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Cite this (KI Biobank - HARMONY, RRID:SCR_008884)

URL: http://ki-su-arc.se/dementia-in-swedish-twins-harmony/

Resource Type: Resource, disease-related portal, topical portal, research forum portal, biomaterial supply resource, portal, material resource, data or information resource

A twin study characterizing the importance of genetic factors for dementia and using discordant twin pairs to study other putative risk factors which control for genetic propensity to develop the disease. Molecular genetic studies have identified a number of mutations and other markers associated with early age of onset Alzheimer''''s disease. However, most cases of late age of onset dementia are considered sporadic, that is, without a clear genetic basis. Twin studies provide a unique opportunity to characterize the importance of genetic factors for dementia. Discordant twin pairs additionally provide the opportunity to study other putative risk factors which controlling for genetic propensity to develop the disease. In the first wave of the Study of Dementia in Swedish Twins, all SATSA twins born before 1935 have been screened for dementia symptoms. Over 190 suspects have been identified. This pilot study has been expanded to the entire registry in the study known as HARMONY. All twins aged 65 and older were invited to participate in a computer assisted telephone screening interview. A total of 13,519 individuals completed the interview (response rate = 75.9%). Dementia screening was based on the TELE, which includes the 10-item MSQ, other cognitive items (counting backwards, recalling three words, and similarities), and questions about health and daily functioning; or on Blessed scores obtained from a proxy interview. Among those screened, 1565 were positive for suspicion of dementia and were referred for complete clinical evaluation by a physician and a nurse. Once the preliminary in-person evaluation suggested that the suspected case was demented, the twin partner was also invited for an identical clinical work-up. Response rate for clinical evaluations is 71.4%. Approximately half of those visited for evaluation have been diagnosed as demented according to DSM-IV criteria, of which two-thirds have Alzheimer''''s disease. An extensive assessment of probable risk exposure is also included. Longitudinal follow-up is yet another feature of the study. Association studies with candidate genes are also being performed. Types of samples * DNA Number of sample donors * 1154 (sample collection completed)


Cite this (National AIDS Research Institute, RRID:SCR_005355)

URL: http://www.nari-icmr.res.in

Resource Type: Resource, topical portal, portal, data or information resource

In the early nineties it became evident that HIV infection was spreading widely in India and the national efforts for control of HIV infection needed to be backed by quality research. It was also realized that AIDS, being a multifaceted disease, needed multi-disciplinary research involving virology, immunology, microbiology, clinical research, epidemiology, field based trials and social and behavioral research. An Institute devoted exclusively to HIV/ AIDS that could undertake research of such a diversity and magnitude was established to meet this requirement. National AIDS Research Institute (NARI) was established in October 1992 in Bhosari, Pune on a seven acre plot. The Institute has progressively expanded its activities in various aspects of research on HIV and AIDS through infra-structural development, capacity building & research programmes. The activities of NARI are supported by the ICMR & numerous extramural agencies. For the fiscal year 2005-2006 the ICMR allocated 5.66 crores for NARI. Additionally, over 13 crores have been generated through extramural sources. The Institute''s research activities are guided by a Scientific Advisory Committee which includes eminent scientists from varied disciplines. All research projects are reviewed & approved by the Ethics Committee which also ensures that research is conducted with highest ethical standards. Establishment of a Community Advisory Board which acts as an interface between the community and the researchers is a pioneering effort by NARI.


    Sageweb

Cite this (Sageweb, RRID:SCR_010217)

URL: http://sageweb.org/

Resource Type: Resource, community building portal, topical portal, database, portal, data or information resource

A resource center that distributes important resources to the biogerontological community and facilitates interactions and collaborative efforts amongst researchers to aid biogerontologists and enhance research into the basic biology of aging. They aim to make SAGEWEB the premier aging-related website containing a variety of different content types including: * Databases related to the basic biology of aging * Software and bioinformatic tools for aging-related science * Educational tools for teachers and students interested in aging biology * Primers on important topics in aging-related science * Videos and podcasts of aging-related topics * Aging-related discussion forums and blogs * Links to additional aging-related labs, conferences, and resources


Cite this (FlyWeb Project, RRID:SCR_010516)

URL: http://imageweb.zoo.ox.ac.uk/wiki/index.php/FlyWeb_project

Resource Type: Resource, topical portal, portal, data or information resource

The FlyWeb Project is linking research image data from FlyTED with related data from the Berkeley Drosophila Genome Project, FlyBase, FlyAtlas and other sources. This project builds on the findings of the data web requirements analysis project Defining Image Access.


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