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on page 1 showing 20 out of 59 results from 1 sources

Cite this (BCBC Cat# 1701, RRID:BCBC_1701)

Source Database: BCBC, catalog # 1701
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This line contains a DNA binding-deficient mutant of Foxo1. The mutation may be useful for assessing the contribution of DNA co-activation in the function of Foxo1.

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Cite this (BCBC Cat# 1221, RRID:BCBC_1221)

Source Database: BCBC, catalog # 1221
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This strain expresses both mutant cyclin D1T286A and a cherry reporter under the regulation of a tetracycline-responsive bi-directional minimal CMV promoter (TRE-Tight; tetO). The cyclin D1-T286A mutant cannot be phosphorylated by GSK-3beta and is resistant to polyubiquitination. Therefore, cyclin D1-T286A remains nuclear throughout the cell cycle and has an extended half-life relative to wild-type cyclin D1. This strain represents an effective tool for generating inducible tissue-specific cyclin D1T286A mutants with a cherry reporter.

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Cite this (BCBC Cat# 195, RRID:BCBC_195)

Source Database: BCBC, catalog # 195
Genetic Background: TM
Affected Genes: Rictor  
Genomic Alteration: 4921505C17Riktm2Mgn
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus Rictor is an essential part of mTOR complex 2 (mTORC2). mTORC2 phosphorylates Ser473 of Akt/PKB. Eliminating this gene disrupts the function of mTORC2, thereby preventing growth factor mediated activation of Akt/PKB. Thus, these mice have utility for studying both the sites of expression and function of rictor.

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Cite this (BCBC Cat# 1301, RRID:BCBC_1301)

Source Database: BCBC, catalog # 1301
Genetic Background: RMCE
Affected Genes: pancreatic and duodenal homeobox 1  
Genomic Alteration: Pdx1tm1
Availability: Cell line is available; Now found at MMRRC
Reference: PMID:21913313
Notes: Diabetes mellitus This mouse contains a cyan fluorescent protein (CFP, Cerulean), tagged with 3 copies of an SV40 NLS knocked into the endogenous Pdx1 gene. This mouse strain enables pre-pancreatic endoderm to be easily identified in the developing mouse embryo and the isolation of Pdx1(+) cells by FACS.

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Cite this (BCBC Cat# 205, RRID:BCBC_205)

Source Database: BCBC, catalog # 205
Genetic Background: TM
Affected Genes: Nkx6.1  
Genomic Alteration: Nkx6.1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus An IRES-DsRed2 cassette was introduced into exon 1 of the Nkx6.1 genomic sequence. The insertion generates a null allele. DsRed2 expression is not detected in these mice.

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Cite this (BCBC Cat# 2301, RRID:BCBC_2301)

Source Database: BCBC, catalog # 2301
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Neurog3nCre
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A nCre-iRES (n-terminal half of Cre followed by internal ribosomal entry site) was inserted after Ngn3ATG. This allele is confirmed to express both nCre and Ngn3 (no visible phenotype in homozygous animals).

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Cite this (BCBC Cat# 1241, RRID:BCBC_1241)

Source Database: BCBC, catalog # 1241
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference: PMID:22888097
Notes: Diabetes mellitus These mice were generated using RMCE to insert an exchange vector containing a modified Rosa26 promoter linked to a Cerulean fluorescent protein (CFP) reporter gene into mESCs containing a Loxed Cassette Acceptor (LCA) allele within the Rosa26 gene locus. The Rosa26 promoter in this mouse was altered by replacing DNA sequences from -60 to +81 with a multimerized retinoic acid response element (DR5) fused to a TATA box. This mouse will facilitate studies of retinoic acid signaling in an intact animal.

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Cite this (BCBC Cat# 215, RRID:BCBC_215)

Source Database: BCBC, catalog # 215
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Ngn3EYFP/+
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A targeting construct was designed to insert an IRES-EYFP and a floxed puro downstream of the coding sequence. Crossing with mice expressing Cre in the germ line excised the puromycin resistance gene. Coding region for Ngn3 is kept intact consequentely homozygous mice express Ngn3 protein , do not develop diabetes and behave like wild-types. in these mice, Ngn3-positive progenitors express EYFP and can be purified by FACS.

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Cite this (BCBC Cat# 2582, RRID:BCBC_2582)

Source Database: BCBC, catalog # 2582
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This mouse contains a bidirectional TetO-regulated fusion gene that has been inserted into a disabled Rosa26 locus. In one direction the tetO/CMV promoter drives expression of CFP (Cerulean). In the other direction it drives Ngn3. Mice containing this allelecan be used to drive the expression of Ngn3 under control of both doxycycline and either an rtTA or tTA transgene.

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Cite this (BCBC Cat# 204, RRID:BCBC_204)

Source Database: BCBC, catalog # 204
Genetic Background: TM
Affected Genes: hypoxanthine guanine phosphoribosyl transferase 1  
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus C57/CBAJ-Hprttm3(Ins2-HBEGF)Ugfm carries a transgene encoding the human diphtheria toxin receptor under the control of rat insulin II promoter, was inserted by homologous recombination at the Hprt locus of the X chromosome. It provides a model for depletion of 50% of beta cells using Diphtheria toxin.

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Cite this (BCBC Cat# 199, RRID:BCBC_199)

Source Database: BCBC, catalog # 199
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The transgene is driven by the Pdx1 promoter whcih targets it in pancreas progenitor during development. These mice express a fusion protein between the pro-endocrine transcription factor Ngn3 and the tamoxifen responsive estrogen receptor. An IRES site allows GFP to be co-expressed with Ngn3-ER. The protein is active only upon tamoxifen injection.

