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p-Elk-1 (B-4) antibody

RRID:AB_627509

Antibody ID

AB_627509

Target Antigen

ELK1 human, mouse, rat

Proper Citation

(Santa Cruz Biotechnology Cat# sc-8406, RRID:AB_627509)

Clonality

monoclonal antibody

Reference

PMID:29681534

Comments

validation status unknown check with seller; recommendations: ELISA; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blot; Western Blotting, Immunoprecipitation, Immunofluorescence, Immunohistochemistry(P), ELISA

Clone ID

B-4

Host Organism

mouse

Vendor

Santa Cruz Biotechnology

Cat Num

sc-8406

Publications that use this research resource

Different Neuronal Activity Patterns Induce Different Gene Expression Programs.

  • Tyssowski KM
  • Neuron
  • 2018 May 2

Literature context:


Abstract:

A vast number of different neuronal activity patterns could each induce a different set of activity-regulated genes. Mapping this coupling between activity pattern and gene induction would allow inference of a neuron's activity-pattern history from its gene expression and improve our understanding of activity-pattern-dependent synaptic plasticity. In genome-scale experiments comparing brief and sustained activity patterns, we reveal that activity-duration history can be inferred from gene expression profiles. Brief activity selectively induces a small subset of the activity-regulated gene program that corresponds to the first of three temporal waves of genes induced by sustained activity. Induction of these first-wave genes is mechanistically distinct from that of the later waves because it requires MAPK/ERK signaling but does not require de novo translation. Thus, the same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations.

Funding information:
  • Cancer Research UK - C20691/A11834(United Kingdom)