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Organism Name
A.129P2(B6)-Esr2tm1Unc/Mmmh
RRID:MMRRC_029908-MU RRID Copied  
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RRID:MMRRC_029908-MU
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Organism Information

URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=29908

Proper Citation: RRID:MMRRC_029908-MU

Description: Mus musculus with name A.129P2(B6)-Esr2tm1Unc/Mmmh from MMRRC.

Species: Mus musculus

Notes: Research areas: Cancer, Cardiovascular, Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: Targeted Mutation ; Collection:

Phenotype: decreased bone mineral density [MP:0000063]| abnormal vertebrae morphology [MP:0000137]| abnormal bone marrow cell number [MP:0000172]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| enlarged heart [MP:0000274]| abnormal myocardial fiber morphology [MP:0000278]| increased bone marrow cell number [MP:0000321]| increased granulocyte number [MP:0000322]| altered response to myocardial infarction [MP:0000343]| accelerated hair follicle regression [MP:0000392]| abnormal stomach morphology [MP:0000470]| abnormal enterocyte morphology [MP:0000479]| abnormal urinary bladder morphology [MP:0000538]| abnormal urinary bladder urothelium morphology [MP:0000540]| abnormal liver morphology [MP:0000598]| enlarged liver [MP:0000599]| enlarged spleen [MP:0000691]| spleen hyperplasia [MP:0000693]| spleen hypoplasia [MP:0000694]| enlarged lymph nodes [MP:0000702]| decreased brain size [MP:0000774]| abnormal substantia nigra morphology [MP:0000836]| abnormal somatosensory cortex morphology [MP:0000859]| uterus hypoplasia [MP:0001121]| abnormal ovary morphology [MP:0001126]| impaired ovarian folliculogenesis [MP:0001129]| absent corpus luteum [MP:0001134]| prostate gland epithelial hyperplasia [MP:0001167]| abnormal lung morphology [MP:0001175]| thin epidermis [MP:0001218]| increased body length [MP:0001257]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| increased aggression towards males [MP:0001354]| increased aggression towards females [MP:0001356]| increased anxiety-related response [MP:0001363]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| reduced long term potentiation [MP:0001473]| increased circulating HDL cholesterol level [MP:0001556]| anemia [MP:0001577]| cardiac hypertrophy [MP:0001625]| increased circulating luteinizing hormone level [MP:0001751]| thymus hypoplasia [MP:0001823]| mammary gland alveolar hyperplasia [MP:0001884]| reduced female fertility [MP:0001923]| male infertility [MP:0001925]| female infertility [MP:0001926]| decreased litter size [MP:0001935]| premature death [MP:0002083]| abnormal astrocyte morphology [MP:0002182]| abnormal seminiferous tubule morphology [MP:0002216]| abnormal pulmonary alveolus morphology [MP:0002270]| abnormal lymphopoiesis [MP:0002401]| abnormal B cell number [MP:0002458]| abnormal immunoglobulin level [MP:0002490]| abnormal sexual interaction [MP:0002566]| asthenozoospermia [MP:0002675]| decreased corpora lutea number [MP:0002680]| oligozoospermia [MP:0002687]| abnormal nociception after inflammation [MP:0002736]| decreased circulating follicle stimulating hormone level [MP:0002790]| colitis [MP:0002816]| increased heart weight [MP:0002833]| increased systemic arterial blood pressure [MP:0002842]| increased insulin sensitivity [MP:0002891]| abnormal bone mineralization [MP:0002896]| abnormal excitatory postsynaptic potential [MP:0002912]| increased vasoconstriction [MP:0003025]| abnormal long bone epiphyseal plate morphology [MP:0003055]| decreased insulin secretion [MP:0003059]| short femur [MP:0003109]| increased erythrocyte cell number [MP:0003131]| increased pre-B cell number [MP:0003132]| neuron degeneration [MP:0003224]| astrocytosis [MP:0003354]| decreased ovulation rate [MP:0003355]| abnormal response/metabolism to endogenous compounds [MP:0003638]| decreased aggression towards males [MP:0003862]| abnormal muscle electrophysiology [MP:0004145]| long femur [MP:0004348]| altered response of heart to induced stress [MP:0004484]| enlarged myocardial fiber [MP:0004564]| decreased circulating insulin-like growth factor I level [MP:0004701]| increased circulating insulin-like growth factor I level [MP:0004702]| abnormal auditory brainstem response [MP:0004738]| abnormal cochlear IHC afferent innervation pattern [MP:0004746]| abnormal surfactant physiology [MP:0004782]| abnormal class switch recombination [MP:0004816]| abnormal large intestine crypts of Lieberkuhn morphology [MP:0004842]| decreased male germ cell number [MP:0004901]| abnormal uterus weight [MP:0004903]| decreased uterus weight [MP:0004905]| abnormal behavior [MP:0004924]| decreased spleen weight [MP:0004953]| increased osteoblast cell number [MP:0004988]| increased double-positive T cell number [MP:0005091]| cachexia [MP:0005150]| increased circulating cholesterol level [MP:0005178]| abnormal serotonin level [MP:0005322]| ascites [MP:0005324]| insulin resistance [MP:0005331]| abnormal circulating protein level [MP:0005416]| abnormal leukopoiesis [MP:0005460]| increased chronic myelocytic leukemia incidence [MP:0005481]| hyporesponsive to tactile stimuli [MP:0005498]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| increased vasodilation [MP:0005590]| abnormal vascular smooth muscle morphology [MP:0005592]| abnormal vascular smooth muscle physiology [MP:0005595]| abnormal muscle contractility [MP:0005620]| decreased dopamine level [MP:0005643]| increased circulating leptin level [MP:0005669]| increased testis tumor incidence [MP:0006262]| abnormal intercalated disk morphology [MP:0006267]| abnormal mammary gland growth during pregnancy [MP:0006269]| abnormal mammary gland growth during lactation [MP:0006270]| increased ovary tumor incidence [MP:0008000]| dilated heart ventricle [MP:0008022]| decreased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD8-positive [MP:0008186]| alpha-beta T cell number [MP:0008254]| increased pro-B cell number [MP:0008547]| increased megakaryocyte cell number [MP:0008859]| abnormal neocortex morphology [MP:0008869]| abnormal hair cycle catagen phase [MP:0008874]| anovulation [MP:0008882]| decreased physiological sensitivity to xenobiotic [MP:0008883]| abnormal enterocyte physiology [MP:0008884]| abnormal enterocyte proliferation [MP:0008948]| abnormal enterocyte apoptosis [MP:0009171]| decreased neuron number [MP:0009257]| enlarged pancreatic islets [MP:0009285]| dilated seminiferous tubules [MP:0009304]| increased gonadal fat pad weight [MP:0009372]| increased retroperitoneal fat pad weight [MP:0009454]| abnormal cumulus oophorus [MP:0009456]| impaired contextual conditioning behavior [MP:0009504]| impaired cued conditioning behavior [MP:0009580]| abnormal mammary gland epithelium morphology [MP:0009646]| increased keratinocyte apoptosis [MP:0009763]| urinary bladder inflammation [MP:0009856]| increased sensitivity to induced morbidity/mortality [MP:0010024]| failure of ejaculation [MP:0010124]| increased total body fat amount [MP:0010386]| decreased bone mineral content [MP:0010967]| abnormal urinary bladder physiology [MP:0010968]| increased compact bone area [MP:0011473]| decreased compact bone area [MP:0011747]

Affected Gene: Esr2

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Data and Source Information

Source: Integrated Animals

Source Database: Mutant Mouse Resource and Research Center (MMRRC)