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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Oct 12, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
NeuroMorpho.OrgResource, service resource, data or information resource, data repository, storage service resource, databaseCentrally curated inventory of digitally reconstructed neurons associated with peer-reviewed publications that contains some of the most complete axonal arborizations digitally available in the community. Each neuron is represented by a unique identifier, general information (metadata), the original and standardized ASCII files of the digital morphological reconstruction, and a set of morphometric features. It contains contributions from over 100 laboratories worldwide and is continuously updated as new morphological reconstructions are collected, published, and shared. Users may browse by species, brain region, cell type or lab name. Users can also download morphological reconstructions for research and analysis. Deposition and distribution of reconstruction files ultimately prevents data loss. Centralized curation and annotation aims at minimizing the effort required by data owners while ensuring a unified format. It also provides a one-stop entry point for all available reconstructions, thus maximizing data visibility and impact.neuron, morphological reconstruction, morphometry, axonal arborization, digital neuronal reconstruction, neuronal reconstruction, neuronal morphology, data sharing, annotation, brain region, neocortex, digital reconstruction, neurogenetics, neurochemistry, neuroscience, neurologySCR_002145(NeuroMorpho.Org, RRID:SCR_002145)George Mason University; Virginia; USA MURI, NINDSrelated to: DONE: Detection of Outlier NEurons, NIF Literature, Computational Neurobiology and Imaging Center, Integrated Manually Extracted Annotation, used by: NIF Data Federation, recommended by: National Library of Medicine, BRAIN Initiative, listed by: re3data.org, NeuroImaging Tools and Resources Collaboratory (NITRC)References (3)Last checked downnif-0000-00006http://www.nitrc.org/projects/neuromorpho_org
Cell Centered DatabaseResource, database, service resource, storage service resource, image repository, data repository, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented June 5, 2017. It has been merged with Cell Image Library. Database for sharing and mining cellular and subcellular high resolution 2D, 3D and 4D data from light and electron microscopy, including correlated imaging that makes unique and valuable datasets available to the scientific community for visualization, reuse and reanalysis. Techniques range from wide field mosaics taken with multiphoton microscopy to 3D reconstructions of cellular ultrastructure using electron tomography. Contributions from the community are welcome. The CCDB was designed around the process of reconstruction from 2D micrographs, capturing key steps in the process from experiment to analysis. The CCDB refers to the set of images taken from microscope the as the Microscopy Product. The microscopy product refers to a set of related 2D images taken by light (epifluorescence, transmitted light, confocal or multiphoton) or electron microscopy (conventional or high voltage transmission electron microscopy). These image sets may comprise a tilt series, optical section series, through focus series, serial sections, mosaics, time series or a set of survey sections taken in a single microscopy session that are not related in any systematic way. A given set of data may be more than one product, for example, it is possible for a set of images to be both a mosaic and a tilt series. The Microscopy Product ID serves as the accession number for the CCDB. All microscopy products must belong to a project and be stored along with key specimen preparation details. Each project receives a unique Project ID that groups together related microscopy products. Many of the datasets come from published literature, but publication is not a prerequisite for inclusion in the CCDB. Any datasets that are of high quality and interest to the scientific community can be included in the CCDB.electron microscope, light microscopy, electron tomography, electron microscopy, image, cell, microscopy, tomographySCR_002168(Cell Centered Database, RRID:SCR_002168)University of California at San Diego; California; USA related to: Cell Image Library (CIL), Cell Image Library (CIL), Whole Brain Catalog, Integrated Manually Extracted Annotation, used by: NIF Data Federation, Integrated Datasets, listed by: re3data.orgReferences (2)Last checked upnif-0000-00007
