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on page 1 showing 20 out of 33 results from 1 sources

Cite this (Allen Brain Atlas API, RRID:SCR_005984)

URL: http://www.brain-map.org/api/index.html

Resource Type: Resource, software resource, software application, source code

API and demo application for accessing the Allen Brain Atlas Mouse Brain data. Data available via the API includes download high resolution images, expression data from a 3D volume, 3D coordinates of the Allen Reference Atlas, and searching genes with similar gene expression profiles using NeuroBlast. Data made available includes: * High resolution images for gene expression, connectivity, and histology experiments, as well as annotated atlas images * 3-D expression summaries registered to a reference space for the Mouse Brain and Developing Mouse Brain * Primary microarray results for the Human Brain and Non-Human Primate * RNA sequencing results for the Developing Human Brain * MRI and DTI files for Human Brain The API consists of the following resources: * RESTful model access * Image download service * 3-D expression summary download service * Differential expression search services * NeuroBlast correlative searches * Image-to-image synchronization service * Structure graph download service

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Cite this (AutoSeg, RRID:SCR_009438)

URL: http://www.nitrc.org/projects/autoseg/

Resource Type: Resource, software resource, image analysis software, data processing software, software application

A novel C++ based application developped at UNC-Chapel Hill that performs automatic brain tissue classification and structural segmentation. AutoSeg is designed for use with human and non-human primate pediatric, adolescent and adult data. AutoSeg uses a BatchMake pipeline script that includes the main steps of the framework entailing N4 bias field correction, rigid registration to a common coordinate image, tissue segmentation, skull-stripping, intensity rescaling, atlas-based registration, subcortical segmentation and lobar parcellation, regional cortical thickness and intensity statistics. AutoSeg allows efficient batch processing and grid computing to process large datasets and provides quality control visualizations via Slicer3 MRML scenes.

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Cite this (CalaTK, RRID:SCR_009547)

URL: http://www.calatk.org/

Resource Type: Resource, software resource, software toolkit

An open-source toolkit for cross-sectional and longitudinal atlas building. The CalaTK project develops innovative methods and tools for longitudinal atlases with a focus on neurodevelopment. The computational toolbox is developed with the objective to analyze the neural developmental patterns observed in human and non-human primate structural and diffusion tensor magnetic resonance (MR) images.

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Cite this (California National Primate Research Center, RRID:SCR_006426)

URL: http://www.cnprc.ucdavis.edu

Resource Type: Resource, organization portal, portal, data or information resource

The National Primate Research Center is a unique resource for investigators studying human health and disease, offering the opportunity to assess the causes of disease, and new treatment methods in nonhuman primate models that closely recapitulate humans. Research performed at the CNPRC and other National Primate Research Centers provides necessary information before proceeding to clinical trials in humans, leading to new drugs, therapies and surgical procedures that benefit human health and quality of life. Its mission is to provide interdisciplinary programs in biomedical research on significant human health-related problems in which nonhuman primates are the models of choice. Established in 1962, the CNPRC is affiliated with the University of California, Davis, and is located on 300 acres. The centers staff of nearly 350 individuals is comprised of scientists; veterinarians; animal care technicians; specialists in pathology and animal husbandry; undergraduate, graduate, and postdoctoral students and other trainees; and laboratory and administrative personnel. The center has a diverse program of research utilizing nonhuman primates. Research projects encompass many aspects of biology and medicine, including AIDS and other infectious diseases; reproductive issues such as those associated with conception, pregnancy, and fetal growth and development; neurodegenerative conditions such as Alzheimer''s disease; nutritional deficiencies; pulmonary disorders such as asthma, emphysema, and other chronic obstructive lung diseases; xenotransplantation; cell- and gene-based therapies; acute and chronic stress; temperament and biobehavioral organization; social relationships; neurobiology; cognitive function; and behavioral development. Members of the scientific staff representing a variety of disciplines including cell and developmental biology, genetics, psychology, physiology, reproductive biology, virology, and immunology typically hold joint appointments in academic departments in Schools (e.g., Medicine and Veterinary Medicine) and Colleges (e.g., Engineering, Letters and Science) on the UC Davis campus. Collaborative investigators also work with Staff Scientists and conduct specific research projects in their area of interest and benefit from the extensive expertise of the scientific staff. Research units include brain, mind, and behavior; reproductive sciences; respiratory diseases; and virology and immunology; as well as an affiliate research program, core services, and the primate services and medicine division. Research opportunities are available for investigators from national and international institutions, as well as scientists within the UC Davis research community. The NPRC is also home to the Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases under the direction of Alice Tarantal, Ph.D. The CNPRC houses and cares for more than 5,000 monkeys. The majority of these monkeys are rhesus macaques, with small populations of cynomolgus monkeys and South American titi monkeys. Organs and tissues are provided when available; other biological samples are provided on special request. Shipping, collecting, and processing costs are charged to the requestor. The CNPRC has 4 service Cores and other associated service opportunities for investigators. These Core facilities provide expertise and resources to support research at the primate center. * Analytical and Resource Core * Behavior Assessment Core * Computational Imaging Core * Inhalation Exposure Core * Other Services

