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on page 1 showing 20 out of 52 results from 1 sources

    Alkermes

Cite this (Alkermes, RRID:SCR_010497)

URL: http://www.alkermes.com/

Resource Type: Resource, commercial organization, organization portal, portal, data or information resource

A biopharmaceutical company that focuses on central nervous system (CNS) diseases. The company is the result of a merger between Alkermes, Inc. and Elan Drug Technologies (EDT), the former drug formulation and manufacturing division of Elan Corporation, plc. The company is headquartered in Dublin, and has an R&D center in Waltham, Massachusetts and manufacturing facilities in Athlone, Ireland; Gainesville, Georgia; and Wilmington, Ohio. Alkermes has more than 20 commercial drug products and candidates that address serious and chronic diseases such as addiction, schizophrenia, diabetes and depression. Among these, five products are primary to the company: risperidone Long-Acting Injection (Risperdal Consta) for schizophrenia and bipolar 1 disorder, paliperidone palmitate (Invega Sustenna in the U.S., Xeplion in Europe) for schizophrenia, 4-aminopyridine (Ampyra in the U.S., Fampyra in Europe) to improve walking in patients with multiple sclerosis, naltrexone for extended-release injectable suspension (Vivitrol) for alcohol and opioid dependence, and exenatide extended-release for injectable suspension (Bydureon) for the treatment of type 2 diabetes. Bydureon is a once-weekly, long-acting form of the drug exenatide (Byetta) and was developed through a partnership between Amylin, Alkermes and Eli Lilly. It is approved in Europe and the U.S. (Wikipedia)

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Cite this (Brain and Body Genetic Resource Exchange, RRID:SCR_008959)

URL: https://bbgre.brc.iop.kcl.ac.uk

Resource Type: Resource, data or information resource, database

A database and associated tools for investigating the genetic basis of neurodisability. It combines phenotype information from patients with neurodevelopmental and behavioral problems with clinical genetic data, and displays this information on the human genome map. Basic access to genetic information (deletions, duplications) relating to participants with neurodevelopmental disorders is provided without an account; access to the full dataset requires an account. The genetic information that is available to view comprises potentially pathogenic copy number variation across the genome, detected by array comparative genome hybridization (aCGH) using a customized 44K oligonucleotide array.

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Cite this (BRAIN Initiative, RRID:SCR_006770)

URL: http://www.nih.gov/science/brain/

Resource Type: Resource, organization portal, portal, data or information resource

A research effort to revolutionize understanding of the human mind and uncover ways to treat, prevent, and cure brain disorders like Alzheimer's, schizophrenia, autism, epilepsy, and traumatic brain injury. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that shows how individual cells and complex neural circuits interact in both time and space. Long desired by researchers seeking new ways to treat, cure, and even prevent brain disorders, this picture will fill major gaps in current knowledge and provide opportunities for exploring exactly how the brain enables the human body to record, process, utilize, store, and retrieve vast quantities of information, all at the speed of thought.

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Cite this (BRAINnet-Brain Research And Integrative Neuroscience Network, RRID:SCR_000712)

URL: http://www.brainnet.net

Resource Type: Resource, knowledge environment, data or information resource, funding resource, database

A neuroscience network providing access to a database of brain, cognitive, genomic and clinical data for research and scientific publication. Data include genomic information, electrical measures of brain and body function, structural and functional MRI, and cognitive and medical history. All data are collected using a standardized assessment protocols. These data are from healthy people and those experiencing a range of brain-related illnesses.

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Cite this (BrainNet Europe Sampling Protocols, RRID:SCR_000484)

URL: http://www.brainnet-europe.org/index.php?option=com_content&view=article&id=99&Itemid=99

Resource Type: Resource, protocol

Sampling protocols produced by the BrainNet Europe Consortium generally with five types of dissection and brain processing procedures defined in all disease related protocols. * Fresh brain dissection * Fresh brain processing * Dissection of formalin-fixed brain * Histology and immunohistochemistry * Processing fresh brain

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Cite this (Brain-Net, RRID:SCR_005017)

URL: http://www.brain-net.net/

Resource Type: Resource, biomaterial supply resource, standard specification, narrative resource, brain bank, tissue bank, material resource, data or information resource

A network of several university centers in Germany that classifies neurological and psychiatric disorders neuropathologically and collects and provides brain tissue for research. The aim and task of the Brain-Net are: the collection of clinically and neuropathologically well-characterized brain tissue samples; the standardization of neuropathological diagnoses according to internationally accepted criteria; and providing a basis for future research projects using genetic, epidemiological, biometric and other issues to neurological and psychiatric disorders.