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Cite this (BCBC Cat# 1101, RRID:BCBC_1101)

Source Database: BCBC, catalog # 1101
Genetic Background: RMCE
Affected Genes: SRY-box containing gene 17  
Genomic Alteration: Sox17tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Sox17CreERT2 mice may be used either to track Sox17-expressing cells or their progeny or to conditionally inactivate genes in Sox17-expressing cells at specific time points by tamoxifen injection. This line is complementary to Sox17-CreGFP and may avoid possible interferences of expression in the extra-embryonic visceral endoderm. We plan to analyze the effects of a direct activation/deletion of the Wnt pathway in the endoderm by crossing the Sox17-CreERT2 with the gain- and loss-of-function of beta-catenin.

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Cite this (BCBC Cat# 240, RRID:BCBC_240)

Source Database: BCBC, catalog # 240
Genetic Background: RMCE
Affected Genes: NK2 transcription factor related, locus 2  
Genomic Alteration: Nkx2.2tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The lacZ gene has been knocked in to the Nkx2.2 genomic locus using RMCE, effectively replacing the two coding exons.

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Cite this (BCBC Cat# 234, RRID:BCBC_234)

Source Database: BCBC, catalog # 234
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Transgenic strain (generated by pronuclear microinjection) of a transgene containing the rat glucagon promoter (1.6kb fragment) upstream of the coding region of the reverse transactivator doxycycline-dependent. The rtTA is flanked by a rabbit beta-globin intron and downstream there is a stop and polyA signal from the same rabbit beta-globin gene.

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Cite this (BCBC Cat# 220, RRID:BCBC_220)

Source Database: BCBC, catalog # 220
Genetic Background: TM
Affected Genes: Pancreatic and duodenal homeobox 1  
Genomic Alteration: Pdx1tmd1Macd
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Mice homozygous for the targeted mutation fail to develop a pancreas. Heterozygous mice have normal pancreatic development, but have partially impaired glucose tolerance in adulthood. The substitution of the targeted Ipf1/Pdx1 gene with tTAoff inactivates the endogenous allele and places tTAoff expression under the control of the endogenous transcriptional regulatory sequences of the Pdx1 locus. Identical to the endogenous allele, mutant locus expression is detectable in the pancreas and adjacent duodenum but not in other visceral organs or salivary glands. This mutant may be useful to direct tetracycline-regulated expression of responder transgenes in studies of pancreatic endocrine/exocrine development and function and diabetes. This mutant can also be bred with other tetO/TRE strains for pancreas-specific applications. This mutant was originally designed to be mated with mice engineered with a heptameric tetracycline operator (tetO)-controlled bicistronic transgene coding for a normal PDX1 protein and with a beta-galactosidase or EGFP reporter (see BCBC mouse M561). The combined modifications allow normal pancreatic development and function until doxycycline-administration renders the mouse conditionally null of the Pdx1 gene. This configuration for conditional expression of Pdx1is most effective when the transgene locus is homozygous. This allows embryonic developmental arrest at desired stages or cessation of function in adult mice by tetracycline administration.

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Cite this (BCBC Cat# 211, RRID:BCBC_211)

Source Database: BCBC, catalog # 211
Genetic Background: TM, OTH
Affected Genes: recombination activating gene 1  
Genomic Alteration: MGI:97848)
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The NOD-Rag1null Prf1null Ins2Akita mouse is the first immunodeficient, spontaneously hyperglycemic mouse strain described that is based on the Ins2Akita mutation. This strain is suitable as hosts for human islet and human beta stem and progenitor cell transplantation in the absence of the need for pharmacological induction of diabetes. This strain of mice also has low levels of innate immunity and can be engrafted with a human immune system for the study of human islet allograft rejection.

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Cite this (BCBC Cat# 242, RRID:BCBC_242)

Source Database: BCBC, catalog # 242
Genetic Background: RMCE
Affected Genes: pancreatic and duodenal homeobox 1  
Genomic Alteration: Pdx1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This is a targeted deletion of Area II 5' cis-regulatory region of Pdx1.

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Cite this (BCBC Cat# 2061, RRID:BCBC_2061)

Source Database: BCBC, catalog # 2061
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A GFP cDNA has been knocked into the Foxo1 locus at the 3' end of the endogenous Foxo1 cDNA to generate a Foxo1-gfp fusion protein that can be used to study Foxo1 translocation in vivo.

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Cite this (BCBC Cat# 206, RRID:BCBC_206)

Source Database: BCBC, catalog # 206
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A transgenic mouse expression tamoxifen-inducible Cre recombinase under rat insulin promoter. Upon the injection of tamoxifen, loxP-flanked DNA sequences in beta cells will be deleted.

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Cite this (BCBC Cat# 661, RRID:BCBC_661)

Source Database: BCBC, catalog # 661
Genetic Background: RMCE
Affected Genes: insulinoma-associated 1  
Genomic Alteration: Insm1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Insm1GFPCre mice contain a GFP-Cre fusion protein which replaces the Insm1 coding sequence. These mice express green fluorescent protein (GFP) under control of theInsm1gene locus. Insm1 is expressed in pancreatic primordium starting at E9.5. Insm1 is also expressed in neural precursor cells and tumors of may be used for lineage tracing of Insm1-positive cells in both wild-type and Insm1-null mice.

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