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on page 1 showing 20 out of 408 results

Cite this (Pediatrics Annotation and Medicine, RRID:SCR_014417)

URL: http://www.megabionet.org

Resource Type: Resource, data or information resource, database

A standardized database for childrens disease classification and annotation. It is also an information exchange platform.

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    LifeGene

Cite this (LifeGene, RRID:SCR_010524)

URL: https://www.lifegene.se/In-english/

Resource Type: Resource, organization portal, biomaterial supply resource, consortium, portal, material resource, data or information resource

Swedish study to get a better understanding of how genes, environment and way of life affect health that will enable access to the longitudinal data on 500,000 participants after ethical approval. Half a million people in Sweden between the ages of 0 and 45 will be recruited as volunteers for 6 to 8 years. People between 18 and 45 will be invited and they may, in turn, bring children and other people that they live with into the project. Participants will be followed for many years with regular online surveys and health checks. Their blood and urine samples will also be stored in a biobank. All the data will form a very large information base, where researchers can follow what happens with people''''s health. The LifeGene test center will measure height, hip, waist and chest measurements. A so-called spirometry test will be conducted which measures lung function, a hearing test and bioimpedance measurement (includes weight, BMI and distribution of body fat and muscle mass). They also take blood and urine samples and measure blood pressure and pulse. LifeGene foresees a lot of different research cooperation. Everything from simple withdrawal of longitudinal data, leverage of LifeGene infrastructure and cooperation between LifeGene and complementing scientific projects covering specific areas in more depth. LifeGene will enable access to unique longitudinal data on 500,000 participants available for researchers after ethical approval. LifeGene is also an infrastructure with Test Centers covering most of Sweden, logistics for sample management from arm-to-freezer and state-of-the-art large scale automatic biobanking enabling low cost, high quality, fast withdrawal of biological samples.

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    FiGS

Cite this (FiGS, RRID:SCR_012037)

URL: http://gexp.kaist.ac.kr/figs/

Resource Type: Resource, analysis service resource, data analysis service, service resource, production service resource

A web-based workbench to conveniently compare the classification performances of many different filter-based gene selection procedures. In addition to the commonly used filter metric-classifier combinations, user can test various additive methodological options by specification of only up- or down-regulated genes to select, applying feature discretization and adding feature vectors to make a new feature. Throughout the comprehensive comparisons, user can identify the best performing gene selection procedure and subsequent classification performance measured by .632+ bootstrap error estimation for the given binary (two-class) microarray data.

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Cite this (The Immunology Database and Analysis Portal (ImmPort), RRID:SCR_012804)

URL: https://www.immport.org/home

Resource Type: Resource, disease-related portal, topical portal, data repository, database, service resource, portal, storage service resource, ontology, controlled vocabulary, data or information resource

Data sharing repository of clinical trials, associated mechanistic studies, and other basic and applied immunology research programs. Platform to store, analyze, and exchange datasets for immune mediated diseases. Data supplied by NIAID/DAIT funded investigators and genomic, proteomic, and other data relevant to research of these programs extracted from public databases. Provides data analysis tools and immunology focused ontology to advance research in basic and clinical immunology.

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Cite this (Baltimore Longitudinal Study of Aging (BLSA), RRID:SCR_013148)

URL: http://www.grc.nia.nih.gov/branches/blsa/blsanew.htm

Resource Type: Resource, disease-related portal, topical portal, database, research forum portal, portal, data or information resource

America''s longest-running scientific study of human aging, begun in 1958. BLSA scientists are learning what happens as people age and how to sort out changes due to aging from those due to disease or other causes. More than 1,400 men and women are study volunteers. They range in age from their 20s to their 90s. This study is currently recruiting healthy seniors over 70.

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Cite this (Genetic Association Database, RRID:SCR_013264)

URL: http://geneticassociationdb.nih.gov/

Resource Type: Resource, data or information resource, database

The Genetic Association Database is an archive of human genetic association studies of complex diseases and disorders. The goal of this database is to allow the user to rapidly identify medically relevant polymorphism from the large volume of polymorphism and mutational data, in the context of standardized nomenclature. The data is from published scientific papers. Study data is recorded in the context of official human gene nomenclature with additional molecular reference numbers and links. It is gene centered. That is, each record is a record of a gene or marker. If a study investigated 6 genes for a particular disorder, there will be 6 records. Anyone may view this database and anyone may submit records. You do not have to be an author on the original study to submit a record. All submitted records will be reviewed before inclusion in the archive. Both genetic and environmental factors contribute to human diseases. Most common diseases are influenced by a large number of genetic and environmental factors, most of which individually have only a modest effect on the disease. Though genetic contributions are relatively well characterized for some monogenetic diseases, there has been no effort at curating the extensive list of environmental etiological factors. From a comprehensive search of the MeSH annotation of MEDLINE articles, they identified 3,342 environmental etiological factors associated with 3,159 diseases. They also identified 1,100 genes associated with 1,034 complex diseases from the NIH Genetic Association Database (GAD), a database of genetic association studies. 863 diseases have both genetic and environmental etiological factors available. Integrating genetic and environmental factors results in the etiome, which they define as the comprehensive compendium of disease etiology.

