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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Sep 14, 2019)

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402 Results - per page

Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
PatientCrossroadsResource, patient registry, topical portal, portal, people resource, data or information resourceA trusted third-party gatekeeper of patient data from participants in a rare disease ecosystem, collecting and managing the information in a scalable, cost-effective manner. Each patient registry provides critical disease knowledge which makes that disease easier to study, increasing the probability a treatment can be developed. PatientCrossroads takes a network approach to patient registry programs. Unlike companies that merely sell registry software, we offer a full range of administration, management, and genetic curation services. What does this consolidated, patient-centric approach to patient registries mean? * Patients can more easily find registries and provide their valuable data (including locations of blood and tissue samples as well as reports of diagnoses, disease symptoms, treatment usage, and lifestyle activities) * Patients can be confident in the privacy of their de-identified data and the knowledge that PatientCrossroads does not sell patient data * Researchers and pharmaceutical companies have a larger, more easily accessible pool of potential patients for research studies and clinical trials targeting specific rare diseases * Pharmaceutical companies can collect post-market surveillance data in a more scalable and cost-effective manner * Rare disease advocacy and research foundations can more easily organize their global patient populations for inclusion in trials and studiesdisease, treatment, clinical, patient, registry, drug discovery, clinical trial, research study, genetics, biorepositorySCR_006279(PatientCrossroads, RRID:SCR_006279)Rare diseaseLast checked downnlx_151889
HDBaseResource, disease-related portal, data set, topical portal, portal, data or information resourceA community website for Huntington''s Disease (HD) research that currently contains Y2H and Mass spectrometry protein-protein interaction data centered around the HD protein (huntingtin) and information on therapeutic studies in mouse. Also available are raw Human and Mouse Affymetrix Microarray data. The protein interaction data is from several sources, including interactions curated from the literature by ISB staff, experimentally determined interactions produced by Bob Hughes and colleagues at Prolexys (currently password protected), and interactions reported in a recent publication by Goehler et al from Eric Wanker''s lab. Content areas that may be covered by the site include the following: * Therapeutic studies in mouse, primarily drug screens. * HD mouse models with a focus on timelines of disease progression. * Antibodies used in HD research. * Microarray gene expression studies. * Genes and proteins relevant to HD research. This includes HD itself, the growing list of proteins thought to interact directly or indirectly with huntingtin (Htt), and other genes and proteins implicated in the disease process. * Molecular pathways thought to be involved in the disease process. * Timelines of disease for Mouse modelsdrug, gene expression, huntingtin, mass spectrometry, microarray, protein interaction, protein-protein interaction, y2h, mouse model, treatment, disease, phenotype, brain, striatum, adipose, muscle, gene, protein, antibody, pathwaySCR_007132(HDBase, RRID:SCR_007132)Institute for Systems Biology; Washington; USA Huntington''s disease, ControlHereditary Disease Foundationuses: CytoscapeLast checked downnif-0000-00153
CardioGenomicsResource, topical portal, portal, data or information resourceThe primary goal of the CardioGenomics PGA is to begin to link genes to structure, function, dysfunction and structural abnormalities of the cardiovascular system caused by clinically relevant genetic and environmental stimuli. The principal biological theme to be pursued is how the transcriptional network of the cardiovascular system responds to genetic and environmental stresses to maintain normal function and structure, and how this network is altered in disease. This PGA will generate a high quality, comprehensive data set for the functional genomics of structural and functional adaptation of the cardiovascular system by integrating expression data from animal models and human tissue samples, mutation screening of candidate genes in patients, and DNA polymorphisms in a well characterized general population. Such a data set will serve as a benchmark for future basic, clinical, and pharmacogenomic studies. Training and education are also a key focus of the CardioGenomics PGA. In addition to ongoing journal clubs and seminars, the PGA will be sponsoring symposia at major conferences, and developing workshops related to the areas of focus of this PGA. Information regarding upcoming events can be found in the Events section of this site, and information about training and education opportunities sponsored by CardioGenomics can be found on the Teaching and Education page. The CardioGenomics project came to a close in 2005. This server, cardiogenomics.med.harvard.edu, remains online in order to continue to distribute data that was generated by investigators under the auspices of the CardioGenomics Program for Genomic Applications (PGA). :Sponsors: This resource is supported by The National Heart, Lung and Blood Institute (NHLBI) of the NIH.genomics, clinical, genetic, environmental, stimulus, cardiovascular, disease, data, expression, gene, dna, polymorphism, population, pharmacogenomic, training, educationSCR_007248(CardioGenomics, RRID:SCR_007248)Harvard University; Cambridge; United States Last checked downnif-0000-30296http://www.cardiogenomics.org
National Resource for AplysiaResource, biomaterial supply resource, material resource, organism supplierCenter where Aplysia californica are cultured and raised for research purposes. Aplysia from the facility serve in research on genomics, human brain function, toxicology for developmental studies, natural products, chemistry for isolation of novel anti-tumor and antibacterial compounds, in the study of transport by digestive tissues and have potential for use in studies of substance addiction and nerve senescence and regeneration.disease, genomics, aplysia californica, research, brainSCR_008361(National Resource for Aplysia, RRID:SCR_008361)University of Miami; Florida; USA NCRR, NIH Office of the DirectorLast checked downnif-0000-25472
Genetic Association DatabaseResource, data or information resource, databaseThe Genetic Association Database is an archive of human genetic association studies of complex diseases and disorders. The goal of this database is to allow the user to rapidly identify medically relevant polymorphism from the large volume of polymorphism and mutational data, in the context of standardized nomenclature. The data is from published scientific papers. Study data is recorded in the context of official human gene nomenclature with additional molecular reference numbers and links. It is gene centered. That is, each record is a record of a gene or marker. If a study investigated 6 genes for a particular disorder, there will be 6 records. Anyone may view this database and anyone may submit records. You do not have to be an author on the original study to submit a record. All submitted records will be reviewed before inclusion in the archive. Both genetic and environmental factors contribute to human diseases. Most common diseases are influenced by a large number of genetic and environmental factors, most of which individually have only a modest effect on the disease. Though genetic contributions are relatively well characterized for some monogenetic diseases, there has been no effort at curating the extensive list of environmental etiological factors. From a comprehensive search of the MeSH annotation of MEDLINE articles, they identified 3,342 environmental etiological factors associated with 3,159 diseases. They also identified 1,100 genes associated with 1,034 complex diseases from the NIH Genetic Association Database (GAD), a database of genetic association studies. 863 diseases have both genetic and environmental etiological factors available. Integrating genetic and environmental factors results in the etiome, which they define as the comprehensive compendium of disease etiology.environmental, etiological, etiology, factor, gene, general human genetics databases, genetic, association, complex, disease, disorder, human, medically, molecular, monogenetic, mutational, nomenclature, polymorphism, scientificSCR_013264(Genetic Association Database, RRID:SCR_013264)National Institute on Aging Agingrelated to: KOBAS, used by: DisGeNETLast checked downnif-0000-21163
