Stroke immediately sets into motion sustained excitotoxicity and calcium dysregulation, causing aberrant activity in neuronal nitric oxide synthase (nNOS) and an imbalance in the levels of nitric oxide (NO). Drugs targeting nNOS-originated toxicity may therefore reduce stroke-induced damage. Recently, we observed that a redox-modulating agent of the NO metabolome, S-nitrosoglutathione (GSNO), confers neurovascular protection by reducing the levels of peroxynitrite, a product of aberrant NOS activity. We therefore investigated whether GSNO-mediated neuroprotection and improved neurological functions depend on blocking nNOS/peroxynitrite-associated injurious mechanisms using a rat model of cerebral ischemia reperfusion (IR).
Pubmed ID: 26174015 RIS Download
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This unknown targets IgG
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal targets AMPK-alpha
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Actin antibody produced in mouse
View all literature mentionsThis polyclonal targets Human nNOS (neuronal), phospho (Ser1417)
View all literature mentionsThis polyclonal targets nNOS (neuronal) antibody
View all literature mentionsThis monoclonal targets LKB1, phospho (Ser428)
View all literature mentionsThis polyclonal targets Phospho-Acetyl-CoA Carboxylase (Ser79)
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View all literature mentionsThis monoclonal targets Nitrated KLH
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Commercial software vendor.
View all literature mentionsThis polyclonal targets AMPK-alpha
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets IgG
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