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Integrated Videos is a virtual database indexing videos and other multimedia from: NIH VideoCast, GoCognitive, UCSF Laboratory for Visual Neuroscience, The Guardian: Science Videos, BioInteractive, CLARITY resources and Journal of Visualized Experiments (JoVE). JoVE is a peer-reviewed, PubMed-indexed journal devoted to the publication of biological research in the video format, and NIH VideoCast is a vast archive of scientific talks given at various NIH meetings and functions.
(last updated: Mar 7, 2022)
Information MultimediaDatabase | Video Link | Title | Description | Author | Category | Date Published | |
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NIHVideo | Strategies for Development of Coronavirus Vaccines That Induce Broadly Reactive Neutralizing Antibodies | COVID-19 Lecture Series Dr. Haynes is the Frederic M. Hanes Distinguished Professor of Medicine and director of the Human Vaccine Institute at Duke University School of Medicine in Durham, North Carolina. He is internationally recognized for his work in T-cell immunology, retrovirology and HIV vaccine development. Dr. Haynes will relay his lab's latest research on the isolation of coronavirus cross-reactive antibodies and the design of pan-coronavirus vaccines that currently show promise in inducing cross-reactive antibodies and neutralizing pre-emergent animal coronaviruses and SARS-CoV-2 variants of concern. He will discuss coronavirus spike protein neutralizing epitopes as well as mRNA-lipid nanoparticle and protein nanoparticle platforms for vaccine development. For more information go to https://www.niaid.nih.gov/research/covid-19-sig | Barton F. Haynes, M.D., Duke University | COVID-19 | 2021-11-18 12:00:00 | 00:48:29 | |
NIHVideo | David Derse Memorial Lecture and Award: Immune responses to SARS-CoV-2 | This Tenth Annual event honors the outstanding research accomplishments of David Derse, Ph.D., a Principal Investigator in the Center for Cancer Research's HIV Dynamics and Replication Program (HIV DRP). Dr. Derse was Head of the Retrovirus Gene Expression Section in the HIV DRP. During his 25 years at the National Cancer Institute, he investigated the molecular mechanisms of retrovirus infection and replication, concentrating most recently on the human viruses HIV-1 and HTLV-1. In 2007, Dr. Derse and his research team discovered how HTLV-1 evades the body's natural defenses to fight off infection, a finding that may eventually lead to improved antiviral therapies and new strategies for preventing some types of cancer. The HIV DRP sponsors the Annual David Derse Memorial Lecture and Award, with support from Hye Kyung Chung-Derse and the National Cancer Institute, to foster the scientific discourse and exchange of innovative ideas that Dr. Derse was well known for promoting throughout his scientific career. Akiko Iwasaki (Waldemar Von Zedtwitz Professor of Immunobiology and Molecular, Cellular and Developmental Biology; Professor of Molecular Cellular and Developmental Biology; Investigator, Howard Hughes Medical Institute) will deliver the tenth lecture in this series on November 16, 2021. The title of her presentation is “SARS-COV-2". For more information go to https://ncifrederick.cancer.gov/events/conferences/tenth-annual-david-derse-memorial-lecture-and-award-2021 | Akiko Iwasaki, Ph.D., Yale School of Medicine Waldemar Von Zedtwitz Professor of Immunobiology and Molecular, Cellular and Developmental Biology; Professor of Molecular Cellular and Developmental Biology; and Investigator, Howard Hughes Medical Institute | Special | 2021-11-16 13:30:00 | 01:29:38 | |
NIHVideo | NIH Rural Health Seminar: Structural-Level Determinants of Rural Health Disparities | The NIH Rural Health Special Interest Group works to raise awareness of rural health issues and improve biomedical, behavioral/social science, intervention and implementation research aimed at improving disease prevention, self-management, and care delivery across the care continuum. Our goal is to advance our understanding of rural health disparities and stimulate research to identify multi-level, evidence-based solutions to improve rural health outcomes. We connect translational, clinical, and community-based researchers from diverse disciplines throughout the NIH, to research communities, and decision makers. Among researchers, we also provide opportunities for professional development, networking, and community engagement. The National Organization of State Offices of Rural