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Cite this (Brain Research Institute Biobank Resources, RRID:SCR_008756)

URL: http://www.bri.ucla.edu/research/resources

Resource Type: Resource, biomaterial supply resource, image collection, tissue bank, brain bank, material resource, data or information resource

Brain bank resources which include postmortem human frozen brain tissue and matched cerebrospinal fluid (CSF) and blood available for scientists to search for etiopathogeneses of human disease. The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid from patients with neurological diseases, including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, and epilepsy, among others. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology. The Neuropathology Laboratory at the UCLA Medical Center maintains a bank of frozen, formalin and paraformaldehyde-fixed and paraffin-embedded postmortem human brain tissues and frozen cerebrospinal fluid (CSF) from patients who die with Alzheimer's disease and other dementing and degenerative illnesses, as well as control materials removed in a similar fashion from patients who are neurologically normal.

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Cite this (Brain Resource Company, RRID:SCR_008019)

URL: http://www.brainresource.com/

Resource Type: Resource, organization portal, assessment test provider, production service resource, training service resource, database, standard specification, narrative resource, service resource, portal, material resource, data or information resource

Commercial provider of cognitive assessments, including their proprietary database, the Brain Resource International Database (BRID). The BRID is a database that allows users to quantify individual differences in brain function, compare individual performance against peers, and provide a robust frame of reference for clinical assessment and treatment decisions. The Brain Resource International Database provides evidence for the brain-behavior connection so important to reliably enabling optimal solutions for mental health and wellbeing. It powers all Brain Resource products. The database has collected over 50,000 datasets. There are over 4,000 healthy controls from the age of 6-100 in our normative database as well as large and growing clinical databases in Depression, Schizophrenia, Mild Cognitive Impairment, PTSD, ADHD and Brain Injury. Test standardization ensures total quality control and robust representative profiles in each disorder.

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Cite this (BrainSpan: Atlas of the Developing Human Brain, RRID:SCR_008083)

URL: http://brainspan.org/

Resource Type: Resource, atlas, expression atlas, reference atlas, data or information resource

An atlas of the developing human brain designed as a foundational resource for studying transcriptional mechanisms involved in human brain development. The atlas consists of a variety of data modalities and data mining tools. It contains RNA sequencing and exon microarray data profiling up to sixteen cortical and subcortical structures across the full course of human brain development, as well as high-resolution neuroanatomical transcriptional profiles of about 300 distinct structures spanning the entire brain for four midgestional prenatal specimens. Also included are a high-resolution in situ hybridization image data covering selected genes and brain regions in developing and adult human brain, and a reference atlas in full color with high-resolution anatomic reference atlases of prenatal (two stages) and adult human brain along with supporting histology, magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) data.

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Cite this (Brain Test, RRID:SCR_006212)

