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on page 1 showing 20 out of 55 results

Cite this (Aging Cell Repository, RRID:SCR_007320)

URL: http://ccr.coriell.org/nia/

Resource Type: Resource, database, biomaterial supply resource, biospecimen repository, service resource, storage service resource, cell repository, material storage repository, material resource, data or information resource

A cell repository containing cells and DNA for studies of aging and the degenerative processes associated with it. Scientists use the highly-characterized, viable, and contaminant-free cell cultures from this collection for research on such diseases as Alzheimer's disease, progeria, Parkinson's disease, Werner syndrome, and Cockayne syndrome. The collections of the Repository include DNA and cell cultures from individuals with premature aging disorders, as well as DNA from individuals of advanced age from the the Baltimore Longitudinal Study of Aging at the Gerontology Research Center and other Longevity Collections. The Repository also includes samples from an Adolescent Study of Obesity, Apparently Healthy Controls, Animal Models of Aging, and both human and animal differentiated cell types. The cells in this resource have been collected over the past three decades using strict diagnostic criteria and banked under the highest quality standards of cell culture. Scientists can use the highly-characterized, viable, and contaminant-free cell cultures from this collection for genetic and cell biology research.

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Cite this (ARK-Genomics: Centre for Functional Genomics, RRID:SCR_002214)

URL: http://www.ark-genomics.org/

Resource Type: Resource, organization portal, database, core facility, service resource, portal, access service resource, data or information resource

A high-throughput technology laboratory focused on studies of genome structure and genetic variation, gene expression and gene function, it provides an extensive range of services including: * DNA sequencing of model and non-model genomes using both Next Generation and Sanger sequencing * Gene expression analysis using both microarrays and Next Generation Sequencing * High throughput genotyping of SNP and copy number variants * Data collection and analysis supported in-house high performance computing facilities and expertise * Extensive EST clone collections for a number of animal species * All of the commercially available microarray tools from Affymetrix, Illumina, Agilent and Nimblegen * Parentage testing using microsatellites and smaller SNP panels ARK-Genomics has developed a network of researchers whom they support through each stage of their genomics research, from grant application, experimental design and technology selection, performing wet laboratory protocols, through to the analysis of the data often in conjunction with commercial partners. An important part of the ARK-Genomics service is the opportunity to engage with other scientists and to raise awareness through their training courses, networking events such as their successful conference series.

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Cite this ( Beta Cell Biology Consortium , RRID:SCR_005136)

URL: http://www.betacell.org/

Resource Type: Resource, organization portal, resource, organism supplier, antibody supplier, database, biomaterial supply resource, biospecimen repository, experimental protocol, consortium, narrative resource, material resource, service resource, portal, storage service resource, cell repository, reagent supplier, data repository, material storage repository, data or information resource

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 1, 2015. Consortium that aims to facilitate interdisciplinary collaborations to advance the understanding of pancreatic islet development and function, with the goal of developing innovative therapies to correct the loss of beta cell mass in diabetes, including cell reprogramming, regeneration and replacement. They are responsible for collaboratively generating the necessary reagents, mouse strains, antibodies, assays, protocols, technologies and validation assays that are beyond the scope of any single research effort. The scientific goals for the BCBC are to: * Use cues from pancreatic development to directly differentiate pancreatic beta cells and islets from stem / progenitor cells for use in cell-replacement therapies for diabetes, * Determine how to stimulate beta cell regeneration in the adult pancreas as a basis for improving beta cell mass in diabetic patients, * Determine how to reprogram progenitor / adult cells into pancreatic beta-cells both in-vitro and in-vivo as a mean for developing cell-replacement therapies for diabetes, and * Investigate the progression of human type-1 diabetes using patient-derived cells and tissues transplanted in humanized mouse models. Many of the BCBC investigator-initiated projects involve reagent-generating activities that will benefit the larger scientific community. The combination of programs and activities should accelerate the pace of major new discoveries and progress within the field of beta cell biology.

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Cite this (Bioreclamation, RRID:SCR_004728)

URL: http://www.bioreclamationivt.com/

Resource Type: Resource, biomaterial supply resource, material resource, commercial organization

A worldwide provider of biological and in vitro products specializing in control and disease state matrices manufactured from human and animal whole blood, plasma, serum, tissues and other fluids which are used in drug discovery, compound development, clinical and research diagnostics. They can immediately add value to drug discovery and preclinical development programs by providing large lots of hepatocytes, other cell types, and subcellular fractions along with associated media. The products enable scientists and biomedical researchers to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and the effects on disease processes.

