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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Aug 10, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
Danish Multiple Sclerosis BiobankResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceWe have collected DNA for more than 15 years, and today we have DNA from more than 1,800 Danish MS patients and 1,200 controls, all kept in the Danish Multiple Sclerosis Biobank in DMSC. In order to increase the sample size for genetic testing, we have participated in the Nordic MS Genetic Network since 1994, and today the Nordic material consists of more than 6,000 MS cases and 6,000 controls. The research in DMSC is focused on the candidate gene approaches and the genetic influence on the differences in treatment response. We are part of the IMSGC (International Multiple Sclerosis Genetic Consortium) and the Wellcome Trust Case Control Consortium (WTCCC), where 23 research groups from 15 countries are performing the largest set of MS genome-wide association study (GWAS), genotyping 11,000 cases and 11,000 controls using 500,000 SNP chip. Primary results have elucidated associations to more than 100 gene variations (SNPs). Following this collaboration we are joining the Immunochip Consortium, where 1,000 Danish cases and 1,000 Danish controls participate in a large scale genetic analysis, investigating best genes/regions/SNPs in MS together with other international MS research groups and 9 other autoimmune diseases research groups, looking for shared autoimmune genes. The risk of MS has been increasing over the last 50 years, especially among women older than 40 years. On this background we have initiated a project looking at aspects of gender differences, including different treatment responses. Furthermore, we have initiated a large-scale vitamin D project, investigating gene variations within the vitamin D pathway, and the importance of vitamin D in clinical and immunological disease activity. In addition, we have collected more than 800 questionnaires from MS patients dealing in detail with lifestyle and environmental exposure for a project studying gene-environmental interactions.dna, multiple sclerosis, control, autoimmune disease, gene, normal control, lifestyle, environment, genetics, genotypingSCR_000089(Danish Multiple Sclerosis Biobank, RRID:SCR_000089)Danish Multiple Sclerosis Center , University of Copenhagen; Copenhagen; Denmark Multiple Sclerosis, Control, Autoimmune disease, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked upnlx_143736
DIAN - Dominantly Inherited Alzheimer NetworkResource, disease-related portal, topical portal, database, biomaterial supply resource, tissue bank, portal, brain bank, material resource, data or information resourceAn international research partnership of leading scientists determined to understand a rare form of Alzheimers disease that is caused by a gene mutation and to establish a research database and tissue repository to support research on Alzheimers disease by other investigators around the world. One goal of DIAN is to study possible brain changes that occur before Alzheimers disease is expressed in people who carry an Alzheimers disease mutation. Other family members without a mutation will serve as a comparison group. People in families in which a mutation has been identified will be tracked in order to detect physical or mental changes that might distinguish people who inherited the mutation from those who did not. DIAN currently involves eleven outstanding research institutions in the United States, United Kingdom, and Australia. John C. Morris, M.D., Friedman Distinguished Professor of Neurology at Washington University School of Medicine in St. Louis, is the principal investigator of the project.gene mutation, dementia, cerebrum, image, middle frontal gyrus, superior temporal gyri, middle temporal gyri, inferior parietal lobe, angular gyrus, occipital lobe, calcarine sulcus, peristriate cortex, anterior cingulate gyrus, genu of the corpus callosum, posterior cingulate gyrus, precuneus, splenium, amygdala, entorhinal cortex, hippocampus, parahippocampal gyrus, striatum, caudate nucleus, anterior commissure, lentiform nuclei, globus pallidus, putamen, thalamus, subthalamic nucleus, midbrain, pons, medulla oblongata, cerebellum, dentate nucleus, spinal cord, frontal lobe, temporal lobe, mamillary body, parietal lobe, lateral geniculate nucleus, occipital lobe, calcarine sulcus, cerebellar hemisphere, dentate nucleus, clinical dementia rating, geriatric depression scale, functional assessment questionnaire, neuropsychiatric inventory-q, united parkinsons disease rating scale (updrs)-motor, hachinski ischemic score, cerebrovascular risk factor, cerebral spinal fluid, plasma, serum, blood, brain tissue, brain, tissue, formalin-fixed, paraffin wax embedded, block, frozen, clinical data, clinical, demographics, psychometrics, apoe genotype, adult human, mri, positron emission tomography, clinical assessment, psychometric testingSCR_000812(DIAN - Dominantly Inherited Alzheimer Network, RRID:SCR_000812)Washington University School of Medicine in St. Louis; Missouri; USA Dominantly inherited Alzheimer's disease, Biological adult child of a parent with a mutated gene known to cause dominantly inherited Alzheimer's disease, Alzheimer's disease, Normal control, AgingNIArelated to: National Cell Repository for Alzheimer's Disease, listed by: One Mind Biospecimen Bank Listing, NITRCLast checked upnlx_149316