Center for Computational Biology at UCLAResource, organization portal, data access protocol, web service, software resource, portal, atlas, data or information resourceCenter focused on the development of computational biological atlases of different populations, subjects, modalities, and spatio-temporal scales with 3 types of resources: (1) Stand-alone computational software tools (image and volume processing, analysis, visualization, graphical workflow environments). (2) Infrastructure Resources (Databases, computational Grid, services). (3) Web-services (web-accessible resources for processing, validation and exploration of multimodal/multichannel data including clinical data, imaging data, genetics data and phenotypic data). The CCB develops novel mathematical, computational, and engineering approaches to map biological form and function in health and disease. CCB computational tools integrate neuroimaging, genetic, clinical, and other relevant data to enable the detailed exploration of distinct spatial and temporal biological characteristics. Generalizable mathematical approaches are developed and deployed using Grid computing to create practical biological atlases that describe spatiotemporal change in biological systems. The efforts of CCB make possible discovery-oriented science and the accumulation of new biological knowledge. The Center has been divided into cores organized as follows: - Core 1 is focused on mathematical and computational research. Core 2 is involved in the development of tools to be used by Core 3. Core 3 is composed of the driving biological projects; Mapping Genomic Function, Mapping Biological Structure, and Mapping Brain Phenotype. - Cores 4 - 7 provide the infrastructure for joint structure within the Center as well as the development of new approaches and procedures to augment the research and development of Cores 1-3. These cores are: (4)Infrastructure and Resources, (5) Education and Training, (6) Dissemination, and (7) Administration and Management. The main focus of the CCB is on the brain, and specifically on neuroimaging. This area has a long tradition of sophisticated mathematical and computational techniques. Nevertheless, new developments in related areas of mathematics and computational science have emerged in recent years, some from related application areas such as Computer Graphics, Computer Vision, and Image Processing, as well as from Computational Mathematics and the Computational Sciences. We are confident that many of these ideas can be applied beneficially to neuroimaging.functional, genetic, biological system, brain, clinical, computational, computational mathematic, disease, health, image processing, physiological, population, structural, neuroimaging, computational neuroscience, imaging genomics, magnetic resonance, pet, spectSCR_000334(Center for Computational Biology at UCLA, RRID:SCR_000334)Laboratory of Neuro Imaging NCRRrelated to: National Centers for Biomedical Computing, listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)Last checked downnif-0000-10492http://ccb.loni.ucla.edu/http://www.nitrc.org/projects/ccb, http://cms.loni.ucla.edu/CCB/
Opal ResearchResource, software resource, data processing software, data analysis software, sequence analysis software, software applicationSoftware which integrates a comprehensive, automated genome annotation engine with the VAAST and Phevor disease gene prioritization tools to rank gene variants on the severity of their impact on protein function and likelihood to cause disease. Each variant in a gene is analyzed for its impact on protein function, conservation and frequency. Each gene is ranked rather than filtered in order to ensure critical targets are not prematurely removed.sequence analysis software, genome interpretation, variant prioritization, disease gene prioritization, next-generation sequencing, clinical interpretation, clinical genomics software, genome, protein function, disease, genomic variant, mutationSCR_000405(Opal Research, RRID:SCR_000405)related to: VAASTPMID:23895124Last checked downSciRes_000140
Alzheimer Society of CanadaResource, regional funding resource, portal, funding resource, data or information resourceA nonprofit health organization that works to improve the quality of life of Canadians affected by Alzheimer's disease and other dementias. This organization also supports research on the cause and potential cures for the disease through education and funding.dementia, alzheimer's, disease, research, funding, nonprofit, canadaSCR_000485(Alzheimer Society of Canada, RRID:SCR_000485)Alzheimer's disease, DementiaLast checked downnlx_158162
Tennenbaum Center for the Biology of CreativityResource, organization portal, portal, data or information resourceThe purpose of this center is to study the molecular, cellular, systems and cognitive mechanisms that result in cognitive enhancements and explain unusual levels of performance in gifted individuals, including extraordinary creativity. Additionally, by understating the mechanisms responsible for enhancements in performance we may be better suited to intervene and reverse disease states that result in cognitive deficits. One of the key topics addressed by the Center is the biological basis of cognitive enhancements, a topic that can be studied in human subjects and animal models. In the past much of the focus in the brain sciences has been on the study of brain mechanisms that degrade cognitive performance (for example, on mutations or other lesions that cause cognitive deficits). The Tennenbaum Center for the Biology of Creativity at UCLA enables an interdisciplinary team of leading scientists to advance knowledge about the biological bases of creativity. Starting with a pilot project program, a series of investigations was launched, spanning disciplines from basic molecular biology to cognitive neuroscience. Because the concept of creativity is multifaceted, initial efforts targeted refinement of the component processes necessary to generate novel, useful cognitive products. The identified core cognitive processes: 1.) Novelty Generation the ability to flexibly and adaptively generate products that are unique; 2.) Working Memory and Declarative Memory the ability to maintain, and then use relevant information to guide goal-directed performance, along with the capacity to store and retrieve this information; and 3.) Response Inhibition the ability to suppress habitual plans and substitute alternate actions in line with changing problem-solving demands. To study the basic mechanisms underlying these complex brain functions we use translational strategies. Starting from foundational studies in basic neuroscience, we forged an interdisciplinary strategy that permits the most advanced techniques for genetic manipulation and basic neurobiological research to be applied in close collaboration with human studies that converge on the same core cognitive processes. Our integrated research program aims to reveal the genetic architecture and fundamental brain mechanisms underlying creative cognition. The work holds enormous promise for both enhancing healthy cognitive performance and designing new treatments for diverse cognitive disorders. Sponsors: The Tennenbaum Center for the Biology of Creativity was inspired by the vision and generosity of Michael Tennenbaum.generation, genetic, animal, biological, brain, brain science, cellular, cognitive, cognitive deficit, cognitive disorder, cognitive neuroscience, creativity, declarative memory, disease, habitual, human, inhibition, mechanism, memory, model, molecular, molecular biology, neurobiological, performance, response, working memorySCR_000668(Tennenbaum Center for the Biology of Creativity, RRID:SCR_000668)Last checked downnif-0000-10497
