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on page 1 showing 15 out of 15 results

    Bioz

Cite this (Bioz, RRID:SCR_015017)

URL: https://www.bioz.com

Resource Type: Resource, software resource, web application

Search engine that mines life sciences papers using Natural Language Processing and Machine Learning to clean, tag and structure the data. Insights focus on experimentation and include objective recommendations, ratings and insights for reagents, lab equipment, assays, protocols and researchers.

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Cite this (European Gram Negative AntiBacterial Engine, RRID:SCR_003859)

URL: http://nd4bb-enable.eu/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

Consortium working to advance the development of potential antibiotics against Gram-negative bacteria, such as Escherichia coli. The project creates and manages a drug discovery engine for testing and optimizing molecules that are still in the earlier stages of drug discovery but have the potential to become future drug candidates capable of treating resistant Gram-negative infections. The project will focus on the discovery and pre-clinical stages of drug development, as well as (potentially) phase 1 clinical trials. ENABLE will run several drug discovery programs in parallel and the consortium seeks external hit and lead programs to join, through a series of open calls during the project. Researchers who have interesting molecules will have the opportunity to collaborate with a diverse range of experts in microbiology, pharmacology and chemistry to help advance their molecule through the drug development process until it is an attractive candidate for clinical testing. Specifically, the project is working towards: # identifying three antibacterial lead molecules which, following extensive testing, have been identified as having promising antimicrobial activity; # identifying two antibacterial clinical candidate molecules # advancing at least one compound into preclinical and phase 1 clinical studies, i.e. early clinical safety testing in humans.

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Cite this (European Management Platform for Emerging and Re-Emerging Infectious Disease Entities (EMPERIE), RRID:SCR_013693)

URL: http://emperie.eu/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

The European Management Platform for Emerging and Re-emerging Infectious Disease Entities (EMPERIE) consortium brings together international experts of different disciplines in an efficient and decisive collaborative network, to coordinate the response and control of an emerging new disease.

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Cite this (Kidney Health Initiative, RRID:SCR_003869)

URL: http://www.asn-online.org/khi/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

Consortium that brings together the kidney community (patient advocacy groups, industry, government agencies, and professional organizations) to overcome existing challenges, including regulatory and nonregulatory barriers, and optimize the development and safety of products that impact kidney health including drugs, devices, biologics, and food products. The goals of the consortium are to: * Facilitate dialogue and research that informs regulatory processes with regard to the kidney health of patients being treated for kidney-related as well as other diseases. * Assess current medical therapies and diagnostics to identify areas in need of greater innovation and/or better defined regulatory pathways. * Develop innovative and efficient trial designs appropriate to answer the most important questions related to kidney health. * Establish expert consensus around common terminology and key definitions related to kidney health. * Develop approaches to the systematic collection of retrospective or prospective data, such as registries and/or global databases, and establishment of data standards. * Coordinate think tanks, public forums, educational exchanges, and other events to promote discussion and updates on topics in kidney health pertaining to drug, device, biologics, and food product development and evaluation. * Create transparent infrastructure and processes that facilitate collaboration and communication among the greater nephrology community and the FDA, including: * Seek input from all stakeholders (including nephrologists and other health professionals, patient groups, industry, the National Institutes of Health, the Centers for Medicare and Medicaid Services, the Health Resources and Services Administration, and other federal agencies). * Leverage previously conducted and ongoing clinical studies, research infrastructure, and databases. * Create an open and efficient mechanism for encouraging and objectively evaluating potential projects submitted to KHI. * Involve consortium members in the selection and execution of projects. * Establish systems to optimize post-market surveillance of products that affect kidney health, either intentionally or via adverse drug reactions. * Author journal articles and white papers regarding key issues, describing opportunities and challenges and proposing solutions, as well as promoting execution of these solutions.

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Cite this (Kinetics for Drug Discovery, RRID:SCR_003868)

URL: http://www.k4dd.eu/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

Project whose goal is to improve understanding of how potential drugs bind with their target, and develop methods and tools to allow researchers to study drug-target interactions with greater ease. These tools would help researchers to determine whether a drug candidate is likely to be safe and effective much earlier in the drug development process. The first goal of the team is to enhance understanding of binding kinetics; exactly how do small molecules interact with their targets? Ultimately, the project aims to develop a range of robust techniques, methods and models that could be easily incorporated into the drug development pathway and enable scientists and drug designers worldwide to reliably predict a molecule's kinetic properties (its "kinotype"). This information will allow drug developers to more easily determine the safety and efficacy of a molecule and will weed out ineffective or unsafe molecules earlier in the drug development process. Eventually, the project also hopes to raise awareness of the importance of considering the kinetic aspects of drug-target interactions throughout drug development.