MCICResource, data set, data or information resourceExpertly collected, well-curated data sets consisting of comprehensive clinical characterization and raw structural, functional and diffusion-weighted DICOM images in schizophrenia patients and gender and age-matched controls are now accessible to the scientific community through an on-line data repository ( This data repository will be useful to 1) educators in the fields of neuroimaging, medical image analysis and medical imaging informatics who need exemplar data sets for courses and workshops; 2) computer scientists and software algorithm developers for testing and validating novel registration, segmentation, and other analysis software; and 3) scientists who can study schizophrenia by further analysis of this cohort and/or by pooling with other data.clinical neuroinformatics, dicom, magnetic resonance, image collection, clinical assessment, diagnose, healthy control, neuropsychological test, psychiatric disorder, schizoaffective disorder, schizophrenia, diffusion-weightedSCR_002310(MCIC, RRID:SCR_002310)Mind Research Network - COINS Schizophrenia, Normal controllisted by: NITRCPMID:23760817Last checked upnlx_155657
Harvard Brain Tissue Resource CenterResource, biomaterial supply resource, biospecimen repository, tissue bank, service resource, brain bank, storage service resource, material resource, material storage repositoryA biomaterial supply resource that acquires, processes, stores, and distributes postmortem brain specimens for brain research. Various types of brain tissue are collected, including those with neurological and psychiatric disorders, along with their parents, siblings and offspring. The HBTRC maintains an extensive collection of postmortem human brains from individuals with Huntington's chorea, Alzheimer's disease, Parkinson's disease, and other neurological disorders. In addition, the HBTRC also has a collection of normal-control specimens.biomaterial supply resource, brain tissue, brain, tissue, Huntington's disease, Parkinson's disease, mental disease, neurological disorder, Alzheimer's disease, schizophrenia, bipolar disorder, relative, parent, sibling, child, lewy body variant Alzheimer's disease, amyotrophic lateral sclerosis, dementia, unipolar depressive disorder, diffuse lewy body disease, dyt-1 dystonia, progressive supranuclear palsy, rett syndrome, Tourette's syndrome, restless legs syndrome, autism, post-mortemSCR_003316(Harvard Brain Tissue Resource Center, RRID:SCR_003316)Harvard Medical School; Massachusetts; USA Huntington's disease, Parkinson's disease, Mental disease, Neurological disorder, Normal control, Alzheimers disease, Schizophrenia, Bipolar Disorder, Lewy Body Variant Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia, Unipolar Depressive Dissorder, Diffuse Lewy Body Disease, DYT-1 Dystonia, Progressive Supranuclear Palsy, Rett Syndrome, Tourette's SyndromeNational Institutes of Health, NIH Blueprint for Neuroscience Research, Private organizationsrelated to: One Mind Biospecimen Bank Listing, Multiple Sclerosis Discovery Forum, listed by: One Mind Biospecimen Bank Listing, Multiple Sclerosis Discovery ForumLast checked upnif-0000-00192
National Neurological AIDS BankResource, biomaterial supply resource, material resource, tissue bank, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented on March 23, 2012. The National Neurologic AIDS Bank (NNAB) is a site of the HIV/CNS Tissue Network. Based in Los Angeles, which has the largest and most diverse AIDS population in the western United States, the NNAB provides researchers with well-characterized neural tissue from HIV-1-infected and seronegative control donors. The NNAB collaborates with the other designated sites, funding agencies, and outside experts to develop local and national tissue networks. There are plans to create a Network Steering Committee, a panel of outside advisers, and a protocol to recruit and characterize human donors. The NNAB collects pre- and post-mortem clinical data and neural tissues using a standardized autopsy protocol, and the bank stores, codes, catalogs, and distributes this tissue. An electronic database and an Internet-based application process that researchers can use to access the Network's resources are being designed.human immunodeficiency virus, aids, seronegative control, normal control, neural tissue, clinical data, pre-mortem, post-mortem, tissueSCR_003583(National Neurological AIDS Bank, RRID:SCR_003583)David Geffen School of Medicine at UCLA; California; USA Human immunodeficiency virus, AIDS, Seronegative control, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_12023