Cerebellar Development Transcriptome DatabaseResource, atlas, database, data or information resourceTranscriptomic information (spatiotemporal gene expression profile data) on the postnatal cerebellar development of mice (C57B/6J & ICR). It is a tool for mining cerebellar genes and gene expression, and provides a portal to relevant bioinformatics links. The mouse cerebellar circuit develops through a series of cellular and morphological events, including neuronal proliferation and migration, axonogenesis, dendritogenesis, and synaptogenesis, all within three weeks after birth, and each event is controlled by a specific gene group whose expression profile must be encoded in the genome. To elucidate the genetic basis of cerebellar circuit development, CDT-DB analyzes spatiotemporal gene expression by using in situ hybridization (ISH) for cellular resolution and by using fluorescence differential display and microarrays (GeneChip) for developmental time series resolution. The CDT-DB not only provides a cross-search function for large amounts of experimental data (ISH brain images, GeneChip graph, RT-PCR gel images), but also includes a portal function by which all registered genes have been provided with hyperlinks to websites of many relevant bioinformatics regarding gene ontology, genome, proteins, pathways, cell functions, and publications. Thus, the CDT-DB is a useful tool for mining potentially important genes based on characteristic expression profiles in particular cell types or during a particular time window in developing mouse brains.gene expression, fluorescence, function, gene, gene chip, genome, bioinformatics, brain, cell, cerebellum, development, in situ hybridization, fluroescence differential display, cerebellar development, microarray, mining, mouse, mrna, ontology, pathway, protein, rt-pcr, molecular neuroanatomy resource, transcriptiome, spatiotemporal, cdna microarray, genechip, postnatal, histochemistry, image, postnatal developmentSCR_013096(Cerebellar Development Transcriptome Database, RRID:SCR_013096)RIKEN Brain Science Institute Brain development, Brain disorderINCF Japan Node, Japanese Ministry of Education Culture Sports Science and Technology MEXT, Japan Science and Technology Agency, Japan Society for the Promotion of Sciencerelated to: Gene Ontology, RIKEN integrated database of mammalsPMID:18603407Last checked upnif-0000-00008
GenePaintResource, atlas, expression atlas, data or information resource, reference atlas, databaseDigital atlas of gene expression patterns in developing and adult mouse. Several reference atlases are also available through this site. Expression patterns are determined by non-radioactive in situ hybridization on serial tissue sections. Sections are available from several developmental ages: E10.5, E14.5 (whole embryos), E15.5, P7 and P56 (brains only). To retrieve expression patterns, search by gene name, site of expression, GenBank accession number or sequence homology. For viewing expression patterns, GenePaint.org features virtual microscope tool that enables zooming into images down to cellular resolution.gene expression, adult mouse, annotated, c57bl6, mouse, mouse embryo, mrna, non radioactive in situ hybridization, light microscopy, molecular neuroanatomy resource, in situ hybridization, embryonic, postnatal, adult, brain, head, annotation, rna probe, sequence, anatomical structureSCR_003015(GenePaint, RRID:SCR_003015)Max Planck Institute for Biophysical Chemistry; Gottingen; Germany BMBF, Burroughs Wellcome Fund, European Union, Max Planck Society, Merck Genome Research Institute, NINDS, Romansky EndowmentReferences (2)Last checked upnif-0000-00009, SCR_017526
Public Expression Profiling ResourceResource, data or information resource, databaseAn experiment in web-database access to large multi-dimensional data sets using a standardized experimental platform to determine if the larger scientific community can be given simple, intuitive, and user-friendly web-based access to large microarray data sets. All data in PEPR is also available via NCBI GEO. The structure and goals of PEPR differ from other mRNA expression profiling databases in a number of important ways. * The experimental platform in PEPR is standardized, and is an Affymetrix - only database. All microarrays available in the PEPR web database should ascribe to quality control and standard operating procedures. A recent publication has described the QC/SOP criteria utilized in PEPR profiles ( The Tumor Analysis Best Practices Working Group 2004 ). * PEPR permits gene-based queries of large Affymetrix array data sets without any specialized software. For example, a number of large time series projects are available within PEPR, containing 40-60 microarrays, yet these can be simply queried via a dynamic web interface with no prior knowledge of microarray data analysis. * Projects in PEPR originate from scientists world-wide, but all data has been generated by the Research Center for Genetic Medicine, Children''''s National Medical Center, Washington DC. Future developments of PEPR will allow remote entry of Affymetrix data ascribing to the same QC/SOP protocols. They have previously described an initial implementation of PEPR, and a dynamic web-queried time series graphical interface ( Chen et al. 2004 ). A publication showing the utility of PEPR for pharmacodynamic data has recently been published ( Almon et al. 2003 ).microarray, expression profiling, affymetrix, metadata standard, gene, time series, data sharing, visualization, data mining, platform, blood, cell, cancer, bone, brain, eye, gut, heart, kidney, liver, lung, muscle, spinal cord, spleen, analysisSCR_007274(Public Expression Profiling Resource, RRID:SCR_007274)NHGRI, NHLBI, NINDS, United States Department of Defenserelated to: Gene Expression Omnibus, listed by: OMICtoolsReferences (2)Last checked downnif-0000-00014, OMICS_00776
