URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=46273

Proper Citation: RRID:MMRRC_046273-MU

Description: Mus musculus with name B6J.Cg-Bsg^tm1.1Riki Lyz2^tm1(cre)Ifo/Mmmh from MMRRC.

Species: Mus musculus

Notes: Research areas: Cell Biology, Immunology and Inflammation, Research Tools; Mutation Type: other ; Collection:

Phenotype: increased bone mineral density [MP:0000062]| decreased bone mineral density [MP:0000063]| osteoporosis [MP:0000066]| osteopetrosis [MP:0000067]| abnormal trabecular bone morphology [MP:0000130]| decreased compact bone thickness [MP:0000135]| abnormal bone marrow cell number [MP:0000172]| decreased hematocrit [MP:0000208]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| decreased leukocyte cell number [MP:0000221]| decreased neutrophil cell number [MP:0000222]| abnormal systemic arterial blood pressure [MP:0000230]| extramedullary hematopoiesis [MP:0000240]| abnormal erythropoiesis [MP:0000245]| cellular necrosis [MP:0000316]| increased granulocyte number [MP:0000322]| decreased bone marrow cell number [MP:0000333]| decreased granulocyte number [MP:0000334]| abnormal intestine morphology [MP:0000477]| abnormal colon morphology [MP:0000495]| abnormal small intestine morphology [MP:0000496]| abnormal liver morphology [MP:0000598]| enlarged liver [MP:0000599]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| abnormal thymus morphology [MP:0000703]| abnormal lymphocyte cell number [MP:0000717]| abnormal lung morphology [MP:0001175]| reddish skin [MP:0001190]| scaly skin [MP:0001192]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| decreased metastatic potential [MP:0001273]| hypoactivity [MP:0001402]| abnormal pilomotor reflex [MP:0001492]| abnormal osteoclast physiology [MP:0001541]| anemia [MP:0001577]| abnormal myelopoiesis [MP:0001601]| hepatic necrosis [MP:0001654]| focal hepatic necrosis [MP:0001656]| postnatal growth retardation [MP:0001732]| abnormal immune system physiology [MP:0001790]| impaired macrophage phagocytosis [MP:0001798]| abnormal immune cell physiology [MP:0001819]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| decreased inflammatory response [MP:0001876]| abnormal lymphatic vessel morphology [MP:0001879]| respiratory distress [MP:0001954]| increased leukemia incidence [MP:0002026]| increased lung adenocarcinoma incidence [MP:0002027]| increased colon adenoma incidence [MP:0002044]| increased lung adenoma incidence [MP:0002048]| abnormal glucose homeostasis [MP:0002078]| premature death [MP:0002083]| abnormal skeleton development [MP:0002113]| abnormal lipid homeostasis [MP:0002118]| abnormal definitive hematopoiesis [MP:0002123]| abnormal blood circulation [MP:0002128]| abnormal kidney morphology [MP:0002135]| altered tumor susceptibility [MP:0002166]| no abnormal phenotype detected [MP:0002169]| decreased susceptibility to hepatic steatosis [MP:0002310]| abnormal spleen red pulp morphology [MP:0002356]| abnormal spleen marginal zone morphology [MP:0002362]| abnormal bone marrow cell morphology/development [MP:0002398]| decreased susceptibility to viral infection [MP:0002410]| decreased susceptibility to bacterial infection [MP:0002411]| increased susceptibility to bacterial infection [MP:0002412]| abnormal megakaryocyte progenitor cell morphology [MP:0002413]| abnormal myeloblast morphology/development [MP:0002414]| abnormal neutrophil differentiation [MP:0002415]| abnormal leukocyte physiology [MP:0002442]| abnormal macrophage morphology [MP:0002446]| abnormal macrophage physiology [MP:0002451]| abnormal macrophage antigen presentation [MP:0002454]| abnormal B cell number [MP:0002458]| abnormal neutrophil physiology [MP:0002463]| impaired complement alternative pathway [MP:0002472]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| granulomatous