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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Sep 14, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
Neuroscience Database GatewayResource, topical portal, portal, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented on September 06, 2013. Resource aimed at promoting awareness and facilitating access to online neuroscience databases.SCR_007297(Neuroscience Database Gateway, RRID:SCR_007297)Society for Neuroscience Last checked downnif-0000-00116
Criterion VenturesResource, topical portal, portal, data or information resourceCriterion Ventures is launching a new venture that will adapt existing financial services and connect them with consumers through affinity groups to address the needs of the cash market of healthcare. Currently, the healthcare industry is dominated by an insurance market. But sitting next to the insurance market is a $300 billion/year cash market for health care. This cash market lacks the rational pricing, products, services and intermediaries needed to deliver health care affordably and in a way that maximizes access. In the end, consumers are not getting the best value per dollar spent. By introducing and bringing to scale innovative products and services, and connecting them to consumers through existing affinity groups whose members are struggling with the impact of the cash portion of healthcare, we will be able to rationalize the market. By creating a rational market we will bring greater value to consumers for their healthcare dollars and increase access to care. The business will draw revenues from four sources: Charging transaction fees to consumers who use our products Charging interest to consumers who take advantage of our lines of credit offerings Interest earned on deposits that we or our partners will hold for consumers Charging management fees to affinity groups for setting up their customized set of products and services. Partners. Thomas H. Cochran, Managing Director, CivilCredit Advisors Catherine (Cathy) Dunham, Director, Access Project Richard Eskow, CEO, Health Knowledge Systems Tim Freundlich, Founder and Managing Principal, Good Capital; Director of Strategic Initiatives, Calvert Foundation Ben Geyerhahn, Principal, Hudson TG Kevin Jones, Founding Principal, Good Capital Claudia Machaver, Consultant Robert Mittman, Founder, Facilitation, Foresight, Strategy Sara Olsen, Founding Partner, SVT Group Mark Rukavina, Executive Director, Access Project Michael Tobman, Principal, Hudson TG Dana Wright, Founder, Take Action, Inc.SCR_008460(Criterion Ventures, RRID:SCR_008460)Last checked downnif-0000-30393http://www.criterionventures.com/ht/d/sp/i/1255/pid/1255
American Neurological AssociationResource, topical portal, training resource, people resource, journal article, portal, meeting resource, job resource, data or information resourceThe American Neurological Association is a professional society of academic neurologists and neuroscientists devoted to advancing the goals of academic neurology; to training and educating neurologists and other physicians in the neurologic sciences; and to expanding both our understanding of diseases of the nervous system and our ability to treat them. Our Goals 1. To disseminate knowledge about the nervous system and its diseases by: Presenting new scientific basic and clinical information at an annual meeting Publishing a scientific journal Formulating and promoting high standards of neurologic practice 2. To promote research into the causes and treatment of diseases of the nervous system by: Attracting promising physicians into academic neurology and supporting their development Advocating financial support from government, industry and individuals for research on the nervous system and its disorders 3. To formulate and promote policies and actions which will support the goals of academic neurology by: Providing a unified voice for academic neurology Setting guidelines and assuring excellence in programs that train and educate physicians in neurology Raising the standard of neurologic training of all physicians A few highlights within the portal: Clinical Neuroscience Pathway Startling breakthroughs in molecular biology and basic neuroscience have defined the cause of many diseases of the nervous system and are transforming the practice of neurology, neurosurgery and psychiatry. Basic research is giving new information on how the brain works and how brain injury occurs-and how it can be prevented or improved. Recognizing the exciting opportunities now available to better understand nervous system function and to design new treatments for neurological diseases, we''ve developed an interdepartmental