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National Mouse Metabolic Phenotyping Centers provide information and data about mouse models of diabetes.
(last updated: May 15, 2018)
Disease Information| Name | Collection | Description | Gene Symbol | Organism | Resource Type |
|---|---|---|---|---|---|
| C57L | MMPC Mouse Strain | mouse | |||
| aldehyde fuchsin | MMPC Protocol | protocol | |||
| C57BL/10 | MMPC Mouse Strain | mouse | |||
| MRL/MpJ | MMPC Mouse Strain | mouse | |||
| B6.Cg-Rictortm1.1Mgn/+ Tg(Nes-cre)1Kln/J | MMPC Mouse Strain | C57BL/6J Neuronal Rictor Heterozygous Knock Out | Nes, Rictor | mouse | mouse |
| C57BL/6J-C3.BliA-Sox10Dom+/- | MMPC Mouse Strain | Sox10 | mouse | mouse | |
| UC Davis - HDL Protocol | MMPC Protocol | protocol | |||
| DBA/2J-Leprdb/db | MMPC Mouse Strain | Lepr | mouse | mouse | |
| C57BL/6J-Cited2Lox/Lox Tg(Alb-Cre) | MMPC Mouse Strain | Floxed Cited2 locus with liver specific knockout using Albumin-Cre construct | Cited2 | mouse | mouse |
| C57BL/6J-Slc2a4 -/- | MMPC Mouse Strain | Slc2a4 | mouse | mouse | |
| C57BL/6J-Slc2a4+/- Tg(OE-Hk) | MMPC Mouse Strain | Hk, oe, Slc2a4 | mouse | mouse | |
| C57BL/6-Apoa4tm1Bres/J | MMPC Mouse Strain | Description Mice homozygous for this targeted mutation are viable and fertile with no protein detectable in plasma, liver, or intestinal tissues. Homozygotes have decreased plasma levels of cholesterol, free fatty acids, and high density (HDL) and very low density lipoprotein (VLDL). These mice may be useful in studies of lipid metabolism, atherosclerosis, heart disease, appetite regulation, intestinal lipid absorption, or inflammatory bowel disease. Development A targeting vector was designed to replace exon 1 of the endogenous gene with a neomycin resistance gene. This construct was electroporated into 129S4/SvJae-derived J1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. Chimeric mice were bred with C57BL/6J and the resulting heterozygous offspring were bred together for many generations prior to arrival at The Jackson Laboratory. | Apoa4 | mouse | mouse |
| B6.129S4- Ppaard tm1Red/+ Tg(Nes-cre)1Kln/J | MMPC Mouse Strain | C57BL/6J Neuronal PPAR Delta Heterozygous KO | Nes, Ppard | mouse | mouse |
| C57BL/6-Acsl1tm1col | MMPC Mouse Strain | Acsl1 | mouse | mouse | |
| C57BL/6J-Klf2tm1Mlkn | MMPC Mouse Strain | C57BL/6J with a lox/lox knockin at the Klf2 gene (Kruppel-like factor 2 (lung)) | Klf2 | mouse | mouse |
| UC Davis - Intraperitoneal Insulin Tolerance Test | MMPC Protocol | protocol | |||
| C57BL/6J-Slc2a4-/- | MMPC Mouse Strain | mouse | |||
| NADH Oxidase Activity | MMPC Protocol | protocol | |||
| NOD.CB17-Prkdcscid/J | MMPC Mouse Strain | Prkdc scid occurred spontaneously in a colony of BALB/c-Ighb (C.B-17) mice maintained at the Institute for Cancer Research in Philadelphia, PA. The Prkdcscid mutation was backcrossed onto the NOD/ShiLt background as follows: an NOD/ShiLt female was bred to a C.B-17-Prkdcscid male; male Prkdcscid/+ offspring of the F1/N1 and subsequent generations were mated to NOD/ShiLt females for a total of 10 crosses to NOD/ShiLt; at generation N10, Prkdcscid was made homozygous by brother-sister inbreeding. | Prkdc | mouse | mouse |
| UC Davis - Hydrogen Peroxide | MMPC Protocol | protocol |
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