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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.

(last updated: Aug 3, 2019)

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DatabaseProper CitationSpeciesNamePhenotypeAvailabilityReferenceNotesAffected GeneGenomic AlterationCatalog IDBackground
BCBCRRID:BCBC_1701Mus musculusFoxo1.DBD (Foxo1tm1(DBD)Dac)Diabetes mellitusCell line is availableThis line contains a DNA binding-deficient mutant of Foxo1. The mutation may be useful for assessing the contribution of DNA co-activation in the function of Foxo1.forkhead box O1  Foxo1tm11701RMCE
BCBCRRID:BCBC_215Mus musculusNgn3EYFP/+ (Neurog3tm1Ggr)Diabetes mellitusCell line is availableA targeting construct was designed to insert an IRES-EYFP and a floxed puro downstream of the coding sequence. Crossing with mice expressing Cre in the germ line excised the puromycin resistance gene. Coding region for Ngn3 is kept intact consequentely homozygous mice express Ngn3 protein , do not develop diabetes and behave like wild-types. in these mice, Ngn3-positive progenitors express EYFP and can be purified by FACS.Neurogenin 3  Ngn3EYFP/+215TM
BCBCRRID:BCBC_2582Mus musculusRosa26Ngn3.CFP (Rosa26(Ngn3.CFP)Mgn)Diabetes mellitusCell line is available; Now found at MMRRCThis mouse contains a bidirectional TetO-regulated fusion gene that has been inserted into a disabled Rosa26 locus. In one direction the tetO/CMV promoter drives expression of CFP (Cerulean). In the other direction it drives Ngn3. Mice containing this allelecan be used to drive the expression of Ngn3 under control of both doxycycline and either an rtTA or tTA transgene.gene trap ROSA 26, Philippe Soriano  Rosa26tm12582RMCE
BCBCRRID:BCBC_2301Mus musculusNgn3nCre (Neurog3tm1.1(nCre)Ggu)Diabetes mellitusCell line is availableA nCre-iRES (n-terminal half of Cre followed by internal ribosomal entry site) was inserted after Ngn3ATG. This allele is confirmed to express both nCre and Ngn3 (no visible phenotype in homozygous animals).Neurogenin 3  Neurog3nCre2301TM
BCBCRRID:BCBC_1241Mus musculusRosa26R26-60-DR5-TA-Cerulean (Rosa26tm1.1(R26-60-DR5-TA-Cerulean)Mgn)Diabetes mellitusCell line is availablePMID:22888097These mice were generated using RMCE to insert an exchange vector containing a modified Rosa26 promoter linked to a Cerulean fluorescent protein (CFP) reporter gene into mESCs containing a Loxed Cassette Acceptor (LCA) allele within the Rosa26 gene locus. The Rosa26 promoter in this mouse was altered by replacing DNA sequences from -60 to +81 with a multimerized retinoic acid response element (DR5) fused to a TATA box. This mouse will facilitate studies of retinoic acid signaling in an intact animal.gene trap ROSA 26, Philippe Soriano  Rosa26tm11241RMCE
BCBCRRID:BCBC_204Mus musculusRIP-DTR X (C57/CBAJ-Hprttm3(Ins2-HBEGF)Ugfm)Diabetes mellitusCell line is availableC57/CBAJ-Hprttm3(Ins2-HBEGF)Ugfm carries a transgene encoding the human diphtheria toxin receptor under the control of rat insulin II promoter, was inserted by homologous recombination at the Hprt locus of the X chromosome. It provides a model for depletion of 50% of beta cells using Diphtheria toxin.hypoxanthine guanine phosphoribosyl transferase 1  204TM
BCBCRRID:BCBC_199Mus musculusPdx1-Ngn3-ER (Tg(Pdx1-Neurog3-ER)1Agb)Diabetes mellitusCell line is availableThe transgene is driven by the Pdx1 promoter whcih targets it in pancreas progenitor during development. These mice express a fusion protein between the pro-endocrine transcription factor Ngn3 and the tamoxifen responsive estrogen receptor. An IRES site allows GFP to be co-expressed with Ngn3-ER. The protein is active only upon tamoxifen injection.199TG
BCBCRRID:BCBC_1101Mus musculusSox17CreERT2 (Sox17tm1.2Mgn)Diabetes mellitusCell line is availableSox17CreERT2 mice may be used either to track Sox17-expressing cells or their progeny or to conditionally inactivate genes in Sox17-expressing cells at specific time points by tamoxifen injection. This line is complementary to Sox17-CreGFP and may avoid possible interferences of expression in the extra-embryonic visceral endoderm. We plan to analyze the effects of a direct activation/deletion of the Wnt pathway in the endoderm by crossing the Sox17-CreERT2 with the gain- and loss-of-function of beta-catenin.SRY-box containing gene 17  Sox17tm11101RMCE
BCBCRRID:BCBC_234Mus musculusGlucagon-rtTA (C57/CBAJ-TgN(Glucagon- rtTA)Ugfm)Diabetes mellitusCell line is availableTransgenic strain (generated by pronuclear microinjection) of a transgene containing the rat glucagon promoter (1.6kb fragment) upstream of the coding region of the reverse transactivator doxycycline-dependent. The rtTA is flanked by a rabbit beta-globin intron and downstream there is a stop and polyA signal from the same rabbit beta-globin gene.234TG