SumsDBResource, data analysis service, database, analysis service resource, production service resource, service resource, storage service resource, atlas, image repository, data repository, data or information resourceTHIS RESOURCE IS NO LONGER IN SERVICE, documented on May 11, 2016. Repository of brain-mapping data (surfaces and volumes; structural and functional data) derived from studies including fMRI and MRI from many laboratories, providing convenient access to a growing body of neuroimaging and related data. WebCaret is an online visualization tool for viewing SumsDB datasets. SumsDB includes: * data on cerebral cortex and cerebellar cortex * individual subject data and population data mapped to atlases * data from FreeSurfer and other brainmapping software besides Caret SumsDB provides multiple levels of data access and security: * Free (public) access (e.g., for data associated with published studies) * Data access restricted to collaborators in different laboratories * Owner-only access for work in progress Data can be downloaded from SumsDB as individual files or as bundles archived for offline visualization and analysis in Caret WebCaret provides online Caret-style visualization while circumventing software and data downloads. It is a server-side application running on a linux cluster at Washington University. WebCaret "scenes" facilitate rapid visualization of complex combinations of data Bi-directional links between online publications and WebCaret/SumsDB provide: * Links from figures in online journal article to corresponding scenes in WebCaret * Links from metadata in WebCaret directly to relevant online publications and figuressegmentation, volume, neuroimaging, brain, fmri, stereotaxic foci, stereotaxic coordinate, brain-mapping, foci, structural mri, mri, cerebral cortex, cerebellar cortex, afni brik, analyze, atlas, nifti, registration, rendering, spatial transformation, surface analysis, surface rendering, visualization, volume rendering, brain mapping, neuroanatomySCR_002759(SumsDB, RRID:SCR_002759)Washington University School of Medicine in St. Louis; Missouri; USA Mental disease, Neurological disorder, NormalHuman Brain Project, NASA, National Partnership for Advanced Computational Infrastructure, NCI, NIMH, NLM, NSFrelated to: Computerized Anatomical Reconstruction and Editing Toolkit, Integrated Manually Extracted Annotation, used by: NIF Data Federation, listed by: Biositemaps, NeuroImaging Tools and Resources Collaboratory (NITRC), re3data.orgLast checked downnif-0000-00016http://brainvis.wustl.edu/wiki/index.php/Sums:About http://www.nitrc.org/projects/sumsdb
Brain Architecture Management SystemResource, data repository, ontology, database, service resource, storage service resource, controlled vocabulary, data or information resourceKnowledge management system designed to handle neurobiological information at different levels of organization of vertebrate nervous system. Database and repository for information about neural circuitry, storing and analyzing data concerned with nomenclature, taxonomy, axonal connections, and neuronal cell types. Handles data and metadata collated from original literature, or inserted by scientists that is\\nassociated to four levels of organization of vertebrate nervous system. Data about expressed molecules, neuron types and classes, brain regions, and networks of brain regions.neurobiology, vertebrate, nervous, system, database, repository, neural, circuitry, analysis, data, nomenclature, taxonomy, axonal, connection, cellSCR_007251(Brain Architecture Management System, RRID:SCR_007251)University of Southern California; Los Angeles; USA Human Brain Project, NIBIB, NIMH, NINDSrelated to: Integrated Manually Extracted Annotation, used by: NIF Data Federation, Integrated Nervous System ConnectivityLast checked downnif-0000-00018http://brancusi.usc.edu/bkms/
