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The innate immune system senses viral DNA that enters mammalian cells, or in aberrant situations self-DNA, and triggers type I interferon production. Here we present an integrative approach that combines quantitative proteomics, genomics and small molecule perturbations to identify genes involved in this pathway. We silenced 809 candidate genes, measured the response to dsDNA and connected resulting hits with the known signaling network. We identified ABCF1 as a critical protein that associates with dsDNA and the DNA-sensing components HMGB2 and IFI204. We also found that CDC37 regulates the stability of the signaling molecule TBK1 and that chemical inhibition of the CDC37-HSP90 interaction and several other pathway regulators potently modulates the innate immune response to DNA and retroviral infection.
Pubmed ID: 23263557 RIS Download
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This unknown targets Rat IgG, whole molecule
View all literature mentionsThis polyclonal targets Calreticulin - ER Marker
View all literature mentionsThis monoclonal targets beta Actin
View all literature mentionsThis monoclonal targets α-tubulin
View all literature mentionsThis polyclonal targets IFI204 antibody produced in rabbit
View all literature mentionsThis polyclonal targets HMGB2 antibody - ChIP Grade
View all literature mentionsThis monoclonal targets CDC37 (D11A3) XP Rabbit mAb
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis monoclonal targets Tbk1
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsDatabase of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations and are derived from four sources: Genomic Context, High-throughput experiments, (Conserved) Coexpression, and previous knowledge. STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers information between these organisms where applicable. The database currently covers 5''214''234 proteins from 1133 organisms. (2013)
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