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on page 1 showing 20 out of 59 results from 1 sources

Cite this (BCBC Cat# 223, RRID:BCBC_223)

Source Database: BCBC, catalog # 223
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Transgenic mice where Ngn3-positive cell are labeled with beta-galactosidase. Due to the stability of beta-galactosidase protein, the early descendants of Ngn3-positve cells are also labeled. To generate the Ngn3 promoter::LacZ construct, a 6.86 kb XbaI-XhoI fragment (6696 bp of 5' genomic and untranslated region sequences and 176 bp of ngn3 coding region) of mouse ngn3 genomic DNA was cloned upstream of the IRES-NLS-LacZ-pA sequence in pBS-INL vector resulting in plasmid pngn3(6.8)-INL. The 10.6 kb Ngn3-IRES-NLS-LacZ insert was released by NotI digestion and microinjected into murine oocyte pronuclei, and transgenic line was generated and maintained by crossing into a CD1 outbred background.

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Cite this (BCBC Cat# 232, RRID:BCBC_232)

Source Database: BCBC, catalog # 232
Genetic Background: RMCE
Affected Genes: NK2 transcription factor related, locus 2  
Genomic Alteration: Nkx2.2tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The reverse tetracycline transactivator (rtTA) is knocked into the Nkx2.2 coding region, effectively knocking out one Nkx2.2 allele.

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Cite this (BCBC Cat# 197, RRID:BCBC_197)

Source Database: BCBC, catalog # 197
Genetic Background: TM
Affected Genes: Peroxisome proliferator-activated receptor gamma  
Genomic Alteration: Ppargtm1.1Mgn
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus These mice carry a conditional allele for PPARgamma that can be used in combination with various cre-expressing transgenes.

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Cite this (BCBC Cat# 1241, RRID:BCBC_1241)

Source Database: BCBC, catalog # 1241
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference: PMID:22888097
Notes: Diabetes mellitus These mice were generated using RMCE to insert an exchange vector containing a modified Rosa26 promoter linked to a Cerulean fluorescent protein (CFP) reporter gene into mESCs containing a Loxed Cassette Acceptor (LCA) allele within the Rosa26 gene locus. The Rosa26 promoter in this mouse was altered by replacing DNA sequences from -60 to +81 with a multimerized retinoic acid response element (DR5) fused to a TATA box. This mouse will facilitate studies of retinoic acid signaling in an intact animal.

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Cite this (BCBC Cat# 1221, RRID:BCBC_1221)

Source Database: BCBC, catalog # 1221
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This strain expresses both mutant cyclin D1T286A and a cherry reporter under the regulation of a tetracycline-responsive bi-directional minimal CMV promoter (TRE-Tight; tetO). The cyclin D1-T286A mutant cannot be phosphorylated by GSK-3beta and is resistant to polyubiquitination. Therefore, cyclin D1-T286A remains nuclear throughout the cell cycle and has an extended half-life relative to wild-type cyclin D1. This strain represents an effective tool for generating inducible tissue-specific cyclin D1T286A mutants with a cherry reporter.

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Cite this (BCBC Cat# 1701, RRID:BCBC_1701)

Source Database: BCBC, catalog # 1701
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This line contains a DNA binding-deficient mutant of Foxo1. The mutation may be useful for assessing the contribution of DNA co-activation in the function of Foxo1.

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Cite this (BCBC Cat# 1262, RRID:BCBC_1262)

Source Database: BCBC, catalog # 1262
Genetic Background: OTH, TM
Affected Genes: interleukin 2 receptor, gamma chain  
Genomic Alteration: Il2rgtm1Wjl
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus NOD-scid IL2rgnull mice are deficient in mature lymphocytes and NK cells, survive beyond 16-month of age, and even after sublethal irradiation resist lymphoma development. Moreover, cytokine-mobilized human peripheral blood stem cells engraft at high levels in NOD-scid IL2rgnull mice and develop into human CD3+CD4+ and CD3+CD8+ T cells, Ig+B cells, myeloid cells, NK cells and plasmacytoid dentritic cells.

