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pan-Tau antibody

RRID:AB_2315052

Antibody ID

AB_2315052

Target Antigen

Proper Citation

(M. Goedert, Medical Research Council Laboratory of Molecular Biology Cat# BR134, RRID:AB_2315052)

Clonality

unknown

Reference

PMID:20503426

Vendor

M. Goedert, Medical Research Council Laboratory of Molecular Biology

Cat Num

BR134

Publications that use this research resource

Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system.

  • Bullmann T
  • J. Comp. Neurol.
  • 2010 Jul 1

Literature context:


Abstract:

Tau is a microtubule-associated protein expressed predominantly in neurons. The transcript of the tau gene is alternatively spliced. Resulting isoforms contain three or four microtubule-binding repeats. The shortest tau isoform contains only three repeats (3R) and is expressed at birth. Previous data on rodents suggested that this isoform is no longer expressed during adulthood. It is replaced by tau isoforms containing four repeats (4R). The adult 4R tau isoforms bind to microtubules with higher affinity than 3R tau isoforms. Therefore, this isoform switch may reflect a need for more dynamic microtubules during development. Recently, we observed in rats that the 3R tau isoform is transiently expressed in adult neurogenesis. Subsequently, we performed an immunohistochemical labeling of the 3R tau isoform on serial sections of the adult rat brain. Interestingly, the 3R tau isoform is not only expressed in neuronal precursor cells. It is also present in mature neurons of the olfactory bulb, magnocellular neurosecretory system, posterolateral hypothalamus, locus coeruleus, raphe nucleus, solitary nucleus, medial septum and diagonal band, olfactory tuberculus, and piriform/olfactory cortex. This expression pattern is similar to that observed for the polysialylated form of the neuronal cell adhesion molecule (PSA-NCAM) and the microtubule-associated proteins doublecortin and collapsin response mediating protein (CRMP-4/TUC-4/Ulip-1), which are also highly expressed during early development. The retention of a juvenile phenotype in some neurons might be associated with a functionally significant neuronal plasticity.

Funding information:
  • NEI NIH HHS - R44 EY012332-03(United States)
  • Wellcome Trust - 086084(United Kingdom)