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on page 1 showing 20 out of 65 results

Cite this (3D DTI Atlas of the Rat Brain In Postnatal Day 5 14 and Adulthood, RRID:SCR_009437)

URL: http://www.nitrc.org/projects/dti_rat_atlas/

Resource Type: Resource, atlas, reference atlas, data or information resource

3D DTI anatomical rat brain atlases have been created by the UNC- Chapel Hill Department of Psychiatry and the CAMID research collaboration. There are three age groups, postnatal day 5, postnatal day 14, and postnatal day 72. The subjects were Sprague-Dawley rats that were controls in a study on cocaine abuse and development. The P5 and P14 templates were made from scans of twenty rats each (ten female, ten male); the P72, from six females. The individual cases have been resampled to isotropic resolution, manually skull-stripped, and deformably registered via an unbiased atlas building method to create a template for each age group. Each template was then manually segmented using itk-SNAP software. Each atlas is made up of 3 files, a template image, a segmentation, and a label file.

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    ABSOLUTE

Cite this (ABSOLUTE, RRID:SCR_005198)

URL: http://www.broadinstitute.org/cancer/cga/absolute

Resource Type: Resource, software resource

Software to estimate purity / ploidy, and from that compute absolute copy-number and mutation multiplicities. When DNA is extracted from an admixed population of cancer and normal cells, the information on absolute copy number per cancer cell is lost in the mixing. The purpose of ABSOLUTE is to re-extract these data from the mixed DNA population. This process begins by generation of segmented copy number data, which is input to the ABSOLUTE algorithm together with pre-computed models of recurrent cancer karyotypes and, optionally, allelic fraction values for somatic point mutations. The output of ABSOLUTE then provides re-extracted information on the absolute cellular copy number of local DNA segments and, for point mutations, the number of mutated alleles.

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Cite this (An efficient P300-based brain-computer interface for disabled subjects, RRID:SCR_001584)

URL: http://mmspg.epfl.ch/cms/page-58322.html

Resource Type: Resource, data set, source code, software resource, data or information resource

A portal containing EEG datasets (in MATLAB format) and the MATLAB software that were used to produce the results in the paper named in the title of this resource. The files published can also be used as a basis for individual research on P300-based brain-computer interfaces. The system is based on the P300 evoked potential and is tested with five severely disabled and four able-bodied subjects. For four of the disabled subjects classification accuracies of 100% are obtained. The bitrates obtained for the disabled subjects range between 10 and 25 bits/min. The effect of different electrode configurations and machine learning algorithms on classification accuracy is tested.

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Cite this (Automatic Registration Toolbox, RRID:SCR_005993)

URL: http://www.nitrc.org/projects/art

Resource Type: Resource, image analysis software, data processing software, software application, image collection, software resource, software toolkit, image processing software, data or information resource

ART ''''acpcdetect'''' program for automatic detection of the AC and PC landmarks and the mid-sagittal plane on 3D structural MRI scans. ART ''''brainwash'''' program for automatic multi-atlas skull-stripping of 3D structural MRI scans. ART ''''3dwarper'''' program of non-linear inter-subject registration of 3D structural MRI scans. Software (art2) for linear rigid-body intra-subject inter-modality (MRI-PET) image registration. Data resource: The ART projects makes available corpus callosum segmentations of 316 normal subjects from the OASIS cross-sectional database. ART ''''yuki'''' program for fast, robust, and fully automatic segmentation of the corpus callosum on 3D structural MRI scans.

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Cite this (Biobank Graz, RRID:SCR_004245)

URL: http://www.medunigraz.at/en/biobank

Resource Type: Resource, production service resource, analysis service resource, biomaterial supply resource, tissue bank, service resource, material resource, data or information resource