Accelerated Cure Project MS RepositoryResource, biomaterial supply resource, biospecimen repository, image collection, service resource, storage service resource, data or information resource, material resource, material storage repositoryA repository of biological samples and data from people with multiple sclerosis, selected other demyelinating diseases, and unaffected controls. The repository not only provides much-needed samples and data to researchers studying MS and other diseases, but also aggregates the results from all of these studies so that they can be analyzed collectively, leading to new findings and breakthroughs. The repository collects blood, DNA, and imaging once per year. The repository currently includes samples and data from over 2,700 subjects with Multiple Sclerosis, Neuromyelitis Optica, Acute Disseminated Encephalomyelitis, Transverse Myelitis, Optic Neuritis, and Clinically Isolated Syndromes, as well as controls. Blood samples are provided as aliquots as serum, plasma, DNA, RNA, and lymphocytes and each sample is accompanied by more than 40 pages of clinical and epidemiological data contributed by the subject and the enrolling neurologist.multiple sclerosis, blood, dna, image, demyelinating disease, control, transverse myelitis, neuromyelitis optica, acute disseminated encephalomyelitis, optic neuritis, clinical data, epidemiological data, clinical, longitudinalSCR_004208(Accelerated Cure Project MS Repository, RRID:SCR_004208)Accelerated Cure Project for Multiple Sclerosis Multiple Sclerosis, Demyelinating disease, Normal control, Transverse Myelitis, Neuromyelitis Optica, Acute Disseminated Encephalomyelitis, Optic Neuritisrelated to: Multiple Sclerosis Discovery Forum, listed by: One Mind Biospecimen Bank Listing, Multiple Sclerosis Discovery Forum, lists: Biospecimens/Biorepositories: Rare Disease-HUB (RD-HUB)Last checked upnlx_22946
Karolisnka BiobankResource, production service resource, analysis service resource, biomaterial supply resource, material analysis service, service resource, storage service resource, biomaterial analysis service, material resource, material storage repositoryKI Biobank is an accredited core facility offering sample collection services. KI Biobank is located at the Department of Medical Epidemiology and Biostatistics. KI Biobank offer infrastructure for pre analytical sample handling and provide researchers guidance on how samples should be taken and labeled. The processes comprise registration, handling, storage and distribution of samples. KI Biobank also offers DNA-extraction from blood and saliva. In order to insure complete traceability on samples and belonging information all processes are controlled by a Laboratory Information Management System (LIMS). For every new study a contract is established describing the study and the disposition rights. We also help in writing Biobank agreements including multicenteravtal and Material Transfer Agreement. KI Biobank is, according to the Biobank law, responsible for all sample collections handled within the core facility and those that are stored on the departments on KI campus. Clinical sample collections are handled by the Biobank units at the respective hospitals within the Stockholm County Council. Besides the samples that are stored centrally at KI Biobank, KI Biobank is also the administrative biobank for research sample collections at Karolinska Institutet that are stored and administrated at the departments. All research sample collections must be reported to KI Biobank. The following types of sample collections are registered in the biobank; sample collections taken within the regular health care that has been transferred to Karolinska Institutet with an agreement of transfer, samples taken from healthy individuals or other persons out of the regular health care and samples that have been taken abroad.asthma, lung disease, cancer, cardiac disease, multiple sclerosis, ms, neurological disease, neurological injury, psychiatric disease, twin, dna-extractionSCR_004355(Karolisnka Biobank, RRID:SCR_004355)Karolinska Institutet; Stockholm; Sweden Asthma, Lung disease, Cancer, Cardiac disease, Multiple Sclerosis, Neurological disease, Neurological injury, Mental disease, Healthy, Normal control, Twin, Late adult humanlisted by: One Mind Biospecimen Bank ListingLast checked downnlx_37545
