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D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified

RRID:AB_2565182

Antibody ID

AB_2565182

Target Antigen

D2-40 Lymphatic Endothelial Marker See NCBI gene human

Proper Citation

(BioLegend Cat# 916601, RRID:AB_2565182)

Clonality

monoclonal antibody

Reference

PMID:28340341

Comments

Applications: IHC

Clone ID

Clone D2-40

Host Organism

mouse

Vendor

BioLegend Go To Vendor

Cat Num

916601

Publications that use this research resource

Tridimensional Visualization and Analysis of Early Human Development.

  • Belle M
  • Cell
  • 2017 Mar 23

Literature context:


Abstract:

Generating a precise cellular and molecular cartography of the human embryo is essential to our understanding of the mechanisms of organogenesis in normal and pathological conditions. Here, we have combined whole-mount immunostaining, 3DISCO clearing, and light-sheet imaging to start building a 3D cellular map of the human development during the first trimester of gestation. We provide high-resolution 3D images of the developing peripheral nervous, muscular, vascular, cardiopulmonary, and urogenital systems. We found that the adult-like pattern of skin innervation is established before the end of the first trimester, showing important intra- and inter-individual variations in nerve branches. We also present evidence for a differential vascularization of the male and female genital tracts concomitant with sex determination. This work paves the way for a cellular and molecular reference atlas of human cells, which will be of paramount importance to understanding human development in health and disease. PAPERCLIP.