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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Sep 14, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared ResourceResource, service resource, core facility, access service resourceVanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource (TMESCSR) provides services that facilitate the generation, storage and regeneration of genetically altered mice.SCR_010200(Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource, RRID:SCR_010200)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156678
Vanderbilt Eicosanoid Core LaboratoryResource, service resource, core facility, access service resourceThe Eicosanoid Core Laboratory facility employs mass spectrometry to quantify lipid oxidation products produced in a variety of vascular (and other) disorders including prostaglandins, leukotrienes, isoprostanes, and their urinary metabolites.SCR_010177(Vanderbilt Eicosanoid Core Laboratory, RRID:SCR_010177)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156654
Penn Automated Claims and Medical Record DatabasesResource, service resource, core facility, access service resourceA core facility in the Center for Pharmacoepidemiology Research and Training created to foster epidemiologic research into therapeutics, using large population-based automated claims databases (Medicaid/Medicare) and medical records databases (GPRD and THIN), and the FDA''s adverse event reporting system (FAERS) database. Goals: * Encourage investigators with diverse training to conduct studies focused on translational therapeutics and drug safety * Provide access to large databases that allow for rapid and cost-effective research on therapeutics and drug safety * Foster collaboration with CTSA sites outside of Penn who wish to use these databases for clinical researchepidemiology, therapeuticsSCR_009643(Penn Automated Claims and Medical Record Databases, RRID:SCR_009643)University of Pennsylvania; Philadelphia; Pennsylvania listed by: Eagle ILast checked downnlx_156115
Dartmouth Trace Element Analysis Core LaboratoryResource, service resource, core facility, access service resourceCore facility that provides the following services: Metals analysis of waters service, Metals analysis of urine, serum and whole blood service, Metals analysis of cell pellets service, Metals analysis of toenails service, Metals analysis of biological tissue service, Metals analysis of soils service, Arsenic speciation in water service, Arsenic speciation in urine service, Mercury speciation in water service, Mercury speciation in sediment service, Mercury speciation in biological tissue service.

The Trace Element Analysis (TEA) laboratory specializes in low-level trace metal analysis and speciation in environmental and biological samples. We use inductively coupled plasma mass spectrometry (ICP-MS) for metals analysis and several ?hyphenated? techniques that couple instruments together for speciation analyses of water, soil and biological tissue samples. The lab has three ICP-MS instruments (Agilent 7700x, Agilent 7500cx, and Element 2 ICP-MS). We can measure most elements in the periodic table with detection limits in the low ppt range or below. Our ICP-MS instruments can also be coupled with cold vapor generation, liquid chromatography and laser ablation. With these hyphenated analyses we can * Detect ultra-low levels of arsenic or mercury (< 1 ng/L) * Differentiate between toxic and nontoxic forms, or species, of arsenic and mercury * Map trace elements within a biological tissue We are interested in new methods and new applications for hyphenated analyses. This includes work in the emerging field of metallomics, which characterizes all of the metal binding molecules in a cell, in blood, or in an organism. The TEA lab supports Dartmouth College researchers in the Superfund Basic Research Program: Toxic Metals in the Northeast. We work especially closely with Superfund Basic Research Program Project 4 Epidemiology, Biomarkers and Exposure Assessment of Metals and Project 7 Bioaccumulation and Trophic Transfer of Toxic Metals in Aquatic Food Webs. For Project 4, we speciate arsenic and provide total concentrations from samples of water and urine. For Project 7, we measure levels of mercury and other metals in freshwater aquatic food webs. The TEA lab also works with other researchers outside Dartmouth on a fee-for-service basis. See website for Services & Price List Instructions For Submitting A Sample For Analysis Login To Submit A Sample For Analysis
inductively coupled plasma mass spectrometrySCR_009777(Dartmouth Trace Element Analysis Core Laboratory, RRID:SCR_009777)Dartmouth College; New Hampshire; USA listed by: Eagle ILast checked downnlx_156244