NIMH Data ArchiveResource, service resource, data or information resource, data repository, storage service resource, databaseResearch data repository for data sharing and collaboration among autism spectrum disorder investigators. Used to accelerate scientific discovery through data sharing, data harmonization and reporting of research results.afni brik, ascii, bshort, bfloat, connectome file format, cifti, clinical neuroinformatics, cor, dicom, imaging genomics, inc, minc2, nifti, os independent, philips par/rec, tex, vrml, phenotype, neuroimaging, genomic, gender, male, female, dti, fmri, mri, spectroscopy, eeg, microarray, snp, cnv, next-generation sequencing, gene regulation, gene expression, genotyping, pedigree, clinical assessmentSCR_004434(NIMH Data Archive, RRID:SCR_004434)National Institute of Mental Health Autism, Autism spectrum disorder, Asperger Syndrome, Normal control, Sibling control, Parental control, Fragile X syndromeCenter for Information Technology, NICHD, NIEHS, NIMH, NINDSrelated to: National Database for Clinical Trials related to Mental Illness, RDoCdb, used by: National Database for Clinical Trials related to Mental Illness, RDoCdb, uses: HED Tags, listed by: NITRC,, hosts: GUID ToolLast checked upnlx_143735
BrainNet EuropeResource, organization portal, biomaterial supply resource, biospecimen repository, consortium, tissue bank, narrative resource, service resource, brain bank, standard specification, storage service resource, portal, material storage repository, material resource, training service resource, data or information resourceConsortium of 19 brain banks across Europe with an aim to harmonize neuropathological diagnostic criteria and develop gold standards for quality, safety and ethics standards for brain banking. The consortium coordinates various inter-laboratory studies to harmonize neuropathological diagnostics throughout Europe. Consensus meetings take place where experts discuss their recent findings. Additionally, they have an extensive stock of human CNS tissue samples registered in a modern database, which is only accessible to BNE Members. Purpose of BNE: * To promote brain banking as a research resource for European neuroscience through the provision of high quality human brain tissue samples. * To determine the effect of pre- and post mortem parameters on preservation of DNA, RNA, proteins and neurochemical substances. * To determine the limits of usability of human post-mortem brain tissue for advanced molecular techniques. * To develop gold standards for tissue handling, tissue quality control and ethics leading to best practice guidelines for brain banking. * To provide training in brain banking and related methodology. * To reach out to neuroscience centers worldwide and promote future expertise in central nervous system (CNS) research. BrainNet Europe also contributes to research on rare diseases, such as: Pick''s disease or other rare forms of dementia, as well as to questions after the events in the aging brain. Anyone can be a donor - irrespective of disease of the central nervous system or not, because for research purposes, one does not only need tissue samples from ill donors, but also from healthy ones for comparison.central nervous system, clinical, brain research, brain tissue, brain, tissue, late adult human, brain bank, gold standard, neuropathological diagnosis, tissue handling, safety, quality control, ethics, post mortem, data sharing, tissue sampling, autopsy, microdissection, diagnosisSCR_004461(BrainNet Europe, RRID:SCR_004461)Ludwig-Maximilians-University; Bavaria; Germany Central nervous system disorder, Normal control, Aging, Neurological disease, Psychiatric disease, Pick''s disease, DementiaEuropean Union FP6related to: Medical University of Vienna Institute of Neurology, Human Brain Tissue Bank, listed by: One Mind Biospecimen Bank Listing, Consortia-pediaLast checked upnlx_45326
NINDS RepositoryResource, biomaterial supply resource, biospecimen repository, service resource, storage service resource, cell repository, data or information resource, material resource, material storage repositoryOpen resource of biological samples (DNA, cell lines, and other biospecimens) and corresponding phenotypic data to promote neurological research. Samples from more than 34,000 unique individuals with cerebrovascular disease, dystonia, epilepsy, Huntington's Disease, motor neuron disease, Parkinsonism, and Tourette Syndrome, as well as controls (population control and unaffected relatives) have been collected. The mission of the NINDS Repository is to provide 1) genetics support for scientists investigating pathogenesis in the central and peripheral nervous systems through submissions and distribution; 2) information support for patients, families, and advocates concerned with the living-side of neurological disease and stroke.nervous system disorder, neurogenetics, genetic, clinical data, cerebrovascular disease, epilepsy, motor