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Publication

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.

BMC biology | 2016

After viral infection and the stimulation of some pattern-recognition receptors, TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans-autophosphorylation. While the activated TBK1 induces type I interferon production by phosphorylating the transcription factor IRF3, the precise molecular mechanisms underlying TBK1 activation remain unclear.

Pubmed ID: 27538435 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

Antibodies used in this publication

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

View all literature mentions

HEK293T (tool)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

HeLa (tool)

RRID:CVCL_0030

Cell line HeLa is a Cancer cell line with a species of origin Homo sapiens

View all literature mentions

Optineurin antibody (antibody)

RRID:AB_447598

This polyclonal targets Optineurin

View all literature mentions

Phospho-I-kappa-B-alpha (Ser32/36) (5A5) Mouse monoclonal Antibody (antibody)

RRID:AB_2267145

This monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)

View all literature mentions

Mouse Anti-EEA1 Monoclonal Antibody, Unconjugated, Clone 14 (antibody)

RRID:AB_397829

This monoclonal targets EEA1

View all literature mentions

Mouse Anti-Giantin Monoclonal Antibody, Unconjugated, Clone 9B6 (antibody)

RRID:AB_880195

This monoclonal targets Giantin

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

NAK (phospho S172) antibody [EPR2867(2)] (antibody)

RRID:AB_10862438

This monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]

View all literature mentions

Optineurin (C-Term) Polyclonal Antibody (antibody)

RRID:AB_10078198

This polyclonal targets Optineurin (C-Term)

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

Anti-GFP (antibody)

RRID:AB_390913

This monoclonal targets GFP

View all literature mentions

Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody (antibody)

RRID:AB_10693472

This monoclonal targets Phospho-TBK1/NAK (Ser172)

View all literature mentions

IRF-3 (D83B9) Rabbit mAb (antibody)

RRID:AB_1904036

This monoclonal targets IRF-3

View all literature mentions

Tom40 (H-300) (antibody)

RRID:AB_793274

This polyclonal targets TOMM40

View all literature mentions

Mouse Anti-LC3 Monoclonal Antibody, Unconjugated, Clone 4E12 (antibody)

RRID:AB_1279144

This monoclonal targets LC3

View all literature mentions

IRF3 (phospho S386) antibody [EPR2346] (antibody)

RRID:AB_1523836

This monoclonal targets Human IRF3 (phospho S386)

View all literature mentions

Rabbit Anti-Pericentrin Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_304461

This polyclonal targets Pericentrin

View all literature mentions

Pericentrin (antibody)

RRID:AB_399295

This monoclonal targets Pericentrin

View all literature mentions

SINTBAD (D1A5) Rabbit mAb (antibody)

RRID:AB_10839270

This monoclonal targets SINTBAD (D1A5) Rabbit mAb

View all literature mentions

Rabbit Anti-Giantin - Golgi Marker Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_448163

This polyclonal targets Giantin - Golgi Marker

View all literature mentions

AZI2 antibody (antibody)

RRID:AB_1140792

This polyclonal targets AZI2 antibody

View all literature mentions

Mouse Anti-Ubiquitin Monoclonal Antibody, Unconjugated, Clone FK2 (antibody)

RRID:AB_2043482

This monoclonal targets Ubiquitin

View all literature mentions

Cytochrome c (antibody)

RRID:AB_396416

This monoclonal targets Cytochrome c

View all literature mentions

IRF3-human (antibody)

RRID:AB_2264929

This polyclonal targets IRF3

View all literature mentions

IKK Monoclonal Antibody (Clone 72B587) (antibody)

RRID:AB_10679144

This monoclonal targets IKK (Clone 72B587)

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb (antibody)

RRID:AB_331768

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb

View all literature mentions

p44/42 MAPK (Erk1/2) Antibody (antibody)

RRID:AB_330744

This polyclonal targets p44/42 MAPK (Erk1/2)

View all literature mentions

Mouse Anti-IKK gamma Monoclonal Antibody, Unconjugated, Clone 54 (antibody)

RRID:AB_398832

This monoclonal targets IKK gamma

View all literature mentions

Monoclonal Anti-Actin antibody produced in mouse (antibody)

RRID:AB_262137

This monoclonal targets Actin antibody produced in mouse

View all literature mentions

Mouse Anti-Ubiquitin, Lys63-Specific Monoclonal antibody, Unconjugated, Clone hwa4c4 (antibody)