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Cite this (LabArchives, RRID:SCR_013973)

URL: http://www.labarchives.com

Resource Type: Resource, software resource, software application, electronic laboratory notebook

An ELN (electronic lab notebook) software application where researchers can record and organize their data in lieu of a paper notebook. Users can store and edit texts, PDFs, spreadsheets, images, sample collections, and other types of data. LabArchives automatically backs up data and data can be accessed anywhere. Users can choose to use the professional edition of LabArhives, the classroom edition, or to purchase an enterprise license.

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Cite this (Medical Research Council Harwell: An International Centre for Mouse Genetics, RRID:SCR_008013)

URL: https://www.har.mrc.ac.uk

Resource Type: Resource, topical portal, training resource, graduate program resource, portal, postdoctoral program resource, data or information resource

Portal at the international forefront in the use of mouse genetics to study the relationship between gene and disease. The models created and studied are used to understand the disease processes that occur when a gene goes wrong. Research at MRC Harwell comprises 11 programs that are grouped into three major sections with extensive cross-talk between sections: Functional Genomics and Disease Mechanisms, Neuroscience, and Metabolism. Harwell, in collaboration with Oxford, also offers graduate and post doc programs. The aim is to have information about the relationship between gene and disease for every gene in the mouse genome, and by extension every gene in the human genome. This will provide a wealth of data and opportunities for advances in medical understanding and treatment. The national centre for mouse genetics at Harwell is in the vanguard of these developments, providing the research programs and expertise, allied to state-of-the-art facilities, to advance medicine and knowledge through the discovery and investigation of mouse models of human disease. The Mammalian Genetics Unit is a major international research center at the forefront of studies in mouse genetics and functional genomics, investigating a wide variety of disease models and enhancing our understanding of the molecular and genetic bases of disease. The Mary Lyon Centre is a national facility for mouse functional genomics, providing world-class expertise, tools and space to generate mouse models of human disease for MRC Harwell and the wider research community.

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Cite this (ONE Study, RRID:SCR_003886)

URL: http://www.onestudy.org/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

Consortium aiming to produce regulatory T cells that are compatible with a kidney transplant patient''''s immune system, as a measure to suppress the body''''s natural immune response against a transplanted organ. If successful, this approach will reduce a transplantation patient''''s life-long dependency on immune suppressing drugs, many of which are often associated with undesirable side effects and can limit the patient''''s daily routine. The consortium goals are to develop and conduct clinical trials of various immunoregulatory T-cell-based products in organ transplantation recipients, allowing a direct comparison of the safety, clinical practicality and therapeutic efficacy of each cell type. The central focus of the project is to: # Production and manufacture of distinct populations of hematopoietic immunoregulatory T cells # Comparatively study the tolerogenic characteristics of these regulatory cell types # Test these cell therapy products side by side in a clinical trial living donor renal transplant recipients The first workstream will work with different T regulatory cell, tolerogenic DC and suppressive macrophage cell products that are currently in development. In addition to these therapeutics, another goal of this workstream is to develop a cell tracking technology that assesses pharmacodynamics and pharmacokinetics of these cell-based therapies. The second workstream is focused on designing and conducting a cell therapy based clinical trial in renal transplantation, taking into consideration ethics, concurrent immunosuppressive drug use, state-of-the-art immune monitoring, innovative all-in-one data capturing systems, and pharmacovigilance. The goal is to have a comparative evaluation of hematopoietic cell therapy safety in renal transplantation. The third workstream aims to learn more about the specific comparative characteristics of suppressive cell types and to use this knowledge to improve later trial designs and foster novel ideas for new or improved suppressive / tolerogenic cell population.

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    Overleaf

Cite this (Overleaf, RRID:SCR_003232)

URL: https://www.writelatex.com

Resource Type: Resource, software resource, software application, commercial organization, authoring tool

A collaboration tool which allows users to edit and publish scientific articles and papers. Overleaf utilizes the convenience of an easy-to-use WYSIWYG manuscript editor with real-time collaboration and structured, fully typeset output produced automatically. Authors can publish immediately and directly to their journal of choice while publishers can reduce their editorial and review turnaround times with powerful change tracking, commenting, and project lifecycle management features. It was formerly known as writeLaTex but changed its name to Overleaf in 2015.

