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  • Related To:Alzheimers Disease Genetics Consortium (facet)
  • Funding Agency:Alzheimers Plan Foundation (facet)
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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Oct 12, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
International Genomics of Alzheimers ProjectResource, data set, organization portal, portal, consortium, data or information resourceConsortium to discover and map the genes that contribute to Alzheimer's disease and completely understand the role inheritance plays. To achieve this goal, they will work to identify all the genes that contribute to the risk of developing this disease. Investigators will have access to combined genetic data from a large number of Alzheimer's disease subjects and compare it to genetic data from an equally large number of elderly people who do not have Alzheimer's. In the initial phase of the work, more than 20,000 people with Alzheimer's and about 20,000 healthy elderly subjects will be compared. As the study progresses, 10,000 additional people with Alzheimer's and the same number of healthy elderly subjects will be added to the study. The subjects for these studies come from different Alzheimer research project locations across Europe, the UK, the US, and Canada. Data is available from their 2014 publication in Translational Psychiatry at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944635/ (http://www.ncbi.nlm.nih.gov/pubmed/24495969) Currently, there is no public access to the raw individual level genetic data because of privacy considerations. Researchers working with US cohorts deposit data in the database of genotypes and phenotypes (dbGaP), where it is available to all researchers who can show that they are able to guarantee the security of the data. After scanning the DNA of over 74,000 patients and controls from 15 countries, the IGAP consortium reported 11 new regions of the genome involved in late-onset Alzheimer's disease. IGAP published its results in Nature Genetics on October 27, http://www.ncbi.nlm.nih.gov/pubmed/24162737gene, inheritance, late adult human, genome-wide association study, database, basic science, biomarker, dna, data sharingSCR_004029(International Genomics of Alzheimers Project, RRID:SCR_004029)Pasteur Institute of Lille; Lille; France , Boston University School of Medicine; Massachusetts; USA , Cardiff University; Wales; United Kingdom , University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA Alzheimers Plan Foundation, alz.org, Diane Fatheree, Jim Prugh, Makray Family Foundationrelated to: alz.org, Alzheimer's Plan Foundation, Makray Family Foundation, Alzheimers Disease Genetics Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology, Boston University School of Medicine, Massachusetts, USA, Cardiff University, Wales, United Kingdom, University of Pennsylvania Perelman School of Medicine, Pennsylvania, USA, Pasteur Institute of Lille, Lille, France, National Institute on Aging, Lille 2 University of Health and Law, Lille, France, uses: NCBI database of Genotypes and Phenotypes, listed by: Consortia-pediaLast checked upnlx_158457
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