Health set aside the third Thursday of November to observe National Rural Health Day annually. One of the main activities of the NIH Rural Health Special Interest Group is to join other agencies to observe this annual National Rural Health Day by hosting a NIH Rural Health Seminar to stimulate multidisciplinary discussions to advance rural health research. The 2021 Rural Health Seminar: Structural-Level Determinants of Rural Health Disparities will enhance our understanding of the structural-level determinants of health that contribute to rural health disparities. The 2021 seminar includes engaging panel discussions, presentations, and early-stage investigator talks where participants will hear from the future generation of rural health researchers. Three tracks organize the seminar and include structural-level sociocultural (e.g., racism and discrimination, sociocultural norms), economic (e.g., poverty) and physical environmental determinants (e.g., chemical, built, neighborhood, food environments) that contribute to rural health disparities. The seminar will close with a track focused on evaluating and measuring structural level determinants, and policy implications. Attendees will come away from this virtual seminar with an understanding of the impact of structural determinates on rural populations and the need for multi-level interventions to reduce rural health disparities. | NIMHD, NIH | Conferences | 2021-11-18 11:00:00 | 05:50:57 | |
NIHVideo | Native American Heritage Month: The Interconnectedness of Culture and Science | Dr. Donald Warne, Director, Indians Into Medicine and Public Health Programs, and Associate Dean, Diversity, Equity, and Inclusion, at the University of North Dakota, will offer a guest lecture about the interconnectedness of culture and science. Discussion will follow. NIH Principal Deputy Director Dr. Lawrence Tabak will offer introductory remarks. THRO Director Dr. David R. Wilson will moderate the event. Donald Warne, MD, MPH serves as the Associate Dean of Diversity, Equity and Inclusion; Chair of the Department of Indigenous Health; Director of the Indians Into Medicine (INMED) and Public Health Programs; and Professor of Family and Community Medicine at the School of Medicine and Health Sciences at the University of North Dakota. Dr. Warne is the Principal Investigator for the Indigenous Trauma & Resilience Research Center at UND, and he also serves as the Senior Policy Advisor to the Great Plains Tribal Leader’s Health Board in Rapid City, SD. Dr. Warne is a member of the Oglala Lakota tribe from Pine Ridge, SD and comes from a long line of traditional healers and medicine men. He received his MD from Stanford University School of Medicine in 1995 and his MPH from Harvard School of Public Health in 2002. His work experience includes: several years as a primary care physician with the Gila River Health Care Corporation in Arizona; Staff Clinician with the National Institutes of Health; Indian Legal Program Faculty with the Sandra Day O’Connor College of Law at Arizona State University; Health Policy Research Director for Inter Tribal Council of Arizona; Executive Director of the Great Plains Tribal Chairmen’s Health Board; and Chair of the Department of Public Health at North Dakota State University. Dr. Warne is also a member of the Stanford University Alumni Hall of Fame. For more information about this event and Tribal health research at NIH, go to www.nih.gov/tribalhealth. | Dr. Donald Warne, Director, Indians Into Medicine (INMED) and Public Health Programs, and Associate Dean, Diversity, Equity and Inclusion, University of North Dakota | Special | 2021-11-17 14:00:00 | 00:57:38 | |
NIHVideo | Advancing Bioprinting and Regenerative Medicine Solutions for Obstetric, Gynecologic, and Pediatric Applications (Day 2) | Conference Concept Proposal: Towards Realizing Bioprinted Tissue Construct for OB/GYN and Pediatric Application | NICHD, NIH | Conferences | 2021-11-17 13:00:00 | 04:07:58 | |
NIHVideo | National Advisory Neurological Disorders and Stroke (NANDS) Council - September 2017 | The 200th meeting of the National Advisory Neurological Disorders and Stroke Council on September 7, 2017.For more information go to https://www.ninds.nih.gov/About-NINDS/Who-We-Are/Advisory-Council | National Institute of Neurological Disorders and Stroke, NIH | National Institute of Neurological Disorders and Stroke | 2017-09-07 08:00:00 | 05:13:32 | |
