central T3 modulates peripheral metabolism.
Pubmed ID: 28683288 RIS Download
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A commercial antibody supplier and provider of various services.
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View all literature mentionsSoftware tool for viewing, analyzing, and registering volumetric medical imaging data sets. It has been written on top of GTK+ and runs on any system that supports this toolkit (Linux, Windows, Mac OS X, etc.). The program incorporates automatic non-orthogonal data reslicing, allowing multiple data set to be fused without imposed constraints on the dimensions, anisotrophy, or voxel sizes of the data. Additional features include 3D ROI (ellipses, cylinders, boxes, and isocontours), multi-slice viewing, volume rendering, and data importing through the (X)MedCon library.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for mass-spectrometry data processing, with the main focus on LC-MS data.
View all literature mentionsSoftware which can acquire, analyze, manage, and share mass spectrometry data. MassLynx controls any Waters mass spectrometry system, from sample and solvent management components to mass spectrometer and auxiliary detectors. The software can acquire nominal mass, exact mass, MS/MS and exact mass MS/MS data. The software system also maintains and consolidates all user sample data. Optional Application Manager programs provide additional information for specific MS analyses and data.
View all literature mentionsA software which acquires and processes data sets, primarily through the Xcalibur system.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsMus musculus with name STOCK Prkaa1tm1.1Sjm/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Nr5a1-cre)7Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.129S1-Mapk8tm1Flv/J from IMSR.
View all literature mentionsThis monoclonal targets Iba1 antibody [1022-5] - Microglial marker
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View all literature mentionsThis polyclonal targets Serine Palmitoyltransferase
View all literature mentionsThis monoclonal targets PKC epsilon antibody [EPR1482(2)]
View all literature mentionsThis polyclonal targets LIPE
View all literature mentionsThis polyclonal targets UCP1
View all literature mentionsThis polyclonal targets IRE1 (phospho S724)
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis monoclonal targets α-tubulin
View all literature mentionsThis polyclonal targets FOS
View all literature mentionsThis polyclonal targets CHUK, IKBKB
View all literature mentionsThis polyclonal targets RELA
View all literature mentionsThis monoclonal targets PKC delta
View all literature mentionsThis polyclonal targets MAPK8, MAPK10
View all literature mentionsThis polyclonal targets EIF2AK3
View all literature mentionsThis polyclonal targets DDIT3
View all literature mentionsThis monoclonal targets Fatty Acid Synthase
View all literature mentionsThis polyclonal targets Phospho-Stat3 (Ser727)
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
View all literature mentionsThis polyclonal targets Phospho-HSL (Ser660)
View all literature mentionsThis monoclonal targets SAPK / JNK, phospho (Thr183 / Tyr185)
View all literature mentionsThis polyclonal targets Phospho-Acetyl-CoA Carboxylase (Ser79)
View all literature mentionsThis monoclonal targets PERK (C33E10) Rabbit mAb
View all literature mentionsThis recombinant monoclonal targets IRE1-alpha
View all literature mentionsThis polyclonal targets AMP-Activated Protein Kinase (AMPK) alpha 2
View all literature mentionsThis polyclonal targets AMP-Activated Protein Kinase (AMPK) alpha 1
View all literature mentionsThis monoclonal targets Acetyl CoA Carboxylase 1 Rabbit mAb
View all literature mentionsThis polyclonal targets ATF6
View all literature mentionsThis polyclonal targets ATF6
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