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on page 1 showing 20 out of 35 results from 1 sources

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Clinical Translational Core , RRID:SCR_015391)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/ClinicalTranslationalCore

Resource Type: Resource, service resource, resource, core facility, access service resource

Core whose services include biospecimen collection and storage, development of lung imaging outcomes, imaging training, and biostatical analysis.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Histology Core , RRID:SCR_015385)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/histology-core

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides light microscopy services like prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections, as well as specialized and routine fixation, tissues processing, ultramicrotomy, staining, photomicrograph production, and analysis.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Michael Hooker Microscopy Core Facility , RRID:SCR_015390)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/michael-hooker-microscopy-core

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides advanced digital light microscopy, image processing and analysis resources for users from the UNC Chapel Hill campus. It also offers instrumentation and instruction to enable users to acquire, process and analyze images from a wide variety of sample types.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Molecular Biology Core , RRID:SCR_015384)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/molecular-biology-core

Resource Type: Resource, service resource, resource, core facility, access service resource

Core facility that provides expertise, equipment, training, and reagents to serve the molecular biology needs for cystic fibrosis research.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mouse Models Core , RRID:SCR_015389)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/mousemodelscore

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides support and expertise for mouse colony maintenance, breeding strategies, mouse lung phenotyping protocols, and submission of live-animal applications to maintain compliance with IACUC guidelines.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mucus and Mucin Biochemistry and Biophysics Core , RRID:SCR_015393)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/mucuscore

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides a service to quantify the concentration of given mucus samples for both total mucus concentration and the absolute relative contributions of each secreted mucin. It also provides quantitation of extracellular DNA. The mucus biphysics subcore component, provides core users with information on the biophysical properties of the mucus layer and its interaction with the cell surface.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Pre-Clinical Core , RRID:SCR_015387)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/pre-clinical-core

Resource Type: Resource, service resource, resource, core facility, access service resource

Core whose objectives include evaluation of pre-clinical drug candidates in vitro, pre-clinical drug candidates ex vivo, and pre-clinical drug candidates in vivo.

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Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center , RRID:SCR_015388)

URL: https://www.med.unc.edu/marsicolunginstitute

Resource Type: Resource, disease-related portal, topical portal, resource, service resource, portal, access service resource, data or information resource

Research team dedicated to finding a cure for cystic fibrosis lung disease. This team utilizes ion transport physiology, transgenic and gene-targeted mouse models, Phase I clinical trials, and more to research this cause.

  • From Current Category

Cite this ( Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Tissue Procurement and Cell Culture Core , RRID:SCR_015394)

URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/TissueProcurmentandCellCultureCore

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides standardized cell cultures for cystic fibrosis research, notably normal, cystic fibrosis and disease control cells, tissues and fluids. Its functions include tissue procurement, airway epithelial cell isolation and culture, collecting airway surface liquid from in vivo and in vitro samples, genetic manipulation of cell cultures, creating and characterizing novel cell lines, and translation of technology and reagents to the greater cystic fibrosis research community.

  • From Current Category

Cite this ( Cystic Fibrosis Center - University of California San Francisco , RRID:SCR_015398)

URL: http://globalprojects.ucsf.edu/project/novel-small-molecule-therapies-cystic-fibrosis

Resource Type: Resource, disease-related portal, topical portal, resource, service resource, portal, access service resource, data or information resource

Research center that focuses on developing novel therapies for cystic fibrosis, enhancing research projects examining the mechanisms of the disease, and developing new small-molecule therapies that can be translated into the clinic.

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Cite this ( Cystic Fibrosis Center University of Pittsburgh , RRID:SCR_015400)

URL: http://www.cfrc.pitt.edu/index.html

Resource Type: Resource, disease-related portal, topical portal, resource, service resource, portal, access service resource, data or information resource

Research center whose goal is to understand and translate the basic mechanisms of cystic fibrosis. It uses the molecular and cell biology of CFTR, CFTR mutants, infection, and inflammation with the overall theme of translating preclinical science into clinical investigations.