IFPMA Clinical Trials PortalResource, data or information resource, databaseIFPMA Clinical Trials Portal is brought to you by IFPMA on behalf of its Member Companies and Associations. IFPMA Clinical Trials Portal ensures: a free and easy-to-use interface for patients and health professionals alike to ongoing clinical trials, clinical trial results and complementary information on related issues; non-promotional and reliable information; industry's commitment to the transparency of clinical trials. * Search by Medical Condition and Drug Name * Language Interfaces (En, Es, Fr, De, Jp) * Glossary and Easy Explanation of Medical Expressions * Geographical Searchclinical, clinical trial, pediatric, disease, cancer, hiv, aids, diabetes, heart diseaseSCR_000791(IFPMA Clinical Trials Portal, RRID:SCR_000791)IFPMA - International Federation of Pharmaceutical Manufacturers and Associations IFPMA - International Federation of Pharmaceutical Manufacturers and AssociationsLast checked downnif-0000-31391
Benaroya Research Institute: Neurological DiseasesResource, department portal, organization portal, portal, data or information resourceBRI investigators study the molecular and genetic mechanisms which underlie some of the most devastating chronic neurological disorders, and conduct clinical trials for new innovative therapies. Neurological studies that are currently studied include Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's Disease, Multiple Sclerosis, and Parkinson's Disease.genetic, chronic, disease, disorder, neurologicalSCR_001576(Benaroya Research Institute: Neurological Diseases, RRID:SCR_001576)Benaroya Research Institute Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's diseaseLast checked downnif-0000-10379http://www.vmresearch.org/disease-information/disease-research/neurological-diseases
EMBASEResource, data or information resource, databaseComprehensive international bibliographic biomedical database that enables users to track and retrieve precise information on drugs and diseases from pre-clinical studies to searches on critical toxicological information. It contains bibliographic records with citations, abstracts and indexing derived from biomedical articles in peer reviewed journals, and is especially strong in its coverage of drug and pharmaceutical research. Embase can help with everything from clinical trials research to pharmacovigilance and is updated online daily and weekly. Its broad biomedical scope covers the following areas: * Drug therapy and research, including pharmaceutics, pharmacology and toxicology * Clinical and experimental (human) medicine * Basic biological science relevant to human medicine * Biotechnology and biomedical engineering, including medical devices * Health policy and management, including pharmacoeconomics * Public, occupational and environmental health, including pollution control * Veterinary science, dentistry, and nursing The Embase Application Programming Interface supports export, RSS feeds, and integration services, making it possible to share data with a wide range of systems.biomedical, drug, disease, regulatory requirement, drug research, pharmacology, pharmaceutics, toxicology, clinical, experimental medicine, health policy, management, public health, occupational health, environmental health, drug dependence, drug abuse, psychiatry, forensic medicine, biomedical engineering, biomedical instrumentation, nursing, dentistry, veterinary medicine, psychology, alternative medicine, clinical trial, pharmacovigilance, pharmacology, drug safety, adverse drug reaction, chemical, bibliographySCR_001650(EMBASE, RRID:SCR_001650)related to: Cochrane Central Register of Controlled TrialsLast checked downnlx_153929
NIDDK Information NetworkResource, community building portal, database, resource, portal, data or information resourceA community-based network to serve the needs of basic and clinical investigators that includes large pools of data and research resources relevant to the mission of NIDDK (National Institute of Diabetes and Digestive and Kidney Disease).dknet, data resource, diabetes, kidney, liver, disease, urology, hematology, digestive, nutrition, endocrine, obesity, metabolicSCR_001606(NIDDK Information Network, RRID:SCR_001606)SciCrunch , University of California at San Diego; California; USA Digestive disease, Kidney disease, Diabetes, Metabolic disease, Endocrine disease, obesity, Urologic diseaseNIDDKrelated to: MTOPS Prostate Samples Analysis Consortium , Neuroscience Information Framework, Diabetes Disease Portal, Kidney and Urinary Pathway Knowledge Base, dbMHC, Islet Cell Resource Centers , DGAP , Nuclear Receptor Resource , dkCOIN , Human Biological Data Interchange , National Gene Vector Biorepository, Creatinine Standardization Program , Glomerular Filtration Rate Calculators , Congressionally Directed Medical Research Program, National Kidney Disease Education Program , Network of Minority Health Research Investigators , National Endocrine and Metabolic Diseases Information Service , Kidney and Urinary Pathway Ontology, National Diabetes Information Clearinghouse , Digestive Diseases Statistics for the United States , Diabetes in America , National Digestive Diseases Information Clearinghouse , Diabetes Control and Complications Trial , National Hematologic Diseases Information Service , National Kidney and Urologic Diseases Information Clearinghouse , Nonhuman Primate Transplantation Tolerance Cooperative Study Group , Type 1 Diabetes Preclinical Testing Program , Diabetes Autoantibody Standardization Program, AASK Clinical Trial and Cohort Study , Maryland Genetics of Interstitial Cystitis , Frequent Hemodialysis Network Nocturnal Trial , Mammalian Gene Collection, Zebrafish Gene Collection, Boston Area Community Health Survey , Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia , Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study , Complementary and Alternative Medicine for Urological Symptoms , Mouse Mutagenesis Center for Developmental Defects , CARDS Database, ACCORD , Program to Reduce Incontinence by Diet and Exercise , Renal Disease Portal, Renin Angiotensin System Study , NIH Data Sharing Repositories, Kidney Development Database, GenePaint Interactive Anatomy Atlas, EMAGE Gene Expression Database, Gene Expression Omnibus, MGnify, uses: NIDDK Central Repository, Addgene, NIF Data Federation, Antibody Registry, Nuclear Receptor Signaling Atlas , GenitoUrinary Development Molecular Anatomy Project , Diabetic Complications Consortium , National Mouse Metabolic Phenotyping Centers , T1DBase , Beta Cell Biology Consortium , Grants.gov, dkNET Community Pilot Funding Opportunities, Integrated Grants, ClinicalTrials.gov, Integrated Animals, Intestinal Stem Cell Consortium, listed by: NIH Data Sharing Repositories, NIDDK Research Resources, lists: Diabetic Complications Consortium , Nephromine, LIPID Metabolites And Pathways Strategy, METLIN, NIDDK Inflammatory Bowel Disease Genetics Consortium, Body Mass Index Calculator, Symptom Score for Benign Prostatic Hyperplasia, Genetics of Kidneys in Diabetes, Type 1 Diabetes - Rapid Access to Intervention Development , TEDDY , Trans-Institute Angiogenesis Research Program , Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease , Current Research Information System, Healthy People, Acute Liver Failure Study Group , Collaborative Islet Transplant Registry , Diabetes Prevention Type 1 , Epidemiology of Diabetes Interventions and Complications , NIH Division of Nutrition Research Coordination, Human Nutrition Research Information Management, Type 1 Diabetes Resource , National Diabetes Education Program , Pediatric Acute Liver Failure Study , Globin Gene Server , NIH Chronic Prostatitis Symptom Index , Sequencing of Idd regions in the NOD mouse genome , Look AHEAD , Teen-Longitudinal Assessment of Bariatric Surgery , Adult to Adult Living Donor Liver Transplantation Cohort Study , Behavior Enhances Drug Reduction of Incontinence , BARI 2D, Childhood Liver Disease Research and Education Network , Standardization of C-peptide measurements , CKID A Prospective Cohort Study of Kidney Disease in Children , Diabetes Prevention Program , Diabetes Prevention Program Outcomes Study , Irritable Bowel Syndrome Outcome Study , Folic Acid for Vascular Outcome Reduction in Transplantation , Type 1 Diabetes TrialNet , Diabetes Research in Children Network, Diabetic Retinopathy Clinical Research Network, Clinical Islet Transplantation Study , Nonalcoholic Steatohepatitis Clinical Research Network , Drug-Induced Liver Injury Network , Family Investigation of