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Cite this (Blood Group Antigen Gene Mutation Database, RRID:SCR_002297)

URL: http://www.ncbi.nlm.nih.gov/projects/gv/rbc/xslcgi.fcgi?cmd=bgmut

Resource Type: Resource, service resource, data or information resource, data repository, storage service resource, database

Database documenting variations in genes that encode antigens for human blood groups, it thus is a locus-specific mutation database (LSDB) that covers multiple genes. In addition to documenting genetic variations, this site also provides information on the blood group systems, the genes that encode them, the serological phenotypes, etc. Blood group systems for which genes or genetic variations have yet to be identified are also documented. For some systems, information on non-human orthologous genes is also made available. Many experts in the study of blood group systems have contributed to the development of this database by providing, among other things, information on the systems and the alleles. In the beginning, this site documented about 200 alleles for 10 blood group systems. Over time, more alleles and systems have been added and as of September 2011, there were over 1250 alleles of 40 genes that encode 30 known blood group systems. BGMUT was singled as one of three model databases from more than 200 mutation databases in a scholarly review in 2002 (Claustres et al., Genome Research. 2002. 12(5):680-8. PubMed ID: 11997335) Please fill the form to submit information on a new allelic variation.

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    CAMRD

Cite this (CAMRD, RRID:SCR_001713)

URL: http://camrd4.mc.duke.edu/

Resource Type: Resource, service resource, access service resource

Research facility of the Department of Radiology at the Duke University Medical Center (DUMC) providing access to a whole-body, commercially manufactured 3 Tesla (Trio, Siemens Medical Systems) MR Imaging and Spectroscopy System with full research capability. The Center is fully equipped to perform clinical and research MR imaging or spectroscopy studies on humans or large animals. A full range of monitoring, anesthesia, RF coil development, computer and instrumental control facilities as well as MR research technologists and physics/chemistry consultation are available to Department of Radiology researchers and their collaborators.

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Cite this (Center for Magnetic Resonance Research, RRID:SCR_003148)

URL: http://www.cmrr.umn.edu/

Resource Type: Resource, biomedical technology research center, service resource, access service resource, training resource

Biomedical technology research center that focuses on development of unique magnetic resonance (MR) imaging and spectroscopy methodologies and instrumentation for the acquisition of structural, functional, and biochemical information non-invasively in humans, and utilizing this capability to investigate organ function in health and disease. The distinctive feature of this resource is the emphasis on ultrahigh magnetic fields (7 Tesla and above), which was pioneered by this BTRC. This emphasis is based on the premise that there exists significant advantages to extracting biomedical information using ultrahigh magnetic fields, provided difficulties encountered by working at high frequencies corresponding to such high field strengths can be overcome by methodological and engineering solutions. This BTRC is home to some of the most advanced MR instrumentation in the world, complemented by human resources that provide unique expertise in imaging physics, engineering, and signal processing. No single group of scientists can successfully carry out all aspects of this type of interdisciplinary biomedical research; by bringing together these multi-disciplinary capabilities in a synergistic fashion, facilitating these interdisciplinary interactions, and providing adequate and centralized support for them under a central umbrella, this BTRC amplifies the contributions of each of these groups of scientists to basic and clinical biomedical research. Collectively, the approaches and instrumentation developed in this BTRC constitute some of the most important tools used today to study system level organ function and physiology in humans for basic and translational research, and are increasingly applied world-wide. CMRR Faculty conducts research in a variety of areas including: * High field functional brain mapping in humans; methodological developments, mechanistic studies, and neuroscience applications * Metabolism, bioenergetics, and perfusion studies of human pathological states (tumors, obesity, diabetes, hepatic encephalopathy, cystic fibrosis, and psychiatric disorders) * Cardiac bioenergetics under normal and pathological conditions * Automated magnetic field shimming methods that are critical for spectroscopy and ultrafast imaging at high magnetic fields * Development of high field magnetic resonance imaging and spectroscopy techniques for anatomic, physiologic, metabolic, and functional studies in humans and animal models * Radiofrequency (RF) pulse design based on adiabatic principles * Development of magnetic resonance hardware for high fields (e.g. RF coils, pre-amplifiers, digital receivers, phased arrays, etc.) * Development of software for data analysis and display for functional brain mapping.

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Cite this ( Cooperative Study Group for Autoimmune Disease Prevention , RRID:SCR_006803)

URL: http://www.niaid.nih.gov/about/organization/dait/pages/csgadp.aspx

Resource Type: Resource, knowledge environment, resource

Collaborative network of investigators with a focus on prevention of autoimmune disease, defined as halting the development of autoimmune disease prior to clinical onset by means other than global immunosuppression, and an emphasis on Type 1 diabetes. Its mission is to engage in scientific discovery that significantly advances knowledge for the prevention and regulation of autoimmune disease. The specific goals enunciated in pursuit of this mission are: * To create improved models of disease pathogenesis and therapy to better understand immune mechanisms that will provide opportunities for prevention strategies * To use these models as validation platforms with which to test new tools applicable to human studies * To encourage core expertise and collaborative projects designed for rapid translation from animal to human studies, emphasizing the development of surrogate markers for disease progression and/or regulation which can be utilized in the context of clinical trials

