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Notch 1 (H-131) antibody

RRID:AB_650334

Antibody ID

AB_650334

Target Antigen

Notch 1 (H-131) mouse, rat, human, mouse, rat, human

Proper Citation

(Santa Cruz Biotechnology Cat# sc-9170, RRID:AB_650334)

Clonality

polyclonal antibody

Reference

PMID:28699891

Comments

Discontinued: 2016; validation status unknown check with seller; recommendations: WB, IP, IF, ELISA; Immunofluorescence; ELISA; Immunoprecipitation; Western Blot

Host Organism

rabbit

Vendor

Santa Cruz Biotechnology

Cat Num

sc-9170

Publications that use this research resource

Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.

  • Semerci F
  • Elife
  • 2017 Jul 12

Literature context:


Abstract:

Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the 'mother' cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.

Funding information:
  • NCI NIH HHS - P30 CA125123()
  • NCRR NIH HHS - S10 RR024574()
  • NIAID NIH HHS - P30 AI036211()
  • NICHD NIH HHS - U54 HD083092()
  • NIDCD NIH HHS - R01 DC006185()
  • NIDCD NIH HHS - R01 DC014832()
  • NIH HHS - S10 OD016167()