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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Oct 5, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
Tumorbank BernResource, biomaterial supply resource, material resource, tissue bankTumorbank Bern - TBB collects high quality clinical samples since 2003 for translational research selected by expert pathologists under controlled conditions of normal and diseased tissue from different origin. The Tumor Bank is approved by the Ethical Commission of Bern, we only collect samples with written informed patient consent. Origin of Tissue: Thoracic Surgery, Gynecology, Urology, Visceral Surgery, Orthopedic Surgery, Head and Neck Surgery, Neurosurgery Tumorbank Bern TBB holds 12,000 samples from 3600 Patients. Please contact us to check if we have samples for your field of research.tissue, tumor, cancer, normal, diseased, clinical, thoracic, gynecology, urology, visceral, orthopedic, head and neck, neurosurgerySCR_004611(Tumorbank Bern, RRID:SCR_004611)University of Bern; Bern; Switzerland Tumor, Cancer, Normal, DiseasedBernese Cancer Leaguelisted by: One Mind Biospecimen Bank ListingLast checked upnlx_60955
Spanish National Tumour Bank NetworkResource, topical portal, database, biomaterial supply resource, tissue bank, portal, material resource, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented August 29, 2016. The need to use human neoplastic tissue under ideal conditions is currently of particular importance due to the development molecular pathology techniques that allow large-scale studies of genetic expression that are also of clinical significance. The Tumour Bank Network (TBN), instigated and coordinated by the Molecular Pathology Programme (MMP) aims to respond to this need by the promoting of Tumour Banks in Spanish hospitals. This will be achieved through the application of homogeneous procedures for the collection, processing and storage of neoplastic and normal tissue samples in such a way as to make molecular studies possible, avoiding that avoid the intrinsic bias of multi-centre studies possible. These Hospital Tumour Banks are based within the Pathology Departments of the collaborating Hospitals, that are interconnected through a computer-based network. In this way, each Centre''s tissue remains in the Hospital itself, thereby playing a key role in the development of the welfare, teaching and research activities within the Hospital. At the same time, it represents a tool to encourage of multi-hospital cancer research and of cooperation between basic and clinical researchers, constituting important collaboration between biomedical disciplines. The design does not correspond to a Central Tumour Bank, but that of a cooperative and coordinated Network of Hospital Banks, based on simple, homogeneous and optimal tissue treatment protocols. This Network is promoted by the Centro Nacional de Investigaciones Oncologicas (CNIO), which thereby undertakes the work of coordinating the network, using and maintaining the database, adhering to quality control. The aim of the CNIO's TBN is to acquire neoplastic and control non-neoplastic material of all types of malignant neoplasias, in the form of tissue fixed in formalin and paraffin embedded, of samples that are unfixed or frozen according to conventional methods as set out in Annexe 1 and even, exceptionally as fresh tissue. When other types of samples are required to carry out a specific project, the central office of the TBN will draw up a protocol with the group leading the project for the collection and maintenance of the tissue and clinicopathological data required for the proposed research. These protocols will be disseminated among the Associated Hospitals in order to gather the previously agreed number cases. Basic data surrounding the processing and preservation conditions for each case will be sent to the central office of the Bank, which under no circumstances will reveal the identity of the patient. Any Spanish cancer research team will be able to request tissue from the Tissue Bank Network. Absolute priority will be afforded to projects whose principal researcher belongs to one of the Associated Centres of the TNB, to other institutions with special agreements concerning the exchange of samples, and to the CNIO's researchers.clinical, neoplastic tissue, non-neoplastic tissue, tissue, fixed, formalin, paraffin embedded, unfixed, frozen, tumor, cancer, normal controlSCR_008707(Spanish National Tumour Bank Network, RRID:SCR_008707)Spanish National Cancer Research Center Tumor, Cancer, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_10273