NIHVideo | Assay Guidance Workshop for Cell-Based Assays and Lead Discovery (Day 2) | The NCATS Assay Guidance Manual (AGM) program is hosting a two-day workshop that will cover a broad range of critical concepts underlying high-content screening and analysis (Day 1) and complex in vitro models (CIVMs) in drug discovery (Day 2). This workshop is designed to disseminate critical information about the implementation of robust cellular assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the AGM. The goal of this workshop is to train scientists on the fundamentals and applications of image-based and 3D cellular assay technologies and engage in a dialogue with those curious to understand it on a deeper level. This workshop also aims to discuss challenges and standards for rigor to enable reproducible results, and provide a future perspective on the utility of complex cellular models in drug discovery.For more information go to https://ncats.corsizio.com/c/610be47733a68a57165e9db7 | NCATS, NIH | Conferences | 2021-11-17 13:00:00 | 04:04:04 | |
NIHVideo | Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center: Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case | Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A CaseFor more information go to https://cc.nih.gov/about/news/grcurrent.html | 1) Daniel S. Chertow, MD, MPH, Tenure-Track Investigator and Head, Emerging Pathogens Section, Critical Care Medicine Department, CC 2) David E. Kleiner, MD, PhD,. Senior Research Physician and Chief, Post-Mortem Section, NCI and 3)Cihan Oguz, PhD Bioinformatics Analyst; NIAID Collaboration Bioinformation Resource (NCBR), Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc. | Clinical Center Grand Rounds | 2021-11-17 12:00:00 | 00:58:09 | |
NIHVideo | Women Leaders in Academic Research: Do What You Love, Love What You Do: An Anthology of Perspectives on Choosing the Right Path for YOU | Life is all about choices. In order to discover the things we love and subsequently pursue them, we are faced with myriad decisions that relate to our own unique circumstances in life. These choices - and the circumstances underscoring them - often go unspoken or under-appreciated when we consider how our peers, mentors, advocates, and role models got to where they are. This talk will unveil key aspects of my personal journey in doing what I love and loving what I do as a biomedical engineer and translationally-minded cancer researcher - which most recently led me back to my alma mater as one of the youngest faculty ever hired at the UVA School of Engineering & Applied Science. As well, this talk will synthesize a rich and unique collection of stories, experiences, and wisdom outside of my own. These anecdotes, carefully curated from a diverse group of scholars spanning science, healthcare and administration, will speak more broadly to and invite discourse on the influences, circumstances and/or decisions that often bear a critical role in shaping our personal and/or career trajectories. Invited monthly lecture series highlighting & honoring women leaders in academic research, especially related disciplines of Interventional Radiology, Biomedical Engineering, Radiology, Imaging Sciences, Data Science, & Image-Guided Oncology. The honorary lecture series was established by the NIH Center for Interventional Oncology as a small effort to help counter the under-representation of women in academic research & the impact of gender disparity & implicit bias on role modeling and mentoring. Monthly topics are open-ended & are geared towards highlighting successful female or other under-represented academic leaders, as role models for trainees. for more information, and archived lectures see: https://www.cc.nih.gov/centerio/women_leaders.html For more information go to https://www.cc.nih.gov/centerio/women_leaders.html | Natasha Sheybani, PhD, University of Virginia | Special | 2021-11-16 14:00:00 | 01:29:17 | |
NIHVideo | Assay Guidance Workshop for Cell-Based Assays and Lead Discovery (Day 1) | The NCATS Assay Guidance Manual (AGM) program is hosting a two-day workshop that will cover a broad range of critical concepts underlying high-content screening and analysis (Day 1) and complex in vitro models (CIVMs) in drug discovery (Day 2). This workshop is designed to disseminate critical information about the implementation of robust cellular assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the AGM. The goal of this workshop is to train scientists on the fundamentals and applications of image-based and 3D cellular assay technologies and engage in a dialogue with those curious to understand it on a deeper level. This workshop also aims to discuss challenges and standards for rigor to enable reproducible results, and provide a future perspective on the utility of complex cellular models in drug discovery.For more information go to https://ncats.corsizio.com/c/610be47733a68a57165e9db7 | NCATS, NIH | Conferences | 2021-11-16 12:30:00 | 04:18:34 | |
