Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

  • Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Search

Type in a keyword to search

on page 1 showing 20 out of 59 results

Cite this (BCBC Cat# 2702, RRID:BCBC_2702)

Source Database: BCBC, catalog # 2702
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This mouse contains a bidirectional Tet0-regulated fusion gene that has been inserted into adisabled Rosa26 loxed cassette acceptor allele by RMCE. In one direction the tetO/CMV promoter drives expression of a red fluorescent protein (Cherry) while in the other direction it drives MafA expression.

  • From Current Category

Cite this (BCBC Cat# 1001, RRID:BCBC_1001)

Source Database: BCBC, catalog # 1001
Genetic Background: RMCE
Affected Genes: pancreas specific transcription factor, 1a  
Genomic Alteration: Ptf1atm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Modified allele of Ptf1a with a biotinylation Tag sequence attached to the amino terminus of Ptf1a.

  • From Current Category

Cite this (BCBC Cat# 245, RRID:BCBC_245)

Source Database: BCBC, catalog # 245
Genetic Background: TM
Affected Genes: Pancreatic and Duodenal homeobox 1  
Genomic Alteration: Pdx1tm5
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus LoxP sites for cre recombinase were inserted to flank Area I-II-III, a conserved 5' cis-regulatory region of Pdx1. This allele was shown to be a conditional hypomorph by Fujitani et al. (2006) (PMID 16418487). Pdx1tm3Cvw (Pdx1deltaI-II-III) is generated by Cre-mediated recombination in the germline of this allele.

  • From Current Category

Cite this (BCBC Cat# 243, RRID:BCBC_243)

Source Database: BCBC, catalog # 243
Genetic Background: TM
Affected Genes: Pancreatic and Duodenal homeobox 1  
Genomic Alteration: Pdx1tm4
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This is a conditional null allele of Pdx1. LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene.

  • From Current Category

Cite this (BCBC Cat# 206, RRID:BCBC_206)

Source Database: BCBC, catalog # 206
Genetic Background: TG
Affected Genes:
Genomic Alteration:
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A transgenic mouse expression tamoxifen-inducible Cre recombinase under rat insulin promoter. Upon the injection of tamoxifen, loxP-flanked DNA sequences in beta cells will be deleted.

  • From Current Category

Cite this (BCBC Cat# 661, RRID:BCBC_661)

Source Database: BCBC, catalog # 661
Genetic Background: RMCE
Affected Genes: insulinoma-associated 1  
Genomic Alteration: Insm1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Insm1GFPCre mice contain a GFP-Cre fusion protein which replaces the Insm1 coding sequence. These mice express green fluorescent protein (GFP) under control of theInsm1gene locus. Insm1 is expressed in pancreatic primordium starting at E9.5. Insm1 is also expressed in neural precursor cells and tumors of may be used for lineage tracing of Insm1-positive cells in both wild-type and Insm1-null mice.

  • From Current Category

Cite this (BCBC Cat# 212, RRID:BCBC_212)

Source Database: BCBC, catalog # 212
Genetic Background: TM
Affected Genes: recombination activating gene 1  
Genomic Alteration: Rag1tm1Mom
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rg null mice.

  • From Current Category

Cite this (BCBC Cat# 2061, RRID:BCBC_2061)

Source Database: BCBC, catalog # 2061
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A GFP cDNA has been knocked into the Foxo1 locus at the 3' end of the endogenous Foxo1 cDNA to generate a Foxo1-gfp fusion protein that can be used to study Foxo1 translocation in vivo.

  • From Current Category

Cite this (BCBC Cat# 242, RRID:BCBC_242)

Source Database: BCBC, catalog # 242
Genetic Background: RMCE
Affected Genes: pancreatic and duodenal homeobox 1  
Genomic Alteration: Pdx1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This is a targeted deletion of Area II 5' cis-regulatory region of Pdx1.