SomaticCallResource, software resourceSoftware program that finds single-base differences (substitutions) between sequence data from tumor and matched normal samples. It is designed to be highly stringent, so as to achieve a low false positive rate. It takes as input a BAM file for each sample, and produces as output a list of differences (somatic mutations). Note: This software package is no longer supported and information on this page is provided for archival purposes only.somatic mutation, substitution, sequence, bam, mutationSCR_001196(SomaticCall, RRID:SCR_001196)Broad Institute Tumor, Cancer, Normallisted by: OMICtoolsLast checked upOMICS_02155
Einstein-Montefiore Institute for Clinical and Translational Research BiorepositoryResource, biomaterial supply resource, tissue bank, service resource, storage service resource, material resource, material storage repositoryPatient-derived specimens are essential to research in genomics, proteomics, and biomarkers. We provide banking for biological fluid and tissue specimens as well as human DNA and RNA. We provide secure archival sample storage as well as clinically-annotated specimen biobanks for defined research projects. The core serves the human research blood and tissue banking needs of clinical and translational researchers. Samples can be banked by an individual PI or by a consortium of investigators. All samples are tracked and archived using a secure tracking database, the Einstein-Montefiore Bio-Repository Databank (EM-BRED), EM-BRED provides qualified investigators with a solution to securely link patient specimens to clinical and pathological data. It consists of a user-friendly query engine that allows for comprehensive specimen search, and ultimately to build clinical annotations of relevance. The facility works under the best practices set out by NCI and ISBER (2006) for collection, storage, and retrieval of human biological materials for research.blood, tissue, dna, rna, clinical data, pathological data, frozen, flash frozen, oct embedded, paraffin embedded, tumor, cancer, non-tumor, adenoma, biliary atresia, carcinoma, clm, liver disease, colorectal metastasis, cryptogenic, etoh, familial hypercholestrolemia, hepatic artery injury, hepatitis b, hepatitis c, primary sclerosing cholangitis, recurrent pyogenic cholangitis with hepatolithiasis, subacute fulminant hepatic failure drug toxicity, databaseSCR_005297(Einstein-Montefiore Institute for Clinical and Translational Research Biorepository, RRID:SCR_005297)Albert Einstein College of Medicine; New York; USA , Montefiore Medical Center; New York; USA Tumor, Cancer, Non-tumor, Adenoma, Biliary atresia, Carcinoma, CLM, Liver disease, Colorectal metastasis, Cryptogenic, ETOH, Familial hypercholestrolemia, Hepatic artery injury, Hepatitis B, Hepatitis C, Primary sclerosing cholangitis, Recurrent pyogenic cholangitis with hepatolithiasis, Subacute fulminant hepatic failure drug toxicityrelated to: Einstein-Montefiore ICTR Research Informatics Core, listed by: One Mind Biospecimen Bank ListingLast checked upnlx_144342
Southwest France Tumour BankResource, biomaterial supply resource, data or information resource, material resource, tissue bank, databaseThe Virtual Tumour Bank of the Canceropole Grand Sud-Ouest''s mission is to federate the cancer research of four French regions: Aquitaine, Languedoc-Roussillon, Limousin and Midi-Pyrenees. This site allows access to an inventory of the specimens stored in the tumor banks of the Greater South-West region, within the laboratories of Pathology of the University Hospital Centers and Cancer Centers of Bordeaux, Limoges, Montpellier, Nimes and Toulouse. You may search by disease or multiple criteria. These specimens are removed from patients primarily to confirm and accurately characterize their cancer diagnosis, and are therefore stored by the tumor bank for diagnostic and/or therapeutic purposes. These samples can be re-qualified for scientific research pending that a number of conditions are met, including the absence of refusal from the person (in compliance with French regulations). So far, the tumor bank is a major tool for cancer treatment and research. This inventory is a further evidence of the coordination effort between the eight concerned tumor banks that have been mobilized at the service of patients and research within the framework of the Canceropole Grand Sud-Ouest programs. These biological resources are made available to research groups that conduct basic or translational programs in the field of oncology. They will not be made available for projects in fields other than oncology.tumor, tissue, tumor tissue, serum, plasma, bodily fluid, frozen, liquid nitrogen, paraffin, dmso, dry, cancer, neoplasm, malignant, benign, oncologySCR_004574(Southwest France Tumour Bank, RRID:SCR_004574)Tumor, Cancer, Neoplasm, Malignant, BenignFrench National Cancer Institutelisted by: One Mind Biospecimen Bank ListingLast checked upnlx_56834