neuron disease, parkinson's disease, parkinsonism, tourette's disorder, normal control, stroke, amyotrophic lateral sclerosis, huntington's disease, dystonia, dementia, neurologically normal, blood, dna, biomarker, plasma, urine, cell line, induced pluripotent stem cell, fibroblast, stem cell, frozen, lymphoblast, biospecimen banking, biospecimen processing, biospecimen distribution, biospecimen, genetics, phenotype, neurological diseaseSCR_004520(NINDS Repository, RRID:SCR_004520)Coriell Cell Repositories Cerebrovascular disease, Epilepsy, Motor neuron disease, Parkinson's disease, Tourette's Disorder, Normal control, Stroke, Amyotrophic Lateral Sclerosis, Huntington's disease, Dystonia, Dementia, Neurologically normal, Neurological disorderNIH Blueprint for Neuroscience Research, NINDSrelated to: PD-DOC, Parkinson's Disease Biomarkers Program, listed by: One Mind Biospecimen Bank Listing, NITRCLast checked upnlx_143800
UK Multiple Sclerosis Tissue BankResource, biomaterial supply resource, material resource, brain bank, tissue bankProcures brain, spinal cord and other tissues bequeathed by donors and makes them available to scientists investigating the cause and treatment of multiple sclerosis. The Tissue Bank achieves this aim by addressing the following objectives: # Increasing the awareness of the importance of human tissue to research amongst the MS and scientific communities. # Being sensitive to the needs of the tissue donor and responsive to the requirements of scientists when collecting and processing donated tissue. # Making available high quality, well-documented samples of tissue to research scientists working to better understand MS. There are approximately 85 000 people with multiple sclerosis in the United Kingdom. The varied symptoms experienced by all these people result from damage taking place within their brain and spinal cord. Understanding the exact nature of this damage is essential if we are to better treat the condition. Vital information about how the brain and spinal cord are damaged in multiple sclerosis can be obtained by using a multitude of experimental approaches to study the affected tissue from people with MS and ''control'' tissue from people without the disease. The donation of tissue for research is therefore fundamental to furthering our understanding of the causes of multiple sclerosis and to developing more effective treatments for the disease. The UK Multiple Sclerosis Tissue Bank welcomes requests for tissue samples for use in research into the cause and treatment of multiple sclerosis. It has available post mortem, cryopreserved brain and spinal cord tissue both fixed and unfixed, and cerebrospinal fluid from patients with and without a history of multiple sclerosis. Freshly dissected tissue samples, or those preserved using unconventional techniques may also be made available by prior arrangement.brain, spinal cord, tissue, cerebral spinal fluid, post-mortemSCR_004609(UK Multiple Sclerosis Tissue Bank, RRID:SCR_004609)Imperial College London; London; United Kingdom Multiple Sclerosis, Normal controlMultiple Sclerosis Society of Great Britain and Northern Irelandlisted by: One Mind Biospecimen Bank ListingLast checked downnlx_60486
Brain Bank for AutismResource, biomaterial supply resource, brain bank, material resource, tissue bankEncourages and facilitates brain tissue donation for use in the best scientific studies to better understand the biological basis of autism down to the cellular and molecular levels and through that understanding bring about the development of effective interventions for those affected by autism spectrum disorders. To ensure the best co-ordinated use of brain tissue, the UK Brain Bank for Autism works in collaboration with the Autism Tissue Program in the US and shares the same Tissue Advisory board. The Brain Bank for Autism & Related Developmental Research was established in 2009. It is an initiative to develop a similar program in the UK to the Autism Tissue Program, which has been developed in the US since 1998. Our Brain Bank is the first extension outside the US of the Autism Tissue Program and is integrated with it. The Brain Bank is based at Oxford University, where it forms part of the Thomas Willis Oxford Brain Collection. It operates in accordance with all UK legal and ethical requirements. The donation of post-mortem brain tissue for this research program is of fundamental importance to our understanding of the causes of autism and to help us develop more effective diagnostic measures and interventions. A separate brain bank for autism is necessary because we need to understand how, in autism, the brain develops over time and how the brain functions as a whole. However, our Brain Bank will promote close cooperation across all relevant brain banks in order to take the research forward. Our research focuses on: * people within the autism spectrum or their family members * people not affected by autism but who are affected by epilepsy * individuals without autism or epilepsy.brain, tissue, autism, autism spectrum disorder, family member, epilepsy, normal control, post-mortemSCR_004664(Brain Bank for Autism, RRID:SCR_004664)University of Oxford; Oxford; United Kingdom Autism, Autism spectrum disorder, Family member, Epilepsy, Normal controlAutisticalisted by: One Mind Biospecimen Bank ListingLast checked upnlx_66413
