URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32103
Proper Citation: RRID:MMRRC_032103-JAX
Description: Mus musculus with name B6.129S6-Ptpn11tm6Bgn/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Hematology, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal bone marrow cell number [MP:0000172]| increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| abnormal erythropoiesis [MP:0000245]| abnormal heart morphology [MP:0000266]| double outlet right ventricle [MP:0000284]| increased granulocyte number [MP:0000322]| decreased bone marrow cell number [MP:0000333]| enlarged liver [MP:0000599]| enlarged spleen [MP:0000691]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| anemia [MP:0001577]| premature death [MP:0002083]| abnormal definitive hematopoiesis [MP:0002123]| thin myocardium [MP:0002652]| increased atrioventricular cushion size [MP:0003808]| heart valve hyperplasia [MP:0003958]| decreased hematopoietic stem cell number [MP:0004810]| abnormal leukopoiesis [MP:0005460]| intermingled spleen red and white pulp [MP:0008475]| decreased cranium height [MP:0008525]| embryonic lethality [MP:0008762]| decreased common myeloid progenitor cell number [MP:0008813]| abnormal splenic cell ratio [MP:0008826]| abnormal liver sinusoid morphology [MP:0008989]| impaired cued conditioning behavior [MP:0009456]| abnormal hippocampus neuron morphology [MP:0009939]| ventricular septal defect [MP:0010402]| atrial septal defect [MP:0010403]| preweaning lethality [MP:0011100]| complete penetrance [MP:0013697]| decreased granulocyte monocyte progenitor cell number [MP:0030166]
Affected Gene: Ptpn11
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)