Ludwig Boltzman Tumour BankResource, biomaterial supply resource, material resource, tissue bank, data or information resourceAs a basis for the experimental cluster projects, and for further future projects a collection of various biological specimens of cancer patients shall be established. All participating Ludwig Boltzmann Institutes (LBIs) are supplying biological specimens from tumor patients and clinical documentation. At the LBI for Gynecology and Gynecologic Oncology a tumor bank for biological specimens from gynecologic cancer patients already exists. All the procedures for sample processing and storage are well established. Existing equipment for storing tissue specimens at -196 degrees C can be used. Materials from the following malignant diseases are collected: Breast cancer Colorectal cancer Neuroendocrine tumors (NET) (Small cell lung cancer (SCLC) and Carcinoid tumors) Types of biological materials: Tissue (fresh frozen) Bone marrow Blood (serum/plasma/cell fractions) Pleural effusions Ascitic fluids Sputum Bronchial lavage Stool The biological specimens are initially processed at the respective LBIs or at their connected lab facilities. Enrichment of blood samples for disseminated tumor cells is done at the LBI for Gynecology and Gynecologic oncology. Long time storage of all materials is done at appropriate temperatures at the same institution. This LBI also coordinates the logistics. All relevant sample-specific and clinical data are surveyed at the respective LBIs and stored centralized in an on-line data bank in anonymized form, respecting all relevant regulations on data protection and security.tissue, bone marrow, blood, serum, plasma, cell fraction, pleural effusion, ascitic fluid, sputum, bronchial lavage, stool, tumor cell, fresh frozen, frozen, tumor, cancer, breast cancer, colorectal cancer, neuroendocrine tumor, small cell lung cancer, carcinoid tumor, gynecologic cancer, clinical data, bodily fluidSCR_004322(Ludwig Boltzman Tumour Bank, RRID:SCR_004322)Ludwig Boltzmann Cluster Translationale Onkologie Tumor, Cancer, Breast cancer, Colorectal cancer, Neuroendocrine tumor, Small cell lung cancer, Carcinoid tumor, Gynecologic cancerlisted by: One Mind Biospecimen Bank ListingLast checked upnlx_33431
Alacris TheranosticsResource, portal, organization portal, service resource, commercial organization, data or information resourceCommercial organization that uses next generation sequencing technologies coupled with computational modeling of tumor and somatic tissues in order to identify individualized therapies for cancer patients. The company also uses these technologies to help pharmaceutical partners stratify patients for their clinical trials. Alacris has an exclusive worldwide commercial license for the computational modeling of tumors and somatic tissues using proprietary computational systems modeling technologies ModCell developed at the Max Planck Institute for Molecular Genetics (MPI-MG) in Berlin coupled with next generation sequencing and genotyping technology developed at Harvard Medical School in Boston. The company also is building up the first next generation sequencing center in Europe for clinical generation sequencing, computational modeling, clinical trial, somatic tissue, genotyping, genomics, oncogenomics, diagnostics, therapy, disease model, drug, personalized medicine, biomarker, drug development, tumor model, analysis, oncologySCR_003953(Alacris Theranostics, RRID:SCR_003953)Tumor, Cancerrelated to: OncoTrackLast checked upnlx_158354
Experimental Pharmacology and Oncology Berlin-BuchResource, portal, organization portal, service resource, commercial organization, data or information resourceA small and medium-sized enterprise (SME) that has expertise in preclinical pharmacology, pharmacokinetics, and toxicology for the characterization of novel anticancer therapeutics and predictive biomarkers like: cytostatics, biologicals (peptides, antibodies), (anti)-hormones, immunomodulators (cytokines), and gene therapeutics. EPO has modern laboratories licensed for animal experiments and gene technology (S2) and a broad panel of murine and human tumor models growing in immunocompetent (SPF-quality, syngeneic strains) or immunodeficient mice (nude, SCID, NOD/SCID). EPO has established imaging technologies to monitor in vivo tumor growth.tumor model, pharmaceutical, oncology, in vitro, in vivo, antitumor, preclinical, pharmacology, pharmacokinetics, toxicology, anticancer, therapeutic, biomarker, imaging, testing, validation, targetSCR_003954(Experimental Pharmacology and Oncology Berlin-Buch, RRID:SCR_003954)Tumor, Cancerrelated to: OncoTrackLast checked upnlx_158355