  • From Current Category

Cite this (BCBC Cat# 220, RRID:BCBC_220)

Source Database: BCBC, catalog # 220
Genetic Background: TM
Affected Genes: Pancreatic and duodenal homeobox 1  
Genomic Alteration: Pdx1tmd1Macd
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus Mice homozygous for the targeted mutation fail to develop a pancreas. Heterozygous mice have normal pancreatic development, but have partially impaired glucose tolerance in adulthood. The substitution of the targeted Ipf1/Pdx1 gene with tTAoff inactivates the endogenous allele and places tTAoff expression under the control of the endogenous transcriptional regulatory sequences of the Pdx1 locus. Identical to the endogenous allele, mutant locus expression is detectable in the pancreas and adjacent duodenum but not in other visceral organs or salivary glands. This mutant may be useful to direct tetracycline-regulated expression of responder transgenes in studies of pancreatic endocrine/exocrine development and function and diabetes. This mutant can also be bred with other tetO/TRE strains for pancreas-specific applications. This mutant was originally designed to be mated with mice engineered with a heptameric tetracycline operator (tetO)-controlled bicistronic transgene coding for a normal PDX1 protein and with a beta-galactosidase or EGFP reporter (see BCBC mouse M561). The combined modifications allow normal pancreatic development and function until doxycycline-administration renders the mouse conditionally null of the Pdx1 gene. This configuration for conditional expression of Pdx1is most effective when the transgene locus is homozygous. This allows embryonic developmental arrest at desired stages or cessation of function in adult mice by tetracycline administration.

  • From Current Category

Cite this (BCBC Cat# 211, RRID:BCBC_211)

Source Database: BCBC, catalog # 211
Genetic Background: TM, OTH
Affected Genes: recombination activating gene 1  
Genomic Alteration: MGI:97848)
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The NOD-Rag1null Prf1null Ins2Akita mouse is the first immunodeficient, spontaneously hyperglycemic mouse strain described that is based on the Ins2Akita mutation. This strain is suitable as hosts for human islet and human beta stem and progenitor cell transplantation in the absence of the need for pharmacological induction of diabetes. This strain of mice also has low levels of innate immunity and can be engrafted with a human immune system for the study of human islet allograft rejection.

  • From Current Category

Cite this (BCBC Cat# 241, RRID:BCBC_241)

Source Database: BCBC, catalog # 241
Genetic Background: RMCE
Affected Genes: NK2 transcription factor related, locus 2  
Genomic Alteration: Nkx2.2tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus The strain carries a mutant Nkx2.2 allele in which conserved residues of the NK2 domain are mutated to alanines.

  • From Current Category

Cite this (BCBC Cat# 2301, RRID:BCBC_2301)

Source Database: BCBC, catalog # 2301
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Neurog3nCre
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A nCre-iRES (n-terminal half of Cre followed by internal ribosomal entry site) was inserted after Ngn3ATG. This allele is confirmed to express both nCre and Ngn3 (no visible phenotype in homozygous animals).

  • From Current Category

Cite this (BCBC Cat# 1241, RRID:BCBC_1241)

Source Database: BCBC, catalog # 1241
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference: PMID:22888097
Notes: Diabetes mellitus These mice were generated using RMCE to insert an exchange vector containing a modified Rosa26 promoter linked to a Cerulean fluorescent protein (CFP) reporter gene into mESCs containing a Loxed Cassette Acceptor (LCA) allele within the Rosa26 gene locus. The Rosa26 promoter in this mouse was altered by replacing DNA sequences from -60 to +81 with a multimerized retinoic acid response element (DR5) fused to a TATA box. This mouse will facilitate studies of retinoic acid signaling in an intact animal.

  • From Current Category

Cite this (BCBC Cat# 215, RRID:BCBC_215)

Source Database: BCBC, catalog # 215
Genetic Background: TM
Affected Genes: Neurogenin 3  
Genomic Alteration: Ngn3EYFP/+
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus A targeting construct was designed to insert an IRES-EYFP and a floxed puro downstream of the coding sequence. Crossing with mice expressing Cre in the germ line excised the puromycin resistance gene. Coding region for Ngn3 is kept intact consequentely homozygous mice express Ngn3 protein , do not develop diabetes and behave like wild-types. in these mice, Ngn3-positive progenitors express EYFP and can be purified by FACS.

