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on page 1 showing 20 out of 120 results from 1 sources

Cite this (BCBC Cat# 1701, RRID:BCBC_1701)

Source Database: BCBC, catalog # 1701
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This line contains a DNA binding-deficient mutant of Foxo1. The mutation may be useful for assessing the contribution of DNA co-activation in the function of Foxo1.

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Cite this (BCBC Cat# 4143, RRID:BCBC_4143)

Source Database: BCBC, catalog # 4143
Genetic Background: TM
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 4077, RRID:BCBC_4077)

Source Database: BCBC, catalog # 4077
Genetic Background: RMCE
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 192, RRID:BCBC_192)

Source Database: BCBC, catalog # 192
Genetic Background: TM
Affected Genes: Glucokinase  
Genomic Alteration: Gcktm2Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This line of mice contains a gkK414E point mutation that was introduced by gene knock-in. This point mutation wasidentified in aMODY-GK pedigree. These mice will be useful for studies of sustained hyperglycemia since they contain only a single mutation and are congenic with the C57BL/6J strain.

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Cite this (BCBC Cat# 1241, RRID:BCBC_1241)

Source Database: BCBC, catalog # 1241
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference: PMID:22888097
Notes: Diabetes mellitus These mice were generated using RMCE to insert an exchange vector containing a modified Rosa26 promoter linked to a Cerulean fluorescent protein (CFP) reporter gene into mESCs containing a Loxed Cassette Acceptor (LCA) allele within the Rosa26 gene locus. The Rosa26 promoter in this mouse was altered by replacing DNA sequences from -60 to +81 with a multimerized retinoic acid response element (DR5) fused to a TATA box. This mouse will facilitate studies of retinoic acid signaling in an intact animal.

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Cite this (BCBC Cat# 205, RRID:BCBC_205)

Source Database: BCBC, catalog # 205
Genetic Background: TM
Affected Genes: Nkx6.1  
Genomic Alteration: Nkx6.1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus An IRES-DsRed2 cassette was introduced into exon 1 of the Nkx6.1 genomic sequence. The insertion generates a null allele. DsRed2 expression is not detected in these mice.

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Cite this (BCBC Cat# 1221, RRID:BCBC_1221)

Source Database: BCBC, catalog # 1221
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This strain expresses both mutant cyclin D1T286A and a cherry reporter under the regulation of a tetracycline-responsive bi-directional minimal CMV promoter (TRE-Tight; tetO). The cyclin D1-T286A mutant cannot be phosphorylated by GSK-3beta and is resistant to polyubiquitination. Therefore, cyclin D1-T286A remains nuclear throughout the cell cycle and has an extended half-life relative to wild-type cyclin D1. This strain represents an effective tool for generating inducible tissue-specific cyclin D1T286A mutants with a cherry reporter.

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Cite this (BCBC Cat# 4142, RRID:BCBC_4142)

Source Database: BCBC, catalog # 4142
Genetic Background: TM
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 204, RRID:BCBC_204)

Source Database: BCBC, catalog # 204
Genetic Background: TM
Affected Genes: hypoxanthine guanine phosphoribosyl transferase 1  
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus C57/CBAJ-Hprttm3(Ins2-HBEGF)Ugfm carries a transgene encoding the human diphtheria toxin receptor under the control of rat insulin II promoter, was inserted by homologous recombination at the Hprt locus of the X chromosome. It provides a model for depletion of 50% of beta cells using Diphtheria toxin.

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Cite this (BCBC Cat# 240, RRID:BCBC_240)

Source Database: BCBC, catalog # 240
Genetic Background: RMCE
Affected Genes: NK2 transcription factor related, locus 2  
Genomic Alteration: Nkx2.2tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The lacZ gene has been knocked in to the Nkx2.2 genomic locus using RMCE, effectively replacing the two coding exons.

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Cite this (BCBC Cat# 196, RRID:BCBC_196)

Source Database: BCBC, catalog # 196
Genetic Background: TM
Affected Genes: Rictor  
Genomic Alteration: 4921505C17Riktm1.1Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference: PMID:16962829
Notes: Diabetes mellitus These mice carrya conditional allele for Rictor, a component mTOR complex 2 (mTORC2). Disruption of the Rictor gene attenuates phosphorylation ofSer473 of Akt/PKB, which is important for a normal response to growth factor stimulation acting through the PI3-kinase signaling pathway.

