URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=43692

Proper Citation: RRID:MMRRC_043692-UCD

Description: Mus musculus with name STOCK Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Rb1^tm3Tyj Rbl2^tm2Tyj Trp53^tm1Brn/Mmucd from MMRRC.

Species: Mus musculus

Notes: Research areas: Apoptosis, Cancer, Cell Biology, Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: other ; Collection:

Phenotype: abnormal myogenesis [MP:0000729]| small testis [MP:0001147]| abnormal spermatogenesis [MP:0001156]| epidermal hyperplasia [MP:0001222]| abnormal epidermis suprabasal layer morphology [MP:0001233]| abnormal epidermis stratum granulosum morphology [MP:0001239]| increased metastatic potential [MP:0001272]| abnormal retina morphology [MP:0001325]| decreased retinal photoreceptor cell number [MP:0001327]| hunched posture [MP:0001505]| postnatal growth retardation [MP:0001732]| male infertility [MP:0001925]| increased tumor incidence [MP:0002020]| increased lung adenocarcinoma incidence [MP:0002027]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| abnormal eye morphology [MP:0002092]| abnormal fertility/fecundity [MP:0002161]| increased brain weight [MP:0002176]| gliosis [MP:0002183]| abnormal bronchiole morphology [MP:0002267]| increased circulating alkaline phosphatase level [MP:0002968]| retina hypoplasia [MP:0002984]| increased neuron apoptosis [MP:0003203]| increased hepatocellular carcinoma incidence [MP:0003331]| abnormal tumor morphology [MP:0003448]| abnormal retinal inner nuclear layer morphology [MP:0003733]| abnormal retinal inner plexiform layer morphology [MP:0003734]| increased osteosarcoma incidence [MP:0003789]| polyploidy [MP:0004025]| transmission ratio distortion [MP:0004179]| decreased testis weight [MP:0004852]| increased brain size [MP:0005238]| abnormal amacrine cell morphology [MP:0005240]| abnormal retinal ganglion layer morphology [MP:0005241]| abnormal lens development [MP:0005545]| abnormal horizontal cell morphology [MP:0006068]| abnormal retinal neuronal layer morphology [MP:0006069]| abnormal retinal apoptosis [MP:0006072]| absent retinal bipolar cells [MP:0006096]| decreased retinal ganglion cell number [MP:0006309]| increased retinoblastoma incidence [MP:0006310]| increased lung tumor incidence [MP:0008014]| increased liver tumor incidence [MP:0008019]| absent retinal ganglion cell [MP:0008068]| decreased retinal cone cell number [MP:0008446]| thin retinal inner nuclear layer [MP:0008511]| disorganized retinal inner nuclear layer [MP:0008512]| thin retinal inner plexiform layer [MP:0008513]| thin retinal outer nuclear layer [MP:0008515]| increased lung small cell carcinoma incidence [MP:0008715]| abnormal neuron differentiation [MP:0009937]| increased pituitary gland tumor incidence [MP:0010320]| increased hibernoma incidence [MP:0010344]| neonatal lethality [MP:0011087]| complete penetrance [MP:0030005]| thick pulmonary interalveolar septum [MP:0001179]| increased lung adenocarcinoma incidence [MP:0002027]| premature death [MP:0002083]| abnormal bronchiole morphology [MP:0002267]| abnormal tumor morphology [MP:0003448]| increased tumor growth/size [MP:0003721]| hematuria [MP:0005161]| increased lung tumor incidence [MP:0008014]| increased lung small cell carcinoma incidence [MP:0008715]| increased urinary bladder carcinoma incidence [MP:0009550]| abnormal cell death [MP:0000313]| abnormal cell proliferation [MP:0000350]| increased cell proliferation [MP:0000351]| abnormal hair follicle morphology [MP:0000377]| abnormal hair cycle [MP:0000427]| enlarged liver [MP:0000599]| mammary gland hyperplasia [MP:0000630]| abnormal branching of the mammary ductal tree [MP:0000662]| tremors [MP:0000745]| weakness [MP:0000746]| paralysis [MP:0000753]| hindlimb paralysis [MP:0000755]| abnormal corpus callosum morphology [MP:0000780]| abnormal cerebral