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Cite this ( Cystic Fibrosis Center - University of Washington Administrative and Enrichment Core , RRID:SCR_015408)

URL: http://depts.washington.edu/cfrtc/administrative-core/

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that manages and oversees the UW CFRTC and its cores and pilot and feasibility programs.

  • From Current Category

Cite this ( Cystic Fibrosis Center - University of Washington Clinical Core , RRID:SCR_015402)

URL: http://depts.washington.edu/cfrtc/clinical/

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that aims to provide preclinical support for novel therapeutics, work with other biomedical cores to enhance and support bacterial and human specimen repositories, and support developmental research and training.

  • From Current Category

Cite this ( Cystic Fibrosis Center - University of Washington Genomics Core , RRID:SCR_015404)

URL: http://depts.washington.edu/cfrtc/genomics/

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides genomics-based tools, data management and analysis tools, and creates platforms that integrate data from the Clinical and Immunology Cores for human samples and bacterial isolates. Its services include consultation and experimental design assistance for using new-generation sequencing technology, data analysis, bioinformatic support, data access and storage, high throughput and new-generation whole-genome sequencing, and RNA-seq analysis of transcriptomes.

  • From Current Category

Cite this ( Cystic Fibrosis Center - University of Washington Host Response Core , RRID:SCR_015405)

URL: http://depts.washington.edu/cfrtc/inflammation/

Resource Type: Resource, service resource, resource, core facility, access service resource

Core whose objective is to obtain information on relevant parameters of the host response that is unique to cystic fibrosis using a variety of techniques, including in vivo and in vitro imaging, immunohistochemistry, imaging and image analysis, cells and bacteria in tissues, and quantification of chemokines, cytokines, and other factors with ELISA.

  • From Current Category

Cite this ( Cystic Fibrosis Center - University of Washington Microbiology Core , RRID:SCR_015403)

URL: http://depts.washington.edu/cfrtc/microbiology/

Resource Type: Resource, service resource, resource, core facility, access service resource

Core facility which provides tools, reagents, and training for microbiological researchers investigating cystic fibrosis. They specifically provide resources for research in anti-bacterial therapies,

  • From Current Category

Cite this ( Cystic Fibrosis Center - University of Washington , RRID:SCR_015401)

URL: http://depts.washington.edu/cfrtc/

Resource Type: Resource, disease-related portal, topical portal, resource, service resource, portal, access service resource, data or information resource

Research center that aims to provide resources and expertise to expedite development of potential new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences, enhance understanding of evolving bacterial ecosystems and resultant host response in CF gastrointestinal and respiratory tracts, and how these interactions impact health. It also aims to develop improved assays, new drug screening assays, biomarkers and improved clinical outcome measures, as well as to better understand the metabolic and inflammatory consequences of CFTR dysfunction.

  • From Current Category

Cite this ( Cystic Fibrosis Research and Translation Centers , RRID:SCR_015383)

URL: https://www.niddk.nih.gov/research-funding/research-programs/cystic-fibrosis-research-translation-centers

Resource Type: Resource, disease-related portal, topical portal, resource, organization portal, portal, data or information resource

Research centers that provide support for basic, preclinical, and clinical research efforts to advance scientific knowledge and new therapies for cystic fibrosis.

  • From Current Category

Cite this ( Gregory Fleming James Cystic Fibrosis Research Center Assay Core , RRID:SCR_015407)

URL: https://www.uab.edu/medicine/cysticfibrosis/about/assay-core

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that provides Ussing chamber capabilities and expertise for testing vectoral anion transport in polarized airway epithelial monolayers, and florescent dye-based methods for evaluating CFTR activity in cells grown on coverslips. The core also performs immunolocalization for proteins relevant to cystic fibrosis pathogenesis.

  • From Current Category

Cite this ( Gregory Fleming James Cystic Fibrosis Research Center Cell Model and Evaluation Core , RRID:SCR_015395)

URL: https://www.uab.edu/medicine/cysticfibrosis/about/cell-model-core

Resource Type: Resource, service resource, resource, core facility, access service resource

Core that assists with patch clamp and single channel analysis relevant to ion channel gating. The core also provides primary murine airway epithelial cells.

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