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Cite this (Computerized Anatomical Reconstruction and Editing Toolkit, RRID:SCR_006260)

URL: http://brainvis.wustl.edu/wiki/index.php/Caret:About

Resource Type: Resource, software resource, software application, image processing software, data visualization software, data processing software

A free, open-source, software package used to visualize and analyze the structural and functional characteristics of cerebral and cerebellar cortex in humans, nonhuman primates, and rodents. It runs on Apple (Mac OSX), Linux, and Microsoft Windows operating systems. The software includes two main programs, caret5 and caret_command. caret5 is a graphical user interface (GUI) for interactively manipulating and viewing neuroimaging data. caret_command is a command line program that allows batch processing of neuroimaging data. Caret 5.61 Functionality * Atlases and associated experimental data (see (Caret:Atlases Atlases)). * Capture images and create movies of surface, volume, and contour (border) data. * Caret-command script builder and executor for algorithm testing and batch processing. * Classify regions of a surface using border and paint operations. * Connect and transfer data to and from the (Sums:About SuMS database). * Flexible overlay system for displaying a variety of data in layers on surfaces or volumes. * Map neuroimaging activation foci (stereotaxic coordinates) to surfaces and volumes. * Map functional and other volume data to surfaces. * Map surface-based data (e.g., cortical areas) onto volumes. * Metadata handling that can encode processing steps, vocabularies, citations. * Multiple windows for simultaneous display of contours, surfaces, and volumes. * Read and write many file formats (Analyze, AFNI, Caret, FreeSurfer, GIfTI, NIfTI, and many others). * Surface-based statistics (based on sulcal depth and other shape characteristics). * Surface inflation and flattening. * Surface reconstruction via segmentation of anatomical volume data (SureFit method). * Surface reconstruction from contours. * Surface region of interest operations. * Visualization of contour, surface, and volumetric data. WebCaret allows Caret-like online visualization of data sets in the Sums DB database without downloading software or data.

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Cite this (Covance, RRID:SCR_001224)

URL: http://www.covance.com/

Resource Type: Resource, organization portal, commercial organization, antibody supplier, biomaterial supply resource, organism supplier, service resource, portal, reagent supplier, material resource, data or information resource

A contract research organization providing drug development and animal testing services. Under the name Covance Research Products Inc., based in Denver, Pennsylvania, the company also deals in the import, breeding and sale of laboratory animals. It breeds dogs, rabbits, guinea pigs, non-human primates, and pigs, and runs the largest non-human primate laboratory in Germany. (Wikipedia)

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    DTI Blog

Cite this (DTI Blog, RRID:SCR_009028)

URL: http://www.diffusion-imaging.com/

Resource Type: Resource, blog, narrative resource, data or information resource

Blog written by Do Tromp and Samuel Hurley (University of Wisconsin, Madison) that intends to show what Diffusion Tensor Imaging (DTI) entails and give a comprehensive overview of available software, analyzing methods and research possibilities. Diffusion-imaging.com invites guest writers to contribute to this website.