cortex morphology [MP:0000788]| abnormal hippocampus morphology [MP:0000807]| abnormal cerebellum morphology [MP:0000849]| abnormal cerebellum external granule cell layer morphology [MP:0000872]| abnormal prostate gland morphology [MP:0001158]| abnormal lung morphology [MP:0001175]| lung hemorrhage [MP:0001182]| hyperpigmentation [MP:0001188]| skin lesions [MP:0001212]| thick epidermis [MP:0001219]| abnormal epidermis stratum basale morphology [MP:0001231]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| increased metastatic potential [MP:0001272]| decreased metastatic potential [MP:0001273]| abnormal retina morphology [MP:0001325]| abnormal locomotor behavior [MP:0001392]| ataxia [MP:0001393]| circling [MP:0001394]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| excessive scratching [MP:0001412]| increased circulating triglyceride level [MP:0001552]| hyperglycemia [MP:0001559]| extended life span [MP:0001661]| postnatal growth retardation [MP:0001732]| decreased IgM level [MP:0001806]| increased mammary adenocarcinoma incidence [MP:0001883]| respiratory failure [MP:0001953]| respiratory distress [MP:0001954]| increased pilomatricoma incidence [MP:0002013]| increased papilloma incidence [MP:0002014]| ovary cysts [MP:0002016]| increased tumor incidence [MP:0002020]| increased T cell derived lymphoma incidence [MP:0002024]| increased leukemia incidence [MP:0002026]| increased lung adenocarcinoma incidence [MP:0002027]| increased sarcoma incidence [MP:0002032]| increased rhabdomyosarcoma incidence [MP:0002036]| increased carcinoma incidence [MP:0002038]| increased lung adenoma incidence [MP:0002048]| decreased tumor incidence [MP:0002052]| decreased incidence of induced tumors [MP:0002053]| seizures [MP:0002064]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| no abnormal phenotype detected [MP:0002169]| gliosis [MP:0002183]| abnormal corpus epididymis morphology [MP:0002661]| increased circulating glucagon level [MP:0002712]| enhanced wound healing [MP:0002724]| abnormal melanocyte morphology [MP:0002877]| increased intestinal adenocarcinoma incidence [MP:0002957]| abnormal cell migration [MP:0003091]| abnormal telomere length [MP:0003155]| increased glucagonoma incidence [MP:0003365]| decreased tumor growth/size [MP:0003447]| abnormal tumor morphology [MP:0003448]| abnormal ovary physiology [MP:0003507]| increased uterus leiomyoma incidence [MP:0003570]| abnormal oviduct morphology [MP:0003574]| increased ovarian carcinoma incidence [MP:0003579]| abnormal prostate gland physiology [MP:0003607]| abnormal chromosome morphology [MP:0003702]| increased tumor growth/size [MP:0003721]| increased mouth tumor incidence [MP:0003750]| increased osteosarcoma incidence [MP:0003789]| abnormal hair shaft morphology [MP:0003809]| aneuploidy [MP:0004024]| increased squamous cell carcinoma incidence [MP:0004207]| increased basal cell carcinoma incidence [MP:0004208]| abnormal limb posture [MP:0004263]| increased incidence of tumors by chemical induction [MP:0004499]| increased incidence of tumors by UV-induction [MP:0004501]| decreased incidence of tumors by chemical induction [MP:0004502]| decreased hematopoietic stem cell number [MP:0004810]| abnormal class switch recombination [MP:0004816]| increased endometrial carcinoma incidence [MP:0004868]| abnormal endometrium morphology [MP:0004896]| enlarged uterus [MP:0004906]| decreased B cell number [MP:0005017]| decreased thyroid-stimulating hormone level [MP:0005134]| increased thyroid-stimulating hormone level [MP:0005135]| increased circulating cholesterol level [MP:0005178]| lethargy [MP:0005202]| abnormal eye anterior chamber morphology [MP:0005205]| abnormal eye posterior chamber morphology [MP:0005299]| dystonia [MP:0005323]| enlarged thyroid gland [MP:0005355]| hemoperitoneum [MP:0005435]| abnormal skin physiology [MP:0005501]| abnormal