program: The Clinical Neuroscience Pathway to provide an enhanced exposure to the neurosciences while pursuing the Doctor of Medicine degree. Program goal: The Clinical Neuroscience Pathway provides medical students with an enriched experience in the neurosciences throughout their four years in medical school. This program will provide students interested in Neurology, Neurosurgery, Ophthalmology, Pathology, or Psychiatry with access to a number of stimulating clinical and research activities. In addition, students will have the opportunity to participate in activities specifically designed for medical students in the program. Pathway students will be eligible for special summer research and year-out opportunities for clinical and basic neuroscience study. John N. Whitaker Visiting Professorships About the Program The ANA offers up to five 5,000 awards annually to fund visits of several days duration by persons who will interact with medical students and by both formal and informal contacts, stimulate them to consider academic neurology careers. The ideal visitor will be a role model of an accomplished academician who is enthusiastic and will effectively illustrate the applications between basic science and clinical neurology. The ANAs Education Committee must approve the visitor. The inviting institution should have acceptance from the visitor prior to submitting the name. The ANA suggests that an honorarium in the amount of 2,000 be given to the visitor. Special consideration will be given to institutions with small departments, but this is not a requirement. The Whitaker Professorships are intended to honor the life and contributions of John N. Whitaker M.D. (1940 - 2001) whose life and career exemplified high achievement as a person, neurological physician, teacher, investigator, mentor and citizen.fellowships, academic neurologists, basic, clinical, nervous system diseases, neurology, neuroscience, publicationsSCR_012926(American Neurological Association, RRID:SCR_012926)Last checked downnif-0000-10653
icyou Health VideosResource, topical portal, portal, video resource, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented on August 18, 2016. icyou is an internet resource of health-related video clips submitted by users. Health topics covered in videos can range anywhere from infectious diseases to fitness and exercise, with videos generally being shorter than 10 minutes in length. Videos also contain information on treatment and procedures, medical fields, and health politics and policy. These videos may or may not be authored by licensed medical personnel. All videos are searchable, and users can also choose to upload their own healthcare-related videos. In addition to gathering healthcare video from the best sources on the Web and beyond, icyou.com can call on its own award-winning health reporting team to cover the latest issues and trends. Through its parent company Benefitfocus, icyou.com has full access to the Benefitfocus Media Studio, a state-of-the-art HD facility located in Charleston, South Carolina. This studio is the only one of its kind devoted solely to creating healthcare-oriented video content. In it, the Benefitfocus Media team creates up-to-the-minute reports, tutorials, features and more that help illuminate its users about the complexities of the many facets of healthcare.exercise, fitness, healthcare, health policy, health politics, health topic, medical fields, medical procedure, treatmentSCR_001167(icyou Health Videos, RRID:SCR_001167)Last checked downnif-0000-11652http://www.icyou.com
The Biomedical Research Foundation - Current ResearchResource, topical portal, portal, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. This laboratory facilities contain core research space for monoclonal antibody production, oligonucleotide and peptide synthesis, gene cloning, DNA sequencing, high performance liquid chromatography, tissue culture, positron emission tomography, magnetic resonance spectroscopy and electron microscopy.drug, electron microscopy, - flow cytometry, gene, abuse, alcohol, automated cell imaging, cancer, cloning, confocal and digital microscopy, dna, dna gene chip analysis, immunology, inflammation, ischemic disorder, liquid chromatography, magnetic resonance spectroscopy, mass spectrometry, monoclonal antibody production, neuroscience, oligonucleotide, peptide, polymerase chain reaction (pcr), positron emission tomography, sequencing, signal transduction, synthesis, tissue cultureSCR_001564(The Biomedical Research Foundation - Current Research, RRID:SCR_001564)Last checked downnif-0000-10446http://www.biomed.org/homehttp://www.biomed.org/bio_med_research.cfm
