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on page 1 showing 20 out of 34 results from 1 sources

    Alkermes

Cite this (Alkermes, RRID:SCR_010497)

URL: http://www.alkermes.com/

Resource Type: Resource, portal, organization portal, commercial organization, data or information resource

A biopharmaceutical company that focuses on central nervous system (CNS) diseases. The company is the result of a merger between Alkermes, Inc. and Elan Drug Technologies (EDT), the former drug formulation and manufacturing division of Elan Corporation, plc. The company is headquartered in Dublin, and has an R&D center in Waltham, Massachusetts and manufacturing facilities in Athlone, Ireland; Gainesville, Georgia; and Wilmington, Ohio. Alkermes has more than 20 commercial drug products and candidates that address serious and chronic diseases such as addiction, schizophrenia, diabetes and depression. Among these, five products are primary to the company: risperidone Long-Acting Injection (Risperdal Consta) for schizophrenia and bipolar 1 disorder, paliperidone palmitate (Invega Sustenna in the U.S., Xeplion in Europe) for schizophrenia, 4-aminopyridine (Ampyra in the U.S., Fampyra in Europe) to improve walking in patients with multiple sclerosis, naltrexone for extended-release injectable suspension (Vivitrol) for alcohol and opioid dependence, and exenatide extended-release for injectable suspension (Bydureon) for the treatment of type 2 diabetes. Bydureon is a once-weekly, long-acting form of the drug exenatide (Byetta) and was developed through a partnership between Amylin, Alkermes and Eli Lilly. It is approved in Europe and the U.S. (Wikipedia)

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Cite this (Beck Hopelessness Scale, RRID:SCR_003683)

URL: http://www.pearsonclinical.com/education/products/100000105/beck-hopelessness-scale-bhs.html

Resource Type: Resource, material resource, commercial organization, assessment test provider

20-item clinical assessment to measure key aspects of hopelessness: feelings about the future, loss of motivation, and expectations. It takes 5 to 10 minutes is self-administered or verbally administered by a trained administrator.

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Cite this (Brain Health Registry, RRID:SCR_010230)

URL: http://brainhealthregistry.org/

Resource Type: Resource, people resource, patient registry

A website aimed at recruiting and assessing subjects for all types of neuroscience studies with the internet. The hope is to accelerate various types of observational studies and clinical trials, and also reduce costs. They are interested in having people, including healthy subjects of all ages, join the registry. Joining only takes a few minutes. The web-based project is designed to speed up cures for Alzheimer's, Parkinson's and other brain disorders. It uses online questionnaires and online neuropsychological tests (which are very much like online brain games).

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Cite this (BrainNet Europe Sampling Protocols, RRID:SCR_000484)

URL: http://www.brainnet-europe.org/index.php?option=com_content&view=article&id=99&Itemid=99

Resource Type: Resource, protocol

Sampling protocols produced by the BrainNet Europe Consortium generally with five types of dissection and brain processing procedures defined in all disease related protocols. * Fresh brain dissection * Fresh brain processing * Dissection of formalin-fixed brain * Histology and immunohistochemistry * Processing fresh brain

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Cite this (Brain Research Institute Biobank Resources, RRID:SCR_008756)

URL: http://www.bri.ucla.edu/research/resources

Resource Type: Resource, biomaterial supply resource, image collection, tissue bank, brain bank, material resource, data or information resource

Brain bank resources which include postmortem human frozen brain tissue and matched cerebrospinal fluid (CSF) and blood available for scientists to search for etiopathogeneses of human disease. The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid from patients with neurological diseases, including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, and epilepsy, among others. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology. The Neuropathology Laboratory at the UCLA Medical Center maintains a bank of frozen, formalin and paraformaldehyde-fixed and paraffin-embedded postmortem human brain tissues and frozen cerebrospinal fluid (CSF) from patients who die with Alzheimer's disease and other dementing and degenerative illnesses, as well as control materials removed in a similar fashion from patients who are neurologically normal.

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Cite this (Brain Resource Company, RRID:SCR_008019)

URL: http://www.brainresource.com/

Resource Type: Resource, organization portal, assessment test provider, production service resource, training service resource, database, standard specification, narrative resource, service resource, portal, material resource, data or information resource

Commercial provider of cognitive assessments, including their proprietary database, the Brain Resource International Database (BRID). The BRID is a database that allows users to quantify individual differences in brain function, compare individual performance against peers, and provide a robust frame of reference for clinical assessment and treatment decisions. The Brain Resource International Database provides evidence for the brain-behavior connection so important to reliably enabling optimal solutions for mental health and wellbeing. It powers all Brain Resource products. The database has collected over 50,000 datasets. There are over 4,000 healthy controls from the age of 6-100 in our normative database as well as large and growing clinical databases in Depression, Schizophrenia, Mild Cognitive Impairment, PTSD, ADHD and Brain Injury. Test standardization ensures total quality control and robust representative profiles in each disorder.

