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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | Effectiveness of Early Parent-Based Language Intervention | Unknown status | Language Delay, Developmental Language Disorders | Other - Heidelberg Parent-based Language Intervention HPLI | Heidelberg University, Other | 24 Months - 27 Months | Phase 3 | Interventional | The purpose of the study is to examine the effectiveness of a highly-structured parent-based language intervention group program for two-year-old children with language delay. | ||
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Clinicaltrials.gov | Transcranial Direct Current Stimulation (tDCS) As A Tool For Prospective Responder Identification Before Vagus Nerve Stimulation (VNS) Implantation | Unknown status | Epilepsy | Procedure - transcranial direct current stimulation | University of Luebeck, Cyberonics, Inc., University Hospital, Bonn, University of Erlangen-Nürnberg Medical School, Epilepsycenter Bielefeld, Other, Industry, Other, Other, Other | 12 Years - N/A | N/A | Interventional | The aim of the study is to establish tDCS as a prognostic tool to predict VNS therapy outcome among patients with pharmacoresistant epilepsy. | ||
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Clinicaltrials.gov | Pulmonary Hypertension Secondary to Idiopathic Pulmonary Fibrosis And Treatment With Sildenafil | Withdrawn | Pulmonary Arterial Hypertension, Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Pulmonary Hypertension | Drug - sildenafil | University of California, Los Angeles, Pfizer, Other, Industry | N/A - N/A | Phase 4 | Interventional | Pulmonary Arterial Hypertension (PAH) in the setting of Idiopathic Pulmonary Fibrosis(IPF)is a risk factor for morbidity and mortality in the peri-lung transplant(LT) setting. Currently there is no significant data to support the use of pulmonary vasodilators for PAH in the setting of interstitial lung disease such as IPF. The majority of IPF patients have PAH either at rest or during exercise. The study hypothesis is that sildenafil may improve morbidity and mortality in the peri-LT setting in both IPF cohorts with either resting or exercise PAH. | ||
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Clinicaltrials.gov | Biological, Genetic, and Lifestyle Risk Factors for Developing Colorectal Adenomas or Polyps in Participants Undergoing Colonoscopy | Active, not recruiting | Colorectal Cancer, Precancerous Condition | Other, Other, Other, Other, Other, Procedure, Procedure, Procedure - biologic sample preservation procedure, cytology specimen collection procedure, medical chart review, questionnaire administration, survey administration, biopsy, evaluation of cancer risk factors, screening colonoscopy | Vanderbilt University, National Cancer Institute (NCI), Other, NIH | 40 Years - 75 Years | Observational | RATIONALE: Collecting and storing samples of tissue, blood, and other body fluids to test in the laboratory and gathering information about health and lifestyle from participants may help doctors learn more about cancer risk factors. PURPOSE: This clinical trial is looking at biological, genetic, and lifestyle risk factors for developing colorectal adenomas or polyps in participants undergoing colonoscopy. | |||
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Clinicaltrials.gov | Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair | Unknown status | Hernia, Ventral, Body Image, Respiratory Function Tests, Quality of Life, Laparoscopy | Procedure, Procedure - Laparoscopic repair, Open midline incisional hernia repair | University Hospital, Geneva, Other | 18 Years - 70 Years | Phase 4 | Interventional | Background: Midline incisional hernia is reported from 0,5 to 11% after abdominal operations. Primary repair without mesh reinforcement is almost abandoned because of high recurrence rates (24 to 46%). Use of prosthetic mesh in incisional hernia repair lowered the recurrence rates under 10%. Recurrence rate alone is not the main quality criterion for incisional hernia repair anymore. Large series and meta-analyses confirmed the value of laparoscopic repair as at least equal if not better compared with open repair. Discomfort, pain, diminished quality of life and body image alteration influences functional well being. No baseline information exists in any of these fields treating pre- or post-operative phases in patients with incisional hernia. Respiratory functions and medico-economic evaluation are other rarely investigated fields that we consider in our trial. The objective of this study is to analyse the functional outcome status of patients after laparoscopic incisional hernia repair compared to open repair. Methods: A randomized controlled non-blinded clinical trial is designed to compare laparoscopic incisional hernia mesh repair with open repair on post operative pain, health related quality of life outcomes, body image and cosmetic measurements, respiratory functions, recurrence rates, and cost. Volunteers will be recruited in Geneva University Hospital, department of surgery, visceral surgery unit. Eligibility criteria is male patient aged over 18 years, with reducible incisional hernia who are candidates for elective surgery and medically fit for general anesthesia.30 patients will be enrolled for each group. Follow-up will take place at 10th, 30th days as well as 3 12 and 24 post operative months by questionnaires and by clinical exam by independent expert. An overall cost-analysis will be realized. Patient enrollment in the study will start in April 2008 and estimated to end in september 2009. | ||