Tribolium castaneum Genome ProjectResource, topical portal, data or information resource, portal, databaseThis portal provides information about the Tribolium castabeum Genome Project. The Tribolium castaneum genome sequence and its analysis has been published in Nature, two companion journal issues (IBMB and DGE) and numerous other publications listed below. The red flour beetle, Tribolium castaneum, a common pest that is also a genetic model for the Coleoptera. The genome has been sequenced to 7-fold coverage using a whole genome shotgun approach and assembled using the HGSC's assembly engine, Atlas, with methods employed for the Drosophila pseudoobscura genome assembly. Approximately 90% of the genome sequence has been mapped to chromosomes in collaboration with Dick Beeman (USDA ARS) and Sue Brown (Kansas State University). Access to the Data :- Genome Assembly: The long term home of the Tribolium genome is Beetlebase. Tcas 3.0 is now available in GenBank and on our FTP site. Note there are no restrictions of any kind on the Tribolium data as it has been published. Version 2 of the assembly, Tcas_2.0 is available for download using the FTP Data link in the sidebar. The assembly is described in detail in the README in that directory. T.cas_1.0 was a preliminary genome assembly that did not include large insert paired end information and has been moved to a previous assemblies folder. A genboree browser of the Tcas2.0 sequence is available here: There are also links to the genboree browser from the blast results (at the bottom of each reported HSP) if you use the blast server on this page. The original linear scaffold file, Tcas2.0/linearScaffolds/Tcas20050914-genome, posted on the ftp site did not include singleton contigs from the assembly and thus did not fully reflect the tribolium genome sequence, missing ~4.4Mb of sequence in 1860 contigs and reptigs or approximately 2.5% of the assembled sequence. A corrected Tcas20051011-genome file containing these missing sequences is now available on the ftp site. The blast databases have also been updated to reflect this change. All other data is correct, and not affected by this change. :- BLAST Searches: The BLAST link is located in the sidebar. :* Linearized chromosome and unplaced scaffold sequences :* Assembled contigs :* Bin0 unassembled reads and Repeat reads Traces are available from the NCBI Trace Archive by using the link in the sidebar, or by using NCBI MegaBLAST with a same species or cross species query. Sponsors: Funding for this project has been provided by the National Human Genome Research Institute (NHGRI U54 HG003273), which is part of the National Institutes of Health (NIH), and the U.S. Department of Agriculture's Agricultural Research Service (USDA ARS Agreement No. 58-5430-3-338).genetic, chromosome, coleoptera, drosophila, genome, model, pest, red flour beetle, sequence, tribolium castaneumSCR_002848(Tribolium castaneum Genome Project, RRID:SCR_002848)Baylor University; Texas; USA Last checked downnif-0000-25607http://www.hgsc.bcm.tmc.edu/project-species-i-Tribolium%20castaneum.hgsc?pageLocation=Tribolium%20castaneum
Honey Bee Genome ProjectResource, topical portal, portal, data or information resourceThe HGSC has sequenced the honey bee, Apis mellifera. The version 4.0 assembly was released in March 2006 and published in October 2006. The genome sequence is being upgraded with additional sequence coverage. The honey bee is important in the agricultural community as a producer of honey and as a facilitator of pollination. It is a model organism for studying the following human health issues: immunity, allergic reaction, antibiotic resistance, development, mental health, longevity and diseases of the X chromosome. In addition, biologists are interested in the honey bee's social organization and behavioral traits. This project was proposed to the HGSC by a group of dedicated insect biologists, headed by Gene Robinson. Following a workshop at the HGSC and a honey bee white paper, the HGSC began the project in 2002. A 6-fold coverage WGS, BAC sequence from pooled arrays, and an initial genome assembly (Amel_v1.0) were released beginning in 2003. This has been a challenging project with difficulty in recovering AT-rich regions. The WGS data had lower coverage in AT-rich regions and BAC data from clones showed evidence of internal deletions. Additional reads from AT enriched DNA addressed these underrepresented regions. The current assembly Amel_4.0 was produced with Atlas and includes 2.7 million reads (1.8 Gb) or 7.5x coverage of the (clonable) genome. About 97% of STSs, 98% of ESTs, and 96% of cDNAs are represented in the 231 Mb assembly. About 2,500 reads were also produced from a strain