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on page 1 showing 20 out of 31 results from 1 sources

Cite this (BCBC Cat# 192, RRID:BCBC_192)

Source Database: BCBC, catalog # 192
Genetic Background: TM
Affected Genes: Glucokinase  
Genomic Alteration: Gcktm2Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This line of mice contains a gkK414E point mutation that was introduced by gene knock-in. This point mutation wasidentified in aMODY-GK pedigree. These mice will be useful for studies of sustained hyperglycemia since they contain only a single mutation and are congenic with the C57BL/6J strain.

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Cite this (BCBC Cat# 1261, RRID:BCBC_1261)

Source Database: BCBC, catalog # 1261
Genetic Background: OTH, TM
Affected Genes: recombination activating gene 1  
Genomic Alteration: Rag1tm1Mom
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rgnull mice. This immunodeficient mouse also develops spontaneous hyperglycemia based on the Ins2Akita mutation.

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Cite this (BCBC Cat# 188, RRID:BCBC_188)

Source Database: BCBC, catalog # 188
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus Hemizygous mice show expression of EGFP in beta lineage cells of the pancreas.

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Cite this (BCBC Cat# 239, RRID:BCBC_239)

Source Database: BCBC, catalog # 239
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Ngn3tTA)
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus The mouse contains a Ngn3 knock-in allele. IRES-tTA-rabbit beta globin polyA signal replaced the entire Ngn3 cDNA coding sequence. This is therefore also a Ngn3 null allele. Ngn3 is a bHLH transcription factor that is required for the differentiation of endocrine islet and some neuronal cells.

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Cite this (BCBC Cat# 196, RRID:BCBC_196)

Source Database: BCBC, catalog # 196
Genetic Background: TM
Affected Genes: Rictor  
Genomic Alteration: 4921505C17Riktm1.1Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference: PMID:16962829
Notes: Diabetes mellitus These mice carrya conditional allele for Rictor, a component mTOR complex 2 (mTORC2). Disruption of the Rictor gene attenuates phosphorylation ofSer473 of Akt/PKB, which is important for a normal response to growth factor stimulation acting through the PI3-kinase signaling pathway.

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Cite this (BCBC Cat# 238, RRID:BCBC_238)

Source Database: BCBC, catalog # 238
Genetic Background: TM
Affected Genes: ROSA26  
Genomic Alteration: Not yet available)
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus Targeted insertion of a LoxP-STOP-LoxP-Myt1 casette into the ROSA26 locus. The presence of Cre recombinase will lead to activation of the 7 zinc finger isoform of Myt1.

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Cite this (BCBC Cat# 4055, RRID:BCBC_4055)

Source Database: BCBC, catalog # 4055
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This mouse line was made by RMCE in the Rosa26[LCA] allele and has yellow fluorescent protein (YFP, Citrine) expressed under control of the ROSA26 promoter. The YFP sequence is preceded by a translational enhancer and followed by intron-containing rabbit beta-globin polyA sequences. This mouse has ubiquitously expressed YFP protein and can be used for transplantation and other experiments where tracing of source cells is required.

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Cite this (BCBC Cat# 185, RRID:BCBC_185)

Source Database: BCBC, catalog # 185
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 193, RRID:BCBC_193)

Source Database: BCBC, catalog # 193
Genetic Background: TM
Affected Genes: Glucokinase  
Genomic Alteration: Gcktm1.1Mgn
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference: PMID:9867845
Notes: Diabetes mellitus Gklox mice may be used to generate cell specific knock-outs of glucokinase, depending which cre-expressing transgenic mouse is used. In humans, glucokinase gene mutations cause maturity onset diabetes of the young (MODY-GK), a disease that is characterized by early onset and persistent hyperglycemia. Thus, these mice are useful in determining how diminished experssion of glucokinase in specific cells causes hyperglycemia.

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Cite this (BCBC Cat# 176, RRID:BCBC_176)

Source Database: BCBC, catalog # 176
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Neurog3tm1
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus A targeted mutation at the Neurogenin 3 locus where EGFP replaces entire coding region of Neurogenin3. The basic phenotype is EGFP expression in developing endocrine cells of pancreas and in glandular regions of the stomach.