inflammation [MP:0002500]| decreased circulating free fatty acid level [MP:0002702]| decreased circulating insulin level [MP:0002727]| glomerulonephritis [MP:0002743]| colitis [MP:0002816]| albuminuria [MP:0002871]| decreased hemoglobin content [MP:0002874]| increased insulin sensitivity [MP:0002891]| delayed wound healing [MP:0002908]| increased circulating alanine transaminase level [MP:0002941]| increased lactate dehydrogenase level [MP:0002944]| increased urine protein level [MP:0002962]| arthritis [MP:0002993]| abnormal cytokine secretion [MP:0003009]| increased insulin secretion [MP:0003058]| enlarged kidney [MP:0003068]| altered response to CNS ischemic injury [MP:0003075]| abnormal redox activity [MP:0003186]| peritoneal inflammation [MP:0003303]| liver fibrosis [MP:0003333]| abnormal gluconeogenesis [MP:0003383]| decreased susceptibility to induced arthritis [MP:0003436]| decreased tumor growth/size [MP:0003447]| abnormal intestinal goblet cell morphology [MP:0003449]| abnormal capillary morphology [MP:0003658]| oxidative stress [MP:0003674]| abnormal microglial cell physiology [MP:0003691]| abnormal physiological neovascularization [MP:0003710]| increased tumor growth/size [MP:0003721]| increased susceptibility to induced arthritis [MP:0003724]| increased autoantibody level [MP:0003725]| abnormal compact bone morphology [MP:0003797]| impaired macrophage chemotaxis [MP:0003799]| hairless [MP:0003815]| pulmonary edema [MP:0003828]| abnormal nephron morphology [MP:0003881]| decreased macrophage cell number [MP:0003884]| increased kidney weight [MP:0003917]| decreased lean body mass [MP:0003961]| increased acute promyelocytic leukemia incidence [MP:0004049]| renal tubular necrosis [MP:0004154]| increased incidence of tumors by chemical induction [MP:0004499]| decreased incidence of tumors by chemical induction [MP:0004502]| increased anti-double stranded DNA antibody level [MP:0004762]| increased anti-single stranded DNA antibody level [MP:0004771]| increased anti-nuclear antigen antibody level [MP:0004794]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| increased hematopoietic stem cell number [MP:0004809]| increased mean systemic arterial blood pressure [MP:0004875]| abnormal vascular wound healing [MP:0004883]| increased energy expenditure [MP:0004889]| skin inflammation [MP:0004947]| increased spleen weight [MP:0004952]| decreased regulatory T cell number [MP:0004974]| abnormal osteoclast morphology [MP:0004982]| increased osteoclast cell number [MP:0004984]| decreased osteoclast cell number [MP:0004985]| increased bone resorption [MP:0004992]| decreased bone resorption [MP:0004993]| increased eosinophil cell number [MP:0005011]| increased lymphocyte cell number [MP:0005013]| increased B cell number [MP:0005014]| decreased lymphocyte cell number [MP:0005016]| decreased B cell number [MP:0005017]| abnormal wound healing [MP:0005023]| decreased susceptibility to parasitic infection [MP:0005026]| increased susceptibility to parasitic infection [MP:0005027]| abnormal MHC II cell surface expression on macrophages [MP:0005040]| abnormal neutrophil morphology [MP:0005065]| impaired granulocyte bactericidal activity [MP:0005074]| decreased acute inflammation [MP:0005087]| increased susceptibility to injury [MP:0005165]| decreased susceptibility to injury [MP:0005166]| lethargy [MP:0005202]| abnormal metabolism [MP:0005266]| decreased fatty acid level [MP:0005282]| improved glucose tolerance [MP:0005292]| abnormal renal glomerulus morphology [MP:0005325]| abnormal myocardium layer morphology [MP:0005329]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| increased circulating aspartate transaminase level [MP:0005343]| increased T cell proliferation [MP:0005348]| decreased susceptibility