DartMouse - Speed CongenicsResource, service resource, core facility, access service resourceCore facility that provides the following services: Medium-density speed congenic backcross service, Medium-density genetic background check service, DNA extraction. DartMouse is a not-for-profit core facility funded by the National Institutes of Health''s National Center for Research Resources. The mission of DartMouse is to facilitate the development of congenic mice in support of pre-clinical projects across the United States. Use of DartMouse allows the generation of congenic mice in 5 generations (~1.5 years), versus the 10 generations (~3 years) required by conventional back-crossing. Facility staff provides expert advice on mouse speed congenic development, mouse genetic background analysis, and mouse genetic mapping. Investigators provide us with mouse tail clippings. From these, DartMouse isolates genomic DNA and performs and analyzes complete genome-wide scans. We return data in graphical and spreadsheet formats, and make specific recommendations on breeder selection. We operate an Illumina BeadStation 500. Chips use a 1449 SNP array covering the mouse genome with an average density of <5 cM.congenic backcrossing, dna extractionSCR_009757(DartMouse - Speed Congenics, RRID:SCR_009757)Dartmouth College; New Hampshire; USA listed by: Eagle ILast checked downnlx_156218,
Dartmouth Multi-Photon ImagingResource, service resource, core facility, access service resourceCore facility that provides the following services: Multi-photon imaging. This SynergyT1 Shared Resource Core includes two microscopes sharing two femtosecond pulsed Ti:Sapphire lasers (tunable between 690 and 1080 nm) for imaging fluorescently-tagged molecules in tissues in vivo and in vitro.fluorescent microscopySCR_009767(Dartmouth Multi-Photon Imaging, RRID:SCR_009767)Dartmouth College; New Hampshire; USA listed by: Eagle ILast checked downnlx_156231
Dartmouth Translational Research Animal CoreResource, service resource, core facility, access service resourceTRAC is affiliated with the the Irradiation and Small Animal Imaging Shared Resource, which together provides irradiation services for basic and translational researchers and state-of-the-art non-invasive in vivo imaging of cultured cells and small animals. Services are used by Dartmouth investigators to irradiate cells in culture and small experimental animals. A separate set of irradiation devices is available through Norris Cotton Cancer Center for clinical and experimental irradiation of human patients.SCR_009778(Dartmouth Translational Research Animal Core, RRID:SCR_009778)Dartmouth College; New Hampshire; USA listed by: Eagle ILast checked downnlx_156245
HSCI and BIDMC Flow Cytometry Core FacilityResource, service resource, core facility, access service resourceCore facility that provides the following services: Cell sorting service, Cell analyzing service, Cell separation service, Cell cytometer service, Data services, Flow cytometry protocol development service, Benchtop flow cytometry analyzer training, Flow cytometry beta-testing service. Committed to meet all of the flow cytometry needs for the BIDMC and the external research community, the Flow Cytometry Core facility offers state of the art instrumentation for routine flow cytometry and cell sorting. It is continuously expanding with the newest software and machinery for both sort and analysis capabilities of up to 30 flourescent parameters. The Flow Cytometry Core facility is available to: answer technical questions; assist you in setting up flow cytometry experiments; assist you with acquiring, analyzing and interpreting your data; assist in data presentation and data storage; provide training on the four benchtop analyzers and on software. To schedule an appointment for regular flow cytometry (user operated), log onto our online web calendar at: activated cell sorting (facs), flow cytometry assaySCR_009816(HSCI and BIDMC Flow Cytometry Core Facility, RRID:SCR_009816)listed by: Eagle ILast checked downnlx_156283,
Vanderbilt Clinical Trials Shared ResourceResource, service resource, core facility, access service resourceThe primary mission of the Clinical Trials Shared Resource (CTSR), as identified in the Cancer Center Support Grant (CCSG), is to assist Cancer Center investigators develop, activate and complete scientifically-meritorious clinical trials in an efficient, cost-effective and technically-sound manner.SCR_010172(Vanderbilt Clinical Trials Shared Resource, RRID:SCR_010172)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156649
Vanderbilt Mouse Kidney Histology and Morphometry CoreResource, service resource, core facility, access service resourceThe overall goal of the Histology and Morphometry Core is 1) to provide a common facility and expertise for the broad spectrum of morphologic studies that may be required for interpretation of studies of various models of kidney disease and their response to interventions; 2) to provide tissue samples from existing archival specimens from various mouse and rat kidney disease models that may be used for exploration and characterization of expression patterns of various novel target molecules; and 3) to develop and enhance existing morphologic techniques to improve the ability of center investigators to localize specific molecules and tissue sections, and to interpret their significance based on the spatial localization and relationship to patterns of injury.SCR_010192(Vanderbilt Mouse Kidney Histology and Morphometry Core, RRID:SCR_010192)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156671
Vanderbilt Mouse Kidney Physiology Core LabResource, service resource, core facility, access service resourceThe objectives of the physiology core are to establish average values and normal ranges for physiologic parameters of renal function in mice, and to develop novel assays of mouse kidney structure and function. Our goal is to provide valuable institutional and national shared resources to facilitate better understanding of kidney diseases and treatments.SCR_010193(Vanderbilt Mouse Kidney Physiology Core Lab, RRID:SCR_010193)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156672