Biobank Graz is a non-profit central Medical University of Graz (MUG) service facility that provides the logistics and infrastructure to optimally support MUG research teams in the collection, processing and storage of biological samples and their associated data. In the course of this, special attention is given to sample and data quality and to the protection of the individual rights of patients. Samples from selected patients at the Graz LKH-University Clinical Centre, who have signed an informed consent declaration, are deposited in Biobank Graz. This means that excess tissue and blood samples are collected and placed in storage. The samples are harvested in the course of routine interventions undertaken by the different departments and institutes of the Graz LKH-University Clinical Centre and approved for use in research projects only after the completion of all necessary laboratory and histopathological analyses. No additional material is removed: in other words, there are no associated drawbacks whatsoever for the patients involved. Biobank Graz operates a quality management system according to ISO 9001:2008 and offers the following services for the processing and storage of biological samples and the handling of data: * Consistently high sample quality through the processing of samples using standardized methods in accordance with written working instructions (SOPs) * Efficient use of resources through the building of shared infrastructure and the development of optimized processes * A high degree of reliability provided by the storage of samples in 24/7 - monitored storage systems. * Processing and storage of all data in accordance with data protection legislation. Biobank Graz comprises both population-based and disease-focused collections of biological materials. It currently contains approx. 3.8 mio samples from approx. 1.2 mio patients representing a nonselected patient group characteristic of central Europe. Because the Institute of Pathology was, until 2003, the exclusive pathology service provider for major parts of the province of Styria, including its capital Graz (population approx. 1.2 mio people), samples from all human diseases, treated by surgery or diagnosed by biopsy, are included in the collection at their natural frequency of occurrence and thus represent cancers and non-cancerous diseases from all organs, and from all age groups. The scientific value of the existing tissue collection is, thus, not only determined by its size and technical homogeneity (all samples have been processed in a single institute under constant conditions for more than 20 years), but also by its population-based character. These features provide ideal opportunities for epidemiological studies and allow the validation of biomarkers for the identification of specific diseases and determination of their response to treatment. Prospectively collected tissues, blood samples and clinical data comprise, on the one hand, randomly selected samples from all diseases and patient groups to provide sufficient numbers of samples for the evaluation of the disease-specificity of any gene or biomarker. On the other hand, Biobank Graz adopts a disease-focused approach for selected diseases (such as breast, colon and liver cancers as well as some metabolic diseases) through the collection of a range of different human biological samples of highest quality and detailed clinical follow-up data. Graz Medical University established the Biobank to provide improved and sustainable access to biological samples and related (clinical) data both for its own academic research and for external research projects of academic and industrial partners. It is a major interest of the university to initiate co-operative research projects. Biological samples and data are available to external institutions performing high-quality research projects which comply with the Biobank''s ethical and legal framework according to the access rules (Contact: COO Karine Sargsyan, MD, PhD).

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Cite this (Bioreclamation, RRID:SCR_004728)

URL: http://www.bioreclamationivt.com/

Resource Type: Resource, biomaterial supply resource, material resource, commercial organization

A worldwide provider of biological and in vitro products specializing in control and disease state matrices manufactured from human and animal whole blood, plasma, serum, tissues and other fluids which are used in drug discovery, compound development, clinical and research diagnostics. They can immediately add value to drug discovery and preclinical development programs by providing large lots of hepatocytes, other cell types, and subcellular fractions along with associated media. The products enable scientists and biomedical researchers to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and the effects on disease processes.

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Cite this (Boston University Biospecimen Archive Research Core, RRID:SCR_005363)

URL: http://www.bumc.bu.edu/busm-pathology/pathology-core-services/biospecimen-archive-research-core-barc/

Resource Type: Resource, biomaterial supply resource, material resource, tissue bank

Biospecimen repository of normal and diseased human material from a variety of tissues and conditions along with clinical annotation. Both frozen aliquots and paraffin embedded tissue are available. Biospecimens are available to qualified researchers with IRB approval. * Preliminary inquires please contact Cheryl Spencer at cheryl.spencer (at) bmc.org

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Cite this (Brad Smith Magnetic Resonance Imaging of Embryos, RRID:SCR_006300)

URL: http://www-personal.umich.edu/~brdsmith/Research.html

Resource Type: Resource, data set, video resource, image collection, data or information resource

Data set of image collections and movies including Magnetic Resonance Imaging of Embryos, Human Embryo Imaging, MRI of Cardiovascular Development, and Live Embryo Imaging. Individual MRI slice images, three-dimensional images, animations, stereo-pair animations, animations of organ systems, and photo-micrographs are included.