NIHVideo | A Vision Engaging Pharmacokinetic Strategies to Treat Substance Abuse Disorders and Overdose | Wednesday Afternoon Lecture Series Dr. Janda is the Ely R. Callaway Jr. Professor of Chemistry and director or the Worm Institute for Research & Medicine at Scripps Research. His research blends medicinal chemistry and molecular biology with neuropharmacology and immunology. Our ability to aid individuals with a substance use disorder is handicapped by the lack of sufficient treatment modalities. Traditional, small-molecule approaches have only been marginally successful. Biologics-based therapeutics offer an alternative to customary pharmacodynamic approaches for treating both substance use disorders as well as lethality threats from many of these drugs. Dr. Janda will discuss the history and basic tenets on vaccination as well as how vaccination can alter the pharmacokinetic properties of drugs without burdening the recipient with untoward side effects. The lecture will detail the chemistry, immunology, and behavioral findings from vaccines against opioids, including heroin and the synthetic opioids fentanyl and carfentanil, as well as a bacterial source to treat nicotine substance disorders and poisoning. For more information go to https://oir.nih.gov/wals | Kim Janda, Ph.D., Scripps Research Institute, La Jolla, California | WALS - Wednesday Afternoon Lectures | 2021-11-10 15:00:00 | 01:00:12 | |
JoVE | 2012: A Year In Review | Here's a look at some of the milestones and highlights of the year 2012 in Journal of Visualized Experiments (JoVE). At the start of 2012, JoVE reached a major milestone by publishing our 1500th article. In this publication, in JoVE Bioengineering, Yu et al. described a method for analyzing the free radical composition of cigarette smoke. This method simulated cigarette puffing with a single-port smoking device, and combined it with electron spin resonance (ESR) spectroscopy to measure the degree to which antioxidant compounds can scavenge free radicals in cigarette smoke. A possible outcome of this research is the creation of less harmful cigarettes. JoVE Bioengineering also contained the most-viewed article of 2012. Owczarczak et al. described a method for hacking a standard inkjet printer, loading ink cartridges with a cell-suspension "bioink," and printing lines of live cells onto glass slides. The thermal inkjet printing process creates temporary pores in the cell membrane, visualized by the incorporation of fluorescently labeled actin monomers. This concept, called "bioprinting," has many potential applications in cell and tissue engineering. Also in 2012, JoVE Bioengineering featured a protocol by Hsia et al. for isolating and purifying spider silk protein, spinning it into fibers, and assessing the fiber strength. This protocol for laboratory-scale production of spider silk, which is stronger than tensile steel, can potentially be extended to large-scale manufacturing. In JoVE Clinical and Translational Medicine, we featured a number of articles related to stroke, one of which. In one article, Möbius-Winkler et al. demonstrated placement of the WATCHMAN left atrial appendage occlusion device from Boston Scientific. This device is designed to prevent strokes by trapping clots within the left atrial appendage of the heart before they exit. Our authors demonstrated how to insert the guide wire through the femoral artery into the heart, advance the device into the left atrium, and deploy the device in the left atrial appendage. Another article focused on stroke, Hamel et al. described the use of a driving simulator to study how patients compensate for visual field defects following stroke. By analyzing the compensatory gaze behavior of patients as they navigated through virtual driving courses with varying degrees of complexity, our authors see great potential for the use of driving simulators in stroke rehabilitation. In JoVE Immunology and Infection, we published an article by Keyel et al. describing the real-time kinetics of immune cell responses to bacterial toxins using live cell microscopy. Combined with high-speed 3D confocal microscopy, this technique