Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

  • Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Search

Type in a keyword to search

on page 1 showing 20 out of 120 results

Cite this (BCBC Cat# 194, RRID:BCBC_194)

Source Database: BCBC, catalog # 194
Genetic Background: TM
Affected Genes: phosphoenolpyruvate carboxykinase 1  
Genomic Alteration: Pck1tm1.1Mgn
Availability: Cell line is available; Now found at MMRRC
Reference: PMID:10938127
Notes: Diabetes mellitus These mice may be used to study tissue-specific functions of phosphoenolpyruvate carboxykinase (Pck1). This enzyme is essential for gluconeogenesis and also is important for regulating anapleurosis/catapleurosis of TCA cycle intermediates. By generating mice that are homozygous for the pcklox allele and that contain a tissue-specific Cre transgene, Pck1 can be deleted from various sites.

  • From Current Category

Cite this (BCBC Cat# 4560, RRID:BCBC_4560)

Source Database: BCBC, catalog # 4560
Genetic Background: RMCE
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

  • From Current Category

Cite this (BCBC Cat# 1221, RRID:BCBC_1221)

Source Database: BCBC, catalog # 1221
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This strain expresses both mutant cyclin D1T286A and a cherry reporter under the regulation of a tetracycline-responsive bi-directional minimal CMV promoter (TRE-Tight; tetO). The cyclin D1-T286A mutant cannot be phosphorylated by GSK-3beta and is resistant to polyubiquitination. Therefore, cyclin D1-T286A remains nuclear throughout the cell cycle and has an extended half-life relative to wild-type cyclin D1. This strain represents an effective tool for generating inducible tissue-specific cyclin D1T286A mutants with a cherry reporter.

  • From Current Category

Cite this (BCBC Cat# 1701, RRID:BCBC_1701)

Source Database: BCBC, catalog # 1701
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This line contains a DNA binding-deficient mutant of Foxo1. The mutation may be useful for assessing the contribution of DNA co-activation in the function of Foxo1.

  • From Current Category

Cite this (BCBC Cat# 4143, RRID:BCBC_4143)

Source Database: BCBC, catalog # 4143
Genetic Background: TM
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

  • From Current Category

Cite this (BCBC Cat# 4077, RRID:BCBC_4077)

Source Database: BCBC, catalog # 4077
Genetic Background: RMCE
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

  • From Current Category

Cite this (BCBC Cat# 223, RRID:BCBC_223)

Source Database: BCBC, catalog # 223
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Transgenic mice where Ngn3-positive cell are labeled with beta-galactosidase. Due to the stability of beta-galactosidase protein, the early descendants of Ngn3-positve cells are also labeled. To generate the Ngn3 promoter::LacZ construct, a 6.86 kb XbaI-XhoI fragment (6696 bp of 5' genomic and untranslated region sequences and 176 bp of ngn3 coding region) of mouse ngn3 genomic DNA was cloned upstream of the IRES-NLS-LacZ-pA sequence in pBS-INL vector resulting in plasmid pngn3(6.8)-INL. The 10.6 kb Ngn3-IRES-NLS-LacZ insert was released by NotI digestion and microinjected into murine oocyte pronuclei, and transgenic line was generated and maintained by crossing into a CD1 outbred background.

  • From Current Category

Cite this (BCBC Cat# 192, RRID:BCBC_192)

Source Database: BCBC, catalog # 192
Genetic Background: TM
Affected Genes: Glucokinase  
Genomic Alteration: Gcktm2Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This line of mice contains a gkK414E point mutation that was introduced by gene knock-in. This point mutation wasidentified in aMODY-GK pedigree. These mice will be useful for studies of sustained hyperglycemia since they contain only a single mutation and are congenic with the C57BL/6J strain.

  • From Current Category

Cite this (BCBC Cat# 232, RRID:BCBC_232)

Source Database: BCBC, catalog # 232
Genetic Background: RMCE
Affected Genes: NK2 transcription factor related, locus 2  
Genomic Alteration: Nkx2.2tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The reverse tetracycline transactivator (rtTA) is knocked into the Nkx2.2 coding region, effectively knocking out one Nkx2.2 allele.

  • From Current Category

Cite this (BCBC Cat# 197, RRID:BCBC_197)

Source Database: BCBC, catalog # 197
Genetic Background: TM
Affected Genes: Peroxisome proliferator-activated receptor gamma  
Genomic Alteration: Ppargtm1.1Mgn
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus These mice carry a conditional allele for PPARgamma that can be used in combination with various cre-expressing transgenes.

  • From Current Category

Cite this (BCBC Cat# 4142, RRID:BCBC_4142)

Source Database: BCBC, catalog # 4142
Genetic Background: TM
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

  • From Current Category

Cite this (BCBC Cat# 4145, RRID:BCBC_4145)

Source Database: BCBC, catalog # 4145
Genetic Background: TM
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

  • From Current Category

Cite this (BCBC Cat# 1261, RRID:BCBC_1261)

Source Database: BCBC, catalog # 1261
Genetic Background: OTH, TM
Affected Genes: recombination activating gene 1  
Genomic Alteration: Rag1tm1Mom
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rgnull mice. This immunodeficient mouse also develops spontaneous hyperglycemia based on the Ins2Akita mutation.