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Clinicaltrials.gov | Incretin Physiology and Beta-cell Function Before and After Weight-loss | Terminated | Obesity | Other - Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate | Glostrup University Hospital, Copenhagen, University of Copenhagen, European Foundation for the Study of Diabetes, Novo Nordisk A/S, Other, Other, Other, Industry | 18 Years - N/A | Observational | To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) in morbidly obese patients and to describe the pathophysiological mechanisms involved in the amelioration of glucose homeostasis during long-term weight loss. | |||
EU Clinical Trials Register | A Long-Term Study of SM-13496 in Patients with Bipolar I Disorder | Country - LT(Completed)SK(Completed) | bipolar i depression | Sumitomo Dainippon Pharma Co., Ltd. | Male, Female | Adults, Elderly | 2015-08-20 | ||||
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Clinicaltrials.gov | Study of Oral Dasatinib in Subjects With Myelodysplastic Syndrome (MDS) and Excess Marrow Blasts | Completed | Myelodysplastic Syndromes | Drug - Dasatinib | H. Lee Moffitt Cancer Center and Research Institute, Bristol-Myers Squibb, Other, Industry | 18 Years - N/A | N/A | Interventional | The main purpose of this study is to learn how patients with myelodysplastic syndrome (MDS) respond to the study drug dasatinib. The study drug, dasatinib, has been approved by the U.S. Food and Drug Administration (FDA) for treatment of leukemia, but has not been approved for the treatment of other kinds of cancer. The use of dasatinib in this study is considered experimental. | ||
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Clinicaltrials.gov | The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure | Completed | Hypertension | Drug, Other - celecoxib (Celebrex), Placebo | University of Delaware, Christiana Care Health Services, Other, Other | 22 Years - 50 Years | Phase 4 | Interventional | The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure. | ||
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Clinicaltrials.gov | Mental Stress Reduction in Defibrillator Patients | Terminated | Cardiomyopathy, Dilated, Arrhythmia, Anger, Stress | Behavioral, Other - Cognitive Behavioral Stress Management (CBSM), Patient Education | US Department of Veterans Affairs, U.S. Fed | 21 Years - 85 Years | Phase 3 | Interventional | The purpose of this study is to assess the effectiveness of a 10 week program of Stress Management versus control Patient Education sessions on cardiac responses to mental stress in veterans with Implantable Cardioverter-Defibrillators | ||
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Clinicaltrials.gov | A Study of CK-1827452 Infusion in Stable Heart Failure | Completed | Heart Failure | Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug - CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, Placebo, Placebo, CK-1827452, Placebo, CK-1827452, CK-1827452, CK-1827452, CK-1827452 | Cytokinetics, Industry | 18 Years - N/A | Phase 2 | Interventional | This study will assess the safety, tolerability, and pharmacodynamics of CK-1827452 infusion in patients with stable heart failure. | ||
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Clinicaltrials.gov | Subcutaneous Continuous Infusion of Interferon Alfa-2b and Ribavirin in Hepatitis C Genotype 1 Nonresponders | Completed | Chronic Hepatitis C | Drug, Drug, Drug - interferon alfa-2b, interferon alfa-2b, interferon alfa-2b | Foundation for Liver Research, Other | 18 Years - 60 Years | Phase 2/Phase 3 | Interventional | For chronic hepatitis C patients unresponsive to previous (PEG-)IFN/RBV combination therapy we propose continuous subcutaneous administration of high-dose IFN-a2b (Intron A®) for 48 weeks in combination with 15 mg/kg/day RBV (Rebetol®) and optimal management of side effects in order to maintain the highest possible dosages of both IFN-a2b and RBV for 48 weeks. We expect improved tolerability with continuous subcutaneous pump delivery of IFN-a2b compared to thrice weekly or daily subcutaneous injection of IFN-a2b, and increased antiviral activity and biologic potency due to sustained and higher levels of a fully potent interferon protein. | ||
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Clinicaltrials.gov | Procrit Versus Placebo to Determine Efficacy in Pre-Operative Major Surgical Oncology Operations | Withdrawn | Cancer | Drug, Drug - Procrit, Placebo | University of Louisville, Ortho Biotech, Inc., Other, Industry | 18 Years - N/A | Phase 2 | Interventional | The purpose of this study is to evaluate the effectiveness of a two-dose regimen of Procrit prior to a major surgical oncology operation. | ||
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Clinicaltrials.gov | Botox Clinical Trial | Withdrawn | Leg Length Inequality, Foot Deformities | Drug, Other - Botox, Saline | Sheffield Children's NHS Foundation Trust, Other | 6 Years - 16 Years | Phase 4 | Interventional | The surgery to correct leg & foot deformities in children is a lengthy, & sometimes, difficult procedure. Metal frames are attached to the leg and / or foot and over a period of time the frame is manipulated to obtain the corrected position. During this period the muscles & skin become very tight which causes pain & may pull the joint out of position. When this happens it is sometimes necessary to stop the treatment before the best position is obtained. This means that not only is the child left with an inadequate result but that further surgery is required in the future. If the tension could be removed whilst the treatment is underway this would reduce the pain, the possibility of joint damage & potentially allow a more satisfactory to be obtained without the need for further surgery. Botulinum toxin or Botox, as it is commonly called, has the potential to temporarily reduce the tension in the muscles without causing permanent damage. | ||
