URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=36521
Proper Citation: RRID:MMRRC_036521-UCD
Description: Mus musculus with name B6N;129S6-Raf1tm1.1Bgn/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| increased cranium width [MP:0000441]| flattened snout [MP:0000447]| enlarged spleen [MP:0000691]| decreased body length [MP:0001258]| decreased body weight [MP:0001262]| decreased body size [MP:0001265]| ocular hypertelorism [MP:0001300]| abnormal cardiovascular system physiology [MP:0001544]| cardiac hypertrophy [MP:0001625]| dilated cardiomyopathy [MP:0002795]| increased heart weight [MP:0002833]| thick ventricular wall [MP:0002953]| cardiac fibrosis [MP:0003141]| increased cardiac output [MP:0003394]| abnormal facial morphology [MP:0003743]| increased left ventricle systolic pressure [MP:0003820]| abnormal heart left ventricle morphology [MP:0003921]| increased response of heart to induced stress [MP:0004485]| enlarged myocardial fiber [MP:0004564]| decreased cardiac muscle contractility [MP:0005140]| increased cardiac muscle contractility [MP:0005599]| cardiac interstitial fibrosis [MP:0005608]| abnormal common myeloid progenitor cell morphology [MP:0006410]| decreased cranium height [MP:0008525]| enlarged heart right atrium [MP:0008727]| increased heart ventricle size [MP:0008772]| increased sensitivity to induced morbidity/mortality [MP:0009763]| increased heart left ventricle size [MP:0010579]| thick interventricular septum [MP:0010724]| abnormal heart left ventricle pressure [MP:0010754]| increased cardiac stroke volume [MP:0011951]
Affected Gene: Raf1
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)