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Cite this (Brain Resource, RRID:SCR_006172)

URL: http://www.brainresource.com/

Resource Type: Resource, organization portal, assessment test provider, database, training service resource, standard specification, narrative resource, service resource, portal, material resource, data or information resource

Create brain products for everyday life which help people train for peak brain health and fitness; reduce stress simply and objectively; provide rapid assessment of brain strengths & weaknesses; and enable landmark tests to predict treatment in Depression and ADHD. Brain Resource uses their international human brain database to make sense of the brain''s complexities and provide a coherent model for measuring brain health. Healthcare stakeholders need timely, evidence-based data and reliable benchmarks in order to improve the way decisions are made in brain health. We empower clinicians, employers, researchers, pharmaceutical companies, health plans and individuals with access to personalized, validated and actionable data. Our cross-disciplinary and multi-dimensional approach has produced a standard for testing and analyzing how the brain works across the lifespan and under varying conditions, influences and compounds. Users tap into this resource by completing assessments which capture the brain basis of an individual''s emotion, thinking and feeling processes, and how they regulate them compared to their peers. What are the interrelationships between genetics, brain structure, brain function, lifestyle and emotions that affect the way we think and behave? How do you determine who is at risk or whether a treatment is working, or when someone is well? The Brain Resource International Database (BRID) is unique in its breadth of measures, it''s power and scope. Evidence-based reports from Brain Resource, underpinned by this great database, can help you find meaningful answers to those questions faster, safer and more cost-effectively than ever before. Brain Resource also undertakes large scale personalized medicine trials including the largest treatment marker study in Depression and ADHD - iSPOT. The findings from these studies have the potential to set a new standard for drug discovery in brain disorders.

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Cite this (Brain Test, RRID:SCR_006212)

URL: https://www.braintest.org/brain_test/BrainTest

Resource Type: Resource, topical portal, portal, data or information resource

A portal of online studies that encourage community participation to tackle the most challenging problems in neuropsychiatry, including attention-deficit / hyperactivity disorder, schizophrenia, and bipolar disorder. Our approach is to engage the community and try to recruit tens of thousands of people to spend an hour of their time on our site. You folks will provide data in both brain tests and questionnaires, as well as DNA, and in return, we will provide some information about your brain and behavior. You will also be entered to win amazon.com gift cards. While large collaborative efforts were made in genetics in order to discover the secrets of the human genome, there are still many mysteries about the behaviors that are seen in complex neuropsychiatric syndromes and the underlying biology that gives rise to these behaviors. We know that it will require studying tens of thousands of people to begin to answer these questions. Having you, the public, as a research partner is the only way to achieve that kind of investment. This site will try to reach that goal, by combining high-throughput behavioral assessment using questionnaires and game-like cognitive tests. You provide the data and then we will provide information and feedback about why you should help us achieve our goals and how it benefits everyone in the world. We believe that through this online study, we can better understand memory and attention behaviors in the general population and their genetic basis, which will in turn allow us to better characterize how these behaviors go awry in people who suffer from mental illness. In the end, we hope this will provide better, more personalized treatment options, and ultimately prevention of these widespread and extremely debilitating brain diseases. We will use the data we collect to try to identify the genetic basis for memory and impulse control, for example. If we can achieve this goal, maybe we can then do more targeted research to understand how the biology goes awry in people who have problems with cognition, including memory and impulse control, like those diagnosed with ADHD, Schizophrenia, Bipolar Disorder, and Autism Spectrum Disorders. By participating in our research, you can learn about mental illness and health and help researchers tackle these complex problems. We can''t do it without your help.

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Cite this (Cancer Genome Anatomy Project, RRID:SCR_003072)

URL: http://cgap.nci.nih.gov/

Resource Type: Resource, topical portal, portal, data or information resource

Project to determine the gene expression profiles of normal, precancer, and cancer cells, whose generated resources are available to the cancer community. Interconnected modules provide access to all CGAP data, bioinformatic analysis tools, and biological resources allowing the user to find in silico answers to biological questions in a fraction of the time it once took in the laboratory. * Genes * Tissues * Pathways * RNAi * Chromosomes * SAGE Genie * Tools

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Cite this (Cancer Methylome System, RRID:SCR_012013)

URL: http://cbbiweb.uthscsa.edu/KMethylomes/

Resource Type: Resource, data or information resource, database

Datbase and web-based system for visualization and analysis of genome-wide methylation data of human cancers.

