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Cite this (BCBC Cat# 228, RRID:BCBC_228)

Source Database: BCBC, catalog # 228
Genetic Background: TM
Affected Genes: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A
Genomic Alteration: Mafatm1.1
Availability: Cell line is available; Now found at MMRRC
Notes: Diabetes mellitus Mafa is a basic leucine-zipper containing member of the large Maf transcription factor family.It is part of the RIPE3b1 activator complex and functions as a key activator of insulin and pdx-1 gene transcription. Mafalox mice may be used to generate both global and cell-specific Mafa null mice, depending on which cre-expressing transgenic mouse is used. Removal of Mafa gene might have a profound effect on beta cell function; thus we can closely monitor the expression of islet hormones, transcription functions and the glucose sensing machinery immunohistochemically. The experiment will provide us with the information about the role of Mafa plays in vivo in islet beta cells and the developing pancreas, thus helping us to understand how transcription activator contribute to the pathogenesis and the treatment of diabetes.

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