of Africanized honey bee and SNPs were extracted. These were released in dbSNP and the NCBI Trace Archive. Analysis of the genome by a consortium of 20 labs has been completed. This produced a gene list derived from five different methods melded through the GLEAN software. Publications include a main paper in Nature and up to forty companion papers in Genome Research and Insect Molecular Biology. Sponsors: Sequencing of the honey bee is jointly funded by National Human Genome Research Institute (NHGRI) and the Department of Agriculture (USDA). Multiple drones from the same queen (strain DH4) were obtained from Danny Weaver of B. Weaver Apiaries. All libraries were made from DNA isolated from these drones. The honey bee BAC library (CHORI-224) was prepared by Pieter de Jong and Katzutoyo Osoegawa at the Children's Hospital Oakland Research Institute.gene, agricultural, allergy, antibiotic, apis mellifera, array, behavioral, biologist, chromosome, development, disease, genome, heath, honey bee, human, immunity, insect, mental heath, organism, pollination, reaction, resistance, sequence, traitSCR_002890(Honey Bee Genome Project, RRID:SCR_002890)Baylor University; Texas; USA Last checked downnif-0000-25604http://www.hgsc.bcm.tmc.edu/project-species-i-Apis%20mellifera.hgsc?pageLocation=Apis%20mellifera
Functional Genomics Data SocietyResource, narrative resource, topical portal, portal, standard specification, data or information resourceThe Functional Genomics Data Society - FGED Society, founded in 1999 as the MGED Society, advocates for open access to genomic data sets and works towards providing concrete solutions to achieve this. Our goal is to assure that investment in functional genomics data generates the maximum public benefit. Our work on defining minimum information specifications for reporting data in functional genomics papers have already enabled large data sets to be used and reused to their greater potential in biological and medical research. We work with other organizations to develop standards for biological research data quality, annotation and exchange. We facilitate the creation and use of software tools that build on these standards and allow researchers to annotate and share their data easily. We promote scientific discovery that is driven by genome wide and other biological research data integration and meta-analysis.functional genomicsSCR_004358(Functional Genomics Data Society, RRID:SCR_004358)IlluminaLast checked downnlx_37824
ADHD-200 SampleResource, disease-related portal, data set, topical portal, portal, data or information resourceA grassroots initiative dedicated to accelerating the scientific community''''s understanding of the neural basis of ADHD through the implementation of open data-sharing and discovery-based science. They believe that a community-wide effort focused on advancing functional and structural imaging examinations of the developing brain will accelerate the rate at which neuroscience can inform clinical practice. The ADHD-200 Global Competition invited participants to develop diagnostic classification tools for ADHD diagnosis based on functional and structural magnetic resonance imaging (MRI) of the brain. Applying their tools, participants provided diagnostic labels for previously unlabeled datasets. The competition assessed diagnostic accuracy of each submission and invited research papers describing novel, neuroscientific ideas related to ADHD diagnosis. Twenty-one international teams, from a mix of disciplines, including statistics, mathematics, and computer science, submitted diagnostic labels, with some trying their hand at imaging analysis and psychiatric diagnosis for the first time. The data for the competition was provided by the ADHD-200 Consortium. Consortium members from institutions around the world provided de-identified, HIPAA compliant imaging datasets from almost 800 children with and without ADHD. A phenotypic file including all of the test set subjects and their diagnostic codes can be downloaded. Winner is presented. The ADHD-200 consortium included: * Brown University, Providence, RI, USA (Brown) * The Kennedy Krieger Institute, Baltimore, MD, USA (KKI) * The Donders Institute, Nijmegen, The Netherlands (NeuroImage) * New York University Medical Center, New York, NY, USA (NYU) * Oregon Health and Science University, Portland, OR, USA (OHSU) * Peking University, Beijing, P.R.China (Peking 1-3) * The University of Pittsburgh, Pittsburgh, PA, USA (Pittsburgh) * Washington University in St. Louis, St. Louis, MO, USA (WashU)mri, fmri, brain, neuroimaging, attention deficit-hyperactivity disorder, anatomical, resting state functional mri, child, adolescent, human, young, early adult human, functional imaging, structural imaging, normal, normal controlSCR_005358(ADHD-200 Sample, RRID:SCR_005358)1000 Functional Connectomes Project Attention deficit-hyperactivity disorderrelated to: Neuro Bureau, listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)Last checked downnlx_144426
