The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation.
Pubmed ID: 28186488 RIS Download
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View all literature mentionsThis unknown targets Mouse IgG1 kappa Isotype Control FITC Clone MOPC-21
View all literature mentionsThis monoclonal targets CD107a (LAMP-1)
View all literature mentionsThis unknown targets Goat Mouse IgG (H L)-HRP Conjugate
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Actin
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View all literature mentionsThis unknown targets Murine IgG Control
View all literature mentionsThis unknown targets mouse-IgG-control
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View all literature mentionsThis monoclonal targets B7-H6 (NCR3LG1)
View all literature mentionsThis monoclonal targets MICB
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View all literature mentionsThis monoclonal targets CAR
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View all literature mentionsThis monoclonal targets EphA2
View all literature mentionsThis monoclonal targets CD166
View all literature mentionsBioinformatics resource system including web server and web service for functional annotation and enrichment analyses of gene lists. Consists of comprehensive knowledgebase and set of functional analysis tools. Includes gene centered database integrating heterogeneous gene annotation resources to facilitate high throughput gene functional analysis.
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
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