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Prenatal viral infection has been identified as a potential risk factor for the development of neurodevelopmental disorders such as schizophrenia and autism. Additionally, dysfunction in gamma-aminobutyric acid, Reelin, and fragile X mental retardation protein (FMRP)-metabotropic glutamate receptor 5 signaling systems has also been demonstrated in these two disorders. In the current report, we have characterized the developmental profiles of selected markers for these systems in cerebella of mice born to pregnant mice infected with human influenza (H1N1) virus on embryonic day 16 or sham-infected controls using SDS-PAGE and Western blotting techniques and evaluated the presence of abnormalities in the above-mentioned markers during brain development. The cerebellum was selected in light of emerging evidence that it plays roles in learning, memory, and emotional processing-all of which are disrupted in autism and schizophrenia. We identified unique patterns of gene and protein expression at birth (postnatal day 0 [P0]), childhood (P14), adolescence (P35), and young adulthood (P56) in both exposed and control mouse progeny. We also identified significant differences in protein expression for FMRP, very-low-density lipoprotein receptor, and glutamic acid decarboxylase 65 and 67 kDa proteins at specific postnatal time points in cerebella of the offspring of exposed mice. Our results provide evidence of disrupted FMRP, glutamatergic, and Reelin signaling in the exposed mouse offspring that explains the multiple brain abnormalities observed in this animal model. © 2016 Wiley Periodicals, Inc.
Pubmed ID: 27735078 RIS Download
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This polyclonal targets Glutamate Decarboxylase 65 & 67
View all literature mentionsThis unknown targets GABRA2
View all literature mentionsThis polyclonal targets GABA A Receptor alpha 1
View all literature mentionsThis polyclonal targets GABA A Receptor alpha 5
View all literature mentionsThis monoclonal targets GABA A Receptor beta 23 Chain extracellular domain of the beta2 & beta3 subunits of the GABA A receptor clone BD17
View all literature mentionsThis monoclonal targets GABA A Receptor beta 3 antibody [S87-25]
View all literature mentionsThis polyclonal targets GABA A Receptor delta antibody
View all literature mentionsThis monoclonal targets NUFIP2
View all literature mentionsThis polyclonal targets Metabotropic Glutamate Receptor 5
View all literature mentionsThis monoclonal targets Reelin, aa164-189 mreelin
View all literature mentionsThis monoclonal targets VLDL-R clone 6A6
View all literature mentionsThis monoclonal targets Rac1
View all literature mentionsThis monoclonal targets HOMER1 monoclonal antibody clone AT1F3
View all literature mentionsThis monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH
View all literature mentionsThis monoclonal targets ENO2
View all literature mentionsThis polyclonal targets Rabbit IgG (whole molecule)-Peroxidase antibody produced in goat
View all literature mentionsThis polyclonal targets Mouse IgG (whole molecule)-Peroxidase antibody produced in rabbit
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