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Cite this ( AASK Clinical Trial and Cohort Study , RRID:SCR_006985)


Resource Type: Resource, disease-related portal, topical portal, resource, research forum portal, portal, clinical trial, data or information resource

Clinical trial investigating whether a specific class of antihypertensive drugs (beta-adrenergic blockers, calcium channel blockers, or angiotensin converting enzyme inhibitors) and/or the level of blood pressure would influence progression of hypertensive kidney disease in African Americans. The initiative consisting of 21 clinical centers and a data-coordinating center is followed by a Continuation of AASK Cohort Study to investigate the environmental, socio-economic, genetic, physiologic, and other co-morbid factors that influence progression of kidney disease in a well-characterized cohort of African Americans with hypertensive kidney disease. Only patients who were previously in the randomized trial are eligible for the cohort study. A significant discovery was made in the treatment strategy for slowing kidney disease caused by hypertension. Angiotensin-converting enzyme (ACE) inhibitors, compared with calcium channel blockers, were found to slow kidney disease progression by 36 percent, and they drastically reduced the risk of kidney failure by 48 percent in patients who had at least one gram of protein in the urine, a sign of kidney failure. ACE inhibitors have been the preferred treatment for hypertension caused by diabetes since 1994; however, calcium channel blockers have been particularly effective in controlling blood pressure in African Americans. The AASK study now recommends ACE inhibitors to protect the kidneys from the damaging effects of hypertension. The Continuation of AASK Cohort Study will be followed at the clinical centers. The patients will be provided with the usual clinical care given to all such patients at the respective centers. Baseline demographic information, selected laboratory tests, and other studies are being obtained at the initiation of the Continuation Study. The patients will be seen quarterly at the centers, and some selected studies done at these visits. Samples will be obtained and stored for additional studies and analyses at a later date.

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Cite this (dbGaP at NCBI, RRID:SCR_002709)


Resource Type: Resource, service resource, data or information resource, data repository, storage service resource, database

Database to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype, including genome-wide association studies, medical sequencing, molecular diagnostic assays, and association between genotype and non-clinical traits. dbGaP provides two types of access for users, open and controlled. Summaries of studies and the contents of measured variables as well as original study document text are generally available to the public, while access to individual-level data including phenotypic data tables and genotypes require varying levels of authorization. The data in dbGaP will be pre-competitive, and will not be protected by intellectual property patents. Investigators who agree to the terms of dbGaP data use may not restrict other investigators' use of primary dbGaP data by filing intellectual property patents on it. However, the use of primary data from dbGaP to develop commercial products and tests to meet public health needs is encouraged. Submitters who are not Federally-funded and affiliated with an NIH IC will need to work with an NIH DAC so that proposed submission can be reviewed for consistency with appropriate policies to protect the privacy of research participants and confidentiality of their data. Submissions to dbGaP will not be accepted without assurance that the submitting institution approves the submission and has verified that the data submission is consistent with all applicable laws and regulations, as well as institutional policies. Submitters must also identify any limits on research uses of the data that are specifically set by individual research participants, e.g., through their informed consent. Open-access data can be browsed online or downloaded from dbGaP without prior permission or authorization.

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Cite this ( NIDDKCentral Repository , RRID:SCR_006542)


Resource Type: Resource, resource, database, biomaterial supply resource, biospecimen repository, production service resource, biomaterial manufacture, service resource, material service resource, storage service resource, data repository, material resource, material storage repository, data or information resource

Data, biosample, and genetic repositories to increase the impact of current and previously funded NIDDKstudies, making the data and biospecimens available to the broader scientific community. These Repositories enable scientists not involved in the original study to test new hypotheses without any new data or biospecimen collection, and provide the opportunity to pool data across several studies to increase the power of statistical analyses. In addition, most NIDDK-funded studies are collecting genetic biospecimens and carrying out high-throughput genotyping making it possible for other scientists to use Repository resources to match genotypes to phenotypes and to perform informative genetic analyses. There are three Repositories: * Biosample Repository - Fisher BioServices, Inc (14665 Rothgeb Drive, Rockville, MD 20850) Receives biosamples collected in many different studies, stores the samples under optimal conditions, and distributes them to qualified investigators. * Genetics Repository - Rutgers, The State University of New Jersey (Rutgers Lab)(604 Allison Road, Nelson Labs C112, Piscataway, NJ 08854) Receives blood samples collected in many different studies, and processes them to create immortalized cell lines, and DNA samples. They also cryopreserve blood cells, extract DNA from blood samples, store samples of DNA under optimal conditions, and distribute DNA samples to qualified investigators. * Central Data Repository (CDR) - RTI International (3040 Cornwallis Rd, Research Triangle Park, NC 27709) Receives, archives, maintains and distributes databases or parts of databases from studies. In addition, they analyze stored data in response to inquiries, assist ongoing studies in preparing data for eventual archiving, coordinate cross-referencing between the three Repositories, and maintain the Central Repository website. The NIDDKCentral Repositories have four major components: * An archive of clinical data and documentation from NIDDK-sponsored studies * A collection of biospecimens and an associated database that identifies specimens collected from ongoing and completed studies funded by NIDDKand links them to the associated phenotypic data * A web portal that makes study-specific information within the Repository easily viewable and that accepts electronic requests for biospecimens and data * A collection of genotyping data from GWAS and sequencing studies housed at the National Center for Biotechnology Information's (NCBI) database of Genotypes and Phenotypes (dbGaP)

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