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URL: http://www.nitrc.org/projects/rmdtitemplate/

Resource Type: Resource, atlas, reference atlas, data or information resource

A population-specific DTI template for young adolescent Rhesus Macaque (Macaca mulatta) monkeys using 271 high-quality scans. Using such a large number of animals in generating a template allows it to account for variability in the species. Their DTI template is based on the largest number of animals ever used in generating a computational brain template. It is anticipated that their DTI template will help facilitate voxel-based and tract specific WM analyses in non-human primate species, which in turn may increase our understanding of brain function, development, and evolution.

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Cite this (fMRI Data Center, RRID:SCR_007278)

URL: http://www.fmridc.org/

Resource Type: Resource, service resource, data or information resource, data repository, storage service resource, database

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 25, 2013 Public curated repository of peer reviewed fMRI studies and their underlying data. This Web-accessible database has data mining capabilities and the means to deliver requested data to the user (via Web, CD, or digital tape). Datasets available: 107 NOTE: The fMRIDC is down temporarily while it moves to a new home at UCLA. Check back again in late Jan 2013! The goal of the Center is to help speed the progress and the understanding of cognitive processes and the neural substrates that underlie them by: * Providing a publicly accessible repository of peer-reviewed fMRI studies. * Providing all data necessary to interpret, analyze, and replicate these fMRI studies. * Provide training for both the academic and professional communities. The Center will accept data from those researchers who are publishing fMRI imaging articles in peer-reviewed journals. The goal is to serve the entire fMRI community.

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Cite this (GeneSeer, RRID:SCR_002626)

URL: http://geneseer.com/

Resource Type: Resource, data or information resource, database

Database to access gene information through common names and allows identification of homologs and paralogs for a given gene. This publicly available tool leverages public sequence data, gene metadata information, and other publicly available data to calculate and display orthologous and paralogous gene relationships for all genes from several species, including yeasts, insects, worms, vertebrates, mammals, and primates such as humans.

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Cite this (IPBIR - Integrated Primate Biomaterials and Information Resource, RRID:SCR_004614)

URL: http://ccr.coriell.org/Sections/Collections/IPBIR/?SsId=18

Resource Type: Resource, biomaterial supply resource, data or information resource, material resource, cell repository

The purpose of the IPBIR - Integrated Primate Biomaterials and Information Resource is to assemble, characterize, and distribute high-quality DNA samples of known provenance with accompanying demographic, geographic, and behavioral information in order to stimulate and facilitate research in primate genetic diversity and evolution, comparative genomics, and population genetics. Further research in these areas will advance our understanding of human origins, the biological basis of cognitive processes, evolutionary history and relationships, and social structure, and will provide critical scientific information needed to facilitate conservation of biological diversity. The derived DNA will be openly available to the broad scientific community who agree to restrict use to non-commercial purposes. DNA and cell culture samples are distributed only to qualified professional persons who are associated with recognized research, medical, or educational organizations engaged in research.

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Cite this (JIP Analysis Toolkit, RRID:SCR_009588)

URL: http://www.nmr.mgh.harvard.edu/~jbm/jip/

Resource Type: Resource, software resource, image analysis software, software toolkit, data processing software, software application

Software toolkit for analysis of rodent and non-human primate fMRI data. The toolkit consists of binary executables, highly portable open-source c code, and image resources that enable 1) Automated registration based upon mutual information (affine, non-linear warps), with flexible control and visualization of each step; 2) visualization of 4-dimensional data using either mosaic or tri-planar display of the z/slice dimension, and integration of a general linear model for graphical display of time series analysis; 3) A simple and flexible 1st-order GLM for fMRI time series analysis, a 1st-order GLM analysis for PET data within the SRTM framework, plus a 2nd-order GLM analysis following the Worsley 2002 scheme, and 4) MRI templates to place your rodent and non-human primate data into standardized spaces.

