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CD80 (B7-1) Monoclonal Antibody (16-10A1), PerCP-eFluor 710, eBioscience(TM)

RRID:AB_2573695

Antibody ID

AB_2573695

Target Antigen

CD80 (B7-1) See NCBI gene mouse

Proper Citation

(Thermo Fisher Scientific Cat# 46-0801-80, RRID:AB_2573695)

Clonality

monoclonal antibody

Reference

PMID:29150240

Comments

Applications: Flow (0.125 µg/test)

Clone ID

Clone 16-10A1

Host Organism

armenian hamster

Vendor

Thermo Fisher Scientific Go To Vendor

Cat Num

46-0801-80 also 46-0801

Publications that use this research resource

Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

  • Chang YH
  • Immunity
  • 2017 Nov 21

Literature context:


Abstract:

T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumulation and control of chronic lymphocytic choriomeningitis virus (LCMV). We found that type I interferon (IFN-I) induced TNFSF ligands GITRL, 4-1BBL, OX40L, and CD70 predominantly on monocyte-derived APCs and CD80 and CD86 predominantly on classical dendritic cells (cDCs). Mice with hypofunctional GITRL in Lyz2+ cells had decreased LCMV-specific CD4+ T cell accumulation and increased viral load. GITR signals in CD4+ T cells occurred after priming to upregulate OX40, CD25, and chemokine receptor CX3CR1. Thus IFN-I (signal 3) induced a post-priming checkpoint (signal 4) for CD4+ T cell accumulation, revealing a division of labor between cDCs and monocyte-derived APCs in regulating T cell expansion.

Funding information:
  • NIA NIH HHS - P01 AG017617(United States)