NIH Knockout Mouse Project (KOMP)Resource, topical portal, portal, data or information resourceA trans-NIH initiative to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. By capitalizing on efficiencies of scale and a centralized production effort, the project intends to make this catalog of mutants available in mouse strain C57BL/6 for two reasons: it is the most widely used strain and it is the strain for which complete genome sequence has been made available. The NIH KOMP initiative aims to: 1) use gene targeting to make the resource of null alleles, marked with a high utility reporter, preferably in C57BL/6; 2) support a repository to house the products of this resource as well as an additional "repatriation" effort to bring into repositories 1000 of the existing high priority mouse knockouts not already stored in a public repository; 3) develop improved C57BL/6 ES cells that show robust germline transmission, so that they may be used in a high throughput pipeline in generating this resource; and 4) implement a data coordination center which will make the status and relevant data of the production effort available to the research community. Towards those ends, NIH awarded five-year cooperative agreements totaling up to $47.2 million to two groups for the creation of the knockout mice lines. Recipients of those awards are Regeneron Pharmaceuticals, Inc., in Tarrytown, N.Y., and a collaborative team from Children's Hospital Oakland Research Institute (CHORI) in Oakland, Calif., the School of Veterinary Medicine, University of California, Davis (UC Davis); and the Wellcome Trust Sanger Institute in Hinxton, England. Under its cooperative agreement, the team plans to systematically create mouse ES cell lines in which 5,000 genes have been knocked out by gene targeting. The VelociGene division of Regeneron, will take aim at a different set of 3,500 genes. Both groups will utilize information from the finished mouse genome sequence to design targeting vectors, which will be built by large-scale, automated technologies. The combined collection of mouse ES cells with knockouts in 8,500 genes will be useful for producing knockout mice. In addition, The Jackson Laboratory will set up a Data Coordination Center that will allow the research community to track the scheduling and progress of knockout production. The center will also serve as a central information resource for all publicly available knockout mutants and will integrate with other databases that contain mouse DNA sequence, additional information on mouse genetics and information on the physical and biochemical characteristics of the knockout mice. The NIH has also provided $4.8 million to establish and support a repository for the Knockout Mouse Project. Finally, NIH awarded cooperative agreements to improve the efficiency of methods for creating knockout lines. They will focus on developing methods to create ES cell lines suitable for high-throughput gene targeting or trapping in C57BL/6.embryonic stem cell, c57bl/6, knock out mouse, gene, mutationSCR_005571(NIH Knockout Mouse Project (KOMP), RRID:SCR_005571)International Knockout Mouse Consortium , National Institutes of Health NIH, NIH Blueprint for Neuroscience Researchrelated to: Monarch Initiative, listed by: NIDDK Information Network, NIDDK Research ResourcesLast checked downnlx_145296
NIMH Resources for Research Training and Career DevelopmentResource, topical portal, training resource, portal, data or information resourceA portal to the National Institute of Mental Health''s Research Training, Career Development, and Related Programs. Topics cover Resources for Applicants, Individual Fellowship Programs, Individual Career Development Programs, Institutional Training Programs, Additional Career Development/Training-Related Opportunities, and Training Programs to Increase Workforce Diversity.research, career development, fellowship, training, careerSCR_005624(NIMH Resources for Research Training and Career Development, RRID:SCR_005624)National Institute of Mental Health NIMHLast checked downnlx_146240
KI Biobank - NOAKResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVCE, documented September 2, 2016.nitric oxide, clinical, therapy, lung diseaseSCR_006008(KI Biobank - NOAK, RRID:SCR_006008)Karolisnka Biobank Asthmalisted by: One Mind Biospecimen Bank ListingLast checked downnlx_151389