Nephropathy of Diabetes , Frequent Hemodialysis Network Daily Trial , HEALTHY study , SISTEr , Urinary Incontinence Treatment Network , TINSAL-T2D , TOMUS , Type 1 Diabetes Genetics Consortium , Center for Inherited Disease Research , Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study (ACCORDION), Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) , Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network (MAPP), Lifestyle Interventions for Expectant Moms (LIFE-Moms) , Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium (HAPO-FUS), Nephrotic Syndrome Study Network (NEPTUNE), CKD Biomarkers Consortium, Porphyria Consortium, Vitamin D to Prevent Type 2 Diabetes (D2d) , Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) , Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) , Clinical Islet Transplantation Consortium (CITC), Restoring Insulin Secretion Consortium (RISE), Assessment Serial Evaluation and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) , Integrated Islet Distribution Program (IIDP) , Adolescent Bariatrics: Assessing Health Benefits and Risks (Teen-LABS), Human Islet Research Network (HIRN) , Rare Kidney Stone Consortium (RKSC), Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction , Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit , Intestinal Stem Cell Consortium , RiVuR , Gastroparesis Clinical Research Consortium , Urologic Diseases in America, United States Renal Data System , HALT PKD , Chronic Renal Insufficiency Cohort Study , Viral Resistance to Antiviral Therapy of Chronic Hepatitis C , Peginterferon and Ribavirin for Pediatric Patients with Chronic Hepatitis C , HALT-C Trial , TRIGR, Treatment Options for type 2 Diabetes in Adolescents and Youth , Study of Nutrition in Acute Pancreatitis , SEARCH for Diabetes in Youth , Organ Procurement and Transplantation Network, Nuclear Receptor Signaling Atlas , NIH Common Fund, Mutant Mouse Regional Resource Centers, GenitoUrinary Development Molecular Anatomy Project , National Mouse Metabolic Phenotyping Centers , IPD-MHC- Major Histocompatibility Complex, High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis , Hepatitis B Research Network, Functional Dyspepsia Treatment Trial , Cooperative Study Group for Autoimmune Disease Prevention , Clinical Outcomes Research Initiative , BISC, Beta Cell Biology Consortium , Autoimmunity Centers of Excellence , HemBase , Longitudinal Assessment of Bariatric Surgery , Minnesota Liver Tissue Cell Distribution System, NIH Knockout Mouse Project (KOMP), Immune Tolerance Network (ITN), Accelerating Medicines Partnership Type 2 Diabetes Knowledge Portal, ReBuilding a Kidney , GOA, NURSA Transcriptomine, STRING, Nuclear Receptor Cistrome, EuReGene, Embryo Images Normal and Abnormal Mammalian Development, Stem Cell Genome Anatomy Projects , Eurexpress - A Transcriptome Atlas Database for Mouse Embryo, Gene Expression Database, ToppGene Suite , GATACA GUDMAP Gene Explorer , Knockout Mouse Project Repository, Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (CHROMus), IMPC, JDRF, NIDDK Central Repository, Biospecimens/Biorepositories: Rare Disease-HUB (RD-HUB), Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC), T1DBase , NCI Specimen Resource Locator, NCBI database of Genotypes and Phenotypes, caHUB, T1D Exchange, NCBI, LANDMark BioBanks, Diabetes Research Centers , Network for Pancreatic Organ Donors with Diabetes, Nutrition and Obesity Research Centers , Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Antibody Validation and Vector Core , Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Cell Culture and Engineering, Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Clinical and Translational Core Resource , Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Mouse Models and Biobank , Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Bioinformatics Resource, Boston Area Diabetes Endocrinology Research Center Cell Biology and Morphology , Boston Area Diabetes Endocrinology Research Center Metabolic Physiology , Boston Area Diabetes Endocrinology Research Center Molecular Biology , Boston Area Diabetes Endocrinology Research Center Pancreatic Islet , Boston Area Diabetes Endocrinology Research Center , Boston Area Diabetes Endocrinology Research Center Transgenic , Boston Children's Hospital Center of Excellence in Molecular Hematology Mouse Embryonic Stem(ES) Cell and Gene Targeting Core , Boston Children's Hospital Center of Excellence in Molecular Hematology , Boston Children's Hospital Center of Excellence in Molecular Hematology Stem Cell Engineering and Analysis Core , Boston Children's Hospital Center of Excellence in Molecular Hematology Zebrafish Core , Boston Nutrition and Obesity Research Centers Adipose Biology and Nutrient Metabolism Core , Boston Nutrition and Obesity Research Centers Administrative Core , Boston Nutrition and Obesity Research Centers Epidemiology and Genetics Core , Boston Nutrition and Obesity Research Centers Functional Genomics and Bioinformatics Core , Boston Nutrition and Obesity Research Centers , Boston Nutrition and Obesity Research Centers Transgenic Core , Center for American Indian and Alaska Native Diabetes Translational Research Administrative Core , Center for American Indian and Alaska Native Diabetes Translational Research National Resource Core , Center for American Indian and Alaska Native Diabetes Translational Research Resource Cores , Center for American Indian and Alaska Native Diabetes Translational Research , Center for Iron and Heme Disorders at the University of Utah Administrative Core , Center for Iron and Heme Disorders at the University of Utah Iron and Heme Core , Center for Iron and Heme Disorders at the University of Utah Metabolomics Core , Center for Iron and Heme Disorders at the University of Utah Mutation Generation and Detection Core , Center for Iron and Heme Disorders at the University of Utah , Center for the Study of Inflammatory Bowel Disease Clinical Core , Center for the Study of Inflammatory Bowel Disease Genetic Animal Models Core , Center for the Study of Inflammatory Bowel Disease Genetics Genomics and Molecular Biology Core , Center for the Study of Inflammatory Bowel Disease Immunology Core , Center for the Study of Inflammatory Bowel Disease Morphology Core , Center for the Study of Inflammatory Bowel Disease , Centers for Diabetes Translation Research , Chicago Center for Diabetes Translation Research Health Disparities and Community-Based Participatory Research Core , Chicago Center for Diabetes Translation Research Outcomes Improvement Core , Chicago Center for Diabetes Translation Research Quantitative Analysis Core , Chicago Center for Diabetes Translation Research , Cincinnati Digestive Health Center Clinical Component-Data Analysis and Management , Cincinnati Children's Hospital Digestive Health Center, Cincinnati Digestive Health Center Integrative Morphology , Cincinnati Digestive Health Center Pluripotent Stem Cell and Organoid Core , Cincinnati Digestive Health Center , Cleveland Digestive Diseases Research Core Center , Cleveland Digestive Diseases Research Core Facilities , Columbia Diabetes Research Center Advanced Tissue Pathology and Imaging Core , Columbia Diabetes Research Center Flow Cytometry and Cell Sorting Core , Columbia Diabetes Research Center Mouse Metabolic Function and Phenotyping Core , Columbia Diabetes Research Center , Columbia Diabetes Research Center Translational Biomarker Analytical Core , Columbia University George M. O'Brien Urology Center , CURE - Digestive Diseases Research Center Administrative Core , CURE - Digestive Diseases Research Center Animal Models Core , CURE - Digestive Diseases Research Center Human Studies Core , CURE - Digestive Diseases Research Center Molecular Biology and Peptidomics Core , CURE - Digestive Diseases Research Center Morphology and Imaging Core , CURE - Digestive Diseases Research Center , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Clinical Translational Core , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Histology Core , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Michael Hooker Microscopy Core Facility, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Molecular Biology Core , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mouse Models Core , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mucus and Mucin Biochemistry and Biophysics Core , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Pre-Clinical Core , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center , Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Tissue Procurement and Cell Culture Core , Cystic Fibrosis Center - University of California San Francisco , Cystic Fibrosis Center University of Pittsburgh , Cystic Fibrosis Center - University of Washington Administrative and Enrichment Core , Cystic Fibrosis Center - University of Washington Clinical Core , University of Washington Genomics Core Cystic Fibrosis Research Translation Center and Research Development Program, Cystic Fibrosis Center - University of Washington Host Response Core , Cystic Fibrosis Center - University of Washington Microbiology Core , Cystic Fibrosis Center - University of Washington , Cystic Fibrosis Research and Translation Centers , Digestive Disease Centers , Duke O'Brien Center for Kidney Research Animal Models Core , Duke O'Brien Center for Kidney Research Clinical and Translational Core , Duke O'Brien Center for Kidney Research Renal Genomics Core , Duke O'Brien Center for Kidney Research , Einstein-Mount Sinai Diabetes Research Center Animal Physiology Core , Einstein-Mount Sinai Diabetes Research Center Biomarker and Analytical Research Core , Einstein-Mount Sinai Diabetes Research Center Human Islet and Adenovirus Core , Einstein-Mount Sinai Diabetes Research Center , Einstein-Mount Sinai Diabetes Research Center Stable Isotope and Metabolomics Core , Einstein-Mount Sinai Diabetes Research Center Translational Research Core , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Antibody Technology , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Arnold Library , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Comparative Medicine , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Electron Microscopy , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Experimental Histopathology Shared Resource , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Flow Cytometry , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Genomics Shared Resource , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Glassware Services , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Proteomics Resource , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Research Freezers and Sample Storage Resource , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Scientific Imaging , Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Specimen Processing/Research Cell Bank , George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core , George M. O'Brien Kidney Center at Yale Mouse Genetics and Cell Line Core , George M. O'Brien Kidney Center at Yale Renal Physiology Core , George M. O'Brien Kidney Center at Yale , George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Animal Models Core , George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Cell Biology and Imaging Core , George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Clinical and Translational Core , George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Physiology Core , George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center , Georgia Center for Diabetes Translation Research Design and Evaluation Core , Georgia Center for Diabetes Translation Research Disparities Core , Georgia Center for Diabetes Translation Research Engagement and Behavior Change Core , Georgia Center for Diabetes Translation Research , Gregory Fleming James Cystic Fibrosis Research Center Assay Core , Gregory Fleming James Cystic Fibrosis Research Center Cell Model and Evaluation Core , Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Animal Models Core , Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Clinical and Translational Core , Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Transmembrane Conductance Regulator Expression Core , Gregory Fleming James Cystic Fibrosis Research Center , Health Delivery Systems Center for Diabetes Translational Research California State Resource Program , Health Delivery Systems Center for Diabetes Translational Research Diabetes and Obesity Prevention Core , Health Delivery Systems Center for Diabetes Translational Research Health Disparities Core , Health Delivery Systems Center for Diabetes Translational Research Health Information Technology Core , Health Delivery Systems Center for Diabetes Translational Research , Hematology Centers , Indiana Diabetes Research Center Islet and Physiology Core , Indiana Diabetes Research Center Microscopy Core , Indiana Diabetes Research Center , Indiana Diabetes Research Center Swine Core , Indiana Diabetes Research Center Translation Core , Indiana O'Brien Center for Advanced Microscopic Analysis Administration Core , Indiana O'Brien Center for Advanced Microscopic Analysis Biosensor Development Core , Indiana O'Brien Center for Advanced Microscopic Analysis Digital Image Analysis Core , Indiana O'Brien Center for Advanced Microscopic Analysis Education Core , Indiana O'Brien Center for Advanced 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Populations Science Core , Johns Hopkins University - University of Maryland Diabetes Research Center Integrated Physiology Core , Johns Hopkins University - University of Maryland Diabetes Research Center Molecular and Translational Genomics Core , Johns Hopkins University - University of Maryland Diabetes Research Center , Joslin Diabetes Center Advanced Genomics and Genetics Core , Joslin Diabetes Center Advanced Microscopy Core , Joslin Diabetes Center Animal Physiology Core , Joslin Diabetes Center Bioinformatics and Biostatistics Core, Joslin Diabetes Center Enrichment Core , Joslin Diabetes Center Flow Cytometry Core , Joslin Diabetes Center Induced Pluripotent Stem Cell Core , Joslin Diabetes Center , Marion Bessin Liver Research Center Animal Models Stem Cells and Cell Therapy , Marion Bessin Liver Research Center Genetic Engineering and Gene Therapy , Marion Bessin Liver Research Center Imaging and Cell Structure , Marion Bessin Liver Research Center , Mayo Clinic Center for 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Core , University of Chicago Diabetes Research and Training Center Molecular Biology and Genetics Core Laboratory , University of Chicago Diabetes Research and Training Center , University of Colorado Anschutz Medical Campus Nutrition and Obesity Research Center , University of Iowa Center for Gene Therapy Cell Tissue Core , University of Iowa Center for Gene Therapy Clinical Core , University of Iowa Center for Gene Therapy Comparative Pathology Core , University of Iowa Center for Gene Therapy , University of Iowa Center for Gene Therapy Vectore Core , University of Michigan Nutrition and Obesity Research Center Administrative Core , University of Michigan Nutrition and Obesity Research Center Animal Phenotyping Core , University of Michigan Nutrition and Obesity Research Center Human Phenotyping Core , University of Michigan Nutrition and Obesity Research Center Integrative Biostatistics and Informatics Core , University of Michigan Nutrition and Obesity Research Center Molecular 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Research Center , University of Washington Nutrition and Obesity Research Center Adipose Tissue and Obesity Core , University of Washington Nutrition and Obesity Research Center Administrative and Enrichment Core , University of Washington Nutrition and Obesity Research Center Analytic Core , University of Washington Nutrition and Obesity Research Center Energy Balance Core , Washington University Center for Diabetes Translation Research Administrative Core in Diabetes Research Core , University of Washington Nutrition and Obesity Research Center , Washington University Center for Diabetes Translation Research Dissemination and Implementation in Diabetes Research Core , Washington University Center for Diabetes Translation Research Health Communication and Health Literacy Core , Washington University Center for Diabetes Translation Research Health Informatics in Diabetes Research Core , USC Liver Transplant Program and Center for Liver Disease Analytical Metabolic Instrumentation Core 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Research Center Cell Biology Core , Washington University St. Louis Nutrition Obesity Research Center , Yale Diabetes Research Center Administrative Core , Yale Cooperative Center of Excellence in Hematology Animal Modeling Core , Yale