START Tumor BankResource, biomaterial supply resource, material resource, tissue bankBiospecimen repository for tumor specimens, available to all researchers actively engaged in cancer research whether they are in University, Academic, or Pharmaceutical industry, with a goal to accelerate the discovery and development of new agents for the treatment and cure of cancer. The START tumor bank was created to make tumor tissue gifted by patients receiving care or treatment at The START Center available to all researchers involved in developing a better understanding of the biology of cancer or those engaged in the discovery of new therapies. The START Tumor Bank is a department within the PK Department and handles skin and tumor biopsies required by clinical trial protocols. A member of the PK Department is present during biopsy procedures for immediate processing of the sample for the trial. Additionally, the Tumor Bank collects and banks the tumor tissues of patients who consent. This tissue is then stored for future use by researchers developing new therapies.tumor, cancer, tissue, tumor tissue, skinSCR_004258(START Tumor Bank, RRID:SCR_004258)South Texas Accelerated Research Therapeutics Tumor, Cancerlisted by: One Mind Biospecimen Bank ListingLast checked upnlx_27097
OECI - Tubafrost: The European Human Frozen Tissue BankResource, database, biomaterial supply resource, tissue bank, cell repository, material resource, data or information resourceIn this web site you will find the central European database of OECI-TuBaFrost collecting the information of biobanks or in the project support environment on human material; i.e., frozen tumor tissue specimens, pathology blocks, blood samples in different forms, cell lines, Tissue Micro Arrays, etc. Our goal is by centralizing the tumor tissues information to facilitate the search of doctors / researchers for tumor materials, which they need for their cancer research there with facilitating cancer research. OECI members only can participate in the OECI-TuBaFrost exchange platform, or those introduced by an OECI member. We are a group of pathology and research departments as well as bio-bankers in clinical based biobanking based in comprehensive cancer centers or hospitals with a competence in comprehensive cancer care across Europe. Each participating institute is involved in cancer research resulting in innovative procedures, new drugs, improved diagnosis and new insights in disease development. The overall result is better care and treatment for cancer patients. To maximize the scientific value of the human tissue samples, information about the clinical status of the patient in combination with the quality and type of samples is very important. A TuBaFrost electronic database will securely store all this information. Within the closed project supporting environments, the data collected will include: * Diagnosis - identification of the type of cancer * Type of tissue collected - the origin, i.e. breast, skin, colorectal * Quality of tissue collected - collection and storage details The tissue is stored in the hospital where the donor was diagnosed/treated. It stays there until it is used or sent to another hospital or research center within the TuBaFrost group. The electronic database will track samples throughout the network. The tissue is not sold. The exchange of tissue to other hospitals is regulated by a contract, which uses the national regulations of the country supplying the tissue. Tissue samples within the TuBaFrost collection will only be used for research, which has been approved by ethics committees. This ensures that the tissue is only used for the best quality research and only for the specific reasons given to the ethics committee.tumor tissue, blood, cell line, tissue, frozen, block, tissue micro array, tumor, cancer, clinical, clinical dataSCR_004280(OECI - Tubafrost: The European Human Frozen Tissue Bank, RRID:SCR_004280)OECI - Organisation for European Cancer Institutes Tumor, CancerEuropean Unionlisted by: One Mind Biospecimen Bank ListingLast checked upnlx_36384
deStructResource, software resourceA software tool for identifying structural variation in tumour genomes from whole genome illumina sequencing.structural variation, genome, genomicsSCR_004747(deStruct, RRID:SCR_004747)Google Code Tumor, Cancerlisted by: OMICtoolsLast checked upOMICS_00314
