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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

(last updated: Oct 12, 2019)

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Resource NameResource TypeDescriptionKeywordsResource IDProper CitationParent OrganizationRelated ConditionFunding AgencyRelationReferenceWebsite StatusAlternate IDsAlternate URLsOld URLs
Genetics of Kidneys in DiabetesResource, biomaterial supply resource, data or information resource, material resource, databaseCollect, store, and distribute genetic samples from cases and controls of type 1 diabetes and diabetic nephropathy for investigator-driven research into the genetic basis of diabetic nephropathy. As the risk of kidney complications in type 1 diabetes appears to have a considerable genetic component, this study assembled a large data resource for researchers attempting to identify causative genetic variants. The types of data collected allowed traditional case-control testing, a rapid and often powerful approach, and family-based analysis, a robust approach that is not influenced by population substructure. To identify genes that are involved in diabetic nephropathy, a large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria and consented to participate were enrolled. When possible, both parents also were enrolled to form family trios. As of November 2005, GoKinD included 3075 participants who comprise 671 case singletons, 623 control singletons, 272 case trios, and 323 control trios. Interested investigators may request the DNA collection and corresponding clinical data for GoKinD participants. Participating scientists will have access to three data sets, each with distinct advantages. The set of 1294 singletons has adequate power to detect a wide range of genetic effects, even those of modest size. The set of case trios, which has adequate power to detect effects of moderate size, is not susceptible to false-positive results because of population substructure. The set of control trios is critical for excluding certain false-positive results that can occur in case trios and may be particularly useful for testing gene-environment interactions. Integration of the evidence from these three components into a single, unified analysis presents a challenge. This overview of the GoKinD study examines in detail the power of each study component and discusses analytic challenges that investigators will face in using this resource. Half of the samples were collected at the Joslin Diabetes Center and the other half were collected from around the country by researchers at The George Washington University. DNA samples were processed by scientists at the University of Minnesota and stored at the U.S. Centers for Disease Control and Prevention. Stored samples were available to the research community through a mechanism that has been determined by JDF. Clinical characteristics of patients, which are stored in a central database, are also made available to participating scientists. A similar collection is being carried out in the United Kingdom. This data resource allows researchers to test hypotheses that might explain why diabetic kidney disease clusters in families. This resource also is suitable for studying other complications and type 1 diabetes itself. For example, a total of 1,110 diabetes case trios was available at the end of three years.)clinical, genetics, genetic variant, gene, data setSCR_000133(Genetics of Kidneys in Diabetes, RRID:SCR_000133)George Washington University; Washington D.C.; USA Diabetic nephropathy, Type 1 diabetes, Kidney disease, Normal, ParentJDRF, NIHlisted by: One Mind Biospecimen Bank Listing, NIDDK Information Network, submitted by: NIDDK Information NetworkPMID:16775037Last checked upnlx_152764
NephromineResource, data or information resource, databaseA growing database of publicly available renal gene expression profiles, a sophisticated analysis engine, and a powerful web application designed for data mining and visualization of gene expression. It provides unique access to datasets from the Personalized Molecular Nephrology Research Laboratory incorporating clinical data which is often difficult to collect from public sources and mouse data.kidney, gene expression, visualization, clinical, expression profile, gene, mouse model, microarraySCR_003813(Nephromine, RRID:SCR_003813) Life Technologies , University of Michigan; Michigan; USA Kidney disease, Healthy, Lupus nephritis, Chronic kidney disease, Diabetic nephropathylisted by: NIDDK Information NetworkLast checked upnlx_158114
American Nephrology Nurses AssociationResource, portal, community building portal, data or information resourceNon-profit professional association that represents nurses who work in all areas of nephrology including hemodialysis, chronic kidney disease, peritoneal dialysis, acute care, and transplantation. Most members work in freestanding dialysis units, hospital outpatient units, and hospital inpatient units. ANNA develops and updates standards of clinical practice, educates practitioners, stimulates and supports research, disseminates knowledge and new ideas, promotes interdisciplinary communication and cooperation, and monitors and addresses issues encompassing the breadth of practice of nephrology nursing.clinical, kidney, nephrology, nurse, health care, dialysis, journal, training resourceSCR_003966(American Nephrology Nurses Association, RRID:SCR_003966)Kidney diseaserelated to: Nephrology Nursing Certification Commission, Kidney Health InitiativeLast checked upnlx_158371