Duke University Kathleen Price Bryan Brain BankResource, biomaterial supply resource, biospecimen repository, tissue bank, service resource, brain bank, storage service resource, material resource, material storage repositoryA research repository of human brains with neurological disorders and normal controls, recruited through the Autopsy and Brain Donation Program coordinator. The Kathleen Price Bryan Brain Bank contains brains from patients with Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Muscular Dystrophy, and other neurological and dementing disorders. The brain tissue is subjected to a detailed neuropathological evaluation and then stored as fixed and frozen hemispheres, paraffin blocks and histological slides. After receipt of an IRB approved request, tissue is supplied to investigators at Duke University, major medical centers and pharmaceutical companies across the United States and worldwide.brain, tissue, brain bank, biospecimen repository, spinal cord, cerebral spinal fluid, dna, fixed hemisphere, frozen hemispheres, paraffin block, histological slide, neurological disorder, alzheimer's disease, parkinson's disease, huntington's disease, dementing disorder, muscular dystrophySCR_005022(Duke University Kathleen Price Bryan Brain Bank, RRID:SCR_005022)Joseph and Kathleen Bryan Alzheimer's Disease Research Center Neurological disorder, Normal control, Alzheimers disease, Dementing disorder, Parkinsons disease, Amyotrophic Lateral Sclerosis, Huntingtons disease, Muscular DystrophyNIAlisted by: One Mind Biospecimen Bank ListingLast checked downnlx_144011
University of Pittsburgh Brain Tissue Donation ProgramResource, biomaterial supply resource, tissue bank, service resource, brain bank, storage service resource, material resource, material storage repositoryBrain tissue donation is a valuable contribution to mental health research. It enables scientists to investigate how the normal brain works, and how the brain is disturbed when it is affected by schizophrenia, depression, bipolar (manic depressive) disease or other related disorders. The Department of Psychiatry at the University of Pittsburgh has established a brain tissue bank to which brain tissue can be donated at no expense. The gift of brain tissue enables scientists to conduct research designed to understand causes, to develop new treatments, and ultimately to find cures for diseases that affect the brain. Brain tissue donation is a gift that makes it possible for researchers to study various types of mental disorders. Donations of brain tissue from individuals without these disorders are also needed to establish comparisons with brain samples from individuals who have these disorders. Any legally competent adult or guardian may indicate during life their interest in donating brain tissue after death. Next-of-kin either of healthy individuals or of those with psychiatric disorders may give consent to donate brain tissue following the death of a loved one. Brain tissue is removed during autopsy at a morgue or hospital and is transported to the University of Pittsburgh Medical Center for examination and study.brain tissue, brain, tissue, mental disease, normal control, schizophrenia, depressive disorder, bipolar disorder, post mortem, early adult, middle adultSCR_005028(University of Pittsburgh Brain Tissue Donation Program, RRID:SCR_005028)University of Pittsburgh Conte Center for the Neuroscience of Mental Disorders Mental disease, Normal control, Schizophrenia, Depressive Disorder, Bipolar Disorderlisted by: One Mind Biospecimen Bank ListingLast checked downnlx_144013
RLS Foundation Brain BankResource, biomaterial supply resource, tissue bank, service resource, brain bank, storage service resource, material resource, material storage repositoryThe Restless Legs Syndrome Foundation established the RLS Foundation Brain Bank at the Harvard Brain Tissue Resource Center in 2000. A part of the Harvard University medical system, the Center (housed at McLean Hospital and commonly referred to as The Brain Bank) began in 1978 as a centralized resource for the collection and distribution of human brain specimens for research and diagnostic studies. Over the years, hundreds of scientists from the nation''s top research and medical centers have requested tissue from The Brain Bank for their investigations. Because