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Cite this (Brain Resource, RRID:SCR_006172)

URL: http://www.brainresource.com/

Resource Type: Resource, organization portal, assessment test provider, database, training service resource, standard specification, narrative resource, service resource, portal, material resource, data or information resource

Create brain products for everyday life which help people train for peak brain health and fitness; reduce stress simply and objectively; provide rapid assessment of brain strengths & weaknesses; and enable landmark tests to predict treatment in Depression and ADHD. Brain Resource uses their international human brain database to make sense of the brain''s complexities and provide a coherent model for measuring brain health. Healthcare stakeholders need timely, evidence-based data and reliable benchmarks in order to improve the way decisions are made in brain health. We empower clinicians, employers, researchers, pharmaceutical companies, health plans and individuals with access to personalized, validated and actionable data. Our cross-disciplinary and multi-dimensional approach has produced a standard for testing and analyzing how the brain works across the lifespan and under varying conditions, influences and compounds. Users tap into this resource by completing assessments which capture the brain basis of an individual''s emotion, thinking and feeling processes, and how they regulate them compared to their peers. What are the interrelationships between genetics, brain structure, brain function, lifestyle and emotions that affect the way we think and behave? How do you determine who is at risk or whether a treatment is working, or when someone is well? The Brain Resource International Database (BRID) is unique in its breadth of measures, it''s power and scope. Evidence-based reports from Brain Resource, underpinned by this great database, can help you find meaningful answers to those questions faster, safer and more cost-effectively than ever before. Brain Resource also undertakes large scale personalized medicine trials including the largest treatment marker study in Depression and ADHD - iSPOT. The findings from these studies have the potential to set a new standard for drug discovery in brain disorders.

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Cite this (Brief Psychiatric Rating Scale, RRID:SCR_003657)

URL: http://www.public-health.uiowa.edu/icmha/outreach/documents/bprs_expanded.pdf

Resource Type: Resource, material resource, assessment test provider

Assessment scale to measure the psychiatric symptoms of patients who might have psychiatric symptoms including depression, anxiety, hallucinations, and strange or unusual behaviors. The symptoms of the patient are rated between 1 and 7 and then the 18-24 items/symptoms are scored and combined to create the final score of the patient. This scale is similar to the PANSS, SANS, and SAPS.

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Cite this (CBU Imaging Wiki, RRID:SCR_003014)

URL: http://www.mrc-cbu.cam.ac.uk/Imaging

Resource Type: Resource, topical portal, portal, data or information resource

Portal where neuroimaging studies are carried out using a Siemens 3T Tim Trio Magnetic Resonance Imaging (or MRI) scanner that is wholly dedicated to studies in Cognitive Neuroscience. From emotions and memories to language and learning, functional neuroimaging is being applied in many different areas of Cognitive Neuroscience. In many cases, this research relies upon support from healthy volunteers although neuroimaging studies are also being conducted in various clinical populations, including depression, anxiety, Parkinson's disease and Alzheimer's disease.

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Cite this (Center for Imaging of Neurodegenerative Diseases, RRID:SCR_001968)

URL: http://www.radiology.ucsf.edu/cind

Resource Type: Resource, biomedical technology research center, training resource

Biomedical technology research center that develops and validates new imaging methods for detecting brain abnormalities in neurodegenerative diseases, including Alzheimer's disease, vascular dementia, frontotemporal dementia, Parkinson's disease, as well as epilepsy, depression, and other conditions associated with nerve loss in the brain. As people around the globe live longer, the impact of neurodegenerative diseases is expected to increase further with dire social and economical consequences for societies if no effective treatments are developed soon. The development at CIND is aimed to improve magnetic resonance imaging (MRI). The ultimate goal of the scientific program is to identify imaging markers that improve accuracy in diagnosing neurodegenerative diseases at early stages, achieve more reliable prognoses of disease progression, and facilitate the discovery of effective treatment interventions. In addition to addressing the general needs for studying neurodegenerative diseases, another focus of CIND concerns brain diseases associated with military service and war combat, such as post traumatic stress disorder (PTSD), brain trauma, gulf war illness and the long-term effects of these conditions on the mental health of veterans. The symbiosis between CIND and the Veterans Administration Medical Center in San Francisco makes this program uniquely suited to serve military veterans.