Andalusian Regional Tumour BankResource, biomaterial supply resource, material resource, tissue bankTHIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. Located in Spain, the Andalusian Regional Tumour Bank is a regional tumor bank. In the last decades cancer knowledge is growing exponentially due human genome knowledge and technological advantages. However, this disease is the biggest problem of health in Europe, with more than 2,5 million new cases per year. The diagnosis and treatment of cancer is now allowing to identify the characteristics that the disease has on each person. The next step is meant to be a great revolution in the treatment of cancer. This scientific development is dependent on the availability of human tumour samples preserved in demanding conditions. Current technology requires the availability of tissue morphological and molecular conditions similar to those that had the sample before being removed. Tumor banks are responsible for these new quality requirements to foster the development of research and health care of patients.tumor tissue, tissue, tumor, cancerSCR_004885(Andalusian Regional Tumour Bank, RRID:SCR_004885)Tumor, Cancerlisted by: One Mind Biospecimen Bank ListingLast checked upnlx_85675
AbsCN-seqResource, software resourceStatistical software to estimate tumor purity, ploidy and absolute copy numbers from next generation sequencing data.r, statistics, purity, ploidy, absolute copy number, next-generation sequencingSCR_006409(AbsCN-seq, RRID:SCR_006409)University of California at San Diego; California; USA Tumor, Cancerlisted by: OMICtoolsPMID:24389661Last checked upOMICS_02202
SocratesResource, software resourceSoftware for detecting genomic rearrangements in tumors that utilizes only split-read data. It features single nucleotide resolution, high sensitivity, and high specificity in simulated data. It takes advantage of parallelism for efficient use of resources.genomic rearrangementSCR_006411(Socrates, RRID:SCR_006411)Walter and Eliza Hall Institute of Medical Research; Victoria; Australia Tumor, Cancerlisted by: OMICtoolsPMID:24389656Last checked upOMICS_02200
ChimerDBResource, data or information resource, databaseKnowledgebase of fusion transcripts collected from various public resources such as the Sanger CGP, OMIM, PubMed, and Mitelman's database. It is an alignment viewer to facilitate examining reliability of fusion transcripts and inferring functional significance.knowledge base, fusion transcript, transcript alignment, alignment viewerSCR_007596(ChimerDB, RRID:SCR_007596)Ewha Womans University; Seoul; South Korea Tumor, CancerGwangju Institute of Science and Technology, Korean Ministry of Education Science and Technology, Korean Ministry of Science and Technology, Korean Rural Development Administration, National Core Research CenterReferences (2)Last checked upnif-0000-02659
Saint-Luc Tumour BankResource, biomaterial supply resource, material resource, data or information resourceWhen a patient suffering or thought to be suffering from cancer is cared for, samples are often taken to determine the precise diagnosis and to determine any treatment necessary. After this essential stage of the patient''s care, unused biological material is sometimes left over. This material is an essential and precious tool for research into cancer. For this reason, patients can decide to make the material available to researchers the world over who study either the development mechanism of cancer or the new treatments available. Residual samples are centralized and stored in the Tumor Bank at the Cliniques Universitaires Saint-Luc Cancer Centre. The research carried out on this material primarily benefits cancer patients. It can help improve existing treatments or discover new drugs, and also allows new diagnostic tools to be tested. Any financial profits obtained from assessing the results obtained are entirely reinvested in the work of the Cancer Centre''s Tumour Bank and in new research projects at the Catholic University of Louvain. Using and sharing material, and verification and retrospective analysis of clinical data, all comply with strict rules. As with donations of blood, marrow or organs, an Ethics Committee oversees the operations of the Tumour Bank and research projects. This committee is responsible for ensuring compliance with current Belgian and legal texts, especially those concerning the protection of patient privacy and rights.clinical data, tumor, cancerSCR_008714(Saint-Luc Tumour Bank, RRID:SCR_008714)Cliniques Universitaires Saint-Luc Cancer Centre Tumor, Cancerlisted by: One Mind Biospecimen Bank ListingLast checked upnlx_12735
University of Rochester Program for Brain Tumors and Spinal TumorsResource, topical portal, biomaterial supply resource, tissue bank, portal, brain bank, material resource, data or information resourceCollaborative neuro-oncology research program with a tissue repository (tumor bank) containing a wide range of clinical specimens, which they make available to researchers in order to study the effects of new drugs on a large number and wide range of tumor specimens. They provide highly coordinated, complex care in neurosurgery, radiation oncology, medical oncology, and neurology to patients afflicted with tumors of the brain and spine by combining the newest technologies and treatments available anywhere in the world. The program is formed from a