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Cite this (Critical Path Initiative, RRID:SCR_012967)

URL: http://www.fda.gov/ScienceResearch/SpecialTopics/CriticalPathInitiative/

Resource Type: Resource, portal, data or information resource

The FDA''s national strategy for transforming the way FDA-regulated products--human drugs, biological products, medical devices, veterinary drugs, foods, and cosmetics--are developed, evaluated, manufactured, and used. Specific key areas of focus identified by FDA experts and the public: * Developing better evaluation tools like biomarkers and new assays * Streamlining clinical trials by modernizing the clinical trial sciences to make trials safe and efficient * Harnessing bioinformatics (e.g., moving from a paper-based to electronic environment for exchanging information and overseeing the safety of FDA-regulated products) * Moving manufacturing into the 21st Century, using tools such as process analytic technology and nanotechnology * Developing products to address urgent public health needs, including, improved antimicrobial testing, new animal models to test bioterrorism countermeasures and vaccine testing * Focusing on at-risk populations, such as pediatrics

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Cite this (CU Denver Advanced Histology Services, RRID:SCR_012286)

URL: http://www.scienceexchange.com/facilities/advanced-histology-services

Resource Type: Resource, service resource, core facility, access service resource

The objective of the Morphology and Phenotyping Core - Advanced Histology Services, is to provide Investigators/clients with the tools and expertise to process and analyze tissue samples. The Core is able to process any type of animal and/or human tissue for research purposes. Our technicians are also highly trained in dermatology and delicate specimen handling. We consistently maintain the highest-quality results by utilizing state-of-the-art equipment and employing nationally-certified technicians. Our aim is to always provide excellent customer service by fulfilling each Investigators/clients'''' specific needs and wants. Core services include recommendations for tissue harvesting and storage, preparation of paraffin blocks, sectioning of paraffin and frozen blocks, standard H&E histology, special staining procedures, and control slide preparation.

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Cite this (Current Research Information System, RRID:SCR_001441)

URL: http://cris.nifa.usda.gov

Resource Type: Resource, data or information resource, database

A database of documentation and reporting for ongoing agricultural, food science, human nutrition, and forestry research, education and extension activities for the United States Department of Agriculture; with a focus on the National Institute of Food and Agriculture (NIFA) grant programs. Projects are conducted or sponsored by USDA research agencies, state agricultural experiment stations, land-grant universities, other cooperating state institutions, and participants in NIFA-administered grant programs, including Small Business Innovation Research and Agriculture and Food Research Initiative.

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Cite this (Drug Related Gene Database, RRID:SCR_003330)

URL: https://confluence.crbs.ucsd.edu/display/NIF/DRG

Resource Type: Resource, service resource, data or information resource, data repository, storage service resource, database

Gene expression data from published journal articles that test hypotheses relevant to the neuroscience of addiction and addictive behavior. Data types include the effects of a particular drug, strain, or knock out on a particular gene, in a particular anatomical region. "Export" (Data Federation) for a fuller description of the methods, drug paradigm and the experimental values. Data submissions are welcome, https://confluence.crbs.ucsd.edu/display/NIF/DRG+Submission+Documentation Funded by an ARRA supplement from the National Institute of Drug Abuse (NIDA), the DRG database was created to facilitate discovery and use of resources relevant to drug abuse research. The database and associated tools were specifically created for providing data that is contained in tables, figures and supplementary materials from published papers in a way that facilitates search across the results of these studies. The current database mainly focuses on gene expression data and exposes data from investigations using DNA microarrays, polymerase chain reaction, immunohistochemistry and in-situ hybridizations. Once loaded, these data are available for query through the NIF interface. During this process, the content is standardized using a generic high level description of a relevant study and map terms to ontologies available through the NIF project (NIFSTD) to enhance semantic search of such data.

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    EarLab

Cite this (EarLab, RRID:SCR_001798)

URL: http://earlab.bu.edu/

Resource Type: Resource, data analysis service, database, analysis service resource, software application, production service resource, service resource, audio track, software resource, data or information resource

Freely-accessible auditory databases as well as custom designed modeling and data analysis software tools. A fully functional online auditory modeling environment is also available, as well as downloadable models in several languages. The models cover many aspects of auditory function and at many different levels of detail ranging from multi-compartment celluar models to high-level abstractions of large portions of the auditory pathway. Currently a few models are available that can be run online and others are available for downloading. EarLab also provides custom cross-platform software for creating your own distributed auditory modeling environment, as well as software for analyzing the results from experimentation. A database of auditory modules is available for online use or download for the distributed auditory modeling environment, as well as instructions and specifications for creating your own modules. All these databases and custom software tools can be used in a wide variety of hearing research applications. This unique resource provides a wealth of information on auditory processing in humans and other animals. Mathematical models are also provided.