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Cite this (Molecular Imaging and Contrast Agent Database, RRID:SCR_006712)

URL: http://www.ncbi.nlm.nih.gov/books/NBK5330/

Resource Type: Resource, narrative resource, data set, data or information resource, book, database

Searchable book regarding molecular imaging and contrast agents (under development, in clinical trials or commercially available for medical applications) that have in vivo data (animal or human) published in peer-reviewed scientific journals prior to June 30 of 2013. 1444 agents are currently listed and there will be no more updates. Also available is a downloadable list of FDA approved contrast agents (Latest update: January 2013) and a Molecular Imaging Probes and Contrast Agents List (MIP & CA List) created by the MICAD staff by screening the PubMed / MedLine databases and other appropriate sources of such information. Only agents used in animal or human studies yielding in vivo data were selected for inclusion in the list. The list is by no means considered complete. No one imaging modality has been given preference over the others and the omission of any agent(s) or the introduction of any errors in the list is purely unintentional. The MIP & CA List is subject to the same copyright and disclaimers as the rest of the MICAD content. The database includes, but is not limited to, agents developed for positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), optical imaging, planar radiography, and planar gamma imaging. The information on each agent is summarized in a book chapter format containing several sections such as Background, Synthesis, in vitro studies, Animal Studies (with sub-sections: rodents, other non-human primate animals, and human primates), Human Studies, and References. In addition, the references are linked to PubMed for retrieval of the publication abstract. Also, each chapter contains links to resources at the National Center for Biotechnology Information (NCBI) and other relevant databases regarding the target of the imaging probe or contrast agent.

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Cite this (National Center for Research Resources - Primate Resources, RRID:SCR_006863)

URL: http://www.ncrr.nih.gov/comparative_medicine/resource_directory/primates.asp

Resource Type: Resource, topical portal, organism supplier, biomaterial supply resource, portal, reagent supplier, material resource, data or information resource

THIS RESOURCE IS NO LONGER IN SERVICE, documented on October 16, 2013. NCRR has been absorbed into other parts of the National Institutes of Health. This organizational structure is no longer available. Provides laboratory scientists and clinical researchers with the resources and tools they need to understand, detect, treat and prevent a wide range of diseases. Animal models, such as nonhuman primates, are a critical component of biomedical research, having profound implications for public health. Scientists depend on laboratory animals and other nonhuman models for investigating biological processes, studying the causes of diseases and testing promising new therapies. Nonhuman primates, in particular, are important for translational research because of their close physiological similarities to humans. They enable discoveries that have direct application to human studies, bridging the gap between basic science and human medicine. Discoveries in animal models are helping scientists test treatments for human conditions such as drug addiction, obesity, malaria, HIV/AIDS and neurodegenerative diseases, accelerating the pace at which these research advances can be translated into treatments for patients. Through its Division of Comparative Medicine, NCRR offers a wide variety of primate resources for NIH-funded scientists across the nation. Additionally, funding opportunities are available to National Primate Research Centers. Eight National Primate Research Centers (NPRCs) located throughout the country provide animals, facilities and expertise in all aspects of nonhuman primate biology and husbandry. These facilities and resources enable collaborative research among NPRC staff scientists, investigators from the NPRC host institution and other NIH-funded researchers. Major areas of research benefiting from the primate centers include AIDS, avian flu, Alzheimer''s disease, Parkinson''s disease, diabetes, asthma and endo-metriosis. The centers????????????????? specialized resources are intended to support investigators who receive their primary research project funding from NIH, but they also may be used by investigators who are funded by other federal, state and local agencies, as well as by research foundations and the private sector. Together the primate centers have more than 28,000 nonhuman primates of 20 different species. This portal covers the following topics: * National Primate Research Centers * Monkey Research Resources * Chimpanzee Research Resources * Chimpanzee Management Program * Specific-Pathogen-Free Macaque Resources * Nonhuman Primate Research Reagents