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Cite this (CERAD - Consortium to Establish a Registry for Alzheimer's Disease, RRID:SCR_003016)

URL: http://cerad.mc.duke.edu/

Resource Type: Resource, organization portal, assessment test provider, database, consortium, portal, material resource, data or information resource

Consortium that developed brief, standardized and reliable procedures for the evaluation and diagnosis of patients with Alzheimer's disease (AD) and other dementias of the elderly. These procedures included data forms, flipbooks, guidebooks, brochures, instruction manuals and demonstration tapes, which are now available for purchase. The CERAD assessment material can be used for research purposes as well as for patient care. CERAD has developed several basic standardized instruments, each consisting of brief forms designed to gather data on normal persons as well as on cognitively impaired or behaviorally disturbed individuals. Such data permit the identification of dementia based on clinical, neuropsychological, behavioral or neuropathological criteria. Staff at participating CERAD sites were trained and certified to administer the assessment instruments and to evaluate the subjects enrolled in the study. Cases and controls were evaluated at entry and annually thereafter including (when possible) autopsy examination of the brain to track the natural progression of AD and to obtain neuropathological confirmation of the clinical diagnosis. The CERAD database has become a major resource for research in Alzheimer's disease. It contains longitudinal data for periods as long as seven years on the natural progression of the disorder as well as information on clinical and neuropsychological changes and neuropathological manifestations.

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Cite this (CNSforum: Image Bank, RRID:SCR_002718)

URL: http://www.cnsforum.com/educationalresources/imagebank/

Resource Type: Resource, image collection, data or information resource

A collection of downloadable central nervous system (CNS) images for teaching, presentations, articles, and other purposes. The following major categories of images are as follows: Brain anatomy, Brain physiology, Anxiety, Depression, Schizophrenia, Dementia, Parkinson's disease, Stroke, and Others.

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Cite this (DepressionTools.org Clinical Significance Calculator, RRID:SCR_003873)

URL: http://www.depressiontools.org/

Resource Type: Resource, analysis service resource, data analysis service, service resource, production service resource

Online instrument that estimates whether a biomarker predicting outcome of depression treatment is likely to be clinically significant.

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Cite this (Edinburgh Postnatal Depression Scale, RRID:SCR_003685)

URL: http://www.fresno.ucsf.edu/pediatrics/downloads/edinburghscale.pdf

Resource Type: Resource, material resource, assessment test provider

A 10 item assessment scale developed to identify women who have postpartum depression (PPD). Items of the scale correspond to various clinical depression symptoms, such as guilt feeling, sleep disturbance, low energy, anhedonia, and suicidal ideation. Overall assessment is done by total score, which is determined by adding together the scores for each of the 10 items. Higher scores indicate more depressive symptoms. The EPDS may be used within 8 weeks postpartum and it also can be applied for depression screening during pregnancy. (Adapted from Wikipedia) Scoring: * 0-9 Not Likely to Have Depression * 10-30 Likely to Have Depression

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Cite this (Hamilton Rating Scale for Depression, RRID:SCR_003686)

URL: http://serene.me.uk/tests/ham-d.pdf

Resource Type: Resource, material resource, assessment test provider

A multiple question assessment scale used to provide an indication of depression and serves as a way to evaluate recovery in patients. It is designed for adults and is used to rate the severity of their depression by probing mood, feelings of guilt, suicide ideation, insomnia, agitation or retardation, anxiety, weight loss, and somatic symptoms. It was designed to be administered by a trained professional using a semi-structured interview. Although Hamilton's original scale had 17 items, other versions were developed to include up to 29 items (HRSD-29).(Adapted from Wikipedia) It takes about 20 minutes to complete the interview and score the results. Scoring: * 0-7 Normal * 8-13 Mild * 14-18 Moderate * 19-22 Severe * > or = 23 Very Severe

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Cite this (Hospital Anxiety and Depression Scale, RRID:SCR_003665)

URL: http://www.hawkesbay.health.nz/file/fileid/47359

Resource Type: Resource, material resource, assessment test provider

Assessment scale commonly used in hospitals to determine the anxiety and depression levels that a patient is experiencing. It contains 14 items, 7 of which are questions about anxiety and the other 7 are about depression.