PatientCrossroadsResource, patient registry, topical portal, portal, people resource, data or information resourceA trusted third-party gatekeeper of patient data from participants in a rare disease ecosystem, collecting and managing the information in a scalable, cost-effective manner. Each patient registry provides critical disease knowledge which makes that disease easier to study, increasing the probability a treatment can be developed. PatientCrossroads takes a network approach to patient registry programs. Unlike companies that merely sell registry software, we offer a full range of administration, management, and genetic curation services. What does this consolidated, patient-centric approach to patient registries mean? * Patients can more easily find registries and provide their valuable data (including locations of blood and tissue samples as well as reports of diagnoses, disease symptoms, treatment usage, and lifestyle activities) * Patients can be confident in the privacy of their de-identified data and the knowledge that PatientCrossroads does not sell patient data * Researchers and pharmaceutical companies have a larger, more easily accessible pool of potential patients for research studies and clinical trials targeting specific rare diseases * Pharmaceutical companies can collect post-market surveillance data in a more scalable and cost-effective manner * Rare disease advocacy and research foundations can more easily organize their global patient populations for inclusion in trials and studiesdisease, treatment, clinical, patient, registry, drug discovery, clinical trial, research study, genetics, biorepositorySCR_006279(PatientCrossroads, RRID:SCR_006279)Rare diseaseLast checked downnlx_151889
HDBaseResource, disease-related portal, data set, topical portal, portal, data or information resourceA community website for Huntington''s Disease (HD) research that currently contains Y2H and Mass spectrometry protein-protein interaction data centered around the HD protein (huntingtin) and information on therapeutic studies in mouse. Also available are raw Human and Mouse Affymetrix Microarray data. The protein interaction data is from several sources, including interactions curated from the literature by ISB staff, experimentally determined interactions produced by Bob Hughes and colleagues at Prolexys (currently password protected), and interactions reported in a recent publication by Goehler et al from Eric Wanker''s lab. Content areas that may be covered by the site include the following: * Therapeutic studies in mouse, primarily drug screens. * HD mouse models with a focus on timelines of disease progression. * Antibodies used in HD research. * Microarray gene expression studies. * Genes and proteins relevant to HD research. This includes HD itself, the growing list of proteins thought to interact directly or indirectly with huntingtin (Htt), and other genes and proteins implicated in the disease process. * Molecular pathways thought to be involved in the disease process. * Timelines of disease for Mouse modelsdrug, gene expression, huntingtin, mass spectrometry, microarray, protein interaction, protein-protein interaction, y2h, mouse model, treatment, disease, phenotype, brain, striatum, adipose, muscle, gene, protein, antibody, pathwaySCR_007132(HDBase, RRID:SCR_007132)Institute for Systems Biology; Washington; USA Huntington''s disease, ControlHereditary Disease Foundationuses: CytoscapeLast checked downnif-0000-00153
CardioGenomicsResource, topical portal, portal, data or information resourceThe primary goal of the CardioGenomics PGA is to begin to link genes to structure, function, dysfunction and structural abnormalities of the cardiovascular system caused by clinically relevant genetic and environmental stimuli. The principal biological theme to be pursued is how the transcriptional network of the cardiovascular system responds to genetic and environmental stresses to maintain normal function and structure, and how this network is altered in disease. This PGA will generate a high quality, comprehensive data set for the functional genomics of structural and functional adaptation of the cardiovascular system by integrating expression data from animal models and human tissue samples, mutation screening of candidate genes in patients, and DNA polymorphisms in a well characterized general population. Such a data set will serve as a benchmark for future basic, clinical, and pharmacogenomic studies. Training and education are also a key focus of the CardioGenomics PGA. In addition to ongoing journal clubs and seminars, the PGA will be sponsoring symposia at major conferences, and developing workshops related to the areas of focus of this