URL: https://www.braintest.org/brain_test/BrainTest

Resource Type: Resource, topical portal, portal, data or information resource

A portal of online studies that encourage community participation to tackle the most challenging problems in neuropsychiatry, including attention-deficit / hyperactivity disorder, schizophrenia, and bipolar disorder. Our approach is to engage the community and try to recruit tens of thousands of people to spend an hour of their time on our site. You folks will provide data in both brain tests and questionnaires, as well as DNA, and in return, we will provide some information about your brain and behavior. You will also be entered to win amazon.com gift cards. While large collaborative efforts were made in genetics in order to discover the secrets of the human genome, there are still many mysteries about the behaviors that are seen in complex neuropsychiatric syndromes and the underlying biology that gives rise to these behaviors. We know that it will require studying tens of thousands of people to begin to answer these questions. Having you, the public, as a research partner is the only way to achieve that kind of investment. This site will try to reach that goal, by combining high-throughput behavioral assessment using questionnaires and game-like cognitive tests. You provide the data and then we will provide information and feedback about why you should help us achieve our goals and how it benefits everyone in the world. We believe that through this online study, we can better understand memory and attention behaviors in the general population and their genetic basis, which will in turn allow us to better characterize how these behaviors go awry in people who suffer from mental illness. In the end, we hope this will provide better, more personalized treatment options, and ultimately prevention of these widespread and extremely debilitating brain diseases. We will use the data we collect to try to identify the genetic basis for memory and impulse control, for example. If we can achieve this goal, maybe we can then do more targeted research to understand how the biology goes awry in people who have problems with cognition, including memory and impulse control, like those diagnosed with ADHD, Schizophrenia, Bipolar Disorder, and Autism Spectrum Disorders. By participating in our research, you can learn about mental illness and health and help researchers tackle these complex problems. We can''t do it without your help.

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Cite this (CANDI Share: Schizophrenia Bulletin 2008, RRID:SCR_009451)

URL: http://www.nitrc.org/projects/cs_schizbull08/

Resource Type: Resource, data set, data or information resource

This project hosts data for CANDI Share Schizophrenia Bulletin 2008 (reference below) as part of the CANDI Neuroimaging Access Point. This set includes preprocessed MRI images and segmentation results of all 4 diagnostic groups (Healthy Controls, N=29; Schizophrenia Spectrum, N=20; Bipolar Disorder with Psychosis, N=19; and Bipolar Disorder without Psychosis, N=35). Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophr Bull. 2008 Jan;34(1):37-46.

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Cite this (CATIE - Clinical Antipsychotic Trials in Intervention Effectiveness, RRID:SCR_005615)

URL: https://clinicaltrials.gov/ct2/show/NCT00014001

Resource Type: Resource, clinical trial

The NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Study was a nationwide public health-focused clinical trial that compared the effectiveness of older (first available in the 1950s) and newer (available since the 1990s) antipsychotic medications used to treat schizophrenia. These newer medications, known as atypical antipsychotics, cost roughly 10 times as much as the older medications. CATIE is the largest, longest, and most comprehensive independent trial ever done to examine existing therapies for this disease. Schizophrenia is a brain disorder characterized by hallucinations, delusions, and disordered thinking. The course of schizophrenia is variable, but usually is recurrent and chronic, often causing severe disability. Previous studies have shown that taking antipsychotic medications consistently is far more effective than taking no medicine and that the drugs are necessary to manage the disease. The aim of the CATIE study was to determine which medications provide the best treatment for schizophrenia. Additional information may be found by following the links, http://www.nimh.nih.gov/trials/practical/catie/index.shtml, http://www.clinicaltrials.gov/ct/show/NCT00014001?order=1

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Cite this (CNSforum: Image Bank, RRID:SCR_002718)

URL: http://www.cnsforum.com/educationalresources/imagebank/

Resource Type: Resource, image collection, data or information resource

A collection of downloadable central nervous system (CNS) images for teaching, presentations, articles, and other purposes. The following major categories of images are as follows: Brain anatomy, Brain physiology, Anxiety, Depression, Schizophrenia, Dementia, Parkinson's disease, Stroke, and Others.

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    COBRE

Cite this (COBRE, RRID:SCR_010482)