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Cite this (EpiTarget, RRID:SCR_003771)

URL: http://www.epitarget.eu/

Resource Type: Resource, portal, data or information resource

A multidisciplinary project focused on the process leading to epilepsy, epileptogenesis, in adults. Their main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Their central premise and vision is that a combinatorial approach is necessary to identify appropriate biomarkers and develop effective antiepileptogenic therapeutics. The project will focus on: * identifying novel biomarkers and their combinations for epileptogenesis after potentially epileptogenic brain insults in clinically relevant animal models, such as traumatic brain injury (TBI) and status epilepticus (SE); * exploring multiple basic mechanisms of epileptogenesis and their mutual interactions; * and translating these findings towards the clinic by validating biomarkers in human samples accessible to the consortium.

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    ESTEVE

Cite this (ESTEVE, RRID:SCR_003948)

URL: http://www.esteve.es/

Resource Type: Resource, portal, organization portal, commercial organization, data or information resource

A pharmaceutical chemical group in Spain with a presence worldwide. It operates in the pharmaceutical sector by researching and developing new drugs, marketing a wide range of ethical and OTC products, generics, vaccines and also products for hospital and veterinary use. Through its subsidiary Esteve Qu??mica is also present in the Active Pharmaceutical Ingredients sector.

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Cite this (EthoVision XT, RRID:SCR_000441)

URL: https://www.noldus.com/ethovision

Resource Type: Resource, software resource

Video tracking software that tracks and analyzes the behavior, movement, and activity of any animal.

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Cite this (European Medicines Agency, RRID:SCR_011215)

URL: http://www.ema.europa.eu/

Resource Type: Resource, funding resource

An agency responsible for the evaluation and supervision of medicines developed by pharmaceutical companies for use in the European Union. Its main responsibility is the protection and promotion of public and animal health through the evaluation and supervision of medicines for human and veterinary use. The Agency also plays a role in stimulating innovation and research in the pharmaceutical sector. The Agency gives scientific advice and other assistance to companies for the development of new medicines. It publishes guidelines on quality-, safety- and efficacy-testing requirements. A dedicated SME Office provides special assistance to small and medium-sized enterprises.

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Cite this (FMAToolbox, RRID:SCR_015533)

URL: http://fmatoolbox.sourceforge.net

Resource Type: Resource, software resource, software application, data analysis software, data processing software

Matlab toolbox used to help analyze electrophysiological and behavioral data recorded from freely moving animals.

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Cite this ( Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Comparative Medicine , RRID:SCR_015326)

URL: http://sharedresources.fredhutch.org/core-facilities/comparative-medicine

Resource Type: Resource, service resource, resource, core facility, access service resource

Core facility that provides a variety of animal housing, veterinary and research support services.

  • From Current Category

    Happy

Cite this (Happy, RRID:SCR_001395)

URL: http://www.well.ox.ac.uk/happy/

Resource Type: Resource, software resource, software application, data analysis software, data processing software, source code

Software package for Multipoint QTL Mapping in Genetically Heterogeneous Animals (entry from Genetic Analysis Software) The method is implemented in a C-program and there is now an R version of HAPPY. You can run HAPPY remotely from their web server using your own data (or try it out on the data provided for download). HAPPY's analysis is essentially two stage; ancestral haplotype reconstruction using dynamic programming, followed by QTL testing by linear regression: * Assume that at a QTL, a chromosome originating from the progenitor strain, labelled s, contributes an unknown additive amount Ts to the phenotype, so that the expected genetic effect for a diploid individual with ancestral alleles labelled s,t at the trait locus is Ts+Tt; a test for a QTL is equivalent to testing for differences between the Ts's. * A dynamic-programming algorithm is used to compute the probability Fn(s,t) that a given individual has the ancestral alleles s, t at locus labelled n, conditional upon all the genotype data for that individual. Then the expected phenotype is 2 Sums Ts Sumt Fn(s,t), and the Ts are estimated by a linear regression of the observed phenotypes on these expected values across all individuals, followed by an analysis of variance to test whether the progenitor estimates differ significantly. * The method's power depends on the ability to distinguish ancestral haplotypes across the interval; clearly the power will be lower if all markers in a region have the same type of non-informative allele distribution, but the markers can share information where there is a mixture. HAPPY is written in ANSI C. It has been compiled and tested on various UNIX platforms (Linux, IRIX, SunOS). It requires the NAG C library, so you will need a license for this product in order to compile the program locally. The source code for HAPPY is available for non-commercial users only by anonymous ftp.

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