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Cite this (Cancer Research Network of the FRSQ, RRID:SCR_004225)

URL: http://www.rrcancer.ca/en/publique/accueil

Resource Type: Resource, organization portal, database, biomaterial supply resource, consortium, tissue bank, portal, material resource, data or information resource

An infrastructure to allow Quebec researchers to have at their disposal tumor banks and the services that support large scale research in genomics and proteomics. The database and the tissue bank of the research network was created to allow rapid access to biological samples and their clinical data. It is spread out over many hospital institutions (in Montreal, Quebec and Sherbrooke). The members of the RRCancer-BTD supply normal, benign and malignant samples from routine surgeries and blood tests. Blood and tissue samples are collected by the provincial biobanks on a regular basis and are coded, classified and stored. The samples can be supplied to a researcher either fresh or frozen or blocks of paraffin or on slices. The sharing of information and biological material is managed according to ethical rules and contributes to increasing the value of research in Quebec. The network has mobilized a significant number of researchers in the area of cancer that unite their efforts to pursue high caliber multidisciplinary research. They are a group of researchers from many different Qu??bec Universities all working in the branch of cancer research. They are located in four hospital centers in Quebec, namely the University of Montreal Hospital Centre (CHUM), the University of Quebec Hospital Centre (CHUQ), the University of Sherbrooke Hospital Centre (CHUS) and the McGill University Hospital Centre (CUSM), as well as in the affiliated research and university centers (Sacr??-Coeur, Maisonneuve-Rosemont and the Montreal Jewish Hospital). The collaborative efforts created and maintained in this network have allowed transfer of knowledge and the sharing of cutting edge technologies. RRCancer favors multidisciplinary cancer research in both fundamental and clinical scopes. The network is based on the desire researchers to work together to prevent cancer and improve therapeutic strategies, all the while continuing the very important task of raining new specialists and graduate students.

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Cite this (Capital Biosciences, RRID:SCR_004879)

URL: http://www.capitalbiosciences.com/

Resource Type: Resource, commercial organization, production service resource, biomaterial supply resource, tissue bank, service resource, material resource, data or information resource

Biological products including Cell Immortalization Products, Clinically Defined Human Tissue, cDNA ORF Clones, Premade Adenoviruses, Purified Proteins, Viral Expression Systems and others as well as services like Custom Recombinant Adenovirus Production, Custom Recombinant Lentivirus Production, Protein Detection and Quantification and Stable Cell Line Production for academic and governmental research institutes, pharmaceutical and biotechnology industry. Capital Biosciences offers most types of human tissues, normal and diseased, with extensive clinical history and follow up information. Standard specimen format: Snap-frozen(flash-frozen), Formalin fixed and paraffin embedded (FFPE) tissues, Blood and blood products, Bone marrow, Total RNA, Genomic DNA, Total Proteins, Primary cell cultures, Viable frozen tissue. Tumor tissue samples include: Bladder cancer, Glioblastoma, Medulloblastoma, Breast Carcinoma, Cervical Cancer, Colorectal Cancer, Endometrial Cancer, Esophageal Cancer, Head and Neck (H&N) Carcinoma, Hepatocellular Carcinoma (HCC), Hodgkin's lymphoma, Kidney, Renal Cell Carcinoma, Lung Cancer, Non-Small Cell (NCSLC), Lung Cancer, Small Cell (SCLC), Melanoma, Mesothelioma, non-Hodgkin's Lymphoma, Ovarian Adenocarcinoma, Pancreatic Cancer, Prostate Cancer, Stomach Cancer.

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Cite this (Cardiovascular Model Repository, RRID:SCR_002679)

URL: https://simtk.org/home/cv-gmodels

Resource Type: Resource, image collection, data set, service resource, storage service resource, data repository, data or information resource

Repository of geometric models collected from on-going and past research projects in the Cardiovascular Biomechanics Research Laboratory at Stanford University. The geometric models are mostly built from imaging data of healthy and diseased individuals. For each of the models, a short description is given with a reference. The geometric models are in VTK PolyData XML .vtp format. * Audience: Biomechanical and computational researchers interested in complex models of cardiovascular applications * Long Term Goals and Related Uses: Allow users to download geometric models for cardiovascular applications. These geometric models can be used for research purposes, such as meshing and scientific visualization. Users are welcome to contact the project administrator, join the project and contribute additional models.