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Cite this (BCBC Cat# 205, RRID:BCBC_205)

Source Database: BCBC, catalog # 205
Genetic Background: TM
Affected Genes: Nkx6.1  
Genomic Alteration: Nkx6.1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus An IRES-DsRed2 cassette was introduced into exon 1 of the Nkx6.1 genomic sequence. The insertion generates a null allele. DsRed2 expression is not detected in these mice.

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Cite this (BCBC Cat# 210, RRID:BCBC_210)

Source Database: BCBC, catalog # 210
Genetic Background: OTH, TG, TM
Affected Genes: interleukin 2 receptor, gamma chain  
Genomic Alteration: Il2rgtm1Wjl
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus NOD-scid IL2rgnullHprttm3(Ins2-HBEGF)Ugfm mice are deficient in mature lymphocytes and NK cells, survive beyond 16 months of age, and even after sublethal irradiation resist lymphoma development. They can be induced to become hypoglycemic when Diphtheria toxin is used. 50% of beta cells will be depleted after diphtheria toxin administration.

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Cite this (BCBC Cat# 204, RRID:BCBC_204)

Source Database: BCBC, catalog # 204
Genetic Background: TM
Affected Genes: hypoxanthine guanine phosphoribosyl transferase 1  
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus C57/CBAJ-Hprttm3(Ins2-HBEGF)Ugfm carries a transgene encoding the human diphtheria toxin receptor under the control of rat insulin II promoter, was inserted by homologous recombination at the Hprt locus of the X chromosome. It provides a model for depletion of 50% of beta cells using Diphtheria toxin.

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Cite this (BCBC Cat# 207, RRID:BCBC_207)

Source Database: BCBC, catalog # 207
Genetic Background: RMCE
Affected Genes: pancreas specific transcription factor, 1a  
Genomic Alteration: Ptf1atm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Mice heterozygous for the tTA replacement of the Ptf1a gene are viable, fertile, of normal size, and do not display any behavioral abnormalities. The replacement places the expression of tTAoff (Gossen & Bujard, PNAS 89:5547, 1992) under the control of the regulatory sequences of the endogenous Ptf1a gene. This mouse was initially designed to be mated to a mouse (see BCBC #M461) bearing a bicistronic Ptf1a-lacZ transgene driven by the tetracycline-regulatory element (TRE: 7 copies of tetO with the CMV minimal promoter). For offspring homozygous for the tTA allele of Ptf1a and hemi- or homozygous for the transgene, the production of PTF1a is due solely to tTA-activation of the transgene, which is repressed by administration of tetracycline/doxycycline. This strategy allows embryonic developmental arrest at desired stages or cessation of gene function in adult mice for the pancreas (similar to that for Pdx1 described in Holland et al., PNAS 99:12236, 2002) and also for the cerebellum, retina, dorsal spinal cord and possibly hypothalamus. This transgenic mouse may be useful in studies of pancreatic endocrine/exocrine development and function, diabetes, and certain defects of the CNS. This tissue-specific expresser of tTA can also be bred with strains bearing other TRE-transgenes for organ-specific conditional expression analyses. Nearly all of the Ptf1a transcription unit has been replaced by a tTAoff coding sequence with accessory translational and RNA-processing signals, as follows, from 5' to 3': the Ptf1a gene transcriptional start and 49-bp of its 5'UTR; the Xenopus laevis beta-globin 5'UTR with Kozak initiator codon; the tTA coding sequence; and a 990-bp rabbit beta-globin gene fragment encoding the last 14-bp of its second exon, the 573-bp second intron, and the 364-bp last exon including a 98-bp 3'UTR with the polyA addition signal and addition site, and 39-bp of 3' beta-globin gene flanking sequence. The Ptf1a locus was modified by recombination-mediated cassette exchange using the cassette exchange allele in Ptf1a-LCA ES cells (Burlison et al., submitted).

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Cite this (BCBC Cat# 240, RRID:BCBC_240)

Source Database: BCBC, catalog # 240
Genetic Background: RMCE
Affected Genes: NK2 transcription factor related, locus 2  
Genomic Alteration: Nkx2.2tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The lacZ gene has been knocked in to the Nkx2.2 genomic locus using RMCE, effectively replacing the two coding exons.

