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Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice. A homozygous hypomorphic mutation in human OTULIN causes a potentially fatal autoinflammatory condition termed OTULIN-related autoinflammatory syndrome (ORAS). Four independent OTULIN mouse models reveal that OTULIN deficiency in immune cells results in cell-type-specific effects, ranging from over-production of inflammatory cytokines and autoimmunity due to accumulation of M1-linked polyubiquitin and spontaneous NF-κB activation in myeloid cells to downregulation of M1-polyubiquitin signaling by degradation of LUBAC in B and T cells. Remarkably, treatment with anti-TNF neutralizing antibodies ameliorates inflammation in ORAS patients and rescues mouse phenotypes. Hence, OTULIN is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis.
Pubmed ID: 27523608 RIS Download
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Commercial antibody supplier and developer for biomedical research. These products are compatible with use in flow cytometry and mass cytometry, immunoprecipitation and chip, western blotting, immunofluorescence microscopy, and quantitative multiplexing.
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View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsA commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.
View all literature mentionsCenter that produces knockout mice and carries out high-throughput phenotyping of each line in order to determine function of every gene in mouse genome. These mice will be preserved in repositories and made available to scientific community representing valuable resource for basic scientific research as well as generating new models for human diseases.
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View all literature mentionsCell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis unknown targets IkappaB-alpha
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 9, 2023. An aggregated data platform for genome sequencing data created by a coalition of investigators seeking to aggregate and harmonize exome sequencing data from a variety of large-scale sequencing projects, and to make summary data available for the wider scientific community. The data set provided on this website spans 61,486 unrelated individuals sequenced as part of various disease-specific and population genetic studies. They have removed individuals affected by severe pediatric disease, so this data set should serve as a useful reference set of allele frequencies for severe disease studies. All of the raw data from these projects have been reprocessed through the same pipeline, and jointly variant-called to increase consistency across projects. They ask that you not publish global (genome-wide) analyses of these data until after the ExAC flagship paper has been published, estimated to be in early 2015. If you''re uncertain which category your analyses fall into, please email them. The aggregation and release of summary data from the exomes collected by the Exome Aggregation Consortium has been approved by the Partners IRB (protocol 2013P001477, Genomic approaches to gene discovery in rare neuromuscular diseases).
View all literature mentionsThe goal of the project is to discover novel genes and mechanisms contributing to heart, lung and blood disorders by pioneering the application of next-generation sequencing of the protein coding regions of the human genome across diverse, richly-phenotyped populations and to share these datasets and findings with the scientific community to extend and enrich the diagnosis, management and treatment of heart, lung and blood disorders. The groups participating and collaborating in the NHLBI GO ESP include: Seattle GO - University of Washington, Seattle, WA Broad GO - Broad Institute of MIT and Harvard, Cambridge, MA WHISP GO - Ohio State University Medical Center, Columbus, OH Lung GO - University of Washington, Seattle, WA WashU GO - Washington University, St. Louis, MO Heart GO - University of Virginia Health System, Charlottesville, VA ChargeS GO - University of Texas Health Sciences Center at Houston
View all literature mentionsOriginal SAMTOOLS package has been split into three separate repositories including Samtools, BCFtools and HTSlib. Samtools for manipulating next generation sequencing data used for reading, writing, editing, indexing,viewing nucleotide alignments in SAM,BAM,CRAM format. BCFtools used for reading, writing BCF2,VCF, gVCF files and calling, filtering, summarising SNP and short indel sequence variants. HTSlib used for reading, writing high throughput sequencing data.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 6,2023. Web interface to the ANNOVAR software, a tool to annotate functional consequences of genetic variation from high-throughput sequencing data, to help biologists without bioinformatics skills to easily submit a list of mutations (even whole-genome variants calls) to the web server, select the desired annotation categories, and receive functional annotation back by emails. Given a list of single nucleotide variants (SNVs) and insertions / deletions in VCF or ANNOVAR input format, wANNOVAR annotates their functional effects on genes (such as amino acid changes for non-synonymous SNPs), calculate their predicted functional importance scores (such as SIFT and PolyPhen scores), retrieve allele frequencies in public databases (such as the 1000 Genomes Project and NHLBI-ESP 6500 exomes), and implement a variants reduction protocol to identify a subset of potentially deleterious variants.
View all literature mentionsA web-based approach of homozygosity mapping that can handle tens of thousands markers. User can upload their own SNP genotype files to the database. Intuitive graphic interface is provided to view the homozygous stretches, with the ability of zooming into single chromosomes or user-defined chromosome regions. The underlying genotypes in all samples are displayed. The software is also integrated with our candidate gene search engine, GeneDistiller, so that users can interactively determine the most promising gene. (entry from Genetic Analysis Software)
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsNational public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets actin
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