most of these studies can be carried out on a very small amount of tissue, each donated brain provides a large number of samples for many researchers. For comparative purposes, brain tissue is needed from healthy individuals, as well as from those who had RLS. When possible, a small portion of frozen tissue taken from each brain donated to the RLS Foundation Collection will be kept available to serve as a resource for future genetic testing. The process of donating your brain to RLS research is broken down into 5 steps. To view these steps, please read our Process Steps in RLS Brain Tissue Collection. To read about the process of donating brain tissue for research, visit our Brain Bank Tissue Donation page.restless legs syndrome, healthy, normal control, brain tissue, brain, tissue, frozen, quick frozen, passive frozen, formalin fixed, paraffin embedded, post-mortemSCR_005089(RLS Foundation Brain Bank, RRID:SCR_005089) Harvard Brain Tissue Resource Center , RLS Foundation , Harvard Medical School; Massachusetts; USA Restless Legs Syndrome, Healthy, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked upnlx_144146
UMKC Neuroscience Brain Tissue Bank and Research LaboratoryResource, biomaterial supply resource, tissue bank, service resource, brain bank, storage service resource, material resource, material storage repositoryTHIS RESOURCE IS NO LONGER IN SERVICE, documented August 31, 2016. The UMKC Neuroscience Brain Tissue Bank and Research Laboratory has been established to obtain, process, and distribute human brain tissue to qualified scientists and clinicians dedicated to neuroscience research. No other living organ approaches the human brain in complexity or capacity. Healthy, it astounds and inspires miracles. Diseased, it confounds and diminishes hope. The use of human brain tissue for research will provide insight into the anatomical and neurochemical aspects of diseased and non-diseased brains. While animal models are helpful and necessary in understanding disease, certain disorders can be more efficiently studied using human brain tissue. Also, modern research techniques are often best applied to human tissue. We also need samples of brain tissue that have not been affected by disease. They help us to compare a 'normal' brain with a diseased one. Also, we have a critical need for brain donations from relatives who have genetically inherited disorders. Tissue preparation consists of fresh quick-frozen tissue blocks or coronal slices (nitrogen vapor frozen; custom dissection of specific anatomic regions) or formalin-fixed coronal slices (custom dissection of specific anatomic regions).brain tissue, brain, tissue, fresh quick-frozen, block, nitrogen vapor frozen, frozen, formalin-fixed, disease, normal, genetically inherited disorder, normal control, matched control, neuroscience, post-mortem, coronal sliceSCR_005148(UMKC Neuroscience Brain Tissue Bank and Research Laboratory, RRID:SCR_005148)University of Missouri-Kansas City School of Medicine; Missouri; USA Disease, Normal, Genetically inherited disorder, Normal control, Matched controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_144161
University of Rochester Program for Brain Tumors and Spinal TumorsResource, topical portal, biomaterial supply resource, tissue bank, portal, brain bank, material resource, data or information resourceCollaborative neuro-oncology research program with a tissue repository (tumor bank) containing a wide range of clinical specimens, which they make available to researchers in order to study the effects of new drugs on a large number and wide range of tumor specimens. They provide highly coordinated, complex care in neurosurgery, radiation oncology, medical oncology, and neurology to patients afflicted with tumors of the brain and spine by combining the newest technologies and treatments available anywhere in the world. The program is formed from a multidisciplinary group with a goal of helping patients navigate the complex issues surrounding brain and spinal cancer care. The researchers are working to increase the number of targets that could be considered for anti-angiogenesis therapy. Many of their studies focus on the blood vessel cells (endothelial cells) themselves, which, unlike tumor cells, rarely mutate and so might be less likely to become resistant to therapy and are also more easily reached through the bloodstream. Their researchers are also attempting to better understand the changes in the blood-brain barrier (BBB) that are associated with fluid accumulation and brain swelling (edema) in neuro-oncology patients. Normal brain tissue is shielded from the rest of the body by the BBB. This barrier is composed of very tight blood vessels that prevent most substances from entering the brain. Brain tumors have a leaky BBB ?????? this feature can be used to identify tumors on MRI