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Cite this (BCBC Cat# 1321, RRID:BCBC_1321)

Source Database: BCBC, catalog # 1321
Genetic Background: TM
Affected Genes: Nkx2.2  
Genomic Alteration: Nkx2.2tm5
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus These mice contain a deletion of the Nkx2.2 coding region to create a null allele.

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Cite this (BCBC Cat# 206, RRID:BCBC_206)

Source Database: BCBC, catalog # 206
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A transgenic mouse expression tamoxifen-inducible Cre recombinase under rat insulin promoter. Upon the injection of tamoxifen, loxP-flanked DNA sequences in beta cells will be deleted.

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Cite this (BCBC Cat# 218, RRID:BCBC_218)

Source Database: BCBC, catalog # 218
Genetic Background: RMCE
Affected Genes: pancreas specific transcription factor, 1a  
Genomic Alteration: Ptf1atm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This mouse strain has a 2-bp site-directed mutation in the endogenous Ptf1a locus that changes codon 298 from tryptophan to alanine. The mutation disrupts the ability of the PTF1a protein to bind RBPJ. Mice heterozygous for the mutation are viable, fertile, of normal size, and do not display any behavioral abnormalities. Mice homozygous for the mutation phenocopy the homozygous Ptf1a-null. Newborn homozygotes are apancreatic, devoid of the dI4 and dILA GABAergic dorsal interneurons, have an incomplete cerebellum, and die shortly after birth.

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Cite this (BCBC Cat# 212, RRID:BCBC_212)

Source Database: BCBC, catalog # 212
Genetic Background: TM
Affected Genes: recombination activating gene 1  
Genomic Alteration: Rag1tm1Mom
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rg null mice.

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Cite this (BCBC Cat# 219, RRID:BCBC_219)

Source Database: BCBC, catalog # 219
Genetic Background: TM
Affected Genes: Recombination signal binding protein for immunoglobulin kappa J region-like  
Genomic Alteration: Rbpjltm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This mouse strain has the Rbpjl gene region spanning exons 7, 8, and 9 replaced with lacZ in-frame. A pgk-neo resistance cassette has been removed by Cre-loxP deletion from the founder. Mice heterozygous and homozygous for the lacZ replacement are viable, fertile, of normal size, and do not display any behavioral abnormalities. In mature mice, the pancreas is one-third smaller than normal, due to less acinar tissue. Expression of the lacZ, measured by bet-galactosidase histostaining is very low.

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Cite this (BCBC Cat# 177, RRID:BCBC_177)

Source Database: BCBC, catalog # 177
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus A transgenic alteration consisting of a SacI fragment containing the glucagon promoter, inserted at SacI of pBS-beta globin-Cre, resulting in Cre expression in pancreatic lineage cells.

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Cite this (BCBC Cat# 216, RRID:BCBC_216)

Source Database: BCBC, catalog # 216
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Mice hemi- or homozygous for the transgene are viable, fertile, normal size, and do not display any behavioral abnormalities. Expression of the bicistronic transgene is directed by a heptameric tetO repeat linked to the CMV minimal promoter (collectively the tetracycline-response element). The mice do not express lacZ until a tetracycline-gransactivator (tTA) protein is produced; thereafter Ptf1a and lacZ genes are highly expressed. This mouse was designed to be mated to an apancreatic targeted mutant with tTAoff in place of the Ptf1a coding sequence (see BCBC strain M321). The combined genetic alterations provide normal pancreatic development and function until doxycycline-administration render the mice conditionally null of Ptf1a. This approach allows embryonic developmental arrest at desired stages or cessation of gene function in adult mice for the pancreas, cerebellum, retina, dorsal spinal cord and possibly hypothalamus. This transgenic mouse may be useful in studies of pancreatic endocrine/exocrine development and function, diabetes, and and certain defects of the CNS. This transgenic can also be bred with other tTA strains for conditional mutation analysis.

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Cite this (BCBC Cat# 2061, RRID:BCBC_2061)

Source Database: BCBC, catalog # 2061
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A GFP cDNA has been knocked into the Foxo1 locus at the 3' end of the endogenous Foxo1 cDNA to generate a Foxo1-gfp fusion protein that can be used to study Foxo1 translocation in vivo.

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