American Society of Diagnostic and Interventional NephrologyResource, portal, training resource, community building portal, data or information resourceSociety that aims to promote the proper application of new and existing procedures to improve the care of patients with kidney disease. They promote education, research, public policy and clinical practice initiatives relating to diagnostic and interventional procedures. ASDIN works closely with other societies and programs to achieve its goals. All professionals involved in the care of patients with kidney disease are welcome to join and become active in the Society. Activities of the Society include: * the establishment of practice standards, * certification of physicians in specific procedures, * accreditation of training programs in specific procedures, * development of training tools and techniques, * sponsoring symposia and training courses, * and the dissemination of information through periodic meetings and through print and other media.nephrology, diagnostic, intervention, clinical, kidneySCR_003968(American Society of Diagnostic and Interventional Nephrology, RRID:SCR_003968)Kidney diseaserelated to: Kidney Health InitiativeLast checked upnlx_158373
American Society of Pediatric NephrologyResource, portal, community building portal, data or information resourceAn organization of pediatric nephrologists and affiliated health care professionals to promote optimal care for children with kidney disease through advocacy, education and research; and to disseminate advances in clinical practice and scientific investigation.pediatric, nephrology, young human, kidney, clinical, funding resource, meeting resource, nephrologist, health care, childSCR_003969(American Society of Pediatric Nephrology, RRID:SCR_003969)Kidney diseaserelated to: Kidney Health InitiativeLast checked upnlx_158376
Arbor Research Collaborative for HealthResource, organization portal, portal, data or information resourceA not-for-profit research organization committed to improve patient care through research that shapes medical policies and practice. In particular, they conduct health outcomes research on chronic disease and end-stage organ failure, with expertise in biostatistical analysis, clinical practice, health economics, public policy, database management and integration, and project coordination. Through research projects that are national and global in scope, their scientific collaborations provide valuable and timely information to the worldwide health care community. They are a leader in interdisciplinary health outcomes and policy research focused on reducing the health and economic burden of chronic diseases and improving the delivery of outcome, patient care, clinical, policy, nephrology, statistics, kidney, transplant, dialysis, epidemiology, public health, clinical practice, policy development, medical payment systemSCR_003972(Arbor Research Collaborative for Health, RRID:SCR_003972)Kidney disease, Organ failure, Chronic diseaserelated to: Kidney Health InitiativeLast checked upnlx_158379
ClinMetOrganization, portal, organization portal, commercial organization, data or information resourceCommercial organization that uses metabolomics to provide pharmaceutical companies with clinically relevant and practical insight into drug response and safety for renal and cardiovascular diseases, obesity and diabetes. Their combination of skills to achieve exhaustive understanding of a disease along with detailed clinical insights, signature panel of urine-based metabolomic biomarkers, proprietary metabolomics and computational expertise will accelerate the speed and success rate of drug development. ClinMet helps drug developers to efficiently transform promising compounds into safe and effective medicines. Their efficacy and toxicity indices enable pharmaceutical companies to make better clinical trial-related decisions and provide an increased understanding of a drug''s mechanism of action.metabolomics, drug, mechanism of action, clinical, clinical trial, drug efficacy, toxicity, drug discovery, drug development, kidney, safety, efficacy, medicineSCR_003979(ClinMet, RRID:SCR_003979)Kidney disease, Cardiovascular disease, Obesity, Diabetesrelated to: Kidney Health InitiativeLast checked upnlx_158384
ERA-EDTAResource, portal, community building portal, data or information resourceAn association of European kidney specialists whose objective is advancement of medical science and of clinical work in nephrology, dialysis, renal transplantation, hypertension and related subjects. They aim at providing up-to-date knowledge, exclusively based on scientific data, independent from governments'' policies and from any influence of the industry. It is registered in England and Wales, but its area of activity mainly covers Europe and the Mediterranean area.kidney, dialysis, transplant, nephrology, medical, clinical, renal transplantation, hypertensionSCR_003982(ERA-EDTA, RRID:SCR_003982)Kidney diseaserelated to: Kidney Health InitiativeLast checked upnlx_158389
MediBeaconResource, portal, organization portal, commercial organization, data or information resourceA commercial optical diagnostic company focused on providing clinicians with critical information to improve patient care. The Optical Renal Function Monitor (ORFM) is their first product platform and is focused on real-time, easy to use, and cost-effective monitoring of kidney function. Their non-invasive monitoring technology works in a similar fashion to pulse oximetry by using a light sensor placed on the skin. After the sensor has been placed, a proprietary biocompatible tracer is administered. The system can then monitor the patient''s real-time point-of-care kidney function. This information will allow for earlier detection of renal issues enabling clinicians to provide earlier, and hence more effective interventions. MediBeacon has created a research grade technique that is clinically applicable for real-time point-of-care Glomerular Filtration Rate measurement (mGFR). MediBeacon has invented a fluorescent tracer agent (MB-102) that is removed from the blood exclusively by the GFR mechanism of the kidneys. Together with their non-invasive detection device, this will deliver a real-time point-of-care measurement of GFR.kidney function, kidney, patient care, clinical, nephrology, glomerular filtration rate, medical deviceSCR_003987(MediBeacon, RRID:SCR_003987)Kidney diseaserelated to: Kidney Health InitiativeLast checked upnlx_158398
