Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice. A homozygous hypomorphic mutation in human OTULIN causes a potentially fatal autoinflammatory condition termed OTULIN-related autoinflammatory syndrome (ORAS). Four independent OTULIN mouse models reveal that OTULIN deficiency in immune cells results in cell-type-specific effects, ranging from over-production of inflammatory cytokines and autoimmunity due to accumulation of M1-linked polyubiquitin and spontaneous NF-κB activation in myeloid cells to downregulation of M1-polyubiquitin signaling by degradation of LUBAC in B and T cells. Remarkably, treatment with anti-TNF neutralizing antibodies ameliorates inflammation in ORAS patients and rescues mouse phenotypes. Hence, OTULIN is critical for restraining life-threatening spontaneous inflammation and maintaining immune homeostasis.
Pubmed ID: 27523608 RIS Download
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View all literature mentionsCell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)
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View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis unknown targets IkappaB-alpha
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 9, 2023. An aggregated data platform for genome sequencing data created by a coalition of investigators seeking to aggregate and harmonize exome sequencing data from a variety of large-scale sequencing projects, and to make summary data available for the wider scientific community. The data set provided on this website spans 61,486 unrelated individuals sequenced as part of various disease-specific and population genetic studies. They have removed individuals affected by severe pediatric disease, so this data set should serve as a useful reference set of allele frequencies for severe disease studies. All of the raw data from these projects have been reprocessed through the same pipeline, and jointly variant-called to increase consistency across projects. They ask that you not publish global (genome-wide) analyses of these data until after the ExAC flagship paper has been published, estimated to be in early 2015. If you''re uncertain which category your analyses fall into, please email them. The aggregation and release of summary data from the exomes collected by the Exome Aggregation Consortium has been approved by the Partners IRB (protocol 2013P001477, Genomic approaches to gene discovery in rare neuromuscular diseases).
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View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets actin
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsNational public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis monoclonal targets NF-KappaB p65, phospho (Ser536)
View all literature mentionsThis monoclonal targets phospho-p38 (phospho T180 + Y182)
View all literature mentionsThis monoclonal targets p38
View all literature mentionsThis polyclonal targets OTULIN / FAM105B
View all literature mentionsThis polyclonal targets IKBKG
View all literature mentionsThis monoclonal targets MAP3K14
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Linear Polyubiquitin
View all literature mentionsThis monoclonal targets Ubiquitin, Lys48-Specific
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis polyclonal targets Human RNF31/HOIP
View all literature mentionsThis polyclonal targets RBCK1 (P-19)
View all literature mentionsThis polyclonal targets RBCK1 / HOIL-1
View all literature mentionsThis monoclonal targets CYLD
View all literature mentionsThis polyclonal targets A20/TNFAIP3
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6A/E (Sca-1)
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD23
View all literature mentionsThis monoclonal targets CD21/CD35
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD4 (L3T4)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets Mouse G-CSF
View all literature mentionsThis monoclonal targets IL-6
View all literature mentionsThis monoclonal targets TNFα
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets actin
View all literature mentions