multidisciplinary group with a goal of helping patients navigate the complex issues surrounding brain and spinal cancer care. The researchers are working to increase the number of targets that could be considered for anti-angiogenesis therapy. Many of their studies focus on the blood vessel cells (endothelial cells) themselves, which, unlike tumor cells, rarely mutate and so might be less likely to become resistant to therapy and are also more easily reached through the bloodstream. Their researchers are also attempting to better understand the changes in the blood-brain barrier (BBB) that are associated with fluid accumulation and brain swelling (edema) in neuro-oncology patients. Normal brain tissue is shielded from the rest of the body by the BBB. This barrier is composed of very tight blood vessels that prevent most substances from entering the brain. Brain tumors have a leaky BBB ?????? this feature can be used to identify tumors on MRI scans. They have identified specific molecules that appear to be associated with the leaky, abnormal vessels while the normal blood vessels with intact BBB produce these molecules at very low levels or not at all. Inhibiting the function of these molecules may help control or prevent disruption of the BBB and limit cerebral edema in brain tumor patients, as well as patients suffering from stroke or traumatic brain injury.brain tissue, brain, tissue, spine, spinal tumor, brain tumor, tumor, cancer, normal control, clinical trial, treatment, acoustic neuroma, anaplastic astrocytoma, brain metastases, brain stem glioma, chordoma, cns lymphoma, craniopharyngioma, ependymoma, gliomatosis cerebri, glioblastoma, low grade glioma, meningioma, medulloblastoma, oligodendroglioma, pineal tumor, pilocytic astrocytoma, pituitary adenoma, premature neuroectodermal tumor, oncology, neurooncology, stroke, traumatic brain injury, cerebral edemaSCR_005343(University of Rochester Program for Brain Tumors and Spinal Tumors, RRID:SCR_005343)Tumor, Brain tumor, Cancer, Spinal tumor, Normal controllisted by: One Mind Biospecimen Bank ListingLast checked downnlx_144398
Computer Integrated Systems for Microscopy and ManipulationResource, biomedical technology research center, service resource, material resource, access service resource, training resourceBiomedical technology research center that develops force technologies applicable over a wide range of biological settings, from the single molecule to the tissue, with integrated systems that orchestrate facile instrument control, multimodal imaging, and analysis through visualization and modeling. The Force Microscope Technologies Core designs instruments in an area of science where there are unusual opportunities: the measurement of forces and the integration with optical microscopy. Force technologies play the obvious role of both measuring events in the sample and modifying the sample during the experiment. It is through the microscope that the force data is correlated with simultaneous 3D optical images. The force technology development includes the magnetic bead technology in the 3D Force Microscope project, Atomic Force Microscopy in the nanoManipulator project, and Control Software to drive the instrumentation. This core is focused on providing the physical capability to perform the experiments and probe structure/property correlations. The Ideal User Interfaces core makes the connection between the user and the instrument, the model building, and the data. This includes control systems that allow the user to move the bead inside the cell culture with a handheld pen and the visualization techniques to view the optical microscope data as a rendered 3D image collocated with the force data. Using data to create, change, and understand a model is the focus of the Advanced Model Fitting and Analysis core. The quantitative reduction of images to structural, shape, and velocity parameters is the goal of Image Analysis. The immediate understanding of correlations across image fields and between data sets in the challenge of Visualization. The power of combining the strength of a computer science graphics group with a microscopy technology group is most evident in the Graphics Hardware Acceleration project, which seeks to harness the speed of graphics processors for microscope data analysis and simulation. The Advanced Technology core pushes the boundaries of the Human Computer Interface through the investigation of improved techniques for the interaction of users with virtual environments, the real time lighting of virtual settings, and the enabling of multi-person collaboration. These techniques are validated and evaluated through physiological measures in virtual environments effectiveness evaluation studies.microscope, visual analytics, image analysis, biomedical, bioinstrumatics, scanning electron microscope, light microscope, microscopySCR_001413(Computer Integrated Systems for Microscopy and Manipulation, RRID:SCR_001413)University of North Carolina at Chapel Hill; North Carolina; USA Thrombosis, Lung disease, CancerNIBIBLast checked upnlx_152648
deCODE geneticsResource, portal, organization portal, commercial organization, data or information resourceA biopharmaceutical company applying its discoveries in human genetics to develop drugs and diagnostics for common diseases. They specialize in gene discovery - their population approach and resources have enabled them to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer. The company's genotyping capacity is now one of the highest in the world. They have a large population-based biobank containing whole blood and DNA samples with extensive relevant phenotypic information from around 120.000 Icelanders. In the company's work in more than 50 disease projects, their statistical and informatics departments have established themselves in data processing and analysis. deCODE genetics is widely recognized as a center of excellence in genetic research.biopharmaceutical, genetics, drug, diagnostic, genotyping, phenotype, data processing, analysis, genetic variant, risk factor, genome, blood, dna, biobank, single nucleotide polymorphismSCR_003334(deCODE genetics, RRID:SCR_003334)Schizophrenia, Cardiovascular disease, Cancer, Type 2 diabetes, Atrial fibrillation, Heart attackrelated to: EU-AIMS, NEWMEDSLast checked upnif-0000-31959, nif-0000-31959, nlx_158361,,
Laser Biomedical Research CenterResource, biomedical technology research center, service resource, access service resource, training resourceBiomedical technology research center that develops the basic scientific understanding and new techniques required for advancing the clinical applications of lasers and spectroscopy. To fulfill the need for a more comprehensive and potentially non-invasive understanding of the human body, the LBRC merges optical spectroscopy, imaging, scattering, and interferometry techniques. Specifically, researchers at the LBRC study the biophysics and biochemistry of healthy and diseased biological structures from the subcellular to the entire-organ scale. For example, spectral diagnosis instruments based on near-infrared Raman scattering, intrinsic fluorescence, diffuse reflectance, and single light scattering provide complementary data on human disease. Combining these techniques into a single, multimodal instrument is applied for diagnostics in various organs, including cervix, oral cavity, Barrett's esophagus, artery, breast, skin, as well as for transcutaneous measurements of blood constituents. The LBRC has been and continues to be a pioneer in the field of developing novel optical probes for use under direct visualization or with endoscopes and biopsy devices. Similarly, new microscopy tools based on interferometry are designed and exploited for measuring cellular structures and their dynamics. In particular, these techniques provide the crucial and unique ability to non-invasively study cells in their native states at remarkably high spatial and temporal resolutions. Using these novel microscopy tools, the LBRC has conducted critical studies to elucidate the fundamental biology of diseases as diverse as malaria and multiple myeloma, and physiological processes such as cell growth and cell division. The interferometry concepts have also been vital in Center's research efforts to develop optical tools for deep-tissue imaging while minimizing the adverse effects of light scattering or diffusion. Furthermore, the unique and powerful combination of the interferometric microscopy and vibrational spectroscopy tools adds a hitherto unexplored dimension to optical sensing by simultaneous probing of morphological and chemical information. A unique feature of the LBRC is its ability to form strong clinical collaborations with outside investigators in areas of common interest that further the Center's mandated research objectives. As a National Research Resource Center, the LBRC makes available its facilities, along with technical and scientific support, to outside researchers for the purpose of pursuing independent research projects in the area of laser biomedical applications. The facilities are available on a time-shared basis, free-of-cost policy to qualified scientists, engineers and physicians throughout the United States.spectroscopy, laser, biomedicine, optical spectroscopy, imaging, scattering, interferometry, optical probe, microscopySCR_000106(Laser Biomedical Research Center, RRID:SCR_000106)Massachusetts Institute of Technology; Massachusetts; USA Pre-cancer, Cancer, Atherosclerosis, Healthy, DiseasedNIBIBLast checked upnlx_152645
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