can also visualize the cellular repair response. Also in JoVE Immunology and Infection, we featured an article by Yap et al. describing methods for diagnosing helminth infections in children. Helminths are parasitic worms that can infect the intestinal tract of humans and animals, and may be distinguished based on their morphology. The same article demonstrated how to measure the impact of helminth infections on physical fitness in children, which is a measure of overall health. In JoVE Neuroscience, we featured a method by Hoffmann et al. , who used tiny headphones to alter the auditory feedback in songbirds, and analyzed the computational and neurophysiological basis of vocal learning in birds when they adjust their singing in response to altered acoustic signals. Also in JoVE Neuroscience, we moved from birds to bees with a method that assesses associative and non-associative tactile learning in honeybees. This method, by Mujagić et al. , allowed bees to scan different metal surfaces with their antennae, then conditioned them to expect sugar water when their antennae touched particular surfaces, and analyzed the corresponding changes in antennal movement. In 2012, we launched a brand-new section: JoVE Applied Physics, which features articles on subjects ranging from plasma physics to material science. The Applied Physics section also contained JoVE's 2000th video article, filmed in a synchrotron radiation facility, where Borisenko et al. showed how to determine the electronic structure of complex materials using angle-resolved photoemission spectroscopy. In the JoVE General section, we published an article by Artioli et al. demonstrating the use of a portable gas analyzer to measure oxygen consumption during complex exercise - such as judo. By analyzing oxygen consumption and collecting blood for measuring plasma lactate concentration, this method can determine the relative contributions of different energy systems to specific aspects of complex exercise. Finally, JoVE followed Dolhi et al. to a permanently ice-covered saline lake in Antarctica. There, scientists drilled through the ice to study single-celled microorganisms called protists that live in the harsh conditions of Antarctica. This Year in Review was just a brief glimpse of a few of over 600 video articles that JoVE offered in 2012. Browse the JoVE archives to see thousands of other videos, and stay tuned for what's coming up this year in JoVE: The Journal of Visualized Experiments. | Wendy Chao; Aaron Kolski-Andreaco | January 3, 2013 | |||
NIHVideo | Instrumenting the Healthcare System for Discovery Research | OPASI ROUNDS Lecture Series The Office of Portfolio Analysis and Strategic Initiatives (OPASI) provides the National Institutes of Health (NIH) and its constituent Institutes and Centers (ICs) with the methods and information necessary to manage their large and complex scientific portfolios, identifies in concert with multiple other inputs important areas of emerging scientific opportunities or rising public health challenges, and assists in the acceleration of investments in these areas, focusing on those involving multiple ICs. | Kohane, Isaac S. National Institutes of Health (U.S.). Office of Portfolio Analysis and Strategic Initiatives. | Special | 2007-09-21 10:00:00 | 01:00:26 | |
NIHVideo | MIG 1/5/97 | National Institutes of Health (U.S.). Mitochondria Interest Group. | Mitochondria | 1998-01-05 18:16:00 | 00:55:19 | ||
JoVE | Live-cell Imaging of Migrating Cells Expressing Fluorescently-tagged Proteins in a Three-dimensional Matrix | Traditionally, cell migration has been studied on two-dimensional, stiff plastic surfaces. However, during important biological processes such as wound healing, tissue regeneration, and cancer metastasis, cells must navigate through complex, three-dimensional extracellular tissue. To better understand the mechanisms behind these biological processes, it is important to examine the roles of the proteins responsible for driving cell migration. Here, we outline a protocol to study the mechanisms of cell migration using the epithelial cell line (MDCK), and a three-dimensional, fibrous, self-polymerizing matrix as a model system. This optically clear extracellular matrix is easily amenable to live-cell imaging studies and better mimics the physiological, soft tissue environment. This report demonstrates a technique for directly visualizing protein localization and dynamics, and deformation of the surrounding three-dimensional matrix. Examination of protein