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Cite this (TCMGeneDIT, RRID:SCR_013396)

URL: http://tcm.lifescience.ntu.edu.tw/index.html

Resource Type: Resource, data or information resource, database

TCMGeneDIT is a database system providing association information about traditional Chinese medicines (TCMs), genes, diseases, TCM effects and TCM ingredients automatically mined from vast amount of biomedical literature. Integrated protein-protein interaction and biological pathways information collected from public databases are also available. In addition, the transitive relationships among genes, TCMs and diseases could be inferred through the shared intermediates. Furthermore, TCMGeneDIT is useful in deducing possible synergistic or antagonistic contributions of the prescription components to the overall therapeutic effects. TCMGeneDIT is a unique database of various association information about TCMs. The database integrating TCMs with life sciences and biomedical studies would facilitate the modern clinical research and the understanding of therapeutic mechanisms of TCMs and gene regulations.

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Cite this (Therapeutically Relevant Multiple Pathways Database, RRID:SCR_013471)

URL: http://xin.cz3.nus.edu.sg/group/trmp/trmp.asp

Resource Type: Resource, data or information resource, database

The Therapeutically Relevant Multiple Pathways Database is designed to provide information about such multiple pathways and related therapeutic targets described in the literatures, the targeted disease conditions, and the corresponding drugs/ligands directed at each of these targets. This database currently contains 11 entries of multiple pathways, 97 entries of individual pathways, 120 targets covering 72 disease conditions along with 120 sets of drugs directed at each of these targets. Each entry can be retrieved through multiple methods including multiple pathway name, individual pathway name and disease name. Additional information provided include protein name, synonyms, Swissprot AC number, species, gene name and location, protein sequence (AASEQ) and gene sequence (NTSEQ) as well as potential therapeutic implications while applicable. Cross-links to other databases are provided which include Genecard, GDB, Locuslink, NCBI, KEGG, OMIM, SwissProt to facilitate the access of more detailed information about various aspects of the particular target or non-target protein. Queries can be submitted by entering or selecting the required information in any one or combination of the fields in the form. User can specify full name or any part of the name in a text field, or choose one item from an selection field. Sponsors: TRMP is supported by the National University of Singapore.

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Cite this (Alzforum Antibody Directory for Neuroscience Research, RRID:SCR_013601)

URL: http://www.alzforum.org/res/com/ant/

Resource Type: Resource, data or information resource, database

The Alzheimer Research Forum is the web''s most dynamic scientific community dedicated to understanding Alzheimer''s disease and related disorders. It also contains a database of providers of antibodies directed against several hundred molecules and proteins of relevant to research on Alzheimer and other neurodegenerative diseases. The web site reports on the latest scientific findings, from basic research to clinical trials; creates and maintains public databases of essential research data and reagents, and produces discussion forums to promote debate, speed the dissemination of new ideas, and break down barriers across the numerous disciplines that can contribute to the global effort to cure Alzheimer''s disease. The ARF team of professional science writers and editors, information technology experts, web developers and producers all work closely with our distinguished and diverse Advisory Board to ensure a high-quality of information and services. We very much welcome our readers'' participation in all aspects of the web site. Sponsors: The Alzheimer Research Forum is an independent nonprofit organization. It is supported by grants and individual donations.

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Cite this (Helmholtz Center Munich German Research Center for Environmental Health, RRID:SCR_013835)

URL: http://www.helmholtz-muenchen.de/en/index.html

Resource Type: Resource, information resource, training resource

An institute that investigates important common diseases which develop from the interaction of lifestyle, environmental factors, and personal genetic background, with a strong focus on diabetes mellitus and chronic lung diseases. The institute's research combines biomedical and environmental research with the aim of identifying human health risks at an early stage, identifying and interpreting the mechanisms that cause disease, developing individualized concepts for the long-term prevention and cure of disease, and improving diagnostics. The institute offers diabetes and lung information services, among others, and higher education training programs.

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Cite this (Pathogen Portal, RRID:SCR_014603)

URL: http://www.pathogenportal.org/portal/portal/PathPort/Home

Resource Type: Resource, portal, data or information resource

A set of web-based resources provided by the Bioinformatics Resource Centers (BRCs), focusing on organisms considered as potential agents of biowarfare or bioterrorism or causing emerging or re-emerging diseases. It provides data sets of host responses to pathogens and genome data, as well as tools to analyze host responses to pathogens.