BCBCRRID:BCBC_220Mus musculusPdx1-tTA (STOCK Pdx1tm1Macd/J)Diabetes mellitusCell line is availableMice homozygous for the targeted mutation fail to develop a pancreas. Heterozygous mice have normal pancreatic development, but have partially impaired glucose tolerance in adulthood. The substitution of the targeted Ipf1/Pdx1 gene with tTAoff inactivates the endogenous allele and places tTAoff expression under the control of the endogenous transcriptional regulatory sequences of the Pdx1 locus. Identical to the endogenous allele, mutant locus expression is detectable in the pancreas and adjacent duodenum but not in other visceral organs or salivary glands. This mutant may be useful to direct tetracycline-regulated expression of responder transgenes in studies of pancreatic endocrine/exocrine development and function and diabetes. This mutant can also be bred with other tetO/TRE strains for pancreas-specific applications. This mutant was originally designed to be mated with mice engineered with a heptameric tetracycline operator (tetO)-controlled bicistronic transgene coding for a normal PDX1 protein and with a beta-galactosidase or EGFP reporter (see BCBC mouse M561). The combined modifications allow normal pancreatic development and function until doxycycline-administration renders the mouse conditionally null of the Pdx1 gene. This configuration for conditional expression of Pdx1is most effective when the transgene locus is homozygous. This allows embryonic developmental arrest at desired stages or cessation of function in adult mice by tetracycline administration.Pancreatic and duodenal homeobox 1  Pdx1tmd1Macd220TM
BCBCRRID:BCBC_211Mus musculusNOD-Rag-Perforin Akita (NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz/Sz)Diabetes mellitusCell line is availableThe NOD-Rag1null Prf1null Ins2Akita mouse is the first immunodeficient, spontaneously hyperglycemic mouse strain described that is based on the Ins2Akita mutation. This strain is suitable as hosts for human islet and human beta stem and progenitor cell transplantation in the absence of the need for pharmacological induction of diabetes. This strain of mice also has low levels of innate immunity and can be engrafted with a human immune system for the study of human islet allograft rejection.recombination activating gene 1  MGI:97848)211TM, OTH
BCBCRRID:BCBC_205Mus musculusNkx6.1DsRed2/+ (B6-Nkx6-1tm1Msan)Diabetes mellitusCell line is availableAn IRES-DsRed2 cassette was introduced into exon 1 of the Nkx6.1 genomic sequence. The insertion generates a null allele. DsRed2 expression is not detected in these mice.Nkx6.1  Nkx6.1tm1205TM
BCBCRRID:BCBC_241Mus musculusNkx2.2:NK2domain mutation (Nkx2-2tm4Suss)Diabetes mellitusCell line is availableThe strain carries a mutant Nkx2.2 allele in which conserved residues of the NK2 domain are mutated to alanines.NK2 transcription factor related, locus 2  Nkx2.2tm1241RMCE
BCBCRRID:BCBC_230Mus musculusHNF6flox (OC-1tm1.1Mga)Diabetes mellitusCell line is available; Now found at MMRRCReferences (3)This line of mice allows for conditional inactivation of the OC-1 (HNF6) gene using Cre recombinase. Thus, HNF6 function can be assessed in the different tissues in which it is expressed.Onecut1  OC230TM
BCBCRRID:BCBC_2702Mus musculusRosa26MafA-Cherry (Rosa26tm1.4(MafA-Cherry)Mgn)Diabetes mellitusCell line is availableThis mouse contains a bidirectional Tet0-regulated fusion gene that has been inserted into adisabled Rosa26 loxed cassette acceptor allele by RMCE. In one direction the tetO/CMV promoter drives expression of a red fluorescent protein (Cherry) while in the other direction it drives MafA expression.gene trap ROSA 26, Philippe Soriano  Rosa26tm12702RMCE
BCBCRRID:BCBC_1001Mus musculusbiotinTag-Ptf1a (Ptf1atm3Macd)Diabetes mellitusCell line is availableModified allele of Ptf1a with a biotinylation Tag sequence attached to the amino terminus of Ptf1a.pancreas specific transcription factor, 1a  Ptf1atm11001RMCE
BCBCRRID:BCBC_240Mus musculusNkx2.2:LacZ (Nkx2-2tm1Suss)Diabetes mellitusCell line is availableThe lacZ gene has been knocked in to the Nkx2.2 genomic locus using RMCE, effectively replacing the two coding exons.NK2 transcription factor related, locus 2  Nkx2.2tm1240RMCE
BCBCRRID:BCBC_245Mus musculusPdx1Flox123 (Pdx1tm5Cvw)Diabetes mellitusCell line is availableLoxP sites for cre recombinase were inserted to flank Area I-II-III, a conserved 5' cis-regulatory region of Pdx1. This allele was shown to be a conditional hypomorph by Fujitani et al. (2006) (PMID 16418487). Pdx1tm3Cvw (Pdx1deltaI-II-III) is generated by Cre-mediated recombination in the germline of this allele.Pancreatic and Duodenal homeobox 1  Pdx1tm5245TM
BCBCRRID:BCBC_243Mus musculusPdx1FloxE2 (Pdx1tm4Cvw)Diabetes mellitusCell line is available; Now found at MMRRCThis is a conditional null allele of Pdx1. LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene.Pancreatic and Duodenal homeobox 1  Pdx1tm4243TM
BCBCRRID:BCBC_206Mus musculusInsulin-CreER (Tg(RIP-Cre/ESR1)Ydor)Diabetes mellitusCell line is availableA transgenic mouse expression tamoxifen-inducible Cre recombinase under rat insulin promoter. Upon the injection of tamoxifen, loxP-flanked DNA sequences in beta cells will be deleted.206TG
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