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Cite this (Neurophysiology Imaging Facility, RRID:SCR_004080)

URL: http://nif.nimh.nih.gov/

Resource Type: Resource, service resource, core facility, access service resource

Neurophysiology imaging core facility that provides anatomical and functional MRI scanning for researchers in the National Institute of Mental Health (NIMH), the National Eye Institute (NEI), and the National Institute for Neurological Disorders and Stroke (NINDS). The shared intramural resource centers on a cutting-edge 4.7T vertical bore scanner dedicated to imaging of nonhuman primates.

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Cite this (New England Primate Research School, RRID:SCR_008290)

URL: http://www.hms.harvard.edu/NEPRC/

Resource Type: Resource, disease-related portal, topical portal, data or information resource, portal, research forum portal

A center that focuses on performing bio-medical research on nonhuman primates to aid in human health research. The center also focuses on training young scientists for professional careers in bio-medical research and primate biology. One of the New England Primate Research School's main accomplishments was the creation of an animal model for AIDS that first demonstrated that vaccine protection could be possible. Recent research has led to the development of novel agents for brain imaging that will aid in the diagnosis and treatment of Parkinson's disease.

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Cite this (NICHD Developmental Neuroethology - Laboratory of Comparative Ethology, RRID:SCR_000416)

URL: http://udn.nichd.nih.gov/

Resource Type: Resource, laboratory portal, portal, organization portal, data or information resource

Understanding the mechanisms underlying the expression and perception of auditory communication in nonhuman primates provides important insights for understanding the neural systems that mediate nonverbal auditory communication in humans. Our research is devoted to understanding the changes in vocal behavior that are associated with maturation and social experience under normative conditions, and to investigating neural systems to define their roles in auditory communication. The anterior cingulate gyrus, in the frontal cerebral cortex, is an essential neural system for the expression of the primate isolation call, a structural and functional equivalent of the cry sounds of humans. Bilateral removal of this structure in adult squirrel monkeys resulted in a long-lasting inability to emit isolation calls. Partial recovery, often over many weeks, initially took the form of production of short, faint and uninflected versions of the typical isolation call. Humans suffering infarct damage to this region likewise show an initial recovery in the form of short, faint, monosyllabic sounds, suggesting that the anterior cingulate gyrus of nonhuman primates is the evolutionary precursor of a neural structure involved in human affective expression and speech. Our working model of isolation call production is that the anterior cingulate gyrus is the site where the command to produce this vocalization is initiated. Since the anterior cingulate region also has reciprocal connections with temporal lobe auditory cortex, a presumptive feedback pathway exists for registering commands to initiate vocalization with the temporal lobe cortex, which plays a major role in perceiving and decoding the acoustic details of species-specific vocalizations. At present, we do not know the role of the anterior cingulate gyrus in the production of infant vocalizations. However, we have found that neonatal removal of the amygdala, an important forebrain component of the limbic system, or portions of the inferotemporal gyrus, which sends projections to the amygdala, result in significant changes in the vocal behavior of infant rhesus macaques. Vocal development is a dynamic process, and a pattern shared by several nonhuman primates has emerged regarding the nature of this process. Infants are highly vocal during periods of brief separation from their caregiver, and we take advantage of this to document the range of vocalizations produced by infants of different ages. In the neonatal period, infants of 3 species of nonhuman primate (rhesus macaque, squirrel monkey and common marmoset) all produce sounds that vary widely in their acoustic structure. Many of these bear a striking similarity to sounds used in a variety of social settings by adults, suggesting that neural systems responsible for generating adult vocalizations are already in place during early infancy. As infants mature, their vocal behavior during brief periods of social separation becomes much more stereotyped. It isn't until much later in development, as individuals engage in a variety of social interactions with peers and adults, that the sounds expressed in early infancy begin to re-appear in adult contexts. The role of individual experience during development is currently being explored to determine the mechanisms leading to the acquisition of adult vocal skills.

