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All viruses with positive-sense RNA genomes replicate on membranous structures in the cytoplasm called replication complexes (RCs). RCs provide an advantageous microenvironment for viral replication, but it is unknown how the host immune system counteracts these structures. Here we show that interferon-gamma (IFNG) disrupts the RC of murine norovirus (MNV) via evolutionarily conserved autophagy proteins and the induction of IFN-inducible GTPases, which are known to destroy the membrane of vacuoles containing bacteria, protists, or fungi. The MNV RC was marked by the microtubule-associated-protein-1-light-chain-3 (LC3) conjugation system of autophagy and then targeted by immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs) upon their induction by IFNG. Further, the LC3 conjugation system and the IFN-inducible GTPases were necessary to inhibit MNV replication in mice and human cells. These data suggest that viral RCs can be marked and antagonized by a universal immune defense mechanism targeting diverse pathogens replicating in cytosolic membrane structures.
Pubmed ID: 28669671 RIS Download
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A commercial graphing software company that offers scientific software for statistical analyses, curve fitting and data analysis. It offers four programs: Prism, InStat, StatMate and QuickCalcs.
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View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
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View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsThis unknown targets LC3B
View all literature mentionsThis monoclonal targets Atg3 (3E8)
View all literature mentionsThis polyclonal targets p62/SQSTM1 antibody produced in rabbit
View all literature mentionsThis monoclonal targets GBP1-5 (G-12)
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal targets FLAG
View all literature mentionsThis monoclonal targets LC3A (D50G8) XP Rabbit mAb
View all literature mentionsThis monoclonal targets β-Actin
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View all literature mentionsThis monoclonal targets GABARAP antibody [EPR4805]
View all literature mentionsThis polyclonal targets Anxa3
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets IRGM antibody
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets Guinea pig
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsThis unknown targets ATG7
View all literature mentionsThis unknown targets Atg16L
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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