Cooperative Center of Excellence in Hematology , Yale Cooperative Center of Excellence in Hematology Cell Preparation and Analysis Core , Yale Cooperative Center of Excellence in Hematology Imaging Core , Harvard Digestive Disease Center, Harvard Digestive Diseases Center Biomedical CORE B: Microscopy and Histopathology, Harvard Digestive Diseases Center Biomedical CORE C: Epithelial Cell and Mucosal Immunology, Harvard Digestive Diseases Center Biomedical CORE D: Gnotobiotic Mice, Microbiology and Metagenomics, Harvard Digestive Diseases Center Clinical Translational Research Program, Harvard Digestive Diseases Center Bio-Repository and Data Registry for Human Material, Hopkins Conte Digestive Diseases Basic and Translational Research Core Center, Hopkins Conte Digestive Diseases Basic and Translational Research Core Center Integrated Physiology Core, Hopkins Conte Digestive Diseases Basic and Translational Research Core Center Image Core, Hopkins Conte Digestive Diseases Basic and Translational Research Core Center Proteomics Core, Hopkins Conte Digestive Diseases Basic and Translational Research Core Center Translational Research Enhancement Core, UCSF Liver Center, UCSF Liver Center Cell Biology Core, UCSF Liver Center Clinical & Translational Core, UCSF Liver Center Immunology Core, UCSF Liver Center Pathology & Imaging Core, University of Chicago Digestive Diseases Research Core Center, University of Chicago Digestive Diseases Research Core Center Integrated Translational Research Core, University of Chicago Digestive Diseases Research Core Center Administrative Core, University of Chicago Digestive Diseases Research Core Center Tissue Engineering and Cell Models Core, University of Chicago Digestive Diseases Research Core 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for Gastrointestinal Biology and Disease Histology Core, University of North Carolina Center for Gastrointestinal Biology and Disease Large Animal Models Core, University of North Carolina Center for Gastrointestinal Biology and Disease Microbiome Core, University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core, University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Host-Microbial Analytic and Repository Core, University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Genetically-Modified Mouse Core, University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Cell Culture Core, Joslin Diabetes Center Molecular Phenotyping and Genotyping Core, University of Pennsylvania Diabetes Research Center, Preventing Early Renal Loss in Diabetes (PERL), Clinical Trials in Organ Transplantation in Children (CTOT-C), Clinical Trials in Organ Transplantation (CTOT) , Stanford Diabetes Research Center , Monogenic Diabetes Registry, Chronic Prostatitis Collaborative Research Network Clinical Trial- Alfuzosin , National Glycohemoglobin Standardization Program, MetaCyto, JOINSOLVER, HASP, NetCirChro, Simmune, ABC Bacterial Transporter Systems Database, Kidney Precision Medicine Project, ValIdated Systematic IntegratiON of epigenomic data , The Human BioMolecular Atlas Program, Prevention of Lower Urinary Tract Symptoms, Illuminating the Druggable Genome , 4D Nucleome, submitted: MTOPS Prostate Samples Analysis Consortium , Body Mass Index Calculator, Symptom Score for Benign Prostatic Hyperplasia, Genetics of Kidneys in Diabetes, Type 1 Diabetes - Rapid Access to Intervention Development , TEDDY , Trans-Institute Angiogenesis Research Program , Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease , Current Research Information System, Healthy People, Acute Liver Failure Study Group , Collaborative Islet Transplant Registry , Diabetes Prevention Type 1 , Epidemiology of Diabetes Interventions and Complications , NIH Division of Nutrition Research Coordination, Human Nutrition Research Information Management, Type 1 Diabetes Resource , National Diabetes Education Program , Pediatric Acute Liver Failure Study , Globin Gene Server , NIH Chronic Prostatitis Symptom Index , Sequencing of Idd regions in the NOD mouse genome , Look AHEAD , Teen-Longitudinal Assessment of Bariatric Surgery , Adult to Adult Living Donor Liver Transplantation Cohort Study , Behavior Enhances Drug Reduction of Incontinence , BARI 2D, Childhood Liver Disease Research and Education Network , Standardization of C-peptide measurements , CKID A Prospective Cohort Study of Kidney Disease in Children , Diabetes Prevention Program , Diabetes Prevention Program Outcomes Study , Irritable Bowel Syndrome Outcome Study , Folic Acid for Vascular Outcome Reduction in Transplantation , Type 1 Diabetes TrialNet , Diabetes Research in Children Network, Diabetic Retinopathy Clinical Research Network, Clinical Islet Transplantation Study , Nonalcoholic Steatohepatitis Clinical Research Network , Drug-Induced Liver Injury Network , Family Investigation of Nephropathy of Diabetes , Frequent Hemodialysis Network Daily Trial , HALT PKD , HEALTHY study , Hepatitis B Research Network, HALT-C Trial , Immune Tolerance Network (ITN), Longitudinal Assessment of Bariatric Surgery , RiVuR , SEARCH for Diabetes in Youth , SISTEr , Urinary Incontinence Treatment Network , Study of Nutrition in Acute Pancreatitis , TINSAL-T2D , Treatment Options for type 2 Diabetes in Adolescents and Youth , TOMUS , TRIGR, Viral Resistance to Antiviral Therapy of Chronic Hepatitis C , Type 1 Diabetes Genetics Consortium , Diabetes Disease Portal, Kidney and Urinary Pathway Knowledge Base, dbMHC, Islet Cell Resource Centers , HemBase , DGAP , Nuclear Receptor Resource , dkCOIN , Human Biological Data Interchange , National Gene Vector Biorepository, Minnesota Liver Tissue Cell Distribution System, Organ Procurement and Transplantation Network, Creatinine Standardization Program , Glomerular Filtration Rate Calculators , Congressionally Directed Medical Research Program, Autoimmunity Centers of Excellence , National Kidney Disease Education Program , Network of Minority Health Research Investigators , Urologic Diseases in America, Gastroparesis Clinical Research Consortium , National Endocrine and Metabolic Diseases Information Service , Kidney and Urinary Pathway Ontology, Functional Dyspepsia Treatment Trial , United States Renal Data System , National Diabetes Information Clearinghouse , Digestive Diseases Statistics for the United States , Diabetes in America , National Digestive Diseases Information Clearinghouse , High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis , Peginterferon and Ribavirin for Pediatric Patients with Chronic Hepatitis C , Cooperative Study Group for Autoimmune Disease Prevention , Diabetes Control and Complications Trial , Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit , National Hematologic Diseases Information Service , National Kidney and Urologic Diseases Information Clearinghouse , Nonhuman Primate Transplantation Tolerance Cooperative Study Group , Type 1 Diabetes Preclinical Testing Program , Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction , Diabetes Autoantibody Standardization Program, AASK Clinical Trial and Cohort Study , Maryland Genetics of Interstitial Cystitis , Frequent Hemodialysis Network Nocturnal Trial , Mammalian Gene Collection, Zebrafish Gene Collection, Boston Area Community Health Survey , Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia , Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study , Complementary and Alternative Medicine for Urological Symptoms , Mouse Mutagenesis Center for Developmental Defects , Center for Inherited Disease Research , National Mouse Metabolic Phenotyping Centers , Clinical Outcomes Research Initiative , CARDS Database, ACCORD , Chronic Renal Insufficiency Cohort Study , Program to Reduce Incontinence by Diet and Exercise , Renal Disease Portal, Renin Angiotensin System Study , NIDDK Research Resources, Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study (ACCORDION), Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) , Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network (MAPP), Lifestyle Interventions for Expectant Moms (LIFE-Moms) , Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium (HAPO-FUS), Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) , Porphyria Consortium, Nephrotic Syndrome Study Network (NEPTUNE), CKD Biomarkers Consortium, Vitamin D to Prevent Type 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vivo - In silico Metabolite Database, XCMS, MetaboAnalyst, Helmsley Cellular Research Hub, Diabetes Biobank Brussels, Integrative Human Microbiome Project, DIAGRAM, Type2Diabetes.org, Trans-Omics for Precision Medicine (TOPMed) Program, BioBankEngine, AllofUs Research Program Biobank, CRowd Extracted Expression of Differential Signatures, National Gene Vector Laboratories, Research-tested Intervention Programs (RTIPs), Grid-Enabled Measures Database, International Institute for the Advancement of Medicine, Datasets2Tools, L1000 Fireworks Display, Harmonizome, L1000 Characteristic Direction Signature Search Engine, Direct Infusion Metabolite Database, HIRN Consortium on Beta Cell Death and Survival, HIRN Consortium on Human Islet Biomimetics, HIRN Consortium on Modeling Autoimmune Interactions, HIRN Consortium on Targeting and Regeneration, HIRN Human Pancreas Analysis Program, HIRN Bioinformatics Center, HLAsupE, PeMtb, Drug Gene Budger, Test, Kidney Precision Medicine Project, ValIdated Systematic IntegratiON of epigenomic data , The Human BioMolecular Atlas Program, Prevention of Lower Urinary Tract Symptoms, Illuminating the Druggable Genome , 4D Nucleome , Test011919Last checked downnlx_153866http://scicrunch.org/dknet