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Cite this (BCBC Cat# 4079, RRID:BCBC_4079)

Source Database: BCBC, catalog # 4079
Genetic Background: RMCE
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 243, RRID:BCBC_243)

Source Database: BCBC, catalog # 243
Genetic Background: TM
Affected Genes: Pancreatic and Duodenal homeobox 1  
Genomic Alteration: Pdx1tm4
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This is a conditional null allele of Pdx1. LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene.

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Cite this (BCBC Cat# 176, RRID:BCBC_176)

Source Database: BCBC, catalog # 176
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Neurog3tm1
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus A targeted mutation at the Neurogenin 3 locus where EGFP replaces entire coding region of Neurogenin3. The basic phenotype is EGFP expression in developing endocrine cells of pancreas and in glandular regions of the stomach.

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Cite this (BCBC Cat# 237, RRID:BCBC_237)

Source Database: BCBC, catalog # 237
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus We generated a transgenic mouse expressing the luciferase optical reporter under control of the mouse insulin I promoter (MIP-Luc-VU) and characterized this model in mice with increased or decreased beta-cell mass and after islet transplantation. MIP-Luc-VU mice emitted strong and consistent bioluminescence emanating exclusively from beta-cells of the pancreatic islet. MIP-Luc-VU islets had normal islet architecture and secreted insulin normally in vivo and in vitro. By tracking changes in β cell mass using bioluminescence imaging (BLI) and post-mortem metrics, streptozotocin-induced, diabetic MIP-Luc-VU mice had a progressive decline in bioluminescence that correlated with a decrease in pancreatic insulin content and beta-cell mass. MIP-Luc-VU animals fed a high fat diet displayed a progressive increase in bioluminescence that reflected an immunohistochemically verified increase in beta-cell mass. MIP-Luc-VU islets transplanted beneath the renal capsule or into the liver emitted bioluminescence proportional to the number of islets transplanted and graft insulin content and could be imaged for more than a year. Since bioluminescence in the MIP-Luc-VU mouse model is proportional to beta-cell mass in the setting of increased and decreased beta-cell mass and after transplantation, this approach should be useful for non-invasively assessing beta-cell mass in pre-clinical mouse models of glucose homeostasis, beta-cell growth and regeneration, and diabetes.

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Cite this (BCBC Cat# 4086, RRID:BCBC_4086)

Source Database: BCBC, catalog # 4086
Genetic Background: RMCE
Affected Genes:
Genomic Alteration:
Availability: Cell line is restricted to public
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 230, RRID:BCBC_230)

Source Database: BCBC, catalog # 230
Genetic Background: TM
Affected Genes: Onecut1  
Genomic Alteration: OC
Availability: Cell line is available; Now found at MMRRC
Reference: PMID:23926259, PMID:21898486, PMID:19766716
Notes: Diabetes mellitus This line of mice allows for conditional inactivation of the OC-1 (HNF6) gene using Cre recombinase. Thus, HNF6 function can be assessed in the different tissues in which it is expressed.

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Cite this (BCBC Cat# 238, RRID:BCBC_238)

Source Database: BCBC, catalog # 238
Genetic Background: TM
Affected Genes: ROSA26  
Genomic Alteration: Not yet available)
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus Targeted insertion of a LoxP-STOP-LoxP-Myt1 casette into the ROSA26 locus. The presence of Cre recombinase will lead to activation of the 7 zinc finger isoform of Myt1.

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Cite this (BCBC Cat# 193, RRID:BCBC_193)

Source Database: BCBC, catalog # 193
Genetic Background: TM
Affected Genes: Glucokinase  
Genomic Alteration: Gcktm1.1Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference: PMID:9867845
Notes: Diabetes mellitus Gklox mice may be used to generate cell specific knock-outs of glucokinase, depending which cre-expressing transgenic mouse is used. In humans, glucokinase gene mutations cause maturity onset diabetes of the young (MODY-GK), a disease that is characterized by early onset and persistent hyperglycemia. Thus, these mice are useful in determining how diminished experssion of glucokinase in specific cells causes hyperglycemia.

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Cite this (BCBC Cat# 206, RRID:BCBC_206)

Source Database: BCBC, catalog # 206
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A transgenic mouse expression tamoxifen-inducible Cre recombinase under rat insulin promoter. Upon the injection of tamoxifen, loxP-flanked DNA sequences in beta cells will be deleted.

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