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Cite this (Pharma-Planta Consortium, RRID:SCR_003880)

URL: http://www.pharma-planta.net/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

Consortium to develop efficient and safe strategies for the production of clinical-grade protein pharmaceuticals in plants, and to define the procedures needed for the production of these proteins in compliance with the strict regulatory standards that govern the manufacture of all pharmaceuticals. Ultimately the consortium aimed to take a candidate product all the way through the development pipeline culminating in a phase I human clinical trial. The consortium has a wide range of expertise spanning the areas of molecular biology, plant biology, immunology, recombinant protein expression technology, vaccinology, and plant biotechnology. The objectives listed at the beginning of the Pharma-Planta project are as follows: # To produce a recombinant pharmaceutical molecule in transgenic plants, which will be developed through all regulatory requirements, GMP (good manufacturing practice) standards and pre-clinical toxicity testing. This will then be evaluated in Phase I human clinical trials. # To develop robust risk assessment practices for recombinant pharmaceutical molecules produced in plants, based on health and environmental impact, working with regulatory authorities within the EU as well as public groups to ensure that the production systems are as safe and as acceptable as possible, and that they comply with all biosafety regulations. # To define and carry out a coordinated program for securing and managing intellectual property that will facilitate the availability of high priority plant-derived recombinant pharmaceuticals to the poor in developing countries while simultaneously allowing the products to be developed commercially in Europe and North America. # To develop and refine new strategies for the expression of recombinant pharmaceuticals in plants, which can be used on a generic basis for molecules that are normally expressed poorly. # To develop and generate transgenic plants expressing a second generation of recombinant molecules that will be used in future clinical trials. In 2011 they reached their benchmark for success launching a phase I clinical study of an antibody that neutralizes HIV, produced in and isolated from tobacco plants. This antibody could one day become an inexpensive component of a microbicide used to prevent the spread of HIV/AIDS. The project has also spun off many additional technologies that are being adopted by researchers all over the world, and has resulted in more than 100 publications in peer-reviewed scientific journals.

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    ReadCube

Cite this (ReadCube, RRID:SCR_013777)

URL: https://www.readcube.com

Resource Type: Resource, software resource

A software resource application which organizes research literature. Users can import PDF articles into the application and create a searchable library. ReadCube enables users to perform keyword searches and provides references as well as note-taking tools. ReadCube also recommends articles to users based on library contents. For publishers, ReadCube enables interactive PDF versions of articles with tools for readers to make notes or perform author and keyword searches.

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    READNA

Cite this (READNA, RRID:SCR_003884)

URL: http://www.cng.fr/READNA/

Resource Type: Resource, organization portal, portal, consortium, data or information resource

Consortium to accelerate new breakthrough DNA sequencing technologies and methods to enhance existing analysis methods. The ultimate aim is to advance DNA sequencing technologies to a level where a human genome can be analyzed at high resolution for less than 1000 euros in less than one day. The goals of the consortium are to revolutionize nucleic acid analysis methods by improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible way, providing methods that allow in situ nucleic acid analysis and methods capable of selectively characterizing mutant DNA in a high background of wildtype DNA, combining RNA and DNA analysis in a single analytical device, providing technology to efficiently analyze DNA methylation (genome-wide, with high resolution and in its long-range context), implementing novel concepts for high-throughput HLA-screening, developing fully integrated solutions for mutational screening of small target regions (such as for screening newborns for cystic fibrosis mutations), developing a device for screening multiple target regions with high accuracy and implementing strategies for effective and high-resolution genotyping of copy number variations. READNA was awarded the Stars of Europe prize in December 2013.

  • From Current Category

Cite this (ShareLaTeX, RRID:SCR_002652)

URL: https://www.sharelatex.com/

Resource Type: Resource, software resource, software application, authoring tool

An collaborative tool which allows users to edit LaTeX documents in their browser. Multiple users can simultaneously access and edit the same LaTeX document and see the changes in real time. The latest version is available online, and the built in chat helps communicate with others while editing.

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    Sparrho

Cite this (Sparrho, RRID:SCR_013782)

URL: http://www.sparrho.com

Resource Type: Resource, software resource

A web application which organizes and recommends new scientific literature to users' news feeds based on keyword searches and user preferences. The site contains materials such as articles, posters, patents, grants, videos, and events.

  • From Current Category

Cite this (Writefull, RRID:SCR_014006)

URL: http://writefullapp.com

Resource Type: Resource, software resource, software application

A software application which provides feedback on writing, wording, and frequency of text by checking against databases of correct language. Users can highlight a chunk of text and use Writefull to see how often the specific text appears in different language databases. Writefull can also offer synonyms and suggestions for wording. Writefull is supported by numerous writing tools which include MS Word and Gmail.

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