MirSNPResource, data or information resource, databaseDatabase of human SNPs in predicted miRNA-mRNA binding sites, based on information from dbSNP135 and mirBASE18. MirSNP is highly sensitive and covers most experiments confirmed SNPs that affect miRNA function. MirSNP may be combined with researchers' own GWAS or eQTL positive data sets to identify the putative miRNA-related SNPs from traits/diseases associated variants. They aim to update the MirSNP database as new versions of mirBASE and dbSNP database become available.single nucleotide polymorphism, mirna, genome-wide association study, expression quantitative trait locus, mirna-mrna binding site, trait, disease, variant, gene, mrnaSCR_001629(MirSNP, RRID:SCR_001629)Peking University; Beijing; China International Science and Technology Cooperation Program of China, National High Technology Research and Development Program of China, National Natural Science Foundation of ChinaPMID:23173617Last checked downnlx_153896http://202.38.126.151/hmdd/mirsnp/search/
Ensembl VariationResource, data analysis service, production service resource, analysis service resource, database, service resource, data or information resourcePublic database that stores areas of genome that differ between individual genomes (variants) and, where available, associated disease and phenotype information. Different types of variants for several species: single nucleotide polymorphisms (SNPs), short nucleotide insertions and/or deletions, and longer variants classified as structural variants (including CNVs). Effects of variants on the Ensembl transcripts and regulatory features for each species are predicted. You can run same analysis on your own data using Variant Effect Predictor. These data are integrated with other data sources in Ensembl, and can be accessed using the API or website. For several different species in Ensembl, they import variation data (SNPs, CNVs, allele frequencies, genotypes, etc) from a variety of sources (e.g. dbSNP). Imported variants and alleles are subjected to quality control process to flag suspect data. In human, they calculate linkage disequilibrium for each variant, by population.genome, disease, phenotype, genomic variant, single nucleotide polymorphism nucleotide, insertion, deletion, structural variant, copy number variation, inversion, translocation, somatic variant, allele frequency, genotype, disease phenotype, inherited diseaseSCR_001630(Ensembl Variation, RRID:SCR_001630)Ensembl related to: dbSNP, Database of Genomic Variants Archive, PubMed, Animal QTLdb, OMIA - Online Mendelian Inheritance in Animals, used by: Monarch InitiativeReferences (4)Last checked downnlx_153897
Kidney and Urinary Pathway Knowledge BaseResource, data analysis service, production service resource, analysis service resource, data set, service resource, storage service resource, data repository, data or information resourceA collection of omics datasets (mRNA, proteins and miRNA) that have been extracted from PubMed and other related renal databases, all related to kidney physiology and pathology giving KUP biologists the means to ask queries across many resources in order to aggregate knowledge that is necessary for answering biological questions. Some microarray raw datasets have also been downloaded from the Gene Expression Omnibus and analyzed by the open-source software GeneArmada. The Semantic Web technologies, together with the background knowledge from the domain's ontologies, allows both rapid conversion and integration of this knowledge base. SPARQL endpoint http://sparql.kupkb.org/sparql The KUPKB Network Explorer will help you visualize the relationships among molecules stored in the KUPKB. A simple spreadsheet template is available for users to submit data to the KUPKB. It aims to capture a minimal amount of information about the experiment and the observations made.kidney, urinary, urine, pathway, molecule, visualizer, gene, protein, mirna, metabolite, mrna, microarray, ortholog, rdf, renal cell, anatomy, animal model, disease, sparql, proteomics, ontology, biomarker, gene expression, physiology, pathologySCR_001746(Kidney and Urinary Pathway Knowledge Base, RRID:SCR_001746)University of Manchester; Manchester; United Kingdom , National Institute of Health and Medical Research; Rennes; France Kidney diseaseEuropean Union, FP7, ICT-2007.4.4 e-LICO projectrelated to: NIDDK Information Network, Gene Expression Omnibus, Gene Ontology, KEGG, submitted by: NIDDK Information NetworkPMID:21624162Last checked downnlx_154134http://www.e-lico.eu/kupkb
Stony Brook University Medical Center: Neuropathology PrimerResource, narrative resource, book, data or information resourceThis is a primer of basic neuropathology- The Central Nervous System and Skeletal Muscle. It is organized in chapters by category of disease with a separate chapter for skeletal muscle. Many of the diseases could be included in more than one chapter because of overlapping pathophysiology; in each case the disorder is included in a single section in the interest of convenience. In order to recognize pathology one must have a basic foundation in normal structure, so the first chapter is an overview of basic regional central nervous system structure and anatomy. It includes an introduction to neurohistology. Other chapters address the pathophysiology of different categories of disease and provide examples of gross and microscopic pathology when they are available.anatomy, central nervous system, disease, gross pathology, microscopic pathology, neurohistology, neuropathology, pathology, pathophysioogy, skeletal muscle, structureSCR_001866(Stony Brook University Medical Center: Neuropathology Primer, RRID:SCR_001866)Last checked downnif-0000-10438http://www.stonybrookmedicalcenter.org/body.cfm?id=1176
Stable Isotope Labeling with Amino Acids in Cell CultureResource, topical portal, portal, data or information resourceStable isotope labeling with amino acids in cell culture (SILAC) is a simple and straightforward approach for in vivo incorporation of a label into proteins for mass spectrometry (MS)-based quantitative proteomics. SILAC relies on metabolic incorporation of a given "light" or "heavy" form of the amino acid into the proteins. The method relies on the incorporation of amino acids with substituted stable isotopic nuclei (e.g. deuterium, 13C, 15N). In an experiment, two cell populations are grown in culture media that are identical except that one of them contains a "light" and the other a "heavy" form of a particular amino acid (e.g. 12C and 13C labeled L-lysine, respectively). When the labeled analog of an amino acid is supplied to cells in culture instead of the natural amino acid, it is incorporated into all newly synthesized proteins. After a number of cell divisions, each instance of this particular amino acid will be replaced by its isotope labeled analog. Since there is hardly any chemical difference between the labeled amino acid and the natural amino acid isotopes, the cells behave exactly like the control cell population grown in the presence of normal amino acid. It is efficient and reproducible as the incorporation of the isotope label is 100%. SILAC Applications: - Differential expression of proteins and identification of disease biomarkers - Cell signaling dynamics - Analysis of yeast pheromone signaling pathway - Identification of methylation sites - Identification of protease substrates - Study of protein complexes/protein interactions - Analysis of signaling pathways and effect of pharmacological inhibitors - Subcellular proteomics Sponsors: Supported in part by an NIH Roadmap grant Technology Center for Networks & Pathways of Lysine Modification.amino acid, analog, biomarker, cell culture, cell division, cell signal, chemical, deuterium, disease, inhibitor, in vivo, isotope, labeling, lysine, mass spectrometry, media, metabolic, methylation site, nucleus, pharmacological, protease, protein, protein complex, protein interaction, proteomics, signaling pathway, subcellular, substrate, yeast pheromoneSCR_001873(Stable Isotope Labeling with Amino Acids in Cell Culture, RRID:SCR_001873)Last checked downnif-0000-10435