localization and dynamics during cellular processes provides key insight into protein functions. Genetically encoded fluorescent tags provide a unique method for observing protein localization and dynamics. Using this technique, we can analyze the subcellular accumulation of key, force-generating cytoskeletal components in real-time as the cell maneuvers through the matrix. In addition, using multiple fluorescent tags with different wavelengths, we can examine the localization of multiple proteins simultaneously, thus allowing us to test, for example, whether different proteins have similar or divergent roles. Furthermore, the dynamics of fluorescently tagged proteins can be quantified using Fluorescent Recovery After Photobleaching (FRAP) analysis. This measurement assays the protein mobility and how stably bound the proteins are to the cytoskeletal network. By combining live-cell imaging with the treatment of protein function inhibitors, we can examine in real-time the changes in the distribution of proteins and morphology of migrating cells. Furthermore, we also combine live-cell imaging with the use of fluorescent tracer particles embedded within the matrix to visualize the matrix deformation during cell migration. Thus, we can visualize how a migrating cell distributes force-generating proteins, and where the traction forces are exerted to the surrounding matrix. Through these techniques, we can gain valuable insight into the roles of specific proteins and their contributions to the mechanisms of cell migration. | Wenting Shih; Soichiro Yamada | December 22, 2011 | |||
NIHVideo | MIG 12/1/97 | National Institutes of Health (U.S.). Mitochondria Interest Group. | Mitochondria | 1997-12-01 18:21:00 | 01:06:03 | ||
NIHVideo | Regulation of Production of IL-10 by T Cells, Macrophages and Dendritic Cells | For more information, visit http://www.nimr.mrc.ac.uk/immunoreg/ogarra The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. | O'Garra, Anne. National Institutes of Health (U.S.) | WALS - Wednesday Afternoon Lectures | 2006-03-08 15:00:00 | 01:01:41 | |
JoVE | Imaging Intranuclear Actin Rods in Live Heat Stressed Drosophila Embryos | The purpose of this protocol is to visualize intranuclear actin rods that assemble in live Drosophila melanogaster embryos following heat stress. Actin rods are a hallmark of a conserved, inducible Actin Stress Response (ASR) that accompanies human pathologies, including neurodegenerative disease. Previously, we showed that the ASR contributes to morphogenesis failures and reduced viability of developing embryos. This protocol allows the continued study of mechanisms underlying actin rod assembly and the ASR in a model system that is highly amenable to imaging, genetics and biochemistry. Embryos are collected and mounted on a coverslip to prepare them for injection. Rhodamine-conjugated globular actin (G-actin ) is diluted and loaded into a microneedle. A single injection is made into the center of each embryo. After injection, embryos are incubated at elevated temperature and intranuclear actin rods are then visualized by confocal microscopy. Fluorescence recovery after photobleaching (FRAP) experiments may be performed on the actin rods; and other actin-rich structures in the cytoplasm can also be imaged. We find that G-actin polymerizes like endogenous G-actin and does not, on its own, interfere with normal embryo development. One limitation of this protocol is that care must be taken during injection to avoid serious injury to the embryo. However, with practice, injecting G-actin into Drosophila embryos is a fast and reliable way to visualize actin rods and can easily be used with flies of any genotype or with the introduction of other cellular stresses, including hypoxia and oxidative stress. | Natalie Biel; Lauren Figard; Anna Marie Sokac | May 15, 2020 | |||
NIHVideo | Natural Products: From Structures to Mechanisms and Potential For Therapeutics | NIH Director's Seminar Series For more information, visit 2005-2006 Director's Seminar Series | Bewley, Carole A. National Institutes of Health (U.S.) | NIH Director's Seminars | 2006-02-17 12:00:00 | 00:55:03 | |
NIHVideo | NCI Director's Awards 2012 | Each year at the NCI Director's Awards ceremony, we recognize the outstanding contributions of our colleagues that aid in the continued advancement of progress at the institute. | Varmus, Harold. National Cancer Institute (U.S.), | Special | 2012-11-15 13:00:00 | 00:48:28 |
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