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Organism Name
A.129P2(B6)-Esr1tm1Ksk/Mmmh
RRID:MMRRC_029880-MU RRID Copied  
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RRID:MMRRC_029880-MU
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Organism Information

URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=29880

Proper Citation: RRID:MMRRC_029880-MU

Description: Mus musculus with name A.129P2(B6)-Esr1tm1Ksk/Mmmh from MMRRC.

Species: Mus musculus

Notes: Research areas: Cancer, Cardiovascular, Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: Targeted Mutation ; Collection:

Phenotype: increased white adipose tissue amount [MP:0000008]| decreased bone mineral density [MP:0000063]| kyphoscoliosis [MP:0000069]| abnormal vertebrae morphology [MP:0000137]| abnormal bone marrow cell number [MP:0000172]| abnormal circulating cholesterol level [MP:0000180]| impaired fertilization [MP:0000242]| abnormal stomach glandular epithelium morphology [MP:0000473]| cortical renal glomerulopathies [MP:0000523]| abnormal hepatocyte morphology [MP:0000607]| abnormal mammary gland development [MP:0000628]| mammary gland hyperplasia [MP:0000630]| decreased thymocyte number [MP:0000715]| abnormal hypothalamus morphology [MP:0000837]| abnormal uterus morphology [MP:0001120]| uterus hypoplasia [MP:0001121]| abnormal ovary morphology [MP:0001126]| impaired ovarian folliculogenesis [MP:0001129]| absent corpus luteum [MP:0001134]| abnormal vagina epithelium morphology [MP:0001140]| abnormal testis morphology [MP:0001146]| seminiferous tubule degeneration [MP:0001154]| abnormal spermatogenesis [MP:0001156]| increased body length [MP:0001257]| decreased body length [MP:0001258]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| increased aggression towards females [MP:0001356]| abnormal mating receptivity [MP:0001376]| reduced male mating frequency [MP:0001380]| abnormal pup retrieval [MP:0001384]| pup cannibalization [MP:0001385]| abnormal maternal nurturing [MP:0001386]| hyperactivity [MP:0001399]| increased circulating HDL cholesterol level [MP:0001556]| hepatic necrosis [MP:0001654]| failure of embryo implantation [MP:0001728]| increased circulating luteinizing hormone level [MP:0001751]| thymus hypoplasia [MP:0001823]| liver inflammation [MP:0001860]| increased mammary adenocarcinoma incidence [MP:0001883]| mammary gland alveolar hyperplasia [MP:0001884]| mammary gland duct hyperplasia [MP:0001885]| reduced male fertility [MP:0001922]| male infertility [MP:0001925]| female infertility [MP:0001926]| premature death [MP:0002083]| abnormal skeleton development [MP:0002113]| abnormal definitive hematopoiesis [MP:0002123]| abnormal kidney physiology [MP:0002136]| abnormal B cell differentiation [MP:0002144]| abnormal innervation [MP:0002184]| abnormal seminiferous tubule morphology [MP:0002216]| abnormal B cell number [MP:0002458]| abnormal immunoglobulin level [MP:0002490]| abnormal sexual interaction [MP:0002566]| increased vertical activity [MP:0002574]| abnormal epididymis morphology [MP:0002631]| small uterus [MP:0002637]| asthenozoospermia [MP:0002675]| oligozoospermia [MP:0002687]| abnormal nociception after inflammation [MP:0002736]| glomerulonephritis [MP:0002743]| short tibia [MP:0002764]| decreased circulating luteinizing hormone level [MP:0002773]| decreased circulating testosterone level [MP:0002780]| increased circulating testosterone level [MP:0002781]| decreased circulating follicle stimulating hormone level [MP:0002790]| decreased heart weight [MP:0002834]| albuminuria [MP:0002871]| increased urine protein level [MP:0002962]| abnormal long bone epiphyseal plate morphology [MP:0003055]| short femur [MP:0003109]| abnormal response/metabolism to endogenous compounds [MP:0003638]| abnormal male reproductive system physiology [MP:0003698]| abnormal female reproductive system physiology [MP:0003699]| abnormal thymus physiology [MP:0003763]| decreased aggression towards males [MP:0003862]| impaired passive avoidance behavior [MP:0004000]| long femur [MP:0004348]| short ulna [MP:0004359]| altered response