University of California at Los Angeles, School of Medicine: Neuro Imaging Lab of ThompsonResource, curriculum material, narrative resource, slide, training material, video resource, data or information resourceThe UCLA laboratory of neuroimaging is working in several areas to enhance knowledge of anatomy, including brain mapping in large human populations, HIV, Schizophrenia, methamphetamine, tumor growth and 4d brain mapping, genetics and detection of abnormalities.engineer, genetics, abnormality, alzheimer's, anatomy, atlas, brain, computational, cortical, dementia, disease, growth, histologic, hiv, human, image, knowledge, mapping, mathematical, mathematician, medical doctor, methamphetamine, model, mri, neuroscientist, pet, polymorphism, population, schizophrenia, spect, structure, tumor, neuroimagingSCR_001924(University of California at Los Angeles, School of Medicine: Neuro Imaging Lab of Thompson, RRID:SCR_001924)University of California at Los Angeles; California; USA Last checked downnif-0000-10496
Wellcome Trust Case Control ConsortiumResource, data or information resourceConsortium of 50 research groups across the UK to harness the power of newly-available genotyping technologies to improve our understanding of the aetiological basis of several major causes of global disease. The consortium has gathered genotype data for up to 500,000 sites of genome sequence variation (single nucleotide polymorphisms or SNPs) in samples ascertained for the disease phenotypes. Analysis of the genome-wide association data generated has lead to the identification of many SNPs and genes showing evidence of association with disease susceptibility, some of which will be followed up in future studies. In addition, the Consortium has gained important insights into the technical, analytical, methodological and biological aspects of genome-wide association analysis. The core of the study comprised an analysis of 2,000 samples from each of seven diseases (type 1 diabetes, type 2 diabetes, coronary heart disease, hypertension, bipolar disorder, rheumatoid arthritis and Crohn's disease). For each disease, the case samples have been ascertained from sites widely distributed across Great Britain, allowing us to obtain considerable efficiencies by comparing each of these case populations to a common set of 3,000 nationally-ascertained controls also from England, Scotland and Wales. These controls come from two sources: 1,500 are representative samples from the 1958 British Birth Cohort and 1,500 are blood donors recruited by the three national UK Blood Services. One of the questions that the WTCCC study has addressed relates to the relative merits of these alternative strategies for the generation of representative population cohorts. Genotyping for this main Case Control study was conducted by Affymetrix using the (commercial) Affymetrix 500K chip. As part of this study a total of 17,000 samples were typed for 500,000 SNPs. There are two additional components to the study. First, the WTCCC award is part-funding a study of host resistance to infectious diseases in African populations. The same approach has been used to type 2,000 cases of tuberculosis (TB) and 2,000 cases of malaria, as well as 2,000 shared controls. As well as addressing diseases of major global significance, and extending WTCCC coverage into the area of infectious disease, the inclusion of samples of African origin has obvious benefits with respect to methodological aspects of genome-wide association analysis. Second, the WTCCC has, for four additional diseases (autoimmune thyroid disease, breast cancer, ankylosing spondylitis, multiple sclerosis), completed an analysis of 15,000 SNPs designed to represent a large proportion of the known non-synonymous coding SNPs across the genome. This analysis has been performed at the WTSI using a custom Infinium chip (Illumina). Data release The genotypic data of the control samples (1958 British Birth Cohort and UK Blood Service) and from seven diseases analyzed in the main study are now available to qualified researchers. Summary genotype statistics for these collections are available directly from the website. Access to the individual-level genotype data and summary genotype statistics is by application to the Consortium Data Access Committee (CDAC) and approval subject to a Data Access Agreement. WTCCC2: A further round of GWA studies were funded in April 2008. These include 15 WTCCC-collaborative studies and 12 independent studies be supported totaling approximately 120,000 samples. Many of the studies represent major international collaborative networks that have together assembled large sample collections. WTCCC2 will perform genome-wide association studies in 13 disease conditions: Ankylosing spondylitis, Barrett's oesophagus and oesophageal adenocarcinoma, glaucoma, ischaemic stroke, multiple sclerosis, pre-eclampsia, Parkinson's disease, psychosis endophenotypes, psoriasis, schizophrenia, ulcerative colitis and visceral leishmaniasis. WTCCC2 will also investigate the genetics of reading and mathematics abilities in children and the pharmacogenomics of statin response. Over 60,000 samples will be analyzed using either the Affymetrix v6.0 chip or the Illumina 660K chip. The WTCCC2 will also genotype 3,000 controls each from the 1958 British Birth cohort and the UK Blood Service control group, and the 6,000 controls will be genotyped on both the Affymetrix v6.0 and Illumina 1.2M chips. WTCCC3: The Wellcome Trust has provided support for a further round of GWA studies in January 2009. These include 5 WTCCC-collaborative studies to be carried out in WTCCC3 and 5 independent studies, across a range of diseases. Many of the studies represent major international collaborative networks that have together assembled large sample collections. WTCCC3 will perform genome-wide association studies in the following 4 disease conditions: primary biliary cirrhosis, anorexia nervosa, pre-eclampsia in UK subjects, and the interactions between donor and recipient DNA related to early and late renal transplant dysfunction. The WTCCC3 will also carry out a pilot in a study of the genetics of host control of HIV-1 infection. Over 40,000 samples will be analyzed using the Illumina 660K chip. The WTCCC3 will utilize the 6,000 control genotypes generated by the WTCCC2.gene, genomic, genetics, microarray, genome-wide association study, snp, genome-wide association, blood, dna, genotype, variation, genome, sequence variant, copy number variation, genetic variation, phenotype, diseaseSCR_001973(Wellcome Trust Case Control Consortium, RRID:SCR_001973)Wellcome Trust Sanger Institute; Hinxton; United Kingdom Bipolar Disorder, Coronary artery disease, Crohn's disease, Rheumatoid arthritis, Type 1 diabetes, Type 2 diabetes, Hypertension, Control, Multiple sclerosis, Breast cancer, Ankylosing spondylitis, Autoimmune thyroid disease, Malaria, Tuberculosis, Inflammatory bowel disease, Barrett's esophagus, Esophageal adenocarcinoma, Glaucoma, Ischemic stroke, Pre-eclampsia, Parkinson's disease, Psychosis endophenotypes, Psoriasis, Schizophrenia, Ulcerative colitis, Visceral leishmaniasis, Primary biliary cirrhosis, Anorexia nervosa, Human immunodeficiency virus, Renal transplant dysfunctionBill and Melinda Gates Foundation, Wellcome Trust, Wellcome Trust Sanger Institute; Hinxton; United Kingdomrelated to: Psychiatric Genomics ConsortiumPMID:17554300Last checked downnif-0000-10551
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