RRID:AB_1587585

This monoclonal targets Ubiquitin, Lys63-Specific

View all literature mentions

Anti-Glutathione S-transferase (antibody)

RRID:AB_395536

This monoclonal targets Glutathione S-transferase

View all literature mentions

Anti-VDAC (antibody)

RRID:AB_10806766

This polyclonal targets VDAC

View all literature mentions

Syntaxin 6 (C34B2) Rabbit mAb (antibody)

RRID:AB_2196500

This monoclonal targets Syntaxin 6 (C34B2) Rabbit mAb

View all literature mentions

Mouse Anti-Human LAMP-2 (H4B4) Monoclonal, Unconjugated, Clone H4b4 (antibody)

RRID:AB_626858

This monoclonal targets Human LAMP2

View all literature mentions

Kinectin 1 (H-190) (antibody)

RRID:AB_2133047

This polyclonal targets KTN1

View all literature mentions

Rabbit Anti-GAPDH Antibody, Unconjugated (antibody)

RRID:AB_796208

This unknown targets GAPDH

View all literature mentions

TRIF Antibody (antibody)

RRID:AB_2256555

This unknown targets Human TRIF

View all literature mentions

Rabbit Anti-Human HA Antibody, Unconjugated (antibody)

RRID:AB_260070

This unknown targets HA

View all literature mentions

Cardif (human), mAb (Adri-1) (antibody)

RRID:AB_10539976

This monoclonal targets Cardif (human) mAb (Adri-1)

View all literature mentions

TRAF3 (H-122) (antibody)

RRID:AB_2209427

This polyclonal targets TRAF3

View all literature mentions

Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb (antibody)

RRID:AB_823547

This monoclonal targets Phospho-IRF-3 (Ser396)

View all literature mentions

Mouse Anti-GM130 Monoclonal Antibody, Unconjugated, Clone 35 (antibody)

RRID:AB_398141

This monoclonal targets GM130

View all literature mentions

GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions

IRF3 (phospho S386) antibody [EPR2346] (antibody)

RRID:AB_1523836

This monoclonal targets Human IRF3 (phospho S386)

View all literature mentions

GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions

Rabbit Anti-Pericentrin Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_304461

This polyclonal targets Pericentrin

View all literature mentions

Rabbit Anti-Giantin - Golgi Marker Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_448163

This polyclonal targets Giantin - Golgi Marker

View all literature mentions

Pericentrin (antibody)

RRID:AB_399295

This monoclonal targets Pericentrin

View all literature mentions

AZI2 antibody (antibody)

RRID:AB_1140792

This polyclonal targets AZI2 antibody

View all literature mentions

SINTBAD (D1A5) Rabbit mAb (antibody)

RRID:AB_10839270

This monoclonal targets SINTBAD (D1A5) Rabbit mAb

View all literature mentions

Mouse Anti-Ubiquitin Monoclonal Antibody, Unconjugated, Clone FK2 (antibody)

RRID:AB_2043482

This monoclonal targets Ubiquitin

View all literature mentions

Cytochrome c (antibody)

RRID:AB_396416

This monoclonal targets Cytochrome c

View all literature mentions

IRF3-human (antibody)

RRID:AB_2264929

This polyclonal targets IRF3

View all literature mentions

IKK Monoclonal Antibody (Clone 72B587) (antibody)

RRID:AB_10679144

This monoclonal targets IKK (Clone 72B587)

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb (antibody)

RRID:AB_331768

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb

View all literature mentions

p44/42 MAPK (Erk1/2) Antibody (antibody)

RRID:AB_330744

This polyclonal targets p44/42 MAPK (Erk1/2)

View all literature mentions

Mouse Anti-IKK gamma Monoclonal Antibody, Unconjugated, Clone 54 (antibody)

RRID:AB_398832

This monoclonal targets IKK gamma

View all literature mentions

Monoclonal Anti-Actin antibody produced in mouse (antibody)

RRID:AB_262137

This monoclonal targets Actin antibody produced in mouse

View all literature mentions

Mouse Anti-Ubiquitin, Lys63-Specific Monoclonal antibody, Unconjugated, Clone hwa4c4 (antibody)

RRID:AB_1587585

This monoclonal targets Ubiquitin, Lys63-Specific

View all literature mentions

Anti-Glutathione S-transferase (antibody)

RRID:AB_395536

This monoclonal targets Glutathione S-transferase

View all literature mentions

Syntaxin 6 (C34B2) Rabbit mAb (antibody)