URL: http://fcon_1000.projects.nitrc.org/indi/retro/cobre.html

Resource Type: Resource, data set, data or information resource

Data set of raw anatomical and functional MR data from 72 patients with Schizophrenia and 75 healthy controls (ages ranging from 18 to 65 in each group). All subjects were screened and excluded if they had: history of neurological disorder, history of mental retardation, history of severe head trauma with more than 5 minutes loss of consciousness, history of substance abuse or dependence within the last 12 months. Diagnostic information was collected using the Structured Clinical Interview used for DSM Disorders (SCID). A multi-echo MPRAGE (MEMPR) sequence was used with the following parameters: TR/TE/TI = 2530/(1.64, 3.5, 5.36, 7.22, 9.08)/900 ms, flip angle = 7??, FOV = 256x256 mm, Slab thickness = 176 mm, Matrix = 256x256x176, Voxel size =1x1x1 mm, Number of echos = 5, Pixel bandwidth =650 Hz, Total scan time = 6 min. With 5 echoes, the TR, TI and time to encode partitions for the MEMPR are similar to that of a conventional MPRAGE, resulting in similar GM/WM/CSF contrast. Rest data was collected with single-shot full k-space echo-planar imaging (EPI) with ramp sampling correction using the intercomissural line (AC-PC) as a reference (TR: 2 s, TE: 29 ms, matrix size: 64x64, 32 slices, voxel size: 3x3x4 mm3). Slice Acquisition Order: Rest scan - collected in the Axial plane - series ascending - multi slice mode - interleaved MPRAGE - collected in the Sag plane - series interleaved - multi slice mode - single shot The following data are released for every participant: * Resting fMRI * Anatomical MRI * Phenotypic data for every participant including: gender, age, handedness and diagnostic information.

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Cite this (deCODE genetics, RRID:SCR_003334)

URL: http://www.decode.com/

Resource Type: Resource, commercial organization, organization portal, portal, data or information resource

A biopharmaceutical company applying its discoveries in human genetics to develop drugs and diagnostics for common diseases. They specialize in gene discovery - their population approach and resources have enabled them to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer. The company's genotyping capacity is now one of the highest in the world. They have a large population-based biobank containing whole blood and DNA samples with extensive relevant phenotypic information from around 120.000 Icelanders. In the company's work in more than 50 disease projects, their statistical and informatics departments have established themselves in data processing and analysis. deCODE genetics is widely recognized as a center of excellence in genetic research.

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Cite this (Genes Cognition and Psychosis Program, RRID:SCR_006292)

URL: http://intramural.nimh.nih.gov/gcap/index.htm

Resource Type: Resource, disease-related portal, topical portal, portal, data or information resource

Schizophrenia related portal that aims to solve the mystery of genetic predisposition to psychosis, develop new methods for early diagnosis and prevention, and discover new treatments that will cure people suffering from it. Our objectives are to fully characterize: # neurobiological mechanisms related to susceptibility genes for schizophrenia and related clinical disorders; # genetic variation in aspects of cognition and emotionality associated with schizophrenia; and # small molecular targets for novel therapies. A unique feature of this Program is that its diverse scientific resources will be focused on a highly specific scientific agenda, that is to acquire the critical biological information about the susceptibility genes associated with schizophrenia and related illnesses. Our mission and goal, to understand the basic mechanisms of serious mental illness, has again guided us into new areas of research and to new insights. We have found evidence of new genes implicated in the cause of schizophrenia and involved in brain functions related to cognition and emotion and we have begun to explore how genes interact with each other and with the environment to individualize risk for these conditions. We are working now with over 20 genes related to schizophrenia. One of the key developments in our research over the past year has been the emergence of some targets for the development of novel therapeutics. We have discovered a new schizophrenia susceptibility gene, KCNH2, which represents the first clear target for the development of novel treatments. Just in this past year, for example, we published the first extensive statistical analysis of how schizophrenia genes may vary in their risk effects based on different genetic background (Nicodemus et al Hum Gen 2006), the first studies of schizophrenia genes interacting in effecting gene expression in brain (Lipska et al Hum Mol Genetics 2006a, Lipska et al Hum Mol Gen 2006 b); the first evidence that the mechanism of genetic association of NRG1 with schizophrenia involves a novel isoform of the gene in human brain (Law et al PNAS 2006), and the first evidence that MAOA may be linked to mood and impulse control because it effects critical mood regulatory neural networks (Meyer-Lindenberg et al PNAS 2006).