  • From Current Category

Cite this (BCBC Cat# 2582, RRID:BCBC_2582)

Source Database: BCBC, catalog # 2582
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus This mouse contains a bidirectional TetO-regulated fusion gene that has been inserted into a disabled Rosa26 locus. In one direction the tetO/CMV promoter drives expression of CFP (Cerulean). In the other direction it drives Ngn3. Mice containing this allelecan be used to drive the expression of Ngn3 under control of both doxycycline and either an rtTA or tTA transgene.

  • From Current Category

Cite this (BCBC Cat# 205, RRID:BCBC_205)

Source Database: BCBC, catalog # 205
Genetic Background: TM
Affected Genes: Nkx6.1  
Genomic Alteration: Nkx6.1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus An IRES-DsRed2 cassette was introduced into exon 1 of the Nkx6.1 genomic sequence. The insertion generates a null allele. DsRed2 expression is not detected in these mice.

  • From Current Category

Cite this (BCBC Cat# 1701, RRID:BCBC_1701)

Source Database: BCBC, catalog # 1701
Genetic Background: RMCE
Affected Genes: forkhead box O1  
Genomic Alteration: Foxo1tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This line contains a DNA binding-deficient mutant of Foxo1. The mutation may be useful for assessing the contribution of DNA co-activation in the function of Foxo1.

  • From Current Category

Cite this (BCBC Cat# 1221, RRID:BCBC_1221)

Source Database: BCBC, catalog # 1221
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano  
Genomic Alteration: Rosa26tm1
Availability: Cell line is available
Reference:
Notes: Diabetes mellitus This strain expresses both mutant cyclin D1T286A and a cherry reporter under the regulation of a tetracycline-responsive bi-directional minimal CMV promoter (TRE-Tight; tetO). The cyclin D1-T286A mutant cannot be phosphorylated by GSK-3beta and is resistant to polyubiquitination. Therefore, cyclin D1-T286A remains nuclear throughout the cell cycle and has an extended half-life relative to wild-type cyclin D1. This strain represents an effective tool for generating inducible tissue-specific cyclin D1T286A mutants with a cherry reporter.

  • From Current Category

Cite this (BCBC Cat# 195, RRID:BCBC_195)

Source Database: BCBC, catalog # 195
Genetic Background: TM
Affected Genes: Rictor  
Genomic Alteration: 4921505C17Riktm2Mgn
Availability: Cell line is available; Now found at MMRRC
Reference:
Notes: Diabetes mellitus Rictor is an essential part of mTOR complex 2 (mTORC2). mTORC2 phosphorylates Ser473 of Akt/PKB. Eliminating this gene disrupts the function of mTORC2, thereby preventing growth factor mediated activation of Akt/PKB. Thus, these mice have utility for studying both the sites of expression and function of rictor.

  • From Current Category

  1. RRID Portal Resources

    Welcome to the RRID Resources search. From here you can search through a compilation of resources used by RRID and see how data is organized within our community.

  2. Navigation

    You are currently on the Community Resources tab looking through categories and sources that RRID has compiled. You can navigate through those categories from here or change to a different tab to execute your search through. Each tab gives a different perspective on data.

  3. Logging in and Registering

    If you have an account on RRID then you can log in from here to get additional features in RRID such as Collections, Saved Searches, and managing Resources.

  4. Searching

    Here is the search term that is being executed, you can type in anything you want to search for. Some tips to help searching:

    1. Use quotes around phrases you want to match exactly
    2. You can manually AND and OR terms to change how we search between words
    3. You can add "-" to terms to make sure no results return with that term in them (ex. Cerebellum -CA1)
    4. You can add "+" to terms to require they be in the data
    5. Using autocomplete specifies which branch of our semantics you with to search and can help refine your search
  5. Save Your Search

    You can save any searches you perform for quick access to later from here.

  6. Query Expansion

    We recognized your search term and included synonyms and inferred terms along side your term to help get the data you are looking for.

  7. Collections

    If you are logged into RRID you can add data records to your collections to create custom spreadsheets across multiple sources of data.

  8. Sources

    Here are the sources that were queried against in your search that you can investigate further.

  9. Categories

    Here are the categories present within RRID that you can filter your data on

  10. Subcategories

    Here are the subcategories present within this category that you can filter your data on

  11. Further Questions

    If you have any further questions please check out our FAQs Page to ask questions and see our tutorials. Click this button to view this tutorial again.

X