RRID:AB_2196500

This monoclonal targets Syntaxin 6 (C34B2) Rabbit mAb

View all literature mentions

Anti-VDAC (antibody)

RRID:AB_10806766

This polyclonal targets VDAC

View all literature mentions

Kinectin 1 (H-190) (antibody)

RRID:AB_2133047

This polyclonal targets KTN1

View all literature mentions

Mouse Anti-Human LAMP-2 (H4B4) Monoclonal, Unconjugated, Clone H4b4 (antibody)

RRID:AB_626858

This monoclonal targets Human LAMP2

View all literature mentions

Rabbit Anti-GAPDH Antibody, Unconjugated (antibody)

RRID:AB_796208

This unknown targets GAPDH

View all literature mentions

TRIF Antibody (antibody)

RRID:AB_2256555

This unknown targets Human TRIF

View all literature mentions

Rabbit Anti-Human HA Antibody, Unconjugated (antibody)

RRID:AB_260070

This unknown targets HA

View all literature mentions

TRAF3 (H-122) (antibody)

RRID:AB_2209427

This polyclonal targets TRAF3

View all literature mentions

Cardif (human), mAb (Adri-1) (antibody)

RRID:AB_10539976

This monoclonal targets Cardif (human) mAb (Adri-1)

View all literature mentions

Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb (antibody)

RRID:AB_823547

This monoclonal targets Phospho-IRF-3 (Ser396)

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

Optineurin (C-Term) Polyclonal Antibody (antibody)

RRID:AB_10078198

This polyclonal targets Optineurin (C-Term)

View all literature mentions

IRF-3 (D83B9) Rabbit mAb (antibody)

RRID:AB_1904036

This monoclonal targets IRF-3

View all literature mentions

Optineurin antibody (antibody)

RRID:AB_447598

This polyclonal targets Optineurin

View all literature mentions

Mouse Anti-Giantin Monoclonal Antibody, Unconjugated, Clone 9B6 (antibody)

RRID:AB_880195

This monoclonal targets Giantin

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

Mouse Anti-EEA1 Monoclonal Antibody, Unconjugated, Clone 14 (antibody)

RRID:AB_397829

This monoclonal targets EEA1

View all literature mentions

Mouse Anti-GM130 Monoclonal Antibody, Unconjugated, Clone 35 (antibody)

RRID:AB_398141

This monoclonal targets GM130

View all literature mentions

Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody (antibody)

RRID:AB_10693472

This monoclonal targets Phospho-TBK1/NAK (Ser172)

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

NAK (phospho S172) antibody [EPR2867(2)] (antibody)

RRID:AB_10862438

This monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

Mouse Anti-Giantin Monoclonal Antibody, Unconjugated, Clone 9B6 (antibody)

RRID:AB_880195

This monoclonal targets Giantin

View all literature mentions

Optineurin (C-Term) Polyclonal Antibody (antibody)

RRID:AB_10078198

This polyclonal targets Optineurin (C-Term)

View all literature mentions

Anti-GFP (antibody)

RRID:AB_390913

This monoclonal targets GFP

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

NAK (phospho S172) antibody [EPR2867(2)] (antibody)

RRID:AB_10862438

This monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

Optineurin antibody (antibody)

RRID:AB_447598

This polyclonal targets Optineurin

View all literature mentions

Mouse Anti-EEA1 Monoclonal Antibody, Unconjugated, Clone 14 (antibody)

RRID:AB_397829

This monoclonal targets EEA1

View all literature mentions

IRF-3 (D83B9) Rabbit mAb (antibody)

RRID:AB_1904036

This monoclonal targets IRF-3

View all literature mentions

Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody (antibody)

RRID:AB_10693472

This monoclonal targets Phospho-TBK1/NAK (Ser172)

View all literature mentions

Phospho-I-kappa-B-alpha (Ser32/36) (5A5) Mouse monoclonal Antibody (antibody)

RRID:AB_2267145

This monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)

View all literature mentions

Phospho-I-kappa-B-alpha (Ser32/36) (5A5) Mouse monoclonal Antibody (antibody)

RRID:AB_2267145

This monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)

View all literature mentions

Phospho-I-kappa-B-alpha (Ser32/36) (5A5) Mouse monoclonal Antibody (antibody)

RRID:AB_2267145

This monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)

View all literature mentions

Phospho-I-kappa-B-alpha (Ser32/36) (5A5) Mouse monoclonal Antibody (antibody)