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Cite this (CardioVascular Research Grid (CVRG), RRID:SCR_004472)

URL: http://www.cvrgrid.org/

Resource Type: Resource, data analysis service, production service resource, analysis service resource, service resource, storage service resource, atlas, image repository, data repository, data or information resource

Infrastructure for sharing cardiovascular data and data analysis tools. Human ExVivo heart data set and canine ExVivo normal and failing heart data sets are available. Canine hearts atlas and human InVivo atlases are available.

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Cite this (CCHMC Pediatric Brain Templates, RRID:SCR_003276)

URL: http://irc.cchmc.org/software/pedbrain.php

Resource Type: Resource, atlas, image collection, reference atlas, data or information resource

Brain imaging data collected from a large population of normal, healthy children that have been used to construct pediatric brain templates, which can be used within statistical parametric mapping for spatial normalization, tissue segmentation and visualization of imaging study results. The data has been processed and compiled in various ways to accommodate a wide range of possible research approaches. The templates are made available free of charge to all interested parties for research purposes only. When processing imaging data from children, it is important to take into account the fact that the pediatric brain differs significantly from the adult brain. Therefore, optimized processing requires appropriate reference data be used because adult reference data will introduce a systematic bias into the results. We have shown that, in the in the case of spatial normalization, the amount of non-linear deformation is dramatically less when a pediatric template is used (left, see also HBM 2002; 17:48-60). We could also show that tissue composition is substantially different between adults and children, and more so the younger the children are (right, see also MRM 2003; 50:749-757). We thus believe that the use of pediatric reference data might be more appropriate.

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Cite this (Cell Line Ontology by Mahadevan, RRID:SCR_010281)

URL: http://purl.bioontology.org/ontology/MCCL

Resource Type: Resource, ontology, data or information resource, controlled vocabulary

A comprehensive ontology on primary and established cell lines-both normal and pathologic. It covers around 400 cell lines. This ontology has been built to include the major domains in the field of biology like anatomy, bio-molecules, chemicals and drugs, pathological conditions and genetic variations around the cell lines. An extensive network of relations has been built across these concepts to enable different combinations of queries. The ontology covers all cell lines from major sources like ATCC, DSMZ, ECACC, ICLC etc. and is built in OWL format.

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Cite this (Chernobyl Tissue Bank, RRID:SCR_010662)

URL: http://www.chernobyltissuebank.com/

Resource Type: Resource, biomaterial supply resource, material resource

The CTB (Chernobyl Tissue Bank) is an international cooperation that collects, stores and disseminates biological samples from tumors and normal tissues from patients for whom the aetiology of their disease is known - exposure to radioiodine in childhood following the accident at the Chernobyl power plant. The main objective of this project is to provide a research resource for both ongoing and future studies of the health consequences of the Chernobyl accident. It seeks to maximize the amount of information obtained from small pieces of tumor by providing multiple aliquots of RNA and DNA extracted from well documented pathological specimens to a number of researchers world-wide and to conserve this valuable material for future generations of scientists. It exists to promote collaborative, rather than competitive, research on a limited biological resource. Tissue is collected to an approved standard operating procedure (SOP) and is snap frozen; the presence or absence of tumor is verified by frozen section. A representative paraffin block is also obtained for each case. Where appropriate, we also collect fresh and paraffin-embedded tissue from loco-regional metastases. Currently we do not issue tissue but provide extracted nucleic acid, paraffin sections and sections from tissue microarrays from this material. The project is coordinated from Imperial College, London and works with Institutes in the Russian Federation (the Medical Radiological Research Centre in Obninsk) and Ukraine (the Institute of Endocrinology and Metabolism in Kiev) to support local scientists and clinicians to manage and run a tissue bank for those patients who have developed thyroid tumors following exposure to radiation from the Chernobyl accident. Belarus was also initially included in the project, but is currently suspended for political reasons.

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Cite this (CNSforum: Image Bank, RRID:SCR_002718)

URL: http://www.cnsforum.com/educationalresources/imagebank/

Resource Type: Resource, image collection, data or information resource

A collection of downloadable central nervous system (CNS) images for teaching, presentations, articles, and other purposes. The following major categories of images are as follows: Brain anatomy, Brain physiology, Anxiety, Depression, Schizophrenia, Dementia, Parkinson's disease, Stroke, and Others.

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