National Kidney FoundationResource, disease-related portal, topical portal, portal, data or information resourceOrganization in the U.S. dedicated to the awareness, prevention and treatment of kidney disease. Initiatives include public and professional education, kidney health screenings, research, and patient services. They publish a number of scientific journals including the American Journal of Kidney Diseases, Advances in Chronic Kidney Disease and the Journal of Renal Nutrition. The NKF also publishes the Kidney Dialysis Outcomes Quality Initiative K/DOQI, a comprehensive set of clinical practice guidelines. (Adapted from Wikipedia)kidney, organ, donation, transplantation, nephrology, clinical, training resource, narrative resource, standard specificationSCR_003990(National Kidney Foundation, RRID:SCR_003990)Kidney diseaserelated to: Kidney Health InitiativeLast checked upnlx_158404
Nephrology Nursing Certification CommissionResource, organization portal, training resource, portal, data or information resourceOrganization that established credentialing mechanisms to promote patient safety and to improve the quality of care provided to nephrology patients. There is a diversity of examinations providing the opportunity for certification at various levels of education, experience, and areas of practice within nephrology nursing. All of the certification examinations are endorsed by American Nephrology Nurses'''' Association (ANNA). The Commission recognizes the value of education, administration, research, and clinical practice in fostering personal and professional growth and currently provides six examinations to validate clinical performance: * The Certified Dialysis Nurse examination * The Certified Dialysis LPN/LVN examination * The Certified Nephrology Nurse examination * The Certified Clinical Hemodialysis Technician * The Certified Clinical Hemodialysis Technician - Advanced * The Certified Nephrology Nurse - Nurse Practitionernephrology, kidney, nursing, certification, clinical, dialysis, hemodialysisSCR_003994(Nephrology Nursing Certification Commission, RRID:SCR_003994)Kidney diseaserelated to: American Nephrology Nurses Association, Kidney Health InitiativeLast checked upnlx_158407
Thrasos TherapeuticsResource, portal, organization portal, commercial organization, data or information resourceA private, clinical-stage biotherapeutics company focused on delivering new solutions to individuals affected by kidney disease. They are committed to developing novel approaches to protect, treat and restore kidney function for this patient group. The company has designed a specific class of peptide compounds that have shown excellent results in controlling experimental kidney diseases, notably, models of diabetic nephropathy (kidney damage associated with diabetes), and acute kidney injury. These proprietary peptides may therefore be able to prevent and treat acute kidney injury, as well as slow and possibly reverse the progression of diabetic nephropathy. They act to control apoptosis (programmed cell death), inflammation and fibrosis (formation of scar tissue).biotherapeutics, clinical, peptideSCR_004052(Thrasos Therapeutics, RRID:SCR_004052)Kidney disease, Acute kidney injury, Diabetic nephropathy, Chronic kidney diseaserelated to: Kidney Health InitiativeLast checked upnlx_158489
AASK Clinical Trial and Cohort Study Resource, disease-related portal, topical portal, resource, research forum portal, portal, clinical trial, data or information resourceClinical trial investigating whether a specific class of antihypertensive drugs (beta-adrenergic blockers, calcium channel blockers, or angiotensin converting enzyme inhibitors) and/or the level of blood pressure would influence progression of hypertensive kidney disease in African Americans. The initiative consisting of 21 clinical centers and a data-coordinating center is followed by a Continuation of AASK Cohort Study to investigate the environmental, socio-economic, genetic, physiologic, and other co-morbid factors that influence progression of kidney disease in a well-characterized cohort of African Americans with hypertensive kidney disease. Only patients who were previously in the randomized trial are eligible for the cohort study. A significant discovery was made in the treatment strategy for slowing kidney disease caused by hypertension. Angiotensin-converting enzyme (ACE) inhibitors, compared with calcium channel blockers, were found to slow kidney disease progression by 36 percent, and they drastically reduced the risk of kidney failure by 48 percent in patients who had at least one gram of protein in the urine, a sign of kidney failure. ACE inhibitors have been the preferred treatment for hypertension caused by diabetes since 1994; however, calcium channel blockers have been particularly effective in controlling blood pressure in African Americans. The AASK study now recommends ACE inhibitors to protect the kidneys from the damaging effects of hypertension. The Continuation of AASK Cohort Study will be followed at the clinical centers. The patients will be provided with the usual clinical care given to all such patients at the respective centers. Baseline demographic information, selected laboratory tests, and other studies are being obtained at the initiation of the Continuation Study. The patients will be seen quarterly at the centers, and some selected studies done at these visits. Samples will be obtained and stored for additional studies and analyses at a later date.african american, blood pressure, beta-adrenergic blocker, calcium channel blocker, angiotensin converting enzyme inhibitor, environment, socio-economic, genetic, physiology, co-morbid factor, gene, adult human, antihypertensive drug, clinical, treatment, longitudinal, demographics, laboratory test, biospecimen, biomaterial supply resourceSCR_006985( AASK Clinical Trial and Cohort Study , RRID:SCR_006985)End-stage renal disease, Kidney failure, Kidney disease, Hypertension, Hypertensive kidney diseaseNIDDKrelated to: NIDDK Information Network, Chronic Renal Insufficiency Cohort Study, listed by: One Mind Biospecimen Bank Listing, submitted by: NIDDK Information NetworkLast checked upnlx_152750
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