RRID:AB_2267145

This monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

Anti-GFP (antibody)

RRID:AB_390913

This monoclonal targets GFP

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

Optineurin antibody (antibody)

RRID:AB_447598

This polyclonal targets Optineurin

View all literature mentions

Optineurin (C-Term) Polyclonal Antibody (antibody)

RRID:AB_10078198

This polyclonal targets Optineurin (C-Term)

View all literature mentions

Mouse Anti-Giantin Monoclonal Antibody, Unconjugated, Clone 9B6 (antibody)

RRID:AB_880195

This monoclonal targets Giantin

View all literature mentions

Mouse Anti-EEA1 Monoclonal Antibody, Unconjugated, Clone 14 (antibody)

RRID:AB_397829

This monoclonal targets EEA1

View all literature mentions

Mouse Anti-GM130 Monoclonal Antibody, Unconjugated, Clone 35 (antibody)

RRID:AB_398141

This monoclonal targets GM130

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

IRF-3 (D83B9) Rabbit mAb (antibody)

RRID:AB_1904036

This monoclonal targets IRF-3

View all literature mentions

Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody (antibody)

RRID:AB_10693472

This monoclonal targets Phospho-TBK1/NAK (Ser172)

View all literature mentions

NAK (phospho S172) antibody [EPR2867(2)] (antibody)

RRID:AB_10862438

This monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]

View all literature mentions

Mouse Anti-GM130 Monoclonal Antibody, Unconjugated, Clone 35 (antibody)

RRID:AB_398141

This monoclonal targets GM130

View all literature mentions

Mouse Anti-Giantin Monoclonal Antibody, Unconjugated, Clone 9B6 (antibody)

RRID:AB_880195

This monoclonal targets Giantin

View all literature mentions

Anti-GFP (antibody)

RRID:AB_390913

This monoclonal targets GFP

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

Optineurin (C-Term) Polyclonal Antibody (antibody)

RRID:AB_10078198

This polyclonal targets Optineurin (C-Term)

View all literature mentions

Optineurin antibody (antibody)

RRID:AB_447598

This polyclonal targets Optineurin

View all literature mentions

Mouse Anti-EEA1 Monoclonal Antibody, Unconjugated, Clone 14 (antibody)

RRID:AB_397829

This monoclonal targets EEA1

View all literature mentions

IRF-3 (D83B9) Rabbit mAb (antibody)

RRID:AB_1904036

This monoclonal targets IRF-3

View all literature mentions

Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody (antibody)

RRID:AB_10693472

This monoclonal targets Phospho-TBK1/NAK (Ser172)

View all literature mentions

NAK (phospho S172) antibody [EPR2867(2)] (antibody)

RRID:AB_10862438

This monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

Mouse Anti-Giantin Monoclonal Antibody, Unconjugated, Clone 9B6 (antibody)

RRID:AB_880195

This monoclonal targets Giantin

View all literature mentions

Mouse Anti-GM130 Monoclonal Antibody, Unconjugated, Clone 35 (antibody)

RRID:AB_398141

This monoclonal targets GM130

View all literature mentions

Anti-GFP (antibody)

RRID:AB_390913

This monoclonal targets GFP

View all literature mentions

Optineurin (C-2) (antibody)

RRID:AB_2156554

This monoclonal targets Optineurin (C-2)

View all literature mentions

Optineurin (C-Term) Polyclonal Antibody (antibody)

RRID:AB_10078198

This polyclonal targets Optineurin (C-Term)

View all literature mentions

Optineurin antibody (antibody)

RRID:AB_447598

This polyclonal targets Optineurin

View all literature mentions

Mouse Anti-EEA1 Monoclonal Antibody, Unconjugated, Clone 14 (antibody)

RRID:AB_397829

This monoclonal targets EEA1

View all literature mentions

IRF-3 (D83B9) Rabbit mAb (antibody)

RRID:AB_1904036

This monoclonal targets IRF-3

View all literature mentions

Phospho-TBK1/NAK (Ser172) (D52C2) XP Rabbit monoclonal Antibody (antibody)

RRID:AB_10693472

This monoclonal targets Phospho-TBK1/NAK (Ser172)

View all literature mentions

NAK (phospho S172) antibody [EPR2867(2)] (antibody)

RRID:AB_10862438

This monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]

View all literature mentions

NAK antibody [EP611Y] (antibody)

RRID:AB_776632

This monoclonal targets NAK

View all literature mentions

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