Vanderbilt Neurochemistry Core LaboratoryResource, service resource, core facility, access service resourceThe Neurochemistry Core Lab performs assays of neurotransmitter concentrations in brain tissue, designs custom assays as well as provides training in HPLC methods.SCR_010194(Vanderbilt Neurochemistry Core Laboratory, RRID:SCR_010194)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156673
Vanderbilt Survey Research Shared ResourceResource, service resource, core facility, access service resourceProvides support for phone interview-based collection of information from study subjects. The Survey Research Shared Resource provides services to investigators related to development and implementation of mail, telephone, web and mixed mode surveys.SCR_010198(Vanderbilt Survey Research Shared Resource, RRID:SCR_010198)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156676
Vanderbilt Zebrafish Aquatic FacilityResource, service resource, core facility, access service resourceThe current zebrafish facility is composed of approximately 100 research tanks available for short and long-term studies, and a significant expansion project is underway. The facility enables investigator access to the unique advantages of the zebrafish model, which provides hundreds of mutant and transgenic zebrafish with unique properties suited for specific experiments. This core?s essential mission is to provide a reliable mechanism for incorporation and propagation of new and existing zebrafish lines into the core.SCR_010202(Vanderbilt Zebrafish Aquatic Facility, RRID:SCR_010202)Vanderbilt University; Tennessee; USA listed by: Eagle ILast checked downnlx_156681
Penn Neurobehavior Testing CoreResource, service resource, core facility, access service resourceCore facility that provides the following services: Behavioral testing training, Behavioral testing consultation service, Neurobehavior Testing Core access, Evaluation of anxiety behavior, Evaluation of circadian activity and rest/activity patterns, Measurement of sleep/wake patterns, Video image analysis of behavioral assays, Tissue harvest and histology prep service, Customized behavior batteries. The Neurobehavior Testing Core provides core facilities and services to test mice in state of the art assays of simple and complex behaviors, including the assessment of circadian rhythms and sleep, learning and memory, motor and sensory function, as well as behavioral assays relevant to translational studies of neurological, neurodevelopmental and psychiatric disorders. The core offers comprehensive behavior phenotyping of your mice or can train your lab personnel to perform the tests in the facility. In addition, we provide consultation on study design including appropriate tests, mouse line/strain, numbers of animals, control groups and breeding strategies. The core will also provide consultation regarding ULAR, IACUC and other regulatory issues. Assistance with data analysis is also available. The behavior apparatus available in the core includes: running wheels and beam splitters to measure circadian activity and rest/activity patterns as well as EEG/EMG recording chambers to measure sleep/wake states. Motor function is assessed using open field activity monitors and Rotarod. Apparatus to measure anxiety-like behavior including zero maze, light/dark chamber, passive/active avoidance chambers and hole poke arenas are also available. Extensive assessment of cognition, learning and memory is conducted with Morris water maze, radial arm maze, 5 choice serial reaction time test and object recognition tests. Tests of behaviors associated with depression (forced swim), schizophrenia (startle/PPI), social interaction (choice and social memory), and drug addiction (conditioned place preference) are also available. Tests of general health and responsiveness are also performed, as these are critical for the evaluation of complex behavior. Support for the core is provided by the Comprehensive Neuroscience Center, the Institute for Translational Medicine and Therapeutics, the Center for Sleep and Circadian Neurobiology and the Perelman School of Medicine.behavioral assay, data analysis, polysomnography, tissue harvesting, histological sample preparationSCR_010024(Penn Neurobehavior Testing Core, RRID:SCR_010024)University of Pennsylvania; Philadelphia; Pennsylvania listed by: Eagle ILast checked upnlx_156495
BIDMC Clinical Research Coordinator Core LaboratoryResource, service resource, core facility, access service resourcePartially funded through Harvard Catalyst, the Clinical Research Coordinator Core is available to support and collaborate with investigators and their research teams in all phases of clinical research, providing services that include assisting with the organization, implementation and completion of clinical research studies.SCR_009663(BIDMC Clinical Research Coordinator Core Laboratory, RRID:SCR_009663)listed by: Eagle ILast checked upnlx_156123
BIDMC Mass Spectrometry CoreResource, service resource, core facility, access service resourceCore facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.