cell physiology [MP:0005621]| increased apoptosis [MP:0006042]| decreased apoptosis [MP:0006043]| increased medulloblastoma incidence [MP:0006283]| increased retinoblastoma incidence [MP:0006310]| increased ovary tumor incidence [MP:0008000]| increased gastric adenocarcinoma incidence [MP:0008010]| increased lung tumor incidence [MP:0008014]| abnormal brain white matter morphology [MP:0008026]| absent B-1a cells [MP:0008203]| decreased pre-B cell number [MP:0008209]| decreased immature B cell number [MP:0008215]| decreased IgG1 level [MP:0008495]| abnormal cytokine level [MP:0008713]| increased lung carcinoma incidence [MP:0008714]| increased lung small cell carcinoma incidence [MP:0008715]| decreased survivor rate [MP:0008770]| chromosomal instability [MP:0008866]| abnormal enterocyte proliferation [MP:0008883]| progressive hair loss [MP:0009004]| endometrium hyperplasia [MP:0009092]| increased pancreatic ductal adenocarcinoma incidence [MP:0009151]| increased pancreas tumor incidence [MP:0009153]| increased prostate intraepithelial neoplasia incidence [MP:0009219]| increased prostate gland adenocarcinoma incidence [MP:0009220]| increased brain tumor incidence [MP:0009277]| increased adenocarcinoma incidence [MP:0009308]| increased duodenum adenocarcinoma incidence [MP:0009311]| increased ovarian teratoma incidence [MP:0009442]| abnormal mammary gland alveolus morphology [MP:0009506]| increased urinary bladder carcinoma incidence [MP:0009550]| increased keratinocyte proliferation [MP:0009583]| hypergranulosis [MP:0009600]| increased skin squamous cell carcinoma incidence [MP:0009704]| decreased oligodendrocyte number [MP:0009808]| increased tumor latency [MP:0009828]| abnormal cerebellar layer morphology [MP:0009956]| abnormal cerebellar granule cell migration [MP:0009977]| abnormal tumor vascularization [MP:0010144]| decreased mammary gland tumor incidence [MP:0010269]| increased classified tumor incidence [MP:0010273]| increased melanoma incidence [MP:0010275]| increased astrocytoma incidence [MP:0010277]| increased glioma incidence [MP:0010278]| increased gastrointestinal tumor incidence [MP:0010279]| increased nervous system tumor incidence [MP:0010281]| decreased skin tumor incidence [MP:0010285]| increased mammary gland tumor incidence [MP:0010299]| increased skin tumor incidence [MP:0010300]| increased hamartoma incidence [MP:0010306]| abnormal tumor latency [MP:0010307]| decreased tumor latency [MP:0010308]| increased mesothelioma incidence [MP:0010309]| increased Schwannoma incidence [MP:0010310]| increased oligodendroglioma incidence [MP:0010312]| increased cholangiocarcinoma incidence [MP:0010315]| increased thyroid tumor incidence [MP:0010316]| increased pituitary gland tumor incidence [MP:0010320]| increased cutaneous melanoma incidence [MP:0010322]| pleural effusion [MP:0010334]| increased hibernoma incidence [MP:0010344]| increased thyroid carcinoma incidence [MP:0010346]| increased pancreatic islet cell carcinoma incidence [MP:0010348]| increased spindle cell carcinoma incidence [MP:0010367]| altered tumor pathology [MP:0010639]| increased glioblastoma incidence [MP:0010727]| abnormal hematopoietic stem cell physiology [MP:0010763]| increased type II pneumocyte number [MP:0010810]| abnormal pulmonary neuroendocrine body morphology [MP:0010918]| postnatal lethality [MP:0011086]| incomplete penetrance [MP:0011400]| lethality [MP:0011804]| complete penetrance [MP:0012043]| increased cell migration [MP:0012411]| increased myoepithelioma incidence [MP:0012431]| increased granulosa cell tumor incidence [MP:0012690]| increased lymphoma incidence [MP:0013184]| abnormal stride length [MP:0013236]| hemorrhagic ascites [MP:0013539]| ovary degeneration [MP:0013751]

Affected Gene: ACTB|tdTomato||EGFP||Rb1|Rbl2||Trp53|

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