BrainInfoResource, topical portal, database, standard specification, narrative resource, portal, atlas, data or information resourcePortal to neuroanatomical information on the Web that helps you identify structures in the brain and provides a variety of information about each structure by porting you to the best of 1500 web pages at 100 other neuroscience sites. BrainInfo consists of three basic components: NeuroNames, a developing database of definitions of neuroanatomic structures in four species, their most common acronyms and their names in eight languages; NeuroMaps, a digital atlas system based on 3-D canonical stereotaxic atlases of rhesus macaque and mouse brains and programs that enable one to map data to standard surface and cross-sectional views of the brains for presentation and publication; and the NeuroMaps precursor: Template Atlas of the Primate Brain, a 2-D stereotaxic atlas of the longtailed (fascicularis) macaque brain that shows the locations of some 250 architectonic areas of macaque cortex. The NeuroMaps atlases will soon include a number of overlays showing the locations of cortical areas and other neuroscientific data in the standard frameworks of the macaque and mouse atlases. Viewers are encouraged to use NeuroNames as a stable source of unique standard terms and acronyms for brain structures in publications, illustrations and indexing systems; to use templates extracted from the NeuroMaps macaque and mouse brain atlases for presenting neuroscientific information in image format; and to use the Template Atlas for warping to MRIs or PET scans of the macaque brain to estimate the stereotaxic locations of structures.brain, neuroanatomySCR_003142(BrainInfo, RRID:SCR_003142) University of California at San Diego; California; USA , University of Washington; Seattle; USA NCRR, NIBIB, NIH Office of the Director, NIMH, NLM, The Human Brain Projectrelated to: INIA19 Primate Brain Atlas, used by: NIF Data Federation, listed by: BiositemapsReferences (4)Last checked upnif-0000-00019
fMRI Data CenterResource, service resource, data or information resource, data repository, storage service resource, databaseTHIS RESOURCE IS NO LONGER IN SERVICE, documented August 25, 2013 Public curated repository of peer reviewed fMRI studies and their underlying data. This Web-accessible database has data mining capabilities and the means to deliver requested data to the user (via Web, CD, or digital tape). Datasets available: 107 NOTE: The fMRIDC is down temporarily while it moves to a new home at UCLA. Check back again in late Jan 2013! The goal of the Center is to help speed the progress and the understanding of cognitive processes and the neural substrates that underlie them by: * Providing a publicly accessible repository of peer-reviewed fMRI studies. * Providing all data necessary to interpret, analyze, and replicate these fMRI studies. * Provide training for both the academic and professional communities. The Center will accept data from those researchers who are publishing fMRI imaging articles in peer-reviewed journals. The goal is to serve the entire fMRI community.fmri, cognitive, cortex, mri, talairach, neuroimaging, cognitive neuroscience, brain, structure, function, magnetic resonance, intellect, image collection, data setSCR_007278(fMRI Data Center, RRID:SCR_007278)University of California at Santa Barbara; California; USA NIMH, NSF, Sun Microsystems Center of Excellence, W. M. Keck Foundationlisted by: NeuroImaging Tools and Resources Collaboratory (NITRC), Biositemaps, re3data.orgPMID:11545705Last checked downnif-0000-00025http://www.nitrc.org/projects/fmridatacenter/
Biomedical Informatics Research NetworkResource, database, software resource, service resource, storage service resource, atlas, data repository, data or information resourceNational initiative to advance biomedical research through data sharing and online collaboration that provides data sharing infrastructure, software tools, strategies and advisory services. Groups may choose whether to share data internally or with external audiences. Hardware and data remain under control of individual user groups.dti, fmri, alzheimer's disease, cognitive impairment, collaborative environment, cyberinfrastructure, data sharing, depressive disorder, information technology, infrastructure, memory dysfunction, microarray, mri, neurodegenerative disease, neuroinformatics, neuroimaging, genetics, biomedical material, neurobiology, electrophysiology, collaboration, biomedical, imaging, imaging system, biomedical engineering, brain, healthSCR_005163(Biomedical Informatics Research Network, RRID:SCR_005163)University of Southern California; Los Angeles; USA NCRR, NIGMS, NIH Blueprint for Neuroscience Researchlisted by: NeuroImaging Tools and Resources Collaboratory (NITRC), Biositemaps, re3data.org, DataCiteReferences (3)Last checked upnif-0000-00027http://www.nitrc.org/projects/birnhttp://www.birncommunity.org/, https://neuroscienceblueprint.nih.gov/factSheet/birn.htm