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Clinicaltrials.gov | Evaluate Tolerability of a Multi-envelope, Prime-boost HIV Vaccine in Healthy Adults | Terminated | HIV Infections | Biological - EnvDNA, PolyEnv1, EnvPro | St. Jude Children's Research Hospital, Other | 18 Years - 35 Years | Phase 1 | Interventional | Vaccines have been very successful in preventing viral infections such as hepatitis B and the measles. Viral vaccines work by causing a person's immune system to make cells that will work against the virus. Due to the success in treating other viral infections, scientists are trying to develop a vaccine for human immunodeficiency virus (HIV). HIV infection is the cause of acquired immune deficiency syndrome (AIDS). AIDS is one of the most serious viral infections we know. This is a research study to evaluate the safety of a possible vaccine against HIV. Researchers want to determine that a person's immune system can respond to the HIV before he or she is exposed to it. Therefore that person may be able to be protected from infection with HIV. | ||
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Clinicaltrials.gov | The Effect of Cataract Extraction on the Contractility of Ciliary Muscle | Unknown status | Presbyopia, Cataract | Other - UBM with pilocarpine in presbyopia | Samsung Medical Center, Other | 55 Years - N/A | N/A | Interventional | The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility. | ||
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Clinicaltrials.gov | Effect of Patient Education in Rheumatic Diseases | Completed | Polyarthritis | Behavioral - Patient education with individual nurse consultations | Norwegian University of Science and Technology, The Research Council of Norway, Other, Other | 18 Years - 80 Years | N/A | Interventional | The purpose of this study is to explore the effect of patient education (PE) in patients with arthritis. PE has become a task that is dictated by law in Norway, and is increasingly used as an element in the treatment of patients with chronic complaints. Our hypothesis is that - PE delivered as group education, followed by an individual nurse consultation increases the patients wellbeing an ability to cope with the disease. | ||
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Clinicaltrials.gov | 3 Nehb Precordial Leads Anterior, Dorsalis and Inferior Allow Accurate Diagnostics of Different Heart Conditions | Unknown status | Acute Myocardial Infarction With ST Segment Elevation | Assaf-Harofeh Medical Center, Other | 18 Years - N/A | Observational | The method of ECG recording with the use of three bipolar leads A (anterior), D dorsalis) and J (or I - inferior) was introduced in 1938 by German electrophysiologist W. Nehb. Being positioned on the chest in the immediate proximity to the heart, and being aligned to the anatomic position of the heart, these leads are very sensitive and allow accurate diagnostics of different heart conditions. All the active leads are placed on anterolateral plane of the chest wall requiring little anatomical window making this technique convenient for express diagnostics using compact electrocardiographic devices without any loss of valuable information. Active electrodes are located on the chest in the following order: 1st- red standard electrode placed in the second intercostal space to the right from sternum corresponding to V1 for standard 12-lead ECG recording, 2nd- green standard lead placed in the position corresponding to V4; 3rd- yellow in the position V7. Then ECG recorded as if in the I standard lead would be defined as Nehb's D, which records the potential on the posterior left ventricle wall; II standard lead would produce Nehb's A which corresponds to the potential on the anterior wall of the left ventricle, and III standard lead would record Nehb's J, which reflects the potential on the diaphragmatic surface of heart. Been simple and informative, this ECG recording modality may be applicable for usage with compact portable cardiographer devices for express diagnosis in different situations and may allow faster and more adequate outpatient response in the case of emergencies. Nehb 3 leads ECG can provide the clinician with portable, reliable, comprehensive and constant ECG monitoring and by this facilitate rapid diagnosis and treatment of STEMI. | ||||
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Clinicaltrials.gov | Induced Sputum Study (0000-065) | Completed | Asthma | Drug, Drug - Comparator: fluticasone, Placebo | Merck Sharp & Dohme Corp., Industry | 18 Years - 55 Years | Phase 1 | Interventional | The primary goals of this study will be to implement innovative processing and detection assays to qualify induced sputum measurements of markers of allergen-induced airway inflammation. The results of this study are intended to form a platform to be used in the clinical development of novel asthma therapeutics. | ||
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Clinicaltrials.gov | A Study of RO5045337 [RG7112] in Patients With Hematologic Neoplasms. | Completed | Hematologic Neoplasms | Drug - RO5045337 | Hoffmann-La Roche, Industry | 18 Years - N/A | Phase 1 | Interventional | This study will determine the maximum tolerated dose of RO5045337 and the optimal associated 4 weekly dosing schedule of RO5045337, administered as monotherapy in patients with hematologic neoplasms. A first cohort of patients will receive the starting dose of 20mg/m2/day orally, once daily for 10 days in each 28 day cycle. Subsequent cohorts of patients will receive dose escalations, and possible changes in dosing schedule, based on tolerability and pharmacokinetic knowledge gained from prior treatment cohorts. Different formulations of RO5045337 will be tested and the food effect evaluated. The anticipated time on study treatment is until disease progression or intolerable toxicity. |
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