PGA. Information regarding upcoming events can be found in the Events section of this site, and information about training and education opportunities sponsored by CardioGenomics can be found on the Teaching and Education page. The CardioGenomics project came to a close in 2005. This server, cardiogenomics.med.harvard.edu, remains online in order to continue to distribute data that was generated by investigators under the auspices of the CardioGenomics Program for Genomic Applications (PGA). :Sponsors: This resource is supported by The National Heart, Lung and Blood Institute (NHLBI) of the NIH.genomics, clinical, genetic, environmental, stimulus, cardiovascular, disease, data, expression, gene, dna, polymorphism, population, pharmacogenomic, training, educationSCR_007248(CardioGenomics, RRID:SCR_007248)Harvard University; Cambridge; United States Last checked downnif-0000-30296http://www.cardiogenomics.org
KI Biobank - EXTResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented August 29, 2016. The aim of EXT (extinction) is to investigate the relation between specific genetic variations and cognitive control process in fear. Blood samples will be collected from about 300 healthy, young individuals (age 18-35).genetic variation, cognitive control, fear, healthy, early adult, geneSCR_008875(KI Biobank - EXT, RRID:SCR_008875)Karolisnka Biobank Healthy, Aginglisted by: One Mind Biospecimen Bank ListingLast checked downnlx_149601
KI Biobank - HARMONYResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceA twin study characterizing the importance of genetic factors for dementia and using discordant twin pairs to study other putative risk factors which control for genetic propensity to develop the disease. Molecular genetic studies have identified a number of mutations and other markers associated with early age of onset Alzheimer''''s disease. However, most cases of late age of onset dementia are considered sporadic, that is, without a clear genetic basis. Twin studies provide a unique opportunity to characterize the importance of genetic factors for dementia. Discordant twin pairs additionally provide the opportunity to study other putative risk factors which controlling for genetic propensity to develop the disease. In the first wave of the Study of Dementia in Swedish Twins, all SATSA twins born before 1935 have been screened for dementia symptoms. Over 190 suspects have been identified. This pilot study has been expanded to the entire registry in the study known as HARMONY. All twins aged 65 and older were invited to participate in a computer assisted telephone screening interview. A total of 13,519 individuals completed the interview (response rate = 75.9%). Dementia screening was based on the TELE, which includes the 10-item MSQ, other cognitive items (counting backwards, recalling three words, and similarities), and questions about health and daily functioning; or on Blessed scores obtained from a proxy interview. Among those screened, 1565 were positive for suspicion of dementia and were referred for complete clinical evaluation by a physician and a nurse. Once the preliminary in-person evaluation suggested that the suspected case was demented, the twin partner was also invited for an identical clinical work-up. Response rate for clinical evaluations is 71.4%. Approximately half of those visited for evaluation have been diagnosed as demented according to DSM-IV criteria, of which two-thirds have Alzheimer''''s disease. An extensive assessment of probable risk exposure is also included. Longitudinal follow-up is yet another feature of the study. Association studies with candidate genes are also being performed. Types of samples * DNA Number of sample donors * 1154 (sample collection completed)interview, late adult human, clinical evaluation, association study, candidate gene, gene, risk factor, twin, longitudinalSCR_008884(KI Biobank - HARMONY, RRID:SCR_008884)Karolisnka Biobank Dementia, Alzheimer''''s disease, Discordant twin, AgingNIHrelated to: Swedish Twin Registry, KI Biobank - SATSA, listed by: One Mind Biospecimen Bank ListingLast checked downnlx_151298http://ki.se/en/meb/dementia-in-swedish-twins-harmony