mass spectrometry assay, post translational modification identification by mass spectrometry, metabolite profilingSCR_009672(BIDMC Mass Spectrometry Core, RRID:SCR_009672)listed by: Eagle ILast checked upnlx_156129
CHOP Clinical Trials OfficeResource, service resource, core facility, access service resourceCore facility that provides the following services: Clinical trials consultation service, Document storage service, Investigational new drug or investigational device exemption application support service, Institutional Review Board submission service, Additional regulatory submissions support service, Protocol development service, Human subject recruitment support service, Study feasibility service, Study placement service. The Clinical Trials Office (CTO) at The Children''s Hospital of Philadelphia is a centralized office that provides resources and assistance to clinical research investigators, enabling them to carry out clinical research in a manner consistent with the Hospital''s goals ? excellent patient care, top-quality education, and innovative research. The CTO has expertise in implementing, conducting, and monitoring clinical trials and provides a variety of services that benefit both novice and experienced clinical researchers. The CTO is designed to ensure the excellence and compliance of an investigator''s clinical research trial. The Children''s Hospital of Philadelphia established the CTO in 1999 as part of the institution''s emphasis on clinical research. Since then, the CTO has experienced rapid growth. The CTO advances the quality and quantity of clinical research at Children''s Hospital and its associated network. Specifically, the CTO supports research at the Hospital by developing and completing submissions to the Hospital''s Institutional Review Board; assisting in the preparation of Investigational New Drug and Investigational Device exemption application submissions to the Federal Drug Administration; conducting clinical research studies under the guidance of principal investigators; and developing budgets and providing research training for investigators, study coordinators, and administrative staff. The CTO staff works in partnership with investigators to ensure the protection of human subjects in accordance with Good Clinical Practice, federal, state and/or local regulations and the requirements of the study sponsor.clinical trial technique, human subject recruitment and protectionSCR_009725(CHOP Clinical Trials Office, RRID:SCR_009725)University of Pennsylvania; Philadelphia; Pennsylvania listed by: Eagle ILast checked upnlx_156187
DF/HCC Cell Manipulation Core FacilityResource, service resource, core facility, access service resourceCore facility that provides the following services: Hematopoietic progenitor cell (HPC) components processing, Tumor cell vaccine generation, Dendritic cell vaccine generation, Validation consultation.

The (Connell and O''Reilly Families) Cell Manipulation Core Facility (CMCF), at Dana-Farber Cancer Institute (DFCI) was created in 1996 to be the manufacturing facility that produces safe and effective novel cellular component therapy that meets regulatory guidelines for clinical use and also facilitates research to be translated from the bench to the bedside. The goal of this facility is to assist DF/HCC investigators in developing new cell-based therapies for cancer and to support clinical research studies designed to evaluate the toxicity and efficacy of these novel treatments. In November 2004, CMCF moved to a newly constructed 6,700 square feet facility on the third floor and ground floor of the Jimmy Fund Building (JFB) at DFCI. The new facility is dedicated to the production of clinical grade cellular products for patients who participate in clinical trials conducted by DF/HCC investigators. All procedures are performed in environmentally controlled conditions according to current Good Manufacturing Practices (cGMP) for cell and tissue processing. The third floor accommodates all of the production areas while space on the ground floor is devoted to the long-term storage of cellular products, tissues and samples in liquid nitrogen and mechanical freezers. The CMCF is available to both clinical and laboratory investigators at all DF/HCC institutions and will provide services to patients at all DF/HCC affiliated hospitals. The staff of the CMCF are committed to working with DF/HCC investigators at all levels of clinical trial development and execution, including pre-clinical development, trial design, DF/HCC and FDA review, data management, quality control, internal and external audits as well as reports and publications. The Cell Manipulation Core Facility (CMCF) has been accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The CMCF services as a Regulatory Core for Center for Human Cell Therapy and is also a member of the Joint Program in Transfusion Medicine.
ex vivo genetic manipulation of cells, vaccine preparation, validationSCR_009734(DF/HCC Cell Manipulation Core Facility, RRID:SCR_009734)Harvard University; Cambridge; United States listed by: Eagle ILast checked upnlx_156196,
Dartmouth-Hitchcock Bioinformatics Shared ResourceResource, software resource, service resource, core facility, access service resource, data or information resourceCore to support the implementation of bioinformatics resources for cancer research at Dartmouth. Provides consultation and collaboration for research projects of NCCC members, regular workshops, seminars, services including applied bioinformatics and data mining, computer programming and software engineering, database development and programming and high performance computing and systems administration.cancer, research, core, service, bioinformatics, data, mining, computer, programming, software, engineering, database, administrationSCR_009758(Dartmouth-Hitchcock Bioinformatics Shared Resource, RRID:SCR_009758)Dartmouth College; New Hampshire; USA listed by: Eagle ILast checked upnlx_156219
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