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Cite this (Sanford Burnham Prebys Medical Discovery Institute Tumor Analysis, RRID:SCR_014858)

URL: http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_TumorAnalysis.aspx

Resource Type: Resource, group, biomaterial supply resource, core facility, service resource, access service resource, material resource

Facility that provides analysis of animal models of human cancer and other diseases. It provides investigators access to a wide variety of human cancer cell lines for xenograft studies, some primary human xenograft models and additional transgenic mouse solid tumors and leukemia models. The core also offers serial passaging of tumors and derivation of 2D and 3D cultures from xenograft tumors, including patient-derived xenograft (PDX) models. These short-term cell cultures established from PDXs enable in vitro analysis including high throughput screening with compounds or RNAi for functional characterization.

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Cite this (Sanford Burnham Prebys Medical Discovery Institute, RRID:SCR_014876)

URL: http://www.sbpdiscovery.org/Pages/Splash.aspx

Resource Type: Resource, group

Non-profit dedicated to conducting collaborative research to find cures for human disease, improve quality of life, and educate and train the next-generation of scientists. It is the overarching organization of more than a dozen core facilities that provide various resources in biomedical research.

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Cite this (Sanford Burnham Prebys Medical Discovery Institute Cell-based Disease Modeling and Screening Core, RRID:SCR_014870)

URL: http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_CellModeling.aspx

Resource Type: Resource, group, instrument supplier, core facility, service resource, access service resource, material resource

Core facility that aims to develop cell based disease models for screening and testing small molecules and drugs, and specializes in culture, scaling, and directed differentiation of human embryonic and induced pluripotent stem cells. It provides resources and expertise to researchers at the Institute and to their external partners to facilitate development of stem cell based assays and patient-specific disease models in screenable formats.

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    DISEASES

Cite this (DISEASES, RRID:SCR_015664)

URL: http://diseases.jensenlab.org/

Resource Type: Resource, database, software application, text-mining software, web application, software resource, data or information resource

Database that integrates evidence on disease-gene associations from automatic text mining, manually curated literature, cancer mutation data, and genome-wide association studies. It also assigns confidence scores that facilitate comparison of the different types and sources of evidence.

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Cite this (Benaroya Research Institute: Neurological Diseases, RRID:SCR_001576)

URL: https://www.benaroyaresearch.org/our-research/clinical-research/currently-enrolling-studies/neurological-disease

Resource Type: Resource, department portal, organization portal, portal, data or information resource

BRI investigators study the molecular and genetic mechanisms which underlie some of the most devastating chronic neurological disorders, and conduct clinical trials for new innovative therapies. Neurological studies that are currently studied include Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's Disease, Multiple Sclerosis, and Parkinson's Disease.

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Cite this (NIDDK Information Network, RRID:SCR_001606)

URL: http://dknet.org/

Resource Type: Resource, resource, database, service resource, portal, storage service resource, data repository, community building portal, data or information resource

Community-based network to serve needs of basic and clinical investigators that includes large pools of data and research resources relevant to mission of National Institute of Diabetes and Digestive and Kidney Disease.

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Cite this (Parkinsons Disease Map, RRID:SCR_016156)

URL: https://pdmap.uni.lu/MapViewer/

Resource Type: Resource, disease-related portal, topical portal, data or information resource, portal, database

Knowledge repository established to describe molecular mechanisms of Parkinson's Disease. It compiles literature-based information on PD into an easy to explore and freely accessible molecular interaction map and offers research-facilitating functionalities such as the overlay of experimental data and the identification of drug targets on the map

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    MirSNP

Cite this (MirSNP, RRID:SCR_001629)

URL: http://cmbi.bjmu.edu.cn/mirsnp

Resource Type: Resource, data or information resource, database

Database of human SNPs in predicted miRNA-mRNA binding sites, based on information from dbSNP135 and mirBASE18. MirSNP is highly sensitive and covers most experiments confirmed SNPs that affect miRNA function. MirSNP may be combined with researchers' own GWAS or eQTL positive data sets to identify the putative miRNA-related SNPs from traits/diseases associated variants. They aim to update the MirSNP database as new versions of mirBASE and dbSNP database become available.

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Cite this (Ensembl Variation, RRID:SCR_001630)

URL: http://uswest.ensembl.org/info/docs/variation/index.html

Resource Type: Resource, data analysis service, production service resource, analysis service resource, database, service resource, data or information resource

Public database that stores areas of genome that differ between individual genomes (variants) and, where available, associated disease and phenotype information. Different types of variants for several species: single nucleotide polymorphisms (SNPs), short nucleotide insertions and/or deletions, and longer variants classified as structural variants (including CNVs). Effects of variants on the Ensembl transcripts and regulatory features for each species are predicted. You can run same analysis on your own data using Variant Effect Predictor. These data are integrated with other data sources in Ensembl, and can be accessed using the API or website. For several different species in Ensembl, they import variation data (SNPs, CNVs, allele frequencies, genotypes, etc) from a variety of sources (e.g. dbSNP). Imported variants and alleles are subjected to quality control process to flag suspect data. In human, they calculate linkage disequilibrium for each variant, by population.

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