Mouse Brain LibraryResource, topical portal, database, image collection, portal, atlas, video resource, data or information resourceCollection of high resolution images and databases of brains from many genetically characterized strains of mice with aim to systematically map and characterize genes that modulate architecture of mammalian CNS. Includes detailed information on genomes of many strains of mice. Consists of images from approximately 800 brains and numerical data from just over 8000 mice. You can search MBL by strain, age, sex, body or brain weight. Images of slide collection are available at series of resolutions. Apple's QuickTime Plugin is required to view available MBL Movies.brain, gene, genome, strain, c57bl/6j, dba/2j, a/j, genetic variant, phenotype, hippocampus, cerebellum, striatum, olfactory bulb, thalamus, neocortex, dorsal nucleus of lateral geniculate body, central nervous systemSCR_001112(Mouse Brain Library, RRID:SCR_001112)University of Tennessee Health Science Center; Tennessee; USA NIMHrelated to: VideoscribblerPMID:10857184Last checked upnif-0000-00030
Internet Brain Volume DatabaseResource, data or information resource, databaseA database of brain neuroanatomic volumetric observations spanning various species, diagnoses, and structures for both individual and group results. A major thrust effort is to enable electronic access to the results that exist in the published literature. Currently, there is quite limited electronic or searchable methods for the data observations that are contained in publications. This effort will facilitate the dissemination of volumetric observations by making a more complete corpus of volumetric observations findable to the neuroscience researcher. This also enhances the ability to perform comparative and integrative studies, as well as metaanalysis. Extensions that permit pre-published, non-published and other representation are planned, again to facilitate comparative analyses. Design strategy: The principle organizing data structure is the "publication". Publications report on "groups" of subjects. These groups have "demographic" information as well as "volume" information for the group as a whole. Groups are comprised of "individuals", which also have demographic and volume information for each of the individuals. The finest-grained data structure is the "individual volume record" which contains a volume observation, the units for the observation, and a pointer to the demographic record for individual upon which the observation is derived. A collection of individual volumes can be grouped into a "group volume" observation; the group can be demographically characterized by the distribution of individual demographic observations for the members of the group.anatomy, volume, dsm-iv, normal, schizophrenia, autistic disorder, bipolar disorder, major depressive disorder, alzheimer's disease, attention deficit-hyperactivity disorder, alcohol dependence, dementia, traumatic brain injury, borderline personality disorder, obsessive-compulsive disorder, asperger syndrome, brain, brain structure, in vivo, ex vivo, male, female, gorilla beringei beringei, pongo pygmaeus, volumetric analysisSCR_002060(Internet Brain Volume Database, RRID:SCR_002060)Harvard Medical School; Massachusetts; USA Normal, Alzheimers disease, Seizure, Complex febrile seizure, Holoprosencephaly, Alcohol dependence, Bipolar Disorder, Traumatic brain injury, SchizophreniaNINDS, The Human Brain Projectrelated to: NIF Data Federation, Integrated Manually Extracted Annotation, listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)PMID:21931990Last checked downnif-0000-00033http://www.nitrc.org/projects/ibvd
Neurogenetics OnlineResource, topical portal, portal, data or information resourcePortal to neurogenetic resources: the mouse brain library, digital atlases of the mouse brain, extensive brain microarray data in WebQTL, and internet access to microscopes and stereology tools.Mouse Brain Library. Mouse Brain Library is an expanding collection of high-resolution histological images, atlases, MRIs, and databases on brain structure of more than 120 different lines of mice. Nervenet also includes several useful genetics and gene mapping databases to download (SNP databases, Map Manager databases, and the Portable Dictionary of the Mouse Genome). The publications section includes revised, expanded, and annotated papers, tutorials, and reviews on neurogenetics, gene mapping, complex trait analysis, stereology, and the control of neuron number.training tools, atlas, qtl, neurogeneticsSCR_007280(Neurogenetics Online, RRID:SCR_007280)Last checked upnif-0000-00035
International Gene Trap ConsortiumResource, organization portal, production service resource, biomaterial supply resource, consortium, material service resource, service resource, portal, cell repository, material resource, biomaterial manufacture, data or information resourceConsortium represents all publicly available gene trap cell lines, which are available on non-collaborative basis for nominal handling fees. Researchers can search and browse IGTC database for cell lines of interest using accession numbers or IDs, keywords, sequence data, tissue expression profiles and biological pathways, can find trapped genes of interest on IGTC website, and order cell lines for generation of mutant mice through blastocyst injection. Consortium members include: BayGenomics (USA), Centre for