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    GWASrap

Cite this (GWASrap, RRID:SCR_013144)

URL: http://jjwanglab.org/gwasrap

Resource Type: Resource, data analysis service, data access protocol, production service resource, analysis service resource, data set, web service, service resource, software resource, data or information resource

GWASrap is a comprehensive web-based bioinformatics tool to systematically support variant representation, annotation and prioritization for data generated from genome-wide association studies (GWAS) and Next Generation Sequencing (NGS). Our web-based framework utilizes state-of-the-art web technologies to maximize user interaction and visualization of the results. For a given SNP dataset with its P-values, GWASrap will first provide a Circos-style plot to visualize any genetic variants at either the genome or chromosome level. The tool then combines different genomic features (SNP/CNV density, disease susceptibility loci, etc.) with comprehensive annotations that give the researcher an intuitive view of the functional significance of the different genomic regions. The detailed statistics of the underlying study are also displayed on the web page, including variant distribution in different functional categories, classic Manhattan plot and QQ plot. Users can perform interactive operations in the Manhattan panel, such as zooming in and out to search regions or markers of interest. The system can also display a comprehensive range of relevant information from variant genetic attributes to nearby genomic elements, such as enhancers or non-coding RNAs. Furthermore, researchers can obtain extensive functional predictions for various features including transcription factor-binding sites, miRNA and miRNA target sites, and their predicted changes caused by the genetic variants. Our system can re-prioritize genetic variants by combining the original statistical value and variant prioritization score based on a simple additive effect equation. Researchers can also re-evaluate the significance of a trait/disease-associated SNP (TAS) using the dynamic linkage disequilibrium (LD) panel or the tree-like network panel. The GWASrap supports input variants in different formats, not only common variants with a dbSNP rs ID but also rare variants from NGS data, which are represented by chromosome and locations. GWASrap provides a range of web services for data retrieving about the annotation information and effect prediction of each variant in dbSNP using the SOAP interface. The WSDL for each service is available in the API tab. Each service returns JSON string including all related information with key/value. GWASrap provides running results about some current published GWAS as well as a category view for each hot disease / trait. The dataset is brought from published database GWAS or curated from literature.

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Cite this (Harvard Brain Tissue Resource Center, RRID:SCR_003316)

URL: http://www.brainbank.mclean.org/

Resource Type: Resource, biomaterial supply resource, biospecimen repository, tissue bank, service resource, brain bank, storage service resource, material resource, material storage repository

A biomaterial supply resource that acquires, processes, stores, and distributes postmortem brain specimens for brain research. Various types of brain tissue are collected, including those with neurological and psychiatric disorders, along with their parents, siblings and offspring. The HBTRC maintains an extensive collection of postmortem human brains from individuals with Huntington's chorea, Alzheimer's disease, Parkinson's disease, and other neurological disorders. In addition, the HBTRC also has a collection of normal-control specimens.

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Cite this (Heptares Therapeutics, RRID:SCR_000499)

URL: http://www.heptares.com/

Resource Type: Resource, organization portal, portal, data or information resource

A drug discovery company focused on small-molecule drugs targeting G-protein-coupled receptors (GPCRs), the largest family of druggable targets. Heptares creates new medicines targeting previously undruggable or challenging GPCRs, a superfamily of receptors linked to many diseases. They are pioneering a structure-based drug design approach to GPCRs, leveraging proprietary technologies for protein stabilization, structure determination, and fragment-based discovery. Their partners include Cubist, MorphoSys, AstraZeneca, MedImmune and Takeda. Their objective is to build a broad pipeline of novel medicines to transform the treatment of serious diseases, including Alzheimer's disease, schizophrenia, diabetes, ADHD and chronic migraine.

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Cite this (Human Imaging Database, RRID:SCR_006126)

URL: http://www.birncommunity.org/tools-catalog/human-imaging-database-hid/

Resource Type: Resource, source code, database, software application, data management software, service resource, storage service resource, software resource, image repository, data repository, data or information resource

THIS RESOURCE IS NO LONGER AVAILABLE. Documented October 5, 2017.

Database management system developed to handle the increasingly large and diverse datasets collected as part of the MBIRN and FBIRN collaboratories and throughout clinical imaging communities at large. The HID can be extended to contain relevant information concerning experimental subjects, assessments of subjects, the experimental data collected, the experimental protocols, and other metadata normally included with experiments.

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