Functional Genomics in Embryonic Stem CellsResource, organization portal, portal, topical portal, data or information resourceThis website is dedicated to the dissemination of information about the European research project FunGenES (Functional Genomics in Embryonic Stem Cells). FunGenES is a research programme carried out on mouse embryonic stem cells with the aim to improve our understanding of cellular self-renewal and differentiation processes into tissue-specific cells. The website contains general knowledge about stem cell research and related issues such as ethics in stem cell related research, and more detailed information about the specific scope and objectives of the FunGenES project. A brochure containing a general project description in PDF format is available for download in the section Publications. FunGenES - Functional Genomics in Embryonic Stem Cells brings together experts in stem cell research from 18 organisations from industry and academic research across Europe. This research initiative is set up as an Integrated Project with a budget of approximately 12 Million Euros, partially funded by the 6th Framework Programme of the European Union. Specialists from Germany, France, Italy, Portugal, Greece and the UK collaborate for a period of 3 years to investigate the functional genomics of mouse embryonic stem (ES) cells. FunGenES aims to achieve a detailed basic understanding of stem cell self-renewal and differentiation. FunGenES investigates the unique ability of mouse embryonic stem cells to develop into any cell of an organ (this ability is also known as pluripotency), creates new tools for functional genomic studies and will thus provide key knowledge to understand the commitment of cells to a particular cell type. This complex process occurs in several steps and controls the development of pluripotent cells into highly specialised cells of an organism. In particular, FunGenES aims to identify genes controlling the development of the pluripotent ES cells into heart cells (cardiomyocytes), nerve cells (neurons), smooth muscle cells, vascular endothelial cells, fat cells (adipocytes), liver cells (hepatocytes) and insulin-producing cells of the pancreas. FunGenES will deliver a gene expression atlas summarising the genetical pathways for cell differentiation. The project aims to contribute to future therapeutic strategies for degenerative diseases such as heart disease, diabetes and Parkinson''s. All these diseases are characterised by the irreversible loss of functional cells. FunGenES was selected from a large number of proposals to be funded as an advanced and promising project in the area of functional genomics in the Life-Science-Health Programme of the European Union. In addition to its ambitious scientific programme, FunGenES aims to inform the general public about stem cell research, its ethical aspects and future therapeutical applications The project is coordinated by Professor Jrgen Hescheler (University of Cologne) Jrgen Hescheler is excited about the potential of the project: By understanding how mammalian genomic information is selectively used in development, we will acquire an essential key to understanding ourselves and our health. Sponsor. The FunGenES Integrated Project was funded by a grant from the European Commission (6th Framework Programme, Thematic Priority: Life sciences, Genomics and Biotechnology for Health, Contract No. : FunGenES LSHG-CT-2003-503494; http://ec.europa.eu/grants/index_en.htm). H.B. and M.T. were also supported by the University Bordeaux 2 (http://www.u-bordeaux2.fr/index.jsp) and CNRS (http://www.cnrs.fr/); A.K.H. received NIH support, grant HL08395 (http://www.nih.gov/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.SCR_008518(Functional Genomics in Embryonic Stem Cells, RRID:SCR_008518)Last checked downnif-0000-30588
George M. O'Brien Kidney Center at Yale Resource, disease-related portal, topical portal, resource, service resource, portal, access service resource, data or information resourceCenter that facilitates translational and clinical research that will advance the prevention and treatment of kidney diseases.kidney disease, clinical researchSCR_015294( George M. O'Brien Kidney Center at Yale , RRID:SCR_015294)Yale School of Medicine; Connecticut; USA kidney diseaseNIDDKlisted by: NIDDK Information NetworkLast checked down
Cystic Fibrosis Center University of Pittsburgh Resource, disease-related portal, topical portal, resource, service resource, portal, access service resource, data or information resourceResearch center whose goal is to understand and translate the basic mechanisms of cystic fibrosis. It uses the molecular and cell biology of CFTR, CFTR mutants, infection, and inflammation with the overall theme of translating preclinical science into clinical investigations.cystic fibrosis mechanism, cystic fibrosis translational research, cystic fibrosis researchSCR_015400( Cystic Fibrosis Center University of Pittsburgh , RRID:SCR_015400)University of Pittsburgh; Pennsylvania; USA Cystic FibrosisCystic Fibrosis Foundation Research Development Program, NIDDKlisted by: NIDDK Information NetworkLast checked down
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