URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=29902
Proper Citation: RRID:MMRRC_029902-UCD
Description: Mus musculus with name STOCK Mfn2tm3Dcc/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cell Biology, Developmental Biology, Neurobiology, Reproduction; Mutation Type: Targeted Mutation ; Collection:
Phenotype: kyphosis [MP:0000160]| abnormal cerebellum morphology [MP:0000849]| small cerebellum [MP:0000852]| Purkinje cell degeneration [MP:0000876]| decreased body weight [MP:0001262]| decreased body size [MP:0001265]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| hunched posture [MP:0001505]| impaired righting response [MP:0001523]| impaired limb coordination [MP:0001524]| premature death [MP:0002083]| no abnormal phenotype detected [MP:0002169]| abnormal innervation [MP:0002184]| neurodegeneration [MP:0002229]| decreased vertical activity [MP:0002757]| increased neuron apoptosis [MP:0003203]| abnormal dopaminergic neuron morphology [MP:0003243]| loss of dopaminergic neurons [MP:0003244]| abnormal striatum morphology [MP:0004077]| abnormal axonal transport [MP:0004768]| bradykinesia [MP:0005156]| abnormal axon morphology [MP:0005404]| abnormal mitochondrion morphology [MP:0006035]| abnormal Purkinje cell dendrite morphology [MP:0008572]| abnormal respiratory electron transport chain [MP:0010955]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011087]| neonatal lethality [MP:0011088]| complete penetrance [MP:0011091]
Affected Gene: Mfn2
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)