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Cite this (Hungarian Neurological-Psychiatric Biobank, RRID:SCR_003715)

URL: http://www.mknt.hu/sites/default/files/NEPSYBANK_0.doc

Resource Type: Resource, biomaterial supply resource, material resource, tissue bank, data or information resource

The Hungarian Society of Clinical Neurgenetics established a nationwide collaboration for prospective collection of human biological materials and databases from patient with neurological and psychiatric diseases. The basic triangle of the NEPSYBANK is the sample, the information and the study management. The present participants of the NEPSYBANK are the Department of Neurology and Psychiatry of the four Medical Universities (in Budapest, Debrecen, Pecs, Szeged) and the National Institute of Psychiatry and Neurology in Budapest. The NEPSYBANK is a disease based biobank collecting both phenotypical and environmental data and biological materials such as DNA/RNA, whole blood, plasma, cerebral spinal fluid, muscle / nerve / skin biopsy, brain, and fibroblast. The target of the diseases is presently (Phase I): stroke syndromes, dementias, movement disorders, motoneuron diseases, epilepsy, multiple sclerosis, schizophrenia, alcohol addiction. In the near future (Phase II.) it is planned to enlarge the scale with headaches, disorders of the peripheral nerves, disorders of neuromuscular transmission, disorders of skeletal muscle, depression, anxiety. DNA/RNA is usually extracted from whole blood, but occasionally different tissues such as muscle, brain etc. can be used as well. The extracting procedures differ among the institutes, but in all cases the concentration and the quality of the DNA/RNA must be registered in the database. Participating institutional biobanks have committed themselves to follow common quality standards, which provide access to samples after prioritization on scientific grounds only. In every case the following data are registered. 1. General data: main bank categories, age, sex, ethnicity, body height, body weight, economic stats, education, type of place of living, marital status, birth complications, alcohol, drugs, smoking. 2. Sample properties (sample ID, type of sample, date of extraction, concentration, and level of purity). General patient data as blood pressure, heart rate, internal medical status, ECG, additional diseases. Disease specific question e.g. in schizophrenia the diagnosis after DSMIV and ICD 10, detailed diagnostic questions after both classification, detailed psychiatric and neurological status, laboratory findings, rating scales, data of neuroimaging, genetic tests, applied medication (with generic name, dose, duration), adverse drug effects and other treatments. The Biobank Information Management System (BIMS) is responsible for linkage of databases containing information on the individual sample donors. If you want to have samples from the NEPSYBANK an application must be submitted containing the following information: short research plan including aims and study design, ethic application with a positive decision, specific demands regarding the right of disposition, agreements with grant organizations which regulate immaterial property, information about financing (academic grants, support from industry). All participants have the right to withdraw their samples through a simple order.

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Cite this (Kutcher Adolescent Depression Scale, RRID:SCR_003687)

URL: http://www.teenmentalhealth.org/images/resources/CAPN_11Item_KADS.pdf

Resource Type: Resource, material resource, assessment test provider

A psychological self-rating scale developed by Dalhousie University professor of psychiatry Stan Kutcher, to assess the level of depression in adolescents. While there are some variations, the 11-item version of the KADS is the most commonly used and most thoroughly verified for efficacy in monitoring outcomes in adolescents who are receiving treatment for major depressive disorder. Its items are worded using standard and colloquial terminology, and responses are scored on a simple 4 choice scale. There are ten questions about depression symptom frequency that the patient rates on a straight 4 point scale according to the following choices: hardly ever, much of the time, most of the time, all the time, and one question relating to the severity of suicidal ideation. Scores on the test range from 0 to 33. Unlike some rating scales, there is no threshold for sub-clinical presentation, or ranges for mild, moderate, and severe symptoms. Higher scores simply indicate more severe current depression symptoms. (Adapted from Wikipedia)

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    LEAD-DBS

Cite this (LEAD-DBS, RRID:SCR_002915)

URL: http://www.lead-dbs.org/

Resource Type: Resource, software resource, software toolkit

MATLAB toolbox for deep-brain-stimulation (DBS) electrode reconstructions and visualizations based on postoperative MRI and computed tomography (CT) imaging. The toolbox also facilitates visualization of localization results in 2D/3D, analysis of DBS-electrode placement's effects on clinical results, simulation of DBS stimulations, diffusion tensor imaging (DTI) based connectivity estimates, and fiber-tracking from the VAT to other brain regions (connectomic surgery).

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Cite this (Limited Access Datasets From NIMH Clinical Trials, RRID:SCR_005614)

URL: http://www.nimh.nih.gov/funding/clinical-trials-for-researchers/datasets/nimh-procedures-for-requesting-data-sets.shtml

Resource Type: Resource, data set, data or information resource

A listing of data sets from NIMH-supported clinical trials. Limited Access Datasets are available from numerous NIMH studies. NIMH requires all investigators seeking access to data from NIMH-supported trials held by NIMH to execute and submit as their request the appropriate Data Use Certification pertaining to the trial. The datasets distributed by NIMH are referred to as limited access datasets because access is limited to qualified researchers who complete Data Use Certifications.

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