Modelling Human Disease (Toronto, Canada), Embryonic Stem Cell Database (University of Manitoba, Canada), Exchangeable Gene Trap Clones (Kumamoto University, Japan), German Gene Trap Consortium provider (Germany), Sanger Institute Gene Trap Resource (Cambridge, UK), Soriano Lab Gene Trap Resource (Mount Sinai School of Medicine, New York, USA), Texas Institute for Genomic Medicine - TIGM (USA), TIGEM-IRBM Gene Trap (Naples, Italy).embryo, embryonic, gene, genome, allele, analysis, assay, bioinformatics, blastocyst, cell, colony, consortium, genotyping, hybridization, in situ, international, knockout, murine, mutant, mutation, probe, qpcr, researcher, scientist, sequence, stem cell, tagging, trap, vector, cell line, embryonic stem cell lineSCR_002305(International Gene Trap Consortium, RRID:SCR_002305)University of California at San Francisco; California; USA NCRRrelated to: Centre for Modeling Human Disease Gene Trap Resource, listed by: One Mind Biospecimen Bank ListingPMID:16381950Last checked upnif-0000-00036https://igtc.org/
Mouse Atlas ProjectResource, atlas, database, data or information resourceDetailed multidimensional digital multimodal atlas of the C57BL/6J mouse nervous system with a high-throughput data and informatics pipeline that can automatically register, annotate, and visualize large scale neuroanatomical and connectivity data produced in commonly used methodologies including histology, neuronal tract tracing, MR imaging, and genetic labeling. Using multimodal imaging methods on adult mouse brains, this high-resolution atlas forms the basis of a useful interchange reference system for the mouse. MAP2.0 interoperates with commonly used publicly available databases to bring together brain architecture, gene expression, and imaging information into a single, simple interface. The project enables scientists to leverage the results of brain atlasing efforts in their investigations of gene function, connectomics, and detailed mouse neuroanatomy. The MAP atlas is comprised of a magnetic resonance microscopy (MRM) and an anatomic delineation volume, and a set of software tools for visualization, navigation, and registration of image volumes. The software tools bundled with the atlas volumes are SHIVA (visualization and analysis), BrainGraph (navigation and connectivity), and GEMporter (registration and importation). A database of ancillary volumes is available online, a supplement to the Mouse Atlas Project core volumes. They represent different developmental time points and methods of preparation. To facilitate the process of selecting and analyzing image data from this collection, we have developed a relational database application to manage and catalog the images and related data. Attributes of the subject such as age, strain, weight and anatomical structure are recorded, as are image volume properties such as modality, resolution and anatomical structure. The ongoing partnership with the Brain Architecture Center has led to the development of a robust and flexible nomenclature and anatomical ontology for MAP2.0. This collaboration extends both Mouse Atlas Project and the Brain Architecture Management System.molecular neuroanatomy resource, adult mouse, mouse, brain, c57bl/6j, magnetic resonance microscopy, diffusion-weighted image, blockface imaging, immunohistochemistry, in situ hybridization, neuroanatomy, mri, dti, brain architecture, gene expression, neuroimaging, ontology, connectivity, histology, neuronal tract tracing, genetic labeling, newborn mouse, experimental protocolSCR_007281(Mouse Atlas Project, RRID:SCR_007281)AgingNIA, NIBIB, NIDA, NIDCD, NINDSrelated to: Synchronized Histological Image Viewing Architecture, LONI Image and Data Archive, LONI SoftwareLast checked downnif-0000-00038http://www.loni.ucla.edu/MAP/
Mouse BIRN Atlasing ToolkitResource, software resource, image analysis software, data visualization software, data processing software, software applicationA workflow environment bringing together heterogenous, online biological image resources, a user's image data and biological atlases in a concise, unified and intuitive workspace. The MBAT viewer displays multiple images on a single virtual canvas allowing easy side-by-side comparisons and image compositing. MBAT is written in Java so it is platform independent and is highly extensible through it's plugin architecture. MBAT integrates three distinct workspaces for online search, image alignment (registration) and image display: * Search Workspace: able to submit a query to multiple databases simultaneously and online literature searches. * Registration Workspace: performs 2D landmark based registration. * Viewer Workspace: displays & composites images and image volumes using high performance graphics hardware. * Atlas Viewer: allows navigation and interrogation of volumetric atlases. * Hierarchy Editor: create logical groupings of atlas labels.gene expression, microarray, light microscopy, electron microscopy, mri imaging, analyze, gnome, java, kde, magnetic resonance, nifti, os independent, win32 (ms windows), mri, registration, alignmentSCR_002814(Mouse BIRN Atlasing Toolkit, RRID:SCR_002814)Laboratory of Neuro Imaging NCRRrelated to: Mouse Biomedical Informatics Research Network, 3D MRI Atlas of Mouse Development, listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)Last checked downnif-0000-00039http://mbat.loni.ucla.edu/