scans. They have identified specific molecules that appear to be associated with the leaky, abnormal vessels while the normal blood vessels with intact BBB produce these molecules at very low levels or not at all. Inhibiting the function of these molecules may help control or prevent disruption of the BBB and limit cerebral edema in brain tumor patients, as well as patients suffering from stroke or traumatic brain injury.brain tissue, brain, tissue, spine, spinal tumor, brain tumor, tumor, cancer, normal control, clinical trial, treatment, acoustic neuroma, anaplastic astrocytoma, brain metastases, brain stem glioma, chordoma, cns lymphoma, craniopharyngioma, ependymoma, gliomatosis cerebri, glioblastoma, low grade glioma, meningioma, medulloblastoma, oligodendroglioma, pineal tumor, pilocytic astrocytoma, pituitary adenoma, premature neuroectodermal tumor, oncology, neurooncology, stroke, traumatic brain injury, cerebral edemaSCR_005343(University of Rochester Program for Brain Tumors and Spinal Tumors, RRID:SCR_005343)Tumor, Brain tumor, Cancer, Spinal tumor, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_144398
KI Biobank - GEMSResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceThe study subjects invited to participate is chosen from the Swedish national Multiple Sclerosis registry and will number around 10 000 individuals to be included during two to three years. The same number of matched controls will also be included in the study. A pilot study with around 100 participants was performed during 2009, and the large scale study started in November 2009. Multiple sclerosis (MS) is a neurological disease that affects the central nervous system. It affects young people and the debut age is between 20 and 40 years. The disease comes with exacerbations but further on leads to disability. The incidence in Sweden is around 5 per 100 000 per year and the prevalence is 125 per 100 000 inhabitants. In total there are estimated around 13000 cases in Sweden and today 9000 of them are registered in the Swedish National Multiple Sclerosis register. Sample types * EDTA whole blood * DNA * Plasma Number of sample donors: 5592 (June 2010)SCR_005893(KI Biobank - GEMS, RRID:SCR_005893)Karolisnka Biobank Multiple sclerosis, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_149471
KI Biobank - EIMSResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceA multi-center population based epidemiological investigation of risk factors for Multiple Sclerosis (MS), where lifestyle- and environmental factors are examined systematically with concurrent genetic information. Newly diagnosed cases of MS in a geographically defined population and randomly chosen controls are identified and asked to answer a questionnaire on lifestyle, previous exposures at work, home and during spare time activities. For both cases and controls blood samples are taken for analysis of putative risk genes since environmental exposures probably contributes to disease only in individuals with certain genotypes. Exposures of interest are different sociodemographic factors, smoking, sunlight exposure, oral contraceptives / hormonal factors, butyrophilin (a milk protein), vaccinations, infections, atopic disease, organic solvents, mineral oils and a number of different psychosocial factors, such as critical lifetime events. Data from more than 1600 cases and 3200 controls are currently collected. (August 2014) The intention is to continue with the data collection over several years in order to analyse how genes and environment interact. The study is a collaboration between different institutions at Karolinska Institutet and neurological centers from 38 different hospitals in Sweden. Sample types * EDTA whole blood * DNA * Plasma * Serumenvironmental exposure, lifestyle, genetics, gene, genotype, sociodemographic factor, smoking, sunlight exposure, oral contraceptive, hormonal factor, butyrophilin, vaccination, infection, atopic disease, organic solvent, mineral oil, psychosocial factor, risk factor, blood, edta whole blood, dna, plasma, serumSCR_005898(KI Biobank - EIMS, RRID:SCR_005898)Karolisnka Biobank Multiple Sclerosis, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_149469
KI Biobank - BROADResource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resourceThe study will collect 1,500 cases with schizophrenia and 1,500 well-matched controls ascertained via high-quality Swedish national hospitalization and population registries. Both cases and controls will be population-based and of Scandinavian ancestry. Types of samples * EDTA whole blood * DNA Number of donors: 10 820 (June 2010)matched control, psychiatric disease, populationSCR_005916(KI Biobank - BROAD, RRID:SCR_005916)Karolisnka Biobank Schizophrenia, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_149508
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