  • From Current Category

Cite this (BCBC Cat# 1262, RRID:BCBC_1262)

Source Database: BCBC, catalog # 1262
Genetic Background: OTH, TM
Affected Genes: interleukin 2 receptor, gamma chain  
Genomic Alteration: Il2rgtm1Wjl
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus NOD-scid IL2rgnull mice are deficient in mature lymphocytes and NK cells, survive beyond 16-month of age, and even after sublethal irradiation resist lymphoma development. Moreover, cytokine-mobilized human peripheral blood stem cells engraft at high levels in NOD-scid IL2rgnull mice and develop into human CD3+CD4+ and CD3+CD8+ T cells, Ig+B cells, myeloid cells, NK cells and plasmacytoid dentritic cells.

  • From Current Category

Cite this (BCBC Cat# 1241, RRID:BCBC_1241)

Source Database: BCBC, catalog # 1241
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference: PMID:22888097
Notes: Diabetes mellitus These mice were generated using RMCE to insert an exchange vector containing a modified Rosa26 promoter linked to a Cerulean fluorescent protein (CFP) reporter gene into mESCs containing a Loxed Cassette Acceptor (LCA) allele within the Rosa26 gene locus. The Rosa26 promoter in this mouse was altered by replacing DNA sequences from -60 to +81 with a multimerized retinoic acid response element (DR5) fused to a TATA box. This mouse will facilitate studies of retinoic acid signaling in an intact animal.

  • From Current Category

Cite this (BCBC Cat# 188, RRID:BCBC_188)

Source Database: BCBC, catalog # 188
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus Hemizygous mice show expression of EGFP in beta lineage cells of the pancreas.

  • From Current Category

Cite this (BCBC Cat# 205, RRID:BCBC_205)

Source Database: BCBC, catalog # 205
Genetic Background: TM
Affected Genes: Nkx6.1  
Genomic Alteration: Nkx6.1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus An IRES-DsRed2 cassette was introduced into exon 1 of the Nkx6.1 genomic sequence. The insertion generates a null allele. DsRed2 expression is not detected in these mice.

  • From Current Category

Cite this (BCBC Cat# 204, RRID:BCBC_204)

Source Database: BCBC, catalog # 204
Genetic Background: TM
Affected Genes: hypoxanthine guanine phosphoribosyl transferase 1  
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus C57/CBAJ-Hprttm3(Ins2-HBEGF)Ugfm carries a transgene encoding the human diphtheria toxin receptor under the control of rat insulin II promoter, was inserted by homologous recombination at the Hprt locus of the X chromosome. It provides a model for depletion of 50% of beta cells using Diphtheria toxin.

  • From Current Category

Cite this (BCBC Cat# 210, RRID:BCBC_210)

Source Database: BCBC, catalog # 210
Genetic Background: OTH, TG, TM
Affected Genes: interleukin 2 receptor, gamma chain  
Genomic Alteration: Il2rgtm1Wjl
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus NOD-scid IL2rgnullHprttm3(Ins2-HBEGF)Ugfm mice are deficient in mature lymphocytes and NK cells, survive beyond 16 months of age, and even after sublethal irradiation resist lymphoma development. They can be induced to become hypoglycemic when Diphtheria toxin is used. 50% of beta cells will be depleted after diphtheria toxin administration.

  • From Current Category

Cite this (BCBC Cat# 239, RRID:BCBC_239)

Source Database: BCBC, catalog # 239
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Ngn3tTA)
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus The mouse contains a Ngn3 knock-in allele. IRES-tTA-rabbit beta globin polyA signal replaced the entire Ngn3 cDNA coding sequence. This is therefore also a Ngn3 null allele. Ngn3 is a bHLH transcription factor that is required for the differentiation of endocrine islet and some neuronal cells.

  • From Current Category

  1. Resource Identification Portal Resources

    Welcome to the RRID Resources search. From here you can search through a compilation of resources used by RRID and see how data is organized within our community.

  2. Navigation

    You are currently on the Community Resources tab looking through categories and sources that RRID has compiled. You can navigate through those categories from here or change to a different tab to execute your search through. Each tab gives a different perspective on data.

  3. Logging in and Registering

    If you have an account on RRID then you can log in from here to get additional features in RRID such as Collections, Saved Searches, and managing Resources.

  4. Searching

    Here is the search term that is being executed, you can type in anything you want to search for. Some tips to help searching:

    1. Use quotes around phrases you want to match exactly
    2. You can manually AND and OR terms to change how we search between words
    3. You can add "-" to terms to make sure no results return with that term in them (ex. Cerebellum -CA1)
    4. You can add "+" to terms to require they be in the data
    5. Using autocomplete specifies which branch of our semantics you with to search and can help refine your search
  5. Save Your Search

    You can save any searches you perform for quick access to later from here.

  6. Query Expansion

    We recognized your search term and included synonyms and inferred terms along side your term to help get the data you are looking for.

  7. Collections

    If you are logged into RRID you can add data records to your collections to create custom spreadsheets across multiple sources of data.

  8. Sources

    Here are the sources that were queried against in your search that you can investigate further.

  9. Categories

    Here are the categories present within RRID that you can filter your data on

  10. Subcategories

    Here are the subcategories present within this category that you can filter your data on

  11. Further Questions

    If you have any further questions please check out our FAQs Page to ask questions and see our tutorials. Click this button to view this tutorial again.

X