of heart to induced stress [MP:0004484]| decreased length of long bones [MP:0004686]| decreased circulating insulin-like growth factor I level [MP:0004701]| abnormal efferent ductules of testis morphology [MP:0004728]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal class switch recombination [MP:0004816]| ovary hemorrhage [MP:0004834]| abnormal testis weight [MP:0004850]| decreased testis weight [MP:0004852]| decreased energy expenditure [MP:0004890]| uterus atrophy [MP:0004894]| abnormal endometrium morphology [MP:0004896]| decreased male germ cell number [MP:0004901]| abnormal uterus weight [MP:0004903]| decreased uterus weight [MP:0004905]| abnormal epididymis epithelium morphology [MP:0004933]| decreased spleen weight [MP:0004953]| decreased thymus weight [MP:0004956]| decreased osteoblast cell number [MP:0004989]| decreased bone strength [MP:0004991]| decreased B cell number [MP:0005017]| increased double-positive T cell number [MP:0005091]| decreased circulating prolactin level [MP:0005121]| cachexia [MP:0005150]| increased circulating cholesterol level [MP:0005178]| decreased circulating estradiol level [MP:0005181]| increased circulating estradiol level [MP:0005182]| impaired glucose tolerance [MP:0005293]| insulin resistance [MP:0005331]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| abnormal circulating protein level [MP:0005416]| hyporesponsive to tactile stimuli [MP:0005498]| increased circulating glucose level [MP:0005559]| teratozoospermia [MP:0005578]| decreased lung weight [MP:0005631]| abnormal pituitary gland physiology [MP:0005646]| decreased aggression [MP:0005656]| increased circulating leptin level [MP:0005669]| increased testis tumor incidence [MP:0006262]| decreased long bone epiphyseal plate size [MP:0006396]| dilated rete testis [MP:0006423]| increased ovary tumor incidence [MP:0008000]| decreased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD8-positive [MP:0008097]| alpha-beta T cell number [MP:0008211]| increased plasma cell number [MP:0008215]| decreased mature B cell number [MP:0008332]| decreased immature B cell number [MP:0008481]| decreased lactotroph cell number [MP:0008487]| increased spleen germinal center number [MP:0008502]| abnormal mesonephros morphology [MP:0008737]| increased IgG3 level [MP:0008828]| abnormal spleen physiology [MP:0008869]| abnormal lymph node cell ratio [MP:0008872]| anovulation [MP:0008874]| abnormal physiological response to xenobiotic [MP:0008893]| decreased physiological sensitivity to xenobiotic [MP:0009118]| detached sperm flagellum [MP:0009130]| increased white fat cell size [MP:0009140]| increased white fat cell number [MP:0009205]| dilated efferent ductules of testis [MP:0009257]| abnormal internal male genitalia morphology [MP:0009285]| dilated seminiferous tubules [MP:0009288]| increased gonadal fat pad weight [MP:0009292]| increased epididymal fat pad weight [MP:0009300]| increased inguinal fat pad weight [MP:0009302]| increased parametrial fat pad weight [MP:0009304]| increased renal fat pad weight [MP:0009444]| increased retroperitoneal fat pad weight [MP:0009648]| ovarian follicular cyst [MP:0009674]| abnormal superovulation [MP:0009780]| decreased birth weight [MP:0009824]| abnormal chondrocyte physiology [MP:0009828]| spermatic granuloma [MP:0009856]| increased tumor latency [MP:0010024]| failure of ejaculation [MP:0010124]| increased total body fat amount [MP:0010299]| decreased bone mineral content [MP:0010792]| increased mammary gland tumor incidence [MP:0010967]| abnormal stomach mucosa morphology [MP:0010968]| increased compact bone area [MP:0011294]| decreased compact bone area [MP:0011353]| renal glomerulus hypertrophy [MP:0011750]| expanded mesangial matrix [MP:0011833]| abnormal seminiferous tubule epithelium morphology [MP:0020040]| abnormal cremaster muscle morphology [MP:0020137]| decreased bone ossification [MP:0020519]

Affected Gene: Esr1

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Data and Source Information

Source: Integrated Animals

Source Database: Mutant Mouse Resource and Research Center (MMRRC)