Mouse Brain AtlasesResource, atlas, data or information resourceHigh-resolution electronic atlases for mouse strains c57bl/6j, a/j, and dba/2j in either coronal or horizontal section. About this Atlas: The anterior-posterior coordinates are taken from an excellent print atlas of a C57BL/6J brain by K. Franklin and G. Paxinos (The Mouse Brain in Stereotaxic Coordinates, Academic Press, San Diego, 1997, ISBN Number 0-12-26607-6; Library of Congress: QL937.F72). The abbreviations we have used to label the sections conform to those in the Franklin-Paxinos atlas. A C57BL/6J mouse brain may contain as many as 75 million neurons, 23 million glial cells, 7 million endothelial cells associated with blood vessels, and 3 to 4 million miscellaneous pial, ependymal, and choroid plexus cells (see data analysis in Williams, 2000). We have not yet counted total cell number in DBA/2J mice, but the counts are probably appreciably lower.The brain and sections were all processed as described in our methods section. The enlarged images have a pixel count of 1865 x 1400 and the resolution is 4.5 microns/pixel for the processed sections.Plans: In the next several years we hope to add several additional atlases of the same sort for other strains of mice. A horizontal C57BL/6J atlas and a DBA/2J coronal atlas were completed by Tony Capra, summer 2000, and additional atlases may be made over the next several years. As describe in the MBL Procedures Section is not hard to make your own strain-specific atlas from the high resolution images in the MBL.genetics, anatomy, coronal, cerebellum, c57bl/6j, dba/2j, a/j, horizontal, morphology, subcortical, volumeSCR_007127(Mouse Brain Atlases, RRID:SCR_007127)Mouse Brain Library Human Brain Project, NIDA, NIMH, NSFLast checked upnif-0000-00044
Mutant Mouse Regional Resource CenterResource, organism supplier, production service resource, biomaterial supply resource, biospecimen repository, material service resource, service resource, storage service resource, cell repository, data or information resource, material resource, biomaterial manufacture, material storage repositoryNational public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.stem cell, mouse strain, embryonic stem cell, embryonic stem cell line, cryopreserved, mutant mouse strain, mutant, transgenic, databaseSCR_002953(Mutant Mouse Regional Resource Center, RRID:SCR_002953)Jackson Laboratory , University of North Carolina at Chapel Hill; North Carolina; USA , National Institutes of Health , University of Missouri; Missouri; USA , University of California at Davis; California; USA NCRR, NIH Blueprint for Neuroscience Research, NIH Office of the Directorrelated to: Federation of International Mouse Resources, Mouse Mutagenesis Center for Developmental Defects , MGI strains, used by: Integrated Animals, listed by: One Mind Biospecimen Bank Listing, Biositemaps, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK Research Resources, NIDDK Information Network, affiliated with: MUGA, MegaMUGA, provides: Knockout Mouse Project RepositoryLast checked upnif-0000-00045
neuromiceResource, biomaterial supply resource, data or information resource, material resource, organism supplier, databaseTHIS RESOURCE IS NO LONGER IN SERVICE, documented on January 08, 2013. A consortium of three facilities whose purpose is to establish, characterize, and distribute novel mutant mouse models with neural and/or behavioral phenotypes, and distribute them to the worldwide research community. Interested scientists are able to obtain information about mouse lines at all three sites in a single unified database. GOALS * Increase genomic and genetic tools for functional gene identification * Provide mice with mutations that alter the nervous system or behavior * Build collaborations between geneticists and neuroscientists The consortium is made up of three mutagenesis and phenotypic screening facilities, focused on identifying alterations in nervous system function and behavior, and established by NIH. They are the Neurogenomics Project at Northwestern University, the Neuroscience Mutagenesis Facility at The Jackson Laboratory, and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium. The NIH Neurogenomics Project at Northwestern University is directed by Dr. Joseph S. Takahashi, who also acts as the Director of the Neuromice.org consortium. Chemical mutagenesis is used to induce mutations throughout the genome and combined with phenotypic screens to detect mice with mutations. In order to maximize the genomic coverage