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Cite this (BCBC Cat# 237, RRID:BCBC_237)

Source Database: BCBC, catalog # 237
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus We generated a transgenic mouse expressing the luciferase optical reporter under control of the mouse insulin I promoter (MIP-Luc-VU) and characterized this model in mice with increased or decreased beta-cell mass and after islet transplantation. MIP-Luc-VU mice emitted strong and consistent bioluminescence emanating exclusively from beta-cells of the pancreatic islet. MIP-Luc-VU islets had normal islet architecture and secreted insulin normally in vivo and in vitro. By tracking changes in β cell mass using bioluminescence imaging (BLI) and post-mortem metrics, streptozotocin-induced, diabetic MIP-Luc-VU mice had a progressive decline in bioluminescence that correlated with a decrease in pancreatic insulin content and beta-cell mass. MIP-Luc-VU animals fed a high fat diet displayed a progressive increase in bioluminescence that reflected an immunohistochemically verified increase in beta-cell mass. MIP-Luc-VU islets transplanted beneath the renal capsule or into the liver emitted bioluminescence proportional to the number of islets transplanted and graft insulin content and could be imaged for more than a year. Since bioluminescence in the MIP-Luc-VU mouse model is proportional to beta-cell mass in the setting of increased and decreased beta-cell mass and after transplantation, this approach should be useful for non-invasively assessing beta-cell mass in pre-clinical mouse models of glucose homeostasis, beta-cell growth and regeneration, and diabetes.

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Cite this (BCBC Cat# 179, RRID:BCBC_179)

Source Database: BCBC, catalog # 179
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This strain relies on the recombination of floxed DNA in insulin-producing beta cells.

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Cite this (BCBC Cat# 182, RRID:BCBC_182)

Source Database: BCBC, catalog # 182
Genetic Background: TM
Affected Genes: insulin promoter factor 1, homeodomain transcription factor  
Genomic Alteration: Ipf1tm1Cvw
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus

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Cite this (BCBC Cat# 1421, RRID:BCBC_1421)

Source Database: BCBC, catalog # 1421
Genetic Background: TM
Affected Genes: recombinant activating gene 1  
Genomic Alteration: MGI:97848)
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus Mice that are homozygous for both targeted mutations are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities when housed under specific pathogen free conditions. These double homozygote mutant mice have no mature T or B lymphocytes, no detectable NK cell cytotoxic activity, and lack serum immunoglobulin. The number of nucleated spleen cells is significantly reduced in double mutant mice, when compared to the single homozygote, NOD.129S7(B6)-Rag1tm1Mom/J (Stock No. 003729). Although an increased number of DX5+CD122+ NK cells are found in the spleens of double mutants, these NK cells have impaired cytotoxic activity. The disruption of Prf1 ablates NK cell cytotoxic activity resulting in increased engraftment levels over that observed with Stock No. 003729. All mutant mice develop thymic lymphomas. This double mutant mouse strain may be useful in studies involving engraftment of human hematolymphoid cells.

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Cite this (BCBC Cat# 180, RRID:BCBC_180)

Source Database: BCBC, catalog # 180
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus All islet endocrine cells inherit a recombination event, if a segment of DNA is loxP-flanked. Transgene encoding Cre recombinase under the control of a human Neurogenin3 promoter.

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Cite this (BCBC Cat# 178, RRID:BCBC_178)

Source Database: BCBC, catalog # 178
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This strain allows Expression of EGFP in pancreatic precursor populations.

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Cite this (BCBC Cat# 183, RRID:BCBC_183)

Source Database: BCBC, catalog # 183
Genetic Background: TM
Affected Genes: insulin promoter factor 1, homeodomain transcription factor  
Genomic Alteration: Ipf1tm2Cvw
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus The homozygous phenotype of these animals show growth retardation and dehydration with lack of gastric emptying; ie. a-pancreatic. Heterozygous phenotype includes expression of beta-galactosidase in developing stomach, bile duct and cystic ducts and early pancreatic buds.

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Cite this (BCBC Cat# 4611, RRID:BCBC_4611)

Source Database: BCBC, catalog # 4611
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available
Reference:
Notes: Diabetes mellitus NSG-HLA-A2/HHD mutant mice are immunodeficient and express human HLA class 1 heavy and light chains. This strain may be useful as a human hematopoietic engraftment host that supports the maturation of human T cells with transplantation http://jaxmice.jax.org/strain/014570.html.

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Cite this (BCBC Cat# 181, RRID:BCBC_181)

Source Database: BCBC, catalog # 181
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus Homozygous phenotype: Postnatal lethal due to neonatal diabetes Pancreas--5% insulin production, no islet formation Gut--no CCK or secretin production Inner ear defects resulting in deafness--no cochlear ganglia and poor vestibular ganglia formation Cerebellar defect resulting in ataxia-- >90% depletion of cerebellar granule cells Hippocampal defects--no dentate gyrus.

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Cite this (BCBC Cat# 190, RRID:BCBC_190)

Source Database: BCBC, catalog # 190
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is reviewable but not available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus

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