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Cite this (NIMH Chemical Synthesis and Drug Supply Program, RRID:SCR_004921)

URL: http://nimh-repository.rti.org/

Resource Type: Resource, production service resource, material service resource, service resource, reagent manufacture, material resource, reagent supplier

A program that synthesizes, purifies, and distributes otherwise unavailable essential compounds to stimulate basic and clinical research in psychopharmacology relevant to mental health in areas such as the molecular pharmacology and signaling of CNS receptors, longitudinal studies to evaluate the molecular, biochemical, and behavioral actions of psychoactive compounds, and functional brain imaging in both primates and humans. WHAT IS AVAILABLE: * Ligands for CNS receptors, radiolabeled compounds for autoradiography and neuroimaging, biochemical markers, drug analogs and metabolites, and reference standards * Synthesis (including GMP) of promising compounds for mental health research, including preclinical toxicology and safety studies, especially compounds for PET neuroimaging * A listing of currently available NIMH CSDSP compounds is available online at www.nimh-repository.rti.org. RTI International scientists can provide investigators with technical assistance and additional information about the compounds on request. Data sheets containing purity, storage, and handling information are supplied with all NIMH CSDSP compounds. WHO IS ELIGIBLE: Investigators involved in basic or clinical research relevant to mental health are eligible to submit requests. To learn more about current NIMH research areas, please visit the NIMH website at www.nimh.nih.gov. NIMH CSDSP compounds are free to qualified academic investigators, but payment may be required from nonacademic requestors. Investigators interested in obtaining radiolabeled compounds but uncertain about what type of label or specific activity would work best for them may obtain help by communicating with the technical contacts listed on the website.

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Cite this (Nonhuman Primate HIV/SIV Vaccine Trials Database, RRID:SCR_002274)

URL: http://www.hiv.lanl.gov/content/vaccine/home.html

Resource Type: Resource, data or information resource, database

An overview of HIV and SIV vaccine trials and their outcomes. It was developed as a tool for compilation, search and comparison of published studies on SIV, HIV and SHIV vaccine trials in nonhuman primates. We used a set of criteria to scan Pubmed for relevant studies to enter into the database. In selecting studies for entry, priority was given to recently published studies in journals generally regarded as the primary source of information pertaining to HIV and SIV vaccine research in nonhuman primates. In most cases, we give priority to challenge studies, where the animals received a live virus to measure the "efficacy" of the immunogen(s) inoculated during the course of the investigation. The HIV Sequence Database focuses on five primary goals: *Collecting HIV and SIV sequence data (all sequences since 1987) *Curating and annotating this data, and making it available to the scientific community *Computer analysis of HIV and related sequences *Production of software for the analysis of (sequence) data *Publication of the data and analyses on this site and in a yearly printed publication, the HIV sequence Compendium, which is available free of charge

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Cite this ( Nonhuman Primate Transplantation Tolerance Cooperative Study Group , RRID:SCR_006847)

URL: http://www.niaid.nih.gov/topics/transplant/research/Pages/fundedBasics.aspx#NHPTCSP

Resource Type: Resource, disease-related portal, topical portal, resource, research forum portal, portal, data or information resource

Cooperative program for research on nonhuman primate models of kidney, islet, heart, and lung transplantation evaluating the safety and efficacy of existing and new treatment regimens that promote the immune system''''s acceptance of a transplant and to understand why the immune system either rejects or does not reject a transplant. This program bridges the critical gap between small-animal research and human clinical trials. The program supports research into the immunological mechanisms of tolerance induction and development of surrogate markers for the induction, maintenance, and loss of tolerance.

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