and recover both dominant and recessive mutations, a dominant G1 screen and a recessive G3 screen are utilized. Phenotypic screens focus on five primary domains: learning and memory, behavioral responses to stress, responses to psychostimulants, circadian rhythmicity, and vision. The Neuroscience Mutagenesis Facility at the Jackson Laboratory is directed by Dr. Wayne N. Frankel. The Neuroscience Mutagenesis Facility is using a three-generation backcross breeding scheme to produce homozygous mutants and will thus recover dominant, semidominant, and recessive mutations. In addition, some mutagenesis will be done in ES cells followed by two generations of breeding. Phenotypic screens focus on identifying mutations affecting: motor function, seizure threshold, hearing, vision, and neurodevelopment. The Neuromutagenesis Project of the Tennessee Mouse Genome Consortium (TMGC) involves researchers throughout the state of Tennessee, under the direction of Dr. Daniel Goldowitz, Ph.D., at the University of Tennessee Health Science Center, Memphis. TMGC also includes researchers at Oak Ridge National Laboratory, Vanderbilt University, Meharry Medical College, University of Tennessee-Knoxville, St. Jude Children's Research Hospital, and the University of Memphis. The Project is using regional mutagenesis, covering regions on chromosomes 10, 14, 15, 19, and X, thus including approximately 15 of the genome in the screened region. Phenotypic screens include: motor and sensory function, learning and memory, neurohistology, aging, alcohol response, abused drug response, visual function, and social behavior. Neuromice.org has stopped taking orders online but mutants are orderable please contact the originating center for availability and pricing details. Live targeted mutant Fragile X model mice are now available for distribution.eye, fragile x syndrome, gene expression phenotype, geneticist, anxiety, ataxia, behavior, b-wave, cocaine, mus, musculoskeletal movement, mutant mouse strain, mutated variant site, mutation, nervous system, nervous system behavior, nervous system function, neuromuscular function, neuroscientist, phenotype, scotopic threshold response, substance-related disorder, tremor, visual perception, mutant, mouse model, neural phenotype, behavioral phenotype, neuron, mutagenesis, learning, memory, stress, psychostimulant, circadian rhythm, vision, motor function, seizure threshold, hearing, neurodevelopment, chromosome, motor function, sensory function, neurohistology, alcohol abuse, drug abuse, visual function, social behaviorSCR_002993(neuromice, RRID:SCR_002993) JAX Neuroscience Mutagenesis Facility , Northwestern University; Illinois; USA AgingNIH Blueprint for Neuroscience Researchrelated to: JAX Neuroscience Mutagenesis Facility, listed by: One Mind Biospecimen Bank ListingLast checked downnif-0000-00046http://www.neuromice.org
EMAGE Gene Expression DatabaseResource, database, service resource, storage service resource, atlas, data repository, data or information resourceA database of in situ gene expression data in the developing mouse embryo and an accompanying suite of tools to search and analyze the data. mRNA in situ hybridization, protein immunohistochemistry and transgenic reporter data is included. The data held is spatially annotated to a framework of 3D mouse embryo models produced by EMAP (e-Mouse Atlas Project). These spatial annotations allow users to query EMAGE by spatial pattern as well as by gene name, anatomy term or Gene Ontology (GO) term. The conceptual framework which houses the descriptions of the gene expression patterns in EMAGE is the EMAP Mouse Embryo Anatomy Atlas. This consists of a set of 3D virtual embryos at different stages of development, as well as an accompanying ontology of anatomical terms found at each stage. The raw data images can be conventional 2D photographs (of sections or wholemount specimens) or 3D images of wholemount specimens derived from Optical Projection Tomography (OPT) or confocal microscopy. Users may submit data using a Data submission tool or without.genetics, 3d model, anatomy, development, mouse morphology, molecular neuroanatomy resource, gene expression, in situ hybridization, immunohistochemistry, embryo, in situ reporter, embryonic mouse, optical projection tomography, confocal microscopy, annotation, pathway, gene association, protein, theiler stage, gene expression, embryology, dna, protein, protein-protein interaction, protein binding, gene, embryology, anatomy, geneticsSCR_005391(EMAGE Gene Expression Database, RRID:SCR_005391)MRCrelated to: HUDSEN Electronic Atlas of the Developing Human Brain, e-mouse Atlas (EMA and EMAGE), e-mouse Atlas (EMA and EMAGE), HUDSEN Human Gene Expression Spatial Database, aGEM, Eurexpress, Gene Expression Database, Gene Ontology, NIDDK Information Network, GUDMAP Ontology, listed by: re3data.orgPMID:19767607Last checked upnif-0000-00080
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