to autoimmune disorder [MP:0005351]| increased susceptibility to fungal infection [MP:0005399]| abnormal circulating protein level [MP:0005416]| increased macrophage cell number [MP:0005425]| tachypnea [MP:0005426]| abnormal glycogen homeostasis [MP:0005438]| thrombocytosis [MP:0005505]| decreased body temperature [MP:0005534]| abnormal body temperature [MP:0005535]| increased circulating creatinine level [MP:0005553]| decreased circulating glucose level [MP:0005560]| increased blood urea nitrogen level [MP:0005565]| abnormal enzyme/coenzyme activity [MP:0005584]| increased susceptibility to type I hypersensitivity reaction [MP:0005596]| increased lung weight [MP:0005630]| abnormal mitochondrial physiology [MP:0006036]| increased apoptosis [MP:0006042]| decreased cerebral infarction size [MP:0006058]| decreased susceptibility to ischemic brain injury [MP:0006059]| abnormal common myeloid progenitor cell morphology [MP:0006410]| increased lung tumor incidence [MP:0008014]| decreased NK cell number [MP:0008045]| decreased memory T cell number [MP:0008050]| abnormal NK cell differentiation [MP:0008053]| abnormal podocyte foot process morphology [MP:0008059]| absent T cells [MP:0008070]| absent B cells [MP:0008071]| abnormal CD4-positive [MP:0008073]| alpha beta T cell number [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008077]| decreased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008079]| abnormal CD8-positive [MP:0008113]| alpha-beta T cell number [MP:0008114]| increased CD8-positive [MP:0008126]| alpha-beta T cell number [MP:0008139]| decreased CD8-positive [MP:0008183]| alpha-beta T cell number [MP:0008236]| abnormal macrophage differentiation [MP:0008240]| abnormal Kupffer cell morphology [MP:0008244]| increased dendritic cell number [MP:0008245]| fused podocyte foot processes [MP:0008260]| absent marginal zone B cells [MP:0008271]| decreased susceptibility to neuronal excitotoxicity [MP:0008396]| abnormal spleen marginal zone macrophage morphology [MP:0008406]| abnormal peritoneal macrophage morphology [MP:0008412]| abnormal alveolar macrophage morphology [MP:0008470]| abnormal autophagy [MP:0008489]| abnormal bone ossification [MP:0008537]| abnormal osteoclast differentiation [MP:0008539]| increased cellular sensitivity to hydrogen peroxide [MP:0008553]| increased cellular sensitivity to oxidative stress [MP:0008554]| abnormal spleen B cell follicle morphology [MP:0008560]| slow postnatal weight gain [MP:0008561]| increased susceptibility to induced colitis [MP:0008565]| decreased susceptibility to induced colitis [MP:0008566]| increased circulating tumor necrosis factor level [MP:0008567]| decreased circulating tumor necrosis factor level [MP:0008574]| increased tumor necrosis factor secretion [MP:0008576]| decreased tumor necrosis factor secretion [MP:0008577]| decreased interferon-beta secretion [MP:0008593]| increased interferon-gamma secretion [MP:0008594]| decreased interferon-gamma secretion [MP:0008596]| decreased circulating interferon-alpha level [MP:0008597]| decreased circulating interferon-beta level [MP:0008599]| increased circulating interferon-gamma level [MP:0008614]| increased circulating interleukin-10 level [MP:0008617]| decreased circulating interleukin-10 level [MP:0008635]| increased circulating interleukin-6 level [MP:0008638]| decreased circulating interleukin-6 level [MP:0008641]| increased circulating interleukin-2 level [MP:0008642]| increased circulating interleukin-17 level [MP:0008655]| increased circulating interleukin-12 level [MP:0008657]| increased circulating interleukin-18 level [MP:0008658]| increased circulating interleukin-1 alpha level [MP:0008660]| increased circulating interleukin-1 beta level [MP:0008661]| decreased circulating interleukin-1 beta level [MP:0008663]| decreased interleukin-1 alpha secretion [MP:0008664]| increased interleukin-1 beta secretion [MP:0008669]| decreased interleukin-1 beta secretion [MP:0008672]| increased interleukin-10 secretion [MP:0008681]| decreased interleukin-10 secretion [MP:0008684]| increased interleukin-12 secretion [MP:0008690]| decreased interleukin-12 secretion [MP:0008699]| increased interleukin-12b secretion [MP:0008700]| increased interleukin-13 secretion [MP:0008704]| increased interleukin-17 secretion [MP:0008705]| increased interleukin-18 secretion [MP:0008706]| increased interleukin-23 secretion [MP:0008713]| increased interleukin-4 secretion [MP:0008719]| decreased interleukin-4 secretion [MP:0008720]| abnormal interleukin-6 secretion [MP:0008721]| increased interleukin-6 secretion [MP:0008722]| decreased interleukin-6 secretion [MP:0008734]| abnormal cytokine level [MP:0008735]| impaired neutrophil recruitment [MP:0008813]| impaired neutrophil chemotaxis [MP:0008943]| abnormal chemokine level [MP:0008973]| abnormal chemokine secretion [MP:0009172]| decreased susceptibility to endotoxin shock [MP:0009269]| increased susceptibility to endotoxin shock [MP:0009278]| decreased common myeloid progenitor cell number [MP:0009314]| increased sensitivity to induced cell death [MP:0009336]| decreased erythroid progenitor cell number [MP:0009543]| small pancreatic islets [MP:0009625]| decreased fat cell size [MP:0009642]| abnormal bone marrow cell physiology [MP:0009763]| increased colon adenocarcinoma incidence [MP:0009764]| increased splenocyte proliferation [MP:0009766]| abnormal thymus corticomedullary boundary morphology [MP:0009767]| abnormal abdominal lymph node morphology [MP:0009788]| abnormal blood homeostasis [MP:0009789]| increased sensitivity to induced morbidity/mortality [MP:0009814]| decreased sensitivity to induced morbidity/mortality [MP:0009815]| increased sensitivity to xenobiotic induced morbidity/mortality [MP:0009858]| decreased sensitivity to xenobiotic induced morbidity/mortality [MP:0010064]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0010182]| decreased susceptibility to bacterial infection induced morbidity/mortality [MP:0010209]| increased prostaglandin level [MP:0010210]| decreased prostaglandin level [MP:0010373]| abnormal cellular extravasation [MP:0010639]| increased circulating creatine level [MP:0010760]| decreased susceptibility to weight gain [MP:0010762]| abnormal circulating chemokine level [MP:0010766]| abnormal circulating cytokine level [MP:0010869]| myeloid hyperplasia [MP:0010873]| altered tumor pathology [MP:0010875]| abnormal macrophage chemotaxis [MP:0010878]| abnormal microglial cell activation [MP:0010879]| abnormal NK cell physiology [MP:0010922]| decreased bone trabecula number [MP:0010954]| decreased trabecular bone mass [MP:0010957]| increased bone volume [MP:0010962]| increased trabecular bone volume [MP:0011014]| decreased trabecular bone volume [MP:0011075]| alveolitis [MP:0011079]| abnormal cellular respiration [MP:0011080]| abnormal aerobic respiration [MP:0011085]| decreased compact bone mass [MP:0011086]| decreased core body temperature [MP:0011089]| abnormal macrophage activation involved in immune response [MP:0011294]| decreased macrophage cytokine production [MP:0011353]| increased macrophage apoptosis [MP:0011369]| postnatal lethality [MP:0011409]| complete penetrance [MP:0011427]| postnatal lethality [MP:0011820]| incomplete penetrance [MP:0012007]| perinatal lethality [MP:0012441]| complete penetrance [MP:0013026]| renal glomerulus hypertrophy [MP:0013630]| expanded mesangial matrix [MP:0014226]| increased renal glomerulus apoptosis [MP:0014229]| increased renal glomerulus basement membrane thickness [MP:0020254]

Affected Gene: Bsg||Lyz2|