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The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its 'phosphorylated' and 'dephosphorylated' states. However, the functional outcome of PS1 phosphorylation and its significance for Alzheimer's disease (AD) pathogenesis is poorly understood. Here, comprehensive analysis using FRET-based imaging reveals that activity-driven and Protein Kinase A-mediated PS1 phosphorylation at three domains (domain 1: T74, domain 2: S310 and S313, domain 3: S365, S366, and S367), with S367 being critical, is responsible for the PS1 pathogenic 'closed' conformation, and resulting increase in the Aβ42/40 ratio. Moreover, we have established novel imaging assays for monitoring PS1 conformation in vivo, and report that PS1 phosphorylation induces the pathogenic conformational shift in the living mouse brain. These phosphorylation sites represent potential new targets for AD treatment.
Pubmed ID: 28132667 RIS Download
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A commercial antibody supplier and provider of various services.
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View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsThe Alzheimer's and Dementia Resource Center (ADRC) facilitates tissue donations for the Brain Bank Research Program in order to help find better treatments, more diagnostic tools and a cure for Alzheimer's disease and dementia. The Brain Bank Program is administered by Mount Sinai Medical Center in Miami Beach and under contract with the Florida Department of Elder Affairs. ADRC also provides caregivers with the educational resources, spiritual comfort and emotional support. The ADRC facilitates training for professional caregivers that meets requirements for the Florida Department of Elder Affairs.
View all literature mentionsCommercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsCommercial organism provider selling mice, rats and other model animals. American corporation specializing in a variety of pre-clinical and clinical laboratory services for the pharmaceutical, medical device and biotechnology industries. It also supplies assorted biomedical products and research and development outsourcing services for use in the pharmaceutical industry. (Wikipedia)
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets Presenilin 1
View all literature mentionsThis unknown targets normal rabbit IgG
View all literature mentionsThis unknown targets mouse-IgG-control
View all literature mentionsThis polyclonal targets phospho-CREB (Ser133)
View all literature mentionsThis monoclonal targets CREB
View all literature mentionsThis polyclonal targets Phosphoserine
View all literature mentionsThis monoclonal targets Presenilin-1, Loop
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal targets Presenilin-1 (S182) antibody produced in rabbit
View all literature mentionsThis monoclonal targets Phosphoserine antibody [PSR-45]
View all literature mentionsThis monoclonal targets PSEN1
View all literature mentionsThis monoclonal targets Presenilin 1 antibody [EP2000Y]
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsThis unknown targets mouse-IgG-control
View all literature mentionsThis monoclonal targets CREB
View all literature mentionsThis polyclonal targets phospho-CREB (Ser133)
View all literature mentionsThis polyclonal targets Phosphoserine
View all literature mentionsThis monoclonal targets Presenilin-1, Loop
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal targets Presenilin-1 (S182) antibody produced in rabbit
View all literature mentionsThis monoclonal targets Phosphoserine antibody [PSR-45]
View all literature mentionsThis monoclonal targets PSEN1
View all literature mentionsThis monoclonal